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公开(公告)号：KR1020080110943A
公开(公告)日：2008-12-22
申请号：KR1020050102895
申请日：2005-10-31
Applicant: (주)아모레퍼시픽
IPC: A61K31/335 , A61P19/02 , A61K8/49
Abstract: A composition for promoting the generation of hyaluronic acid containing Musk T is provided to realize the prevention and treatment of the degenerative arthritis. A composition for promoting the generation of hyaluronic acid contains Musk T with the concentration of 1.0 ~ 10 mug/ml as an active ingredient. The composition is for the oral or external use. The composition for treating degenerative arthritis contains a composition for promoting the generation of hyaluronic acid. A skin anti-aging composition contains a composition for promoting the generation of hyaluronic acid.
Abstract translation: 提供了用于促进含有Musk T的透明质酸的产生的组合物，以实现对退行性关节炎的预防和治疗。 用于促进透明质酸产生的组合物含有浓度为1.0〜10ug / ml的Musk T作为活性成分。 组合物用于口服或外用。 用于治疗退行性关节炎的组合物含有促进透明质酸产生的组合物。 皮肤抗衰老组合物含有促进透明质酸产生的组合物。
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公开(公告)号：KR1020080079802A
公开(公告)日：2008-09-02
申请号：KR1020070020263
申请日：2007-02-28
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/007 , A61K8/97
Abstract: A composition comprising an extract of Scrophularia buergeriana Miq. and an extract of poria cocos wolf is provided to prevent or improve skin dryness, atopic dermatitis, cotagious dermatitis or eczema and be usefully used as a cosmetic or a pharmaceutical composition for reinforcing skin barrier function and inducing skin keratinocyte differentiation. A skin external application composition for moisturizing comprises 0.0001-30 wt.% of an extract of Scrophularia buergeriana Miq. as an effective ingredient. The composition further comprises an extract of Poria cocos wolf. In the composition, the extract of the Scrophularia buergeriana Miq. is prepared by extracting or fractionating the Scrophularia buergeriana Miq. with a solvent selected from the group consisting of water, ethanol, methanol, hexane, ethylacetate and butanol. Further, the skin external application composition is used as ointment, gel, cream or powder.
Abstract translation: 一种组合物，其包含玄参（Scrophularia buergeriana Miq）的提取物。 并提供茯苓狼提取物以预防或改善皮肤干燥，特应性皮炎，共病性皮炎或湿疹，并且可用作增强皮肤屏障功能和诱导皮肤角质形成细胞分化的化妆品或药物组合物。 用于保湿的皮肤外用组合物包含0.0001-30重量％的Scrophularia buergeriana Miq的提取物。 作为有效成分。 该组合物还包含茯苓的提取物。 在组合物中，Sc藜提取物 通过提取或分馏糠Sc（Scrophularia buergeriana Miq）制备。 使用选自水，乙醇，甲醇，己烷，乙酸乙酯和丁醇的溶剂。 此外，皮肤外用组合物用作软膏剂，凝胶剂，霜剂或粉剂。
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公开(公告)号：KR1020080071782A
公开(公告)日：2008-08-05
申请号：KR1020070010081
申请日：2007-01-31
Applicant: (주)아모레퍼시픽
Abstract: A skin whitening composition comprising D-aspartate is provided to inhibit melanogenesis effectively and stably without cytotoxicity and without side effects by inhibiting generation of proopiomelanocorin(POMC) from skin cells when applied to skin. A skin whitening composition comprises 0.01-20 wt.% of D-aspartate as an effective ingredient. The composition further comprises at least one whitening agent selected from the group consisting of kojic acid, arbutin, vitamin C and an extract of Broussonetia kazinoki.
