公开(公告)号：EP2315002A3

公开(公告)日：2012-12-05

申请号：EP10012503.8

申请日：1999-05-17

Applicant: Life Technologies Corporation

Inventor： Gambini, Michael R. ,  Atwood, John G. ,  Young, Eugene F. ,  Lakatos, Edward J. ,  Cerrone, Anthony L.

IPC: G01N21/25 ,  G01N21/64 ,  G01N21/03

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: A filter module (30) suitable for an optical instrument (A) for monitoring polymerase chain reaction replication of DNA in a reaction apparatus (B) that includes a thermal cycler block for holding a plurality of vials containing a suspension of ingredients for the reaction, the optical instrument including a housing suitable for receiving the filter module, the filter module comprising: a beam splitter (6) an excitation filter (7); an emission filter (8); and a support frame (34, 36, 40, 44); wherein:
the beam splitter (6), the excitation filter (7) and the emission filter (8) are affixed to the support frame;
the filter module (30) is suitable for being received in the housing of the optical instrument;
the beam splitter (6), the excitation filter (7) and the emission filter (8), and thereby the filter module (30), are associated with a selected dye for the suspension; and
the filter module (3) is removable from the housing of the optical instrument for replacement with another filter module associated with another selected dye.

Abstract translation: 本发明涉及一种特别适用于DNA PCR监测的光学仪器。 仪器包括多个间隔开的反应成分容器（1b），适于将激发光束（22）引向多个容器（1b）的光源（11），沿激发设置的场透镜（3） 在光源（11）和多个容器（1b）之间的光束路径和沿着激发光束路径设置并被布置成接收从场透镜（3）发射的发射光束（26）的检测器（10），其也被布置 沿着多个容器（1b）和检测器（10）之间的发射光束路径。

公开(公告)号：EP2391884A1

公开(公告)日：2011-12-07

申请号：EP09810743.6

申请日：2009-12-23

Applicant: Carl Zeiss OIM GmbH

Inventor： REIMANN, Joachim ,  HUSS, Volker ,  SCHÖLLKOPF, Volker ,  KNUPFER, Klaus-Georg

IPC: G01N21/88 ,  G01N21/95 ,  G01N21/15

CPC classification number: G01N21/8806 ,  G01N21/15 ,  G01N21/9515 ,  G01N2021/151 ,  G01N2021/1772 ,  G01N2021/1774 ,  G01N2021/8812 ,  G01N2021/8816 ,  G01N2021/8835 ,  G01N2201/0245 ,  G01N2201/0614 ,  G01N2201/0626 ,  G01N2201/0634 ,  G01N2201/0694

Abstract: The invention relates to a device for optically inspecting an at least partially reflecting surface of an item, having a first and at least one second crossbeam (12, 14) each forming a section (32) largely in the shape of a circular segment. The crossbeams (12, 14) are disposed at a longitudinal distance (D) from one another, defining a longitudinal axis (17). The two crossbeams (12, 14) are held at the longitudinal distance (D) by means of a plurality of longitudinal beams (16). The longitudinal beams (16) are disposed at a defined radial distance (38) from the sections (32) in the shape of circular segments. The crossbeams (12, 14) support a light-transparent diffusing screen (34) forming a tunnel-shaped inspection space (36). A plurality of light sources (48) are disposed outside of the tunnel-shaped inspection space (36) behind the diffusing screen, said sources being controllable individually or in small groups in order to generate variable light-dark patterns (90) on the diffusing screen. At least one camera (74, 78) is set up in the tunnel-shaped inspection space (36).

公开(公告)号：EP2391883A1

公开(公告)日：2011-12-07

申请号：EP10702974.6

申请日：2010-01-29

Applicant: Micronics, Inc.

Inventor： BATTRELL, C., Frederick ,  DAIBER, Troy, D. ,  HUNTER, William, Samuel ,  KOTLARSKI, Peter ,  WELTI, Neal, Arthur ,  GARDNER, Richard, John, Louis ,  YEAP, Chin, Eng

IPC: G01N21/64 ,  B01L3/00

CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

Abstract: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.

