公开(公告)号：EP2280712A4

公开(公告)日：2013-01-02

申请号：EP09733217

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

IPC: A61K31/585 ,  A61K9/00 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/58 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/585 ,  A61K47/34

公开(公告)号：EP2276459A4

公开(公告)日：2011-11-16

申请号：EP09733288

申请日：2009-04-17

Applicant: MEDTRONIC INC ,  WARSAW ORTHOPEDIC INC

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/255 ,  A61P29/00

CPC classification number: A61K31/255 ,  A61K9/0024 ,  A61K9/204

公开(公告)号：EP2229171A4

公开(公告)日：2011-04-27

申请号：EP09733201

申请日：2009-04-17

Applicant: MEDTRONIC INC

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  SHAW KATARA ,  WOHABREBBI AMIRA ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

IPC: A61K47/34 ,  A61K9/20 ,  A61K31/4458 ,  A61P29/00

CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/7007 ,  A61K31/4458

公开(公告)号：EP2187866A4

公开(公告)日：2010-09-15

申请号：EP09732088

申请日：2009-04-13

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  COX S MARK ,  MCKAY WILLIAM F ,  REMSEN KATHY L

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/573 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

Abstract: Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

Abstract translation: 提供长时间急性疼痛的有效治疗。 通过在目标部位或其附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。