Abstract translation: 提供包含D-天冬氨酸的皮肤美白组合物，用于在施用于皮肤时通过抑制皮肤细胞产生原花青素（POMC）而有效地和稳定地抑制黑素生成而没有细胞毒性并且没有副作用。 皮肤美白组合物含有0.01-20重量％的D-天冬氨酸作为有效成分。 组合物还包含至少一种选自曲酸，熊果苷，维生素C和布鲁氏菌属的提取物的增白剂。
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公开(公告)号：KR1020080003182A
公开(公告)日：2008-01-07
申请号：KR1020060124102
申请日：2006-12-07
Applicant: (주)아모레퍼시픽
CPC classification number: C01B33/12 , A61K8/25 , A61K8/34 , A61Q19/00 , A61Q19/007 , C01P2004/61 , C01P2006/12 , C01P2006/16 , C07C31/207 , C07C31/245
Abstract: Porous silica complex powder is provided to have an excellent performance in moisturizing and water retention, by adsorbing or collecting pentaerythritol derivatives and higher alcohol or polyol on porous silica. Complex powder is prepared by adsorbing or collecting pentaerythritol derivatives and higher alcohol or polyol containing 16-22 carbons on porous silica. The higher alcohol is 2-octyl dodecanol. The polyol is selected from a group consisting of dipropylene glycol, a sorbitols solution, glycerol, molasses, polyethylene glycol, glucose, propylene glycol, and 1,3-butylene glycol. The pentaerythritol derivatives and the higher alcohol or the polyol are mixed at a weight ratio of 1:0.1-0.6. Further, a particle size of the complex powder is 0.2-50mum, and a pore of the complex powder is 1-50nm.
Abstract translation: 提供多孔二氧化硅复合粉末，通过在多孔二氧化硅上吸附或收集季戊四醇衍生物和高级醇或多元醇，具有优异的保湿和保水性能。 通过在多孔二氧化硅上吸附或收集含有16-22个碳的季戊四醇衍生物和高级醇或多元醇制备复合粉末。 高级醇是2-辛基十二烷醇。 多元醇选自二丙二醇，山梨糖醇溶液，甘油，糖蜜，聚乙二醇，葡萄糖，丙二醇和1,3-丁二醇。 季戊四醇衍生物和高级醇或多元醇以1：0.1-0.6的重量比混合。 此外，复合粉末的粒径为0.2〜50μm，复合粉末的孔径为1-50nm。
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公开(公告)号：KR1020080003178A
公开(公告)日：2008-01-07
申请号：KR1020060119434
申请日：2006-11-30
Applicant: (주)아모레퍼시픽
Abstract: A composite powder, and a cosmetic composition containing the composite powder are provided to improve water content, moisturizing effect and moisturizing power keeping effect. A composite powder comprises porous silica; and a mixture of a pentaerythritol derivative and water which is adsorbed to and trapped in the porous silica. Preferably the mixture comprises further a C16-C22 alcohol; and/or glycerin. Preferably the pentaerythritol derivative is represented by the formula 1, wherein R is independently identical or different one another and is H, or a C1-C24 saturated or unsaturated and linear or branched alkyl group containing or not containing a hydroxyl group; m is identical or different one another and is an integer of 0-10; and n is identical or different one another and is an integer of 1-10.
Abstract translation: 提供复合粉末和含有复合粉末的化妆品组合物，以提高含水量，保湿效果和保湿功效。 复合粉末包括多孔二氧化硅; 以及季戊四醇衍生物和水的混合物，其被吸附并捕获在多孔二氧化硅中。 优选地，该混合物还包含C16-C22醇; 和/或甘油。 优选地，季戊四醇衍生物由式1表示，其中R独立地相同或不同，为H，或含有或不含羟基的C1-C24饱和或不饱和和直链或支链烷基; m相同或不同，为0-10的整数; 且n相同或不同，为1-10的整数。
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Patent Agency Ranking
公开(公告)号：KR100775095B1
公开(公告)日：2007-11-08
申请号：KR1020060116740
申请日：2006-11-24
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition for whitening skin containing tyrosol derivatives is provided to suppress pigment permeation, improve spots and freckles, and whiten the skin by inhibiting melanin formation without side effects. A skin external composition for whitening skin contains 0.001-10 wt.% of tyrosol derivatives represented by the formula(1), wherein Ar1 is the structural formula(1-a), Ar2 is the structural formula(1-b), m is an integer of 1 or 2 and n is an integer of 2 or 3, and is formulated as soft lotion, astringent lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, gel, pack, powder, body lotion, body cream, body oil or body essence.
