公开(公告)号：JP2008193981A

公开(公告)日：2008-08-28

申请号：JP2007034141

申请日：2007-02-14

Applicant: National Univ Corp Shizuoka Univ ,  Shizuoka Prefecture ,  国立大学法人静岡大学 ,  静岡県

Inventor： SUZUKI KAN ,  HANAI TAKAYUKI

IPC: C12P1/00

Abstract: PROBLEM TO BE SOLVED: To provide a new use of marine deep water, and to provide a method for simply and efficiently producing useful substances.
SOLUTION: This method for producing the useful substance comprises a production process for producing the useful substances from a microbial population in the marine deep water, while irradiating the collected marine deep water with light, and a recovery process for recovering the useful substance from the marine deep water after the production process. Here, it is preferable that the marine deep water be circulated, for example, in one direction, more preferably, in many directions.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供海洋深水的新用途，并提供简单有效地生产有用物质的方法。 解决方案：用于生产有用物质的方法包括用于从海洋深水中的微生物群体生产有用物质的方法，同时用光照射收集的海洋深水，以及回收有用物质的回收方法 从海洋深水后的生产过程。 这里，优选例如在一个方向上，更优选在多个方向上循环海洋深水。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008170245A

公开(公告)日：2008-07-24

申请号：JP2007003042

申请日：2007-01-11

Applicant: Shizuoka Prefecture ,  静岡県

Inventor： KUME KAZUNARI ,  HORIIKE TOSHIYUKI ,  HONMA NOBUYUKI ,  YAMASHITA SHOHEI ,  FUSAIE MASAHIRO

IPC: G01N1/22

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a novel useful search device which has a simple structure, prevents increase in production cost, eases post-treatment, shows a proper collection efficiency of a chemical substance and facilitates searching of an occurring region. SOLUTION: The base part 23 of a support element 21 and the body 5 of a closure cover 3 are constituted of a magnetic material, and a fixing element is constituted of a magnet 29 for producing magnetic attracting action between the closure cover 3 and the magnetic material of the support element 21. When the magnet 29 and the base part 23 of the support element 21 are respectively brought into contact with each other, at the opposed position of the outer and inner surfaces of the body 5 of the closure cover 3, the support element 21 is fixed to the closure cover 3 by a magnetic attractve force, and a diffusion sampler 15 is supported so that its axis becomes substantially parallel to the opening part 9 of the closure cover 3. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：为了提供一种结构简单的新颖有用的搜索装置，防止生产成本的增加，易于后处理，显示化学物质的适当收集效率，并且便于搜索发生的区域。 解决方案：支撑元件21的基部23和封盖3的主体5由磁性材料构成，并且固定元件由用于在封闭盖3之间产生磁吸引作用的磁体29构成 和支撑元件21的磁性材料。当支撑元件21的磁体29和基部23分别彼此接触时，在封闭件的主体5的外表面和内表面的相对位置 盖3，支撑元件21通过磁吸引力固定到封闭盖3，并且扩散取样器15被支撑成使得其轴线基本上平行于封闭盖3的开口部分9。版权所有： （C）2008，JPO＆INPIT

公开(公告)号：JP2008058208A

公开(公告)日：2008-03-13

申请号：JP2006237181

申请日：2006-09-01

Applicant: Bl:Kk ,  Shizuoka Prefecture ,  株式会社ビーエル ,  静岡県

Inventor： OTA TOSHIYA ,  IIZUKA CHIKAYO ,  YAMADA SHINYA ,  MOCHIZUKI TAKESHI ,  NANBA YASUHARU

IPC: G01N33/543 ,  C07K16/00 ,  C12N15/09 ,  C12P19/34 ,  C40B40/08 ,  G01N33/531

Abstract: PROBLEM TO BE SOLVED: To provide a sandwich type immunoassay using recombination protein having a bonding property to an antigen, especially an immuno-chromatography method, and recombination protein suitable for use for this. SOLUTION: In the sandwich type immunoassay using a first bonding material and a second bonding material to antigen to be measured, at least one of the first bonding material and second bonding material is made of recombination protein having a heavy chain variant-part and light chain variant-part of the antibody to the antigen. Preferably, the recombination protein is single-chain variant-part fragment type antibody (scFv antibody) obtained by a phage displaying method. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：使用具有与抗原结合特性的重组蛋白质，特别是免疫色谱法，以及适用于此的重组蛋白质提供夹层型免疫测定法。 解决方案：在使用第一接合材料和第二接合材料对要测量的抗原的夹心型免疫测定中，第一接合材料和第二接合材料中的至少一个由具有重链变体部分的重组蛋白质 和轻链变体部分抗原的抗体。 优选地，重组蛋白是通过噬菌体展示法获得的单链变体部分片段型抗体（scFv抗体）。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008031156A

