公开(公告)号：WO2007114947A2

公开(公告)日：2007-10-11

申请号：PCT/US2007008506

申请日：2007-04-04

Applicant: SINGULEX INC ,  GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

Inventor： GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

IPC: G06F15/00

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。

公开(公告)号：WO2005025642A3

公开(公告)日：2005-10-27

申请号：PCT/US2004028003

申请日：2004-08-27

Applicant: BAUMEISTER TODD JOHN

Inventor： BAUMEISTER TODD JOHN

IPC: A61L2/00 ,  A61L2/10 ,  A61M20060101 ,  A61M1/36

CPC classification number: A61L2/0011 ,  A01N1/02 ,  A01N1/0242 ,  A01N1/0294 ,  A61M1/3681 ,  A61M2205/053 ,  A61M2205/12

Abstract: A device (60) for irradiating blood is provided, the device including a chamber (62) having an elongate configuration defining a hollow interior, the chamber formed of reflective material, a tubular cassette (74) sized and shaped to be received in the interior (70) of the chamber, the tubular cassette (74) having an inside diameter sized and shaped to receive a reflective core (78) having an elongate configuration with an exterior diameter smaller than the interior diameter of the cassette to provide a space (75) for receiving and holding blood stationary, and an array of light-emitting members (80) arranged on the chamber for emitting light of at least one wavelength into the interior (70) of the chamber (62) for irradiating and treating the blood inside the cassette (74).

Abstract translation: 提供了一种用于照射血液的装置（60），该装置包括具有限定中空内部的细长构型的腔室（62），该腔室由反射材料形成，管状盒（74）的尺寸和形状被容纳在内部 （70），所述管状盒（74）的内径尺寸和形状适于容纳反射芯（78），所述反射芯具有细长结构，其外径小于所述盒的内径，以提供空间（75 ），用于接收和保持血液静止的发光元件阵列（80），布置在所述腔室上用于将至少一个波长的光发射到所述腔室（62）的内部（70）中，用于照射和处理血液内部 盒（74）。

公开(公告)号：WO1995017351A1

公开(公告)日：1995-06-29

申请号：PCT/GB1994002795

申请日：1994-12-22

Applicant: PROCEFF LIMITED ,  TODD, John, James ,  HOPWOOD, Adrian

Inventor： PROCEFF LIMITED

IPC: C02F03/20

CPC classification number: C02F3/085 ,  B01F3/04248 ,  B01F13/0238 ,  C02F3/10 ,  C02F3/201 ,  C02F3/203 ,  Y02W10/15

Abstract: A treatment vessel (50) contains a fluidizable bed (70) of loose particulate material comprising particles of sharp sand adhered to granules of polyethylene to provide a habitat for microorganisms effective in wastewater treatment. The material has a desired density slightly greater than 1.0 g/cc, a specific surface area in excess of 600 m /m , and a particule size range of about 3 mm to 10 mm. The bed and wastewater is fluidized and aerated by air bubbles emitted from self-sealing aerators (71) disposed at the base of the bed and arranged for placement and removal from above the water level. The loose material can rest directly on the aerator surface.

Abstract translation: 处理容器（50）包含松散颗粒材料的可流化床（70），其包括附着到聚乙烯颗粒上的锋利砂粒子，以提供对废水处理有效的微生物栖息地。 该材料具有稍大于1.0g / cc，比表面积超过600m 2 / m 3的期望密度，并且颗粒尺寸范围为约3mm至10mm。 床和废水通过从设置在床的底部的自密封充气器（71）排出的气泡流化和充气，并布置用于从水面上方放置和移除。 松散的材料可以直接放在曝气器表面上。

公开(公告)号：WO1992019546A1

公开(公告)日：1992-11-12

申请号：PCT/GB1992000800

申请日：1992-05-01

Applicant: TODD, John, James

IPC: C02F03/20

CPC classification number: C02F3/201 ,  B01F3/04269 ,  B01F2003/04297 ,  Y02W10/15

Abstract: An apertured flexible membrane (10) extends over a domed support (11). A central gas supply tube (50, 82) terminates in gas outlets (51) oriented to direct the gas to flow horizontally into the space (40) between the membrane and the support to inflate the membrane away from the support so that gas from the inflated space discharges through the apertures (60) as fine bubbles and such that when the gas supply ceases the membrane collapses back into area contact with the support to seal all the apertures. This reduces clogging. The aerator is useful in the aeration of sewage or waste water and in fish or eel farms.

Abstract translation: 多孔柔性膜（10）在圆顶支撑件（11）上延伸。 中心气体供应管（50,82）终止于取向为引导气体水平地流入膜和支撑件之间的空间（40）中的气体出口（51），以将膜从支撑体中膨胀，使得来自 充气空间通过孔（60）作为微小气泡排放，并且使得当气体供应停止时，膜折叠回与支撑件的区域接触以密封所有孔。 这减少了堵塞。 曝气器可用于污水或废水以及鱼或鳗鱼养殖场的曝气。

公开(公告)号：WO2012172376A2

公开(公告)日：2012-12-20

申请号：PCT/GB2012/051397

申请日：2012-06-18

Applicant: PERSONNEL HYGIENE SERVICES LIMITED ,  TODD, John

Inventor： TODD, John

IPC: A47K10/48

CPC classification number: A47K10/48

Abstract: A hand dryer (1) includes a fan (4), and a housing defining a fan chamber (16) arranged to receive blown air from the fan (4). The fan chamber 16 comprises an outlet (44) defining the air outlet of the dryer (1) through which air is blown directly to the outside atmosphere. The fan chamber (16) is configured such that it tapers towards the outlet (44) to accelerate air flow therethrough. The outlet (44) comprises an elongate slot and the fan chamber (16) tapers to the elongate slot to optimise drying airflow for hand drying with the letterbox configuration providing an airflow which effectively spans a user's hands during drying.