Abstract translation: 提供含有酪醇衍生物的皮肤美白皮肤外用组合物，以抑制颜料渗透，改善斑点和雀斑，并通过抑制黑色素形成而使副作用变白来增白皮肤。 用于美白皮肤的皮肤外用组合物含有0.001-10重量％的由式（1）表示的酪醇衍生物，其中Ar 1是结构式（1-a），Ar 2是结构式（1-b），m是 1或2的整数，n为2或3的整数，并配制为柔软洗剂，涩味洗剂，营养乳液，营养霜，按摩霜，精华液，眼霜，眼睛精华，清洁霜，清洁泡沫，清洁 水，凝胶，包装，粉末，身体乳液，身体霜，身体油或身体精华。
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公开(公告)号：KR1020070095709A
公开(公告)日：2007-10-01
申请号：KR1020060026238
申请日：2006-03-22
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/97 , A61K2800/782 , A61Q19/00
Abstract: A cosmetic composition is provided to inhibit the amount of sebum produced from sebocytes by inhibiting the formation and activity of SREBP-1(Sterol Regulatory Element Binding Protein-1), thereby capable of effectively improving sebum metabolism and acne. A cosmetic composition comprises 0.001-30 wt.% of at least one selected from the group consisting of catechin such as epigallocatechin gallate(EGCG), gallocatechin gallate(GCG) and a mixture thereof and flavonols such as quercetin, kaempferol and myricetin as effective ingredients and is characterized in that it inhibit the formation and activity of SREBP-1 which is a transcription factor.
Abstract translation: 提供化妆品组合物，通过抑制SREBP-1（甾醇调节元件结合蛋白-1）的形成和活性来抑制由皮脂细胞产生的皮脂的量，从而能够有效地改善皮脂代谢和痤疮。 化妆品组合物包含0.001-30重量％的选自儿茶素如表没食子儿茶素没食子酸酯（EGCG），没食子儿茶素没食子儿茶素（GCG）及其混合物中的至少一种，和黄酮醇如槲皮素，山奈酚和杨梅素作为有效成分 其特征在于它抑制作为转录因子的SREBP-1的形成和活性。
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公开(公告)号：KR1020070091964A
公开(公告)日：2007-09-12
申请号：KR1020060021797
申请日：2006-03-08
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition is provided to inhibit TNF-alpha(Tumor Necrosis Factor-alpha) and the expression of MMP-1 through activation of PPAR-alpha(Peroxisome Proliferator Activated Receptor-alpha), thereby inhibiting skin aging. A skin external composition comprises 0.001-10 wt.% of at least one kind selected from the group consisting of epigallocatechin(EGCG), gallocatechingallate(GCG), epicatechin gallate(ECG), catechin gallate(CG), catechin(C), gallic acid, quercetin, kaempferol, theobromine, theophylline, theanine, quinic acid, an ethanol extract of green tea leaves, an aqueous extract of green tea leaves, an extract of catechin 1 including 70% of catechin and an extract of catechin 2 including 50% of EGCG as an effective ingredient.
Abstract translation: 提供皮肤外用组合物以通过激活PPAR-α（过氧化物酶体增殖剂活化受体-α）抑制TNF-α（肿瘤坏死因子-α）和MMP-1的表达，从而抑制皮肤老化。 皮肤外用组合物包含0.001-10重量％的选自下组的至少一种：表没食子儿茶素（EGCG），gallocatechingallate（GCG），表儿茶素没食子酸酯（ECG），儿茶素没食子酸酯（CG），儿茶素（C） 酸，槲皮素，山奈酚，可可碱，茶碱，茶氨酸，奎尼酸，绿茶叶的乙醇提取物，绿茶叶的水提物，儿茶素1的提取物，其中儿茶素含量为70％，儿茶素2提取物含50％ 的EGCG作为有效成分。
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公开(公告)号：KR100757043B1
公开(公告)日：2007-09-07
申请号：KR1020060101316
申请日：2006-10-18
Applicant: (주)아모레퍼시픽
Abstract: A cationic polymer nanocapsule comprising useful active ingredients and a cosmetic composition containing the same nanocapsule are provided to enhance the skin penetration of useful active ingredients having low skin penetration. A cationic polymer nanocapsule has the molecular weight of 5,000-100,000 dalton, surface potential of 5-100 Mv and particle size of 50-500 nm, and comprises at least one useful active ingredient selected from retinol, retinyl acetate, retinyl palmitate, alpha-tocopherol, tocopherol acetate, tocopheryl linoleate, tocopheryl nicotinate, linoleic acid, coenzyme Q-10, resveratrol, plant extract essential oil, ursolic acid, oleanolic acid, useful Glycyrrhiza uralensis and lipoic acid. A cosmetic composition comprises 0.1-10 wt.% of the cationic polymer nanocapsule and is formulated as soft lotion, nutrition lotion, massage cream, nutrition cream, pack, gel, essence, lipstick, makeup base, foundation, lotion, ointment, cream, patch or spray.