公开(公告)日：2008-02-14

申请号：JP2007161257

申请日：2007-06-19

Applicant: National Univ Corp Shizuoka Univ ,  Shizuoka Prefecture ,  Yamasa Shoyu Co Ltd ,  ヤマサ醤油株式会社 ,  国立大学法人静岡大学 ,  静岡県

Inventor： MURATA TAKEOMI ,  HIDARI KAZUYA ,  USUI YASUICHI ,  SUZUKI TAKASHI ,  SUZUKI YASUO ,  TAKEDA SATOSHI ,  YAMADA KOHEI ,  NOGUCHI TOSHITADA

IPC: A61K31/7028 ,  A61P31/12 ,  C07H15/04

Abstract: PROBLEM TO BE SOLVED: To obtain an antiviral agent that has a strong adsorption inhibitory activity and infection inhibitory activity against viruses and is inexpensively produced. SOLUTION: The sialyl-poly-N-acetyllactosamine-containing artificial polypeptide is obtained by modifying the sialosugar chain part of a sialyl-N-acetyllactosamine-containing artificial polypeptide. The sialyl-N-acetyllactosamine-containing artificial sugar chain polypeptide is obtained by changing an α polyglutamic acid having a backbone of a sialyl-N-acetyllactosamine-containing artificial polypeptide into a γ-polyglutamic acid being a natural substance and inexpensive and changing a linker part. The sialyl-poly-N acetyllactosamine-containing artificial sugar chain polypeptide is obtained by changing a sialosugar chain part to a sialyl-poly-N-acetyllactosamine. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：获得具有强吸附抑制活性和对病毒感染抑制活性的抗病毒剂，并且成本低廉。 解决方案：通过改变含唾液酸-N-乙酰基乳糖胺的人造多肽的唾液酸链部分获得含唾液酸聚N-乙酰基乳糖胺的人造多肽。 含有唾液酰-N-乙酰乳糖胺的人造糖链多肽通过将具有唾液酸-N-乙酰基乳糖胺的人造多肽的骨架的α聚谷氨酸变为天然物质的γ-聚谷氨酸而得到，并且改变了接头 部分。 通过将唾液酸 - 多聚N-乙酰基乳糖胺改性唾液酸链部分，得到含唾液酸聚-N-乙酰乳糖胺的人造糖链多肽。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2008029710A

公开(公告)日：2008-02-14

申请号：JP2006208482

申请日：2006-07-31

Applicant: HAMAMATSU KAGAKU GIJUTSU KENKY ,  SHIZUOKA PREFECTURE

Inventor： TAKIGAWA MASAHIRO ,  KAWATSU KAZUJI ,  HARIYUKI TATSUYA

IPC: A61M37/00 ,  A61B17/20

Abstract: PROBLEM TO BE SOLVED: To provide a microneedle type patch punctured in the skin without its needle tip reaching the corium and administering medicine such as a vaccine material therefrom and to provide its manufacturing method. SOLUTION: This microneedle type patch is integrally formed with a plurality of projecting microneedles 2 on the back face of a sheet-shaped patch part 1 and punctures the needles into the skin while closely sticking the back face of the patch part 1 to the skin of a patient; and the length dimension (t) of the needle 2 from the base to the tip is defined as approximately 50-100 μm. COPYRIGHT: (C)2008,JPO&INPIT