Abstract translation: 公开了一种用于液体样品中荧光测定的紧凑型微处理器控制仪器，该仪器具有带有用于接收微流控盒的对接托架的浮动台和具有用于控制源LED的板上嵌入式微处理器的扫描检测器头，发射信号放大和 在检测器头内的隔离，低噪声，高增益环境中进行滤波。 多个光通道可以并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。 通过使用带有反射镜面的加热块与包围液体样品的热光学窗口紧密接触，可以改善扫描期间对气泡干扰的灵敏度和抗性。

公开(公告)号：EP1078245B1

公开(公告)日：2008-08-06

申请号：EP99924365.2

申请日：1999-05-17

Applicant: Applera Corporation

Inventor： GAMBINI, Michael, R. ,  ATWOOD, John, G. ,  YOUNG, Eugene, F. ,  LAKATOS, Edward, J. ,  CERRONE, Anthony, L.

IPC: G01N21/25 ,  C12Q1/68 ,  B01L7/00 ,  G01N21/03 ,  G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Abstract translation: 本发明涉及一种特别适用于DNA PCR监测的光学仪器。 仪器包括多个间隔开的反应成分容器（1b），适于将激发光束（22）引向多个容器（1b）的光源（11），沿着激发设置的场透镜（3） 在光源（11）和多个容器（1b）之间的光束路径和沿着激发光束路径设置并被布置成接收从场透镜（3）发射的发射光束（26）的检测器（10），其也被布置 沿着多个容器（1b）和检测器（10）之间的发射光束路径。

公开(公告)号：EP1633482A2

公开(公告)日：2006-03-15

申请号：EP04785691.9

申请日：2004-05-10

Applicant: Bayer HealthCare LLC

Inventor： BROCK, David, A. ,  HESSER, Donald, R. ,  KRAUTH, Gary, H. ,  ZUIDEMA, Jack, L. ,  BOGER, David, L. ,  SHELDRAKE, Kevin, J.

IPC: B01L3/00 ,  B01L9/00

CPC classification number: G01N21/8483 ,  B01L9/52 ,  B01L2300/0825 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N2021/0325 ,  G01N2201/0245 ,  G01N2201/12792

Abstract: A tray assembly (200) for use with an apparatus adapted to inspect a liquid sample, including a support tray (202) insertable within an inspection location within the liquid sample inspection apparatus so that a light source of the apparatus illuminates a liquid sample carried on the support tray and a detector of the apparatus receives light from the liquid sample when the support tray is positioned at the inspection location, and an insert (204) supported within the support tray and having a first surface (206) adapted to receive a first type of liquid carrier and a second surface (206) adapted to receive a second type of liquid carrier different from the first type of liquid carrier.

公开(公告)号：EP0364539B1

公开(公告)日：1994-08-24

申请号：EP89903718.8

申请日：1989-03-13

Applicant: BODENSEEWERK PERKIN-ELMER GMBH

Inventor： ROGASCH, Klaus, Peter ,  TAMM, Rolf

IPC: G01N21/31 ,  G01N21/74

CPC classification number: G01N21/3103 ,  G01N21/72 ,  G01N21/74 ,  G01N2021/3111 ,  G01N2021/3118 ,  G01N2021/745 ,  G01N2201/0245

Abstract: An atomic absorption spectrometer with electrothermal atomization of the test sample and background compensation by exploitation of the Zeeman effect contains an oven (130) which is heated perpendicular to the direction of propagation of the measuring light beam (18) of the atomic absorption spectrometer, for the electrothermal atomization of the test sample, and a switchable electromagnet (44) for generating a magnetic field at the site of the test sample and which runs parallel to the direction of propagation of the measuring light beam (18), so that when the electromagnet (44) is switched on, a longitudinal Zeeman effect occurs in the absorption lines. The electromagnet (44) has pole pieces (46, 48) with aligned passages (50, 52) through which the measuring light beam (18) passes. Contacts (128, 176) whose centrelines are perpendicular to the centreline of the measuring light beam (18) and which hold the cross-heated oven (130) are mounted in a contact support (96) arranged on the pole pieces (48, 50). Magnet coils (60, 62) are arranged directly on the pole pieces (46, 48). The contact support (96) and coil holders (56, 58) constitute a single component.