Abstract translation: 提供了包含有用的活性成分和含有相同纳米胶囊的化妆品组合物的阳离子聚合物纳米胶囊，以增强具有低皮肤渗透性的有用活性成分的皮肤渗透。 阳离子聚合物纳米胶囊具有5,000-100,000道尔顿的分子量，5-100Mv的表面电位和50-500nm的粒度，并且包含至少一种有用的活性成分，其选自视黄醇，乙酸视黄酯，棕榈酸视黄酯， 生育酚，生育酚乙酸酯，生育酚亚油酸酯，生育酚酰基烟酸酯，亚油酸，辅酶Q-10，白藜芦醇，植物提取物精油，熊果酸，齐墩果酸，有用的甘草和硫辛酸。 化妆品组合物包含0.1-10重量％的阳离子聚合物纳米胶囊，并配制成软洗剂，营养乳液，按摩膏，营养霜，包装，凝胶，精华，口红，化妆基质，粉底液，软膏，霜剂， 贴片或喷雾。
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150.发明授权
公开(公告)号：KR100740575B1
公开(公告)日：2007-07-18
申请号：KR1020060029631
申请日：2006-03-31
Applicant: (주)아모레퍼시픽
IPC: C07D319/18 , C07D317/60
Abstract: 2,3-Dihydroxybenzoic acid derivatives, a preparation method thereof, and a skin-whitening cosmetic composition containing the same compounds are provided to inhibit activity of tyrosinase and melanin formation while cytotoxicity of the compounds is very low, so that the compounds are useful for improvement of pigmentation in the skin. The method for preparing the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1) comprises the steps of: (A) reacting 2,3-dihydroxybenzoic acid with acetic acid anhydride in the presence of base to prepare a 2,3-diacetyloxybenzoic acid compound represented by the formula(2); (B) preparing an amide compound represented by the formula(3) from the 2,3-diacetyloxybenzoic acid compound by using ethylchloroformate and amine having a lipophilic group; and (C) hydrolyzing an acetyl group of the amide compound represented by formula (3) to prepare 2,3-dihydroxybenzoic acid represented by the formula (1), wherein R is 4-ethoxyphenyl, 2-cyclohexenylethyl, cycloheptyl, cyclohexyl, tert-octyl, 4-isopropylphenyl, 2,3-dihydrobenzo[1,4]dioxin-7-yl, benzo[1,3]-dioxol-6-yl or adamantyl-1-yl; and the amine having the lipophilic group is an amine selected from 4-ethoxyphenylamine, 2-cyclohexenylethylamine, cycloheptylamine, cyclohexylamine, tert-octylamine, 4-isopropylphenylamine, 2,3-dihydrobenzo[1,4]dioxin-7-amine, benzo[1,3]-dioxol-6-amine or adamantyl-1-amine. The skin-whitening cosmetic composition contains 0.01-20 wt.% of the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1).
Abstract translation: 提供了2,3-二羟基苯甲酸衍生物，其制备方法和含有相同化合物的美白化妆品组合物，以抑制酪氨酸酶的活性和黑色素形成，同时化合物的细胞毒性非常低，使得该化合物可用于 改善皮肤色素沉着。 制备式（1）代表的2,3-二羟基苯甲酸衍生物的方法包括以下步骤：（A）使2,3-二羟基苯甲酸与乙酸酐在碱存在下反应，制得2,3-二羟基苯甲酸衍生物， 由式（2）表示的二乙酰氧基苯甲酸化合物; （B）使用氯甲酸乙酯和具有亲油性基团的胺，由2,3-二乙酰氧基苯甲酸化合物制备式（3）所示的酰胺化合物; （C）水解式（3）所示的酰胺化合物的乙酰基，制备式（1）所示的2,3-二羟基苯甲酸，其中R为4-乙氧基苯基，2-环己烯基乙基，环庚基，环己基，叔丁基 - 辛基，4-异丙基苯基，2,3-二氢苯并[1,4]二氧杂环己烯-7-基，苯并[1,3] - 二氧杂环戊烯-6-基或金刚烷基-1-基; 具有亲脂性基团的胺是选自4-乙氧基苯胺，2-环己烯基乙胺，环庚胺，环己胺，叔辛胺，4-异丙基苯胺，2,3-二氢苯并[1,4]二氧杂环己烯-7-胺，苯并[ 1,3] - 二氧六环-6-胺或金刚烷基-1-胺。 该美白化妆品组合物含有0.01-20重量％的由式（1）表示的2,3-二羟基苯甲酸衍生物。
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