公开(公告)号：JP2007215412A

公开(公告)日：2007-08-30

申请号：JP2006036377

申请日：2006-02-14

Applicant: Shizuoka Prefecture ,  静岡県

Inventor： AKIYAMA YASUTO ,  TAKIGAWA MASAKO ,  YONEMURA YUTAKA

IPC: C12Q1/68 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574

Abstract: PROBLEM TO BE SOLVED: To provide a method for judging malignant metastatic stomach cancer, a method for evaluating the risk of peritoneal metastasis and recurrence of the stomach cancer, a method for judging the effectiveness of an anticancer agent and a kit for them by elucidating the mechanism of the disseminating peritoneal metastasis of the stomach cancer and by identifying a protein becoming a target of a new treating agent or a tumor marker having a high specificity. SOLUTION: This method for judging malignant metastatic cancer is provided by comparing the two dimensional electrophoretic images of cell lysate of stomach cancer cell line MKN45 and its peritoneal disseminated metastatic cell line clone MKN45P by using a two-dimensional difference gel electrophoresis (2D-DIGE) method, and then picking up spots having the significantly different amounts of expressed proteins between the both cell lines by a statistical method, performing a mass spectrum analysis [MALDI-TOF (Matrix Assisted Laser Desorption Time of flight) MS: proteomics analyzer 4700] on protein at each of the spots and performing the search of data base. As a result, several kinds of proteins increase or decrease in the peritoneal disseminated metastatic cell line as compared with those of the stomach cancer cell line can be identified. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种判断恶性转移性胃癌的方法，评价腹膜转移和胃癌复发的风险的方法，用于判断抗癌剂的有效性的方法及其试剂盒 通过阐明胃癌传播腹膜转移的机制，并通过鉴定成为具有高特异性的新的治疗剂或肿瘤标志物的靶标的蛋白质。 解决方案：通过使用二维差分凝胶电泳（2D）比较胃癌细胞系MKN45的细胞裂解物及其腹膜播散转移细胞系克隆MKN45P的二维电泳图像，提供了判断恶性转移性癌症的方法 -DIGE）方法，然后通过统计学方法拾取具有显着不同量的表达蛋白质的斑点，进行质谱分析[MALDI-TOF（基质辅助激光解吸飞行时间）MS：蛋白质组学分析仪 4700]在蛋白质的每个点，并执行数据库的搜索。 结果，与胃癌细胞系相比，腹膜播散转移细胞系中的几种蛋白质增加或减少。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007098315A

公开(公告)日：2007-04-19

申请号：JP2005293168

申请日：2005-10-06

Applicant: Shizuoka Prefecture ,  静岡県

Inventor： SUGIYAMA OSAMU ,  NAKAYAMA HIROSHI ,  MANO TAKESHI ,  SHIBUYA YOSHIO

IPC: B01J35/02 ,  A61L9/00 ,  A61L9/16 ,  B01D39/14 ,  B01D53/86 ,  B01J37/02 ,  B01J37/08 ,  C02F1/32 ,  C02F1/72

Abstract: PROBLEM TO BE SOLVED: To provide a method for stably producing a porous film of a titanium oxide photocatalyst, which has a large effective surface area and high photocatalytic activity. SOLUTION: The method for producing the porous film of the titanium oxide photocatalyst comprises; a first spraying step of spraying a first dispersion containing titanium alkoxide and inorganic particles toward the surface of a base material heated to the temperature higher than room temperature; a second spraying step of spraying a second dispersion containing the inorganic particles toward the surface of the base material heated to ≥120°C; and a step of further heating the resulting base material without a break. Each of dispersions is sprayed while moving a spray nozzle to the horizontal direction of the base material surface, so that a uniform porous structure is formed over a wide range of the base material surface. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供一种稳定地制备氧化钛光催化剂的多孔膜的方法，其具有大的有效表面积和高的光催化活性。 解决方案：制备氧化钛光催化剂多孔膜的方法包括： 第一喷射步骤，向加热到高于室温的基材的表面喷射含有钛醇盐和无机颗粒的第一分散体; 第二喷射步骤，向加热至≥120℃的基材的表面喷射含有无机颗粒的第二分散体; 以及不间断地进一步加热所得到的基材的步骤。 在将喷嘴移动到基材表面的水平方向上时，分散体喷雾，从而在基材表面的宽范围内形成均匀的多孔结构。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006350375A

公开(公告)日：2006-12-28

申请号：JP2006216450

申请日：2006-08-09

Applicant: SHIZUOKA PREFECTURE ,  MEIDEN SOFTWARE CORP

Inventor： MIYAMOTO TADAHIKO ,  SANO SADAHIKO ,  UCHIYAMA TATSUHIKO ,  KAMOSHITA KENICHI ,  UEMATSU HIROSHI ,  HARAGUCHI TAKAFUMI

IPC: G09B21/04 ,  G06F3/048

Abstract: PROBLEM TO BE SOLVED: To solve the problem, wherein a support apparatus assisting conversation of a user who is handicapped in speech functions or auditory sense lacks customization properties. SOLUTION: The communication support apparatus for conversation training, based on a conversation information symbol implanted from a customization support apparatus, is provided with a means for recording operational records including determination and response time, when selecting the conversation information symbol of the user. The customization support apparatus for editing the conversation information symbol, including a picture symbol and a voice for performing conversation training by the visual and auditory senses, is provided with a means for analyzing the operational records that include determination and response time, when selecting the conversation information symbol of the user transferred from the communication support apparatus. Thus, the conversation information symbol is updated, and the support apparatus adapted to the degree of handicap can be provided. COPYRIGHT: (C)2007,JPO&INPIT