公开(公告)号：TW201447274A

公开(公告)日：2014-12-16

申请号：TW103104702

申请日：2014-02-13

Applicant: 國立大學法人九州大學 ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION ,  牛尾電機股份有限公司 ,  USHIO DENKI KABUSHIKI KAISHA

Inventor： 興雄司 ,  OKI, YUJI ,  森田金市 ,  MORITA, KINICHI

IPC: G01N21/64 ,  G01N35/08 ,  G01N37/00

CPC classification number: G01N21/6428 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0403 ,  B01L2400/0442 ,  B01L2400/046 ,  G01N21/03 ,  G01N21/05 ,  G01N33/5304 ,  G01N33/536 ,  G01N33/56966 ,  G01N2021/6482 ,  G01N2201/0245

Abstract: [課題]可使用可拋棄的微晶片，於需要分析的現場，高精度進行各種分析。[解決手段]於平板電腦終端(3)(處理裝置)的顯示器(3a)上，配置微晶片(1)，將檢體(4)往該微晶片(1)的流通路徑滴下，在微晶片內部(流通路徑)使檢體的反應產生。對該微晶片(1)，照射從平板電腦終端(3)的顯示器(3a)放出之光線，藉由該照射光，測定在微晶片(1)內產生的反應。例如，作為測定方法，採用使用照射光的激發螢光法時，觀測到對應前述反應的螢光，藉由目視來觀察或藉由平板電腦終端(3)的內藏相機來檢測該光線。該檢測訊號係藉由平板電腦終端(3)的運算裝置被運算處理，進行分析，分析結果會被輸入至外部。

Abstract in simplified Chinese: [课题]可使用可抛弃的微芯片，于需要分析的现场，高精度进行各种分析。[解决手段]于平板电脑终端(3)(处理设备)的显示器(3a)上，配置微芯片(1)，将检体(4)往该微芯片(1)的流通路径滴下，在微芯片内部(流通路径)使检体的反应产生。对该微芯片(1)，照射从平板电脑终端(3)的显示器(3a)放出之光线，借由该照射光，测定在微芯片(1)内产生的反应。例如，作为测定方法，采用使用照射光的激发萤光法时，观测到对应前述反应的萤光，借由目视来观察或借由平板电脑终端(3)的内藏相机来检测该光线。该检测信号系借由平板电脑终端(3)的运算设备被运算处理，进行分析，分析结果会被输入至外部。

公开(公告)号：WO2013163129A1

公开(公告)日：2013-10-31

申请号：PCT/US2013/037712

申请日：2013-04-23

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC. ,  JASPERSE, Jeffrey, R. ,  DESMARAIS, Normand, P.

Inventor： JASPERSE, Jeffrey, R. ,  DESMARAIS, Normand, P.

IPC: G01N21/35

CPC classification number: G01N21/76 ,  G01N21/645 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6476 ,  G01N2201/0245 ,  G01N2201/0634 ,  G01N2201/0636 ,  G01N2201/0666

Abstract: A sample analyzer has an illuminator for illuminating an assay sample to cause luminescence, and a support for a sample vessel containing the assay sample. The support is adapted to position the assay sample proximate the illuminator. A detector is positioned along an optical axis extending from the illuminator, through the positioned assay sample, to the detector, so as to detect the luminescence from the assay sample. A reflector is removably disposed between the illuminator and the assay sample so as to reflect a portion of the luminescence back through the positioned assay sample toward the detector.