Abstract translation: 手干燥器（1）包括风扇（4）和限定了用于接收来自风扇（4）的吹风的风扇室（16）的壳体。 风扇室16包括限定干燥器（1）的空气出口的出口（44），空气通过该出口直接吹向外部气氛。 风扇室（16）构造成使得其朝向出口（44）逐渐变细，以加速通过其中的空气流动。 出口（44）包括细长的狭槽，并且风扇室（16）逐渐变细到细长槽，以优化干燥气流，以便用信箱配置进行手干，从而提供在干燥期间有效跨越使用者的手的气流。

公开(公告)号：WO2009126380A8

公开(公告)日：2010-11-04

申请号：PCT/US2009036086

申请日：2009-03-04

Applicant: SINGULEX INC ,  GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD A ,  HELD DOUGLAS ,  AGEE SARA

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD A ,  HELD DOUGLAS ,  AGEE SARA

IPC: G01N33/53

CPC classification number: G01N33/577 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/412 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7264 ,  A61B5/7275 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6872 ,  G01N33/6887 ,  G01N33/6896 ,  G01N33/74 ,  G01N33/92 ,  G01N2333/4712 ,  G01N2333/475 ,  Y02A90/26 ,  Y10T436/143333

Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.

Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者中的病症的方法，包括检测来自受试者的第一样品中的第一标志物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTn1） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。

公开(公告)号：WO2010144358A1

公开(公告)日：2010-12-16

申请号：PCT/US2010/037613

申请日：2010-06-07

Applicant: SINGULEX, INC. ,  GOIX, Philippe, J. ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas ,  AGEE, Sara

Inventor： GOIX, Philippe, J. ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas ,  AGEE, Sara

IPC: G01N33/68 ,  G01N33/52

CPC classification number: G01N33/6869 ,  G01N33/6893 ,  G01N2333/32 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/32 ,  G01N2800/325 ,  G01N2800/60

Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.

Abstract translation: 心血管疾病，例如充血性心力衰竭，经常在临床症状发作后首先诊断，消除早期干预的可能性。 本发明提供了多标志物免疫测定，包括心脏病理学和血管炎症生物标志物，产生用于血浆中CHF早期检测的更敏感的测定。 由心脏病理学（cTnl，BNP）和血管炎症（IL-6，TNFa，IL-17a）生物标记组成的小组提供了与CHF相关的94％的灵敏度。

公开(公告)号：WO2010033838A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/057532

申请日：2009-09-18

Applicant: SINGULEX, INC. ,  TODD, John

Inventor： TODD, John

IPC: G01N33/537 ,  G01N33/543

CPC classification number: G01N33/6827 ,  G01N33/54333 ,  G01N33/6869 ,  G01N33/74 ,  G01N2333/46 ,  G01N2333/4712 ,  G01N2333/475 ,  G01N2333/525 ,  G01N2333/535 ,  G01N2333/54 ,  G01N2333/5412 ,  G01N2333/5418 ,  G01N2333/545 ,  G01N2333/555

Abstract: Single molecule analysis of species of use in analytical, diagnostic or prognostic assays is disclosed In exemplary embodiments, the assays utilize samples prepared by the disclosed methods, affording assays of unexpected sensitivity and robustness The method is described in a non-limiting manner by reference to cytokine assays

Abstract translation: 公开了在分析，诊断或预后测定中使用的物种的单分子分析。在示例性实施方案中，测定法利用通过公开的方法制备的样品，提供意想不到的灵敏度和鲁棒性的测定。该方法以非限制性方式通过参考 细胞因子测定

公开(公告)号：WO2009029550A2

公开(公告)日：2009-03-05

申请号：PCT/US2008/074124

申请日：2008-08-22

Applicant: SINGULEX, INC. ,  TODD, John, A. ,  LU, Ann

Inventor： TODD, John, A. ,  LU, Ann

IPC: G01N33/53 ,  C07K16/00

CPC classification number: G01N33/57434 ,  C07K16/3069 ,  G01N33/57415 ,  G01N33/58 ,  G01N2333/96455 ,  G01N2800/52 ,  G01N2800/54

Abstract: The invention described herein provides methods, compositions, kits, and systems for the sensitive detection of prostate specific antigen. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of prostate specific antigen.

Abstract translation: 本文描述的本发明提供了用于敏感检测前列腺特异性抗原的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及前列腺特异性抗原释放的病症中的诊断，预后和测定方法中是有用的。

公开(公告)号：WO2008131274A3

公开(公告)日：2008-10-30

申请号：PCT/US2008/060893

申请日：2008-04-18

Applicant: BAUMEISTER, Todd, John

Inventor： BAUMEISTER, Todd, John

IPC: B23D33/02 ,  B27B27/06

Abstract: A device for stabilizing a workpiece on a work table is provided that includes a cam member having a spiral-shaped bearing face that engages the workpiece when the workpiece moves in a first direction to urge the workpiece against a table top, fence, or other structure to prevent kickback and that rotates in an opposite direction to allow the workpiece to move without interference toward a working tool associated with the work table. A torsion spring urges the cam member to rotate into constant contact with the workpiece to provide instant reaction to a kickback situation. In addition, the cam member guides the workpiece as it moves on the work table. A base enables adjustment longitudinally, laterally, and orthogonally with respect to the work table.