公开(公告)号：JP2006296417A

公开(公告)日：2006-11-02

申请号：JP2006035780

申请日：2006-02-13

Applicant: Pentax Corp ,  Shizuoka Prefecture ,  ペンタックス株式会社 ,  静岡県

Inventor： SUGIYAMA KANJI ,  OHATA KATSUHIKO ,  SUZUKI MITSUAKI ,  OZAKI FUMIE ,  ISHIKAWA TAKESHI ,  YOSHITAKE TOMOHIKO ,  KISHIRO KIKUKA

IPC: C12N1/20 ,  G01N30/00 ,  G01N30/88 ,  G01N33/48

Abstract: PROBLEM TO BE SOLVED: To provide a method for concentrating and eluting legionella bacteria enabling the bacteria in a liquid for treating the bacteria to be easily and efficiently retrieved, and to provide a kit for the method. SOLUTION: The method for concentrating and eluting legionella bacteria from a liquid 3 for treating the bacteria containing the same comprises the first step of contacting the liquid 3 with a carrier 1 where an area at least near the surface is composed mainly of a calcium phosphate-based compound to deposit the legionella bacteria on the carrier 1 and the second step of contacting a buffer solution 4 containing a buffering agent in a concentration of 25-500 mM with the resultant carrier 1 to isolate the legionella bacteria into the buffer solution 4 to concentrate and elute the bacteria(retrieve the bacteria into the buffer solution 4). COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种浓缩和洗脱军团菌细菌的方法，使得液体中的细菌能够容易且有效地回收细菌，并提供该方法的试剂盒。 解决方案：从用于处理含有它的细菌的液体3浓缩和洗脱军团菌细菌的方法包括使液体3与载体1接触的第一步骤，其中至少接近表面的区域主要由 磷酸钙类化合物将军团菌细菌沉积在载体1上，第二步是将含有25-500mM浓度的缓冲剂的缓冲溶液4与所得载体1接触，以将军团菌细菌分离成缓冲溶液 4浓缩和洗脱细菌（将细菌回收到缓冲溶液4中）。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006248974A

公开(公告)日：2006-09-21

申请号：JP2005067087

申请日：2005-03-10

Applicant: Kumiai Chem Ind Co Ltd ,  Shizuoka Prefecture ,  クミアイ化学工業株式会社 ,  静岡県

Inventor： HAKAMATA TETSUJI ,  YAMAGUCHI AKIRA ,  KATO KIMIHIKO ,  KAGEYAMA CHIZUKO ,  INAGAKI HIDEHIRO ,  IYOSUMI HIROYUKI ,  OZAKI KOICHI ,  WATANABE SATORU ,  MIURA ICHIRO

IPC: A01N37/44 ,  C07C227/40 ,  C07C229/28

Abstract: PROBLEM TO BE SOLVED: To provide a novel substance which is a natural substance originally existing in the natural world and can be used as an antibacterial or bactericidal agent in the agricultural field and the industrial field. SOLUTION: The industrial antibacterial or bactericidal agent has 2-amino-3-cyclopropylbutanoic acid as an active ingredient. This active ingredient compound can be extracted and isolated from Amanita cokeri of one kind of mushroom. The compound can be also extracted and isolated from Amanita castanopsidis Hongo of one kind of mushroom, and also can be produced by a chemical synthesis method. As the 2-amino-3-cyclopropylbutanoic acid, any one of a syn-form, an anti-form, and a mixture thereof is effective. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种原始存在于天然界中的天然物质的新型物质，可用作农业领域和工业领域的抗菌或杀菌剂。

解决方案：工业抗菌或杀菌剂具有2-氨基-3-环丙基丁酸作为活性成分。 这种活性成分的化合物可以从一种蘑菇的天竺葵草提取和分离。 该化合物也可以从一种蘑菇的马鞭草甘蓝提取和分离，也可以通过化学合成法生产。 作为2-氨基-3-环丙基丁酸，合成形式，抗形式及其混合物中的任一种是有效的。 版权所有（C）2006，JPO＆NCIPI