Abstract translation: 样品分析仪具有用于照射测定样品以产生发光的照明器，以及含有测定样品的样品容器的支架。 该支架适于将测定样品定位在靠近照明器处。 检测器沿着从照明器延伸的光轴定位，通过定位的测定样品到检测器，以便检测来自测定样品的发光。 反射器可拆卸地设置在照明器和测定样品之间，以便通过定位的测定样品将一部分发光反射回检测器。

公开(公告)号：WO2011058488A1

公开(公告)日：2011-05-19

申请号：PCT/IB2010/055032

申请日：2010-11-05

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  DE BOER, Ruth, W. I. ,  KLUNDER, Derk, J. W. ,  VAN HERPEN, Maarten, M. J. W. ,  PENTERMAN, Roel ,  LUB, Johan ,  DE WITZ, Christianne, R. M.

Inventor： DE BOER, Ruth, W. I. ,  KLUNDER, Derk, J. W. ,  VAN HERPEN, Maarten, M. J. W. ,  PENTERMAN, Roel ,  LUB, Johan ,  DE WITZ, Christianne, R. M.

IPC: G01N21/64 ,  B01L9/00 ,  G02B21/34

CPC classification number: G01N21/648 ,  B01L9/52 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  G01N33/54373 ,  G01N2021/0367 ,  G01N2201/0245 ,  G02B21/26 ,  G02B21/34

Abstract: This invention relates to a chip holder kit for a wire-grid sensor, where the chip holder kit includes a base plate, where a first aperture is formed at the front side of the base plate, a second aperture is formed at the rear side of the base plate, and an overlapping region where the first and the second apertures overlap. The second aperture has an area that substantially matches the area of the wire-grid sensor and is adapted to removable receive the wire-grid sensor. The first aperture is adapted to removably receive the polarization structure and the first and second apertures are arranged such that when the wire-grid sensor and the polarizer are received in the overlapping region the polarizer filters any incoming excitation light to a transverse electric mode (TE) polarized excitation light before the wire-grid sensor is illuminated.

Abstract translation: 本发明涉及一种用于线栅传感器的芯片保持器套件，其中芯片保持器套件包括基板，其中在基板的前侧形成有第一孔，第二孔形成在底板的后侧 基板和第一和第二孔重叠的重叠区域。 第二孔具有与线栅传感器的面积基本匹配的区域，并适于可移除地接收线栅传感器。 第一孔径适于可移除地接收偏振结构，并且第一和第二孔布置成使得当线栅传感器和偏振器被接收在重叠区域中时，偏振器将任何进入的激发光束滤波成横向电模式（TE ）线栅传感器点亮之前的偏振激发光。

公开(公告)号：WO2010053486A1

公开(公告)日：2010-05-14

申请号：PCT/US2008/082671

申请日：2008-11-06

Applicant: LI-COR, INC. ,  FURTAW, Michael D. ,  ECKLES, Robert D. ,  BURBA, Georgiy G. ,  MCDERMITT, Dayle K. ,  WELLES, Jonathan M.

Inventor： FURTAW, Michael D. ,  ECKLES, Robert D. ,  BURBA, Georgiy G. ,  MCDERMITT, Dayle K. ,  WELLES, Jonathan M.

IPC: G01N21/25 ,  G01N21/01 ,  G01N21/00 ,  G01K7/02 ,  G01L7/00 ,  G01D21/02

CPC classification number: G01N21/05 ,  G01N21/15 ,  G01N21/276 ,  G01N21/3504 ,  G01N2021/317 ,  G01N2021/3513 ,  G01N2021/399 ,  G01N2201/0245 ,  G01N2201/1211

Abstract: Gas analyzer systems and methods for measuring concentrations of gasses and in particular dry mole fraction of components of a gas. The systems and method allow for rapid measurement of the gas density and/or dry mole fraction of gases for a number of environmental monitoring applications, including high speed flux measurements. A novel coupling design allows for tool-free removal of a cell enclosing a flow path to enable in field cleaning of optical components.

Abstract translation: 气体分析仪系统和测量气体浓度的方法，特别是气体组分的干摩尔分数。 这些系统和方法允许快速测量多种环境监测应用的气体密度和/或气体的干摩尔分数，包括高速通量测量。 新的耦合设计允许无需移除封闭流动通道的电池，从而可以对光学部件进行现场清洁。