公开(公告)号：JP2009264868A

公开(公告)日：2009-11-12

申请号：JP2008113584

申请日：2008-04-24

Applicant: Ushio Inc ,  ウシオ電機株式会社

Inventor： TOMITA MAMORU

IPC: G01N21/77 ,  G01N33/49 ,  G01N35/02 ,  G01N37/00

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: PROBLEM TO BE SOLVED: To make it possible to obtain the quantity of light required for measurement and to enable high-precision measurement, even if a rotary body or the like is deformed due to a change in an environmental temperature or the like.
SOLUTION: As an initializing processing which is performed before a μTAS chip holding a sample (blood) is set, a measuring chamber is heated to a preset temperature by a heating means 35. A rotational position where a light value of the light received at a light-receiving part 43 through an aperture part 23 reaches a threshold value or more is sought while a rotary body 25 is rotated by a minute amount, and the rotational position is stored as a measurement position. Next, the μTAS chip is set to a chip holding part 22, and a processing before measurement, which includes weighing of a sample liquid in the μTAS chip, mixing of the sample liquid and a reagent, delivering a measurement liquid to a measuring area or the like, is performed. Then the rotary body 25 is rotated to the measurement position, a light from a light source 41 is introduced into the measuring area of the μTAS chip through the aperture 23, the light passing through the measuring area is received by the light-receiving part 43, and thus absorbance of this measurement liquid is measured.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题为了使得可以获得测量所需的光量并且能够进行高精度测量，即使旋转体等由于环境温度等的变化而变形 。

解决方案：作为在设置保持样品（血液）的μTAS芯片之前进行的初始化处理，通过加热装置35将测量室加热到预设温度。光的光值 当旋转体25旋转微小时，在光接收部分43处通过孔部分23被接收达到阈值或更大，并且旋转位置被存储为测量位置。 接下来，将μTAS芯片设置为芯片保持部22，以及测量前的处理，包括称量μTAS芯片中的样品液体，将样品液体和试剂混合，将测量液体输送到测量区域，或 等等。 然后旋转体25旋转到测量位置，来自光源41的光通过孔23被引入μTAS芯片的测量区域中，通过测量区域的光被光接收部分43接收 ，测定该测定液的吸光度。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009519466A

公开(公告)日：2009-05-14

申请号：JP2008545638

申请日：2006-12-04

Applicant: バイオ−ラッド ラボラトリーズ,インコーポレイティド

Inventor： ワイ． チュー，ダニエル

IPC: G01N33/53 ,  G01N21/01 ,  G01N37/00

CPC classification number: G01N21/253 ,  G01N2201/0446 ,  G01N2201/1042

Abstract: マイクロアレイのスキャニングは、マイクロアレイの部位のうち全てではない複数の部位を露出するマスクを通じて実行される。 マスクがマイクロアレイに対して可動、または、マイクロアレイがマスクに対して可動の何れかであるか、または両方である。 マスクは、スキャンヘッドが加速するかまたは減速するかの何れかのスキャンヘッドの軌道内の部位上において、スキャンヘッドとマイクロアレイとの間の光路を遮断しているので、マスクは、マイクロアレイ上の部位への照明を、スキャンヘッドが安定しかつ目標速度により移動している間に照明される部位に制限する手段として有効である。 さらに、マスクは、スキャンされた部位の隣接する部位への光流出を防止するので、マイクロアレイ画像内のバックグラウンドノイズを減少させるのに有効である。
【選択図】図１

公开(公告)号：JP2008298795A

公开(公告)日：2008-12-11

申请号：JP2008207923

申请日：2008-08-12

Applicant: Technische Univ Delft ,  テクニシェ ユニヴェルシテイト デルフト

Inventor： IORDANOV VENTZESLAV PETROV ,  SARRO PASQUALINA MARIA ,  WOLFFENBUTTEL REINOUD FELIX ,  VELLEKOOP MICHAEL JOHANNES

IPC: G01N21/78 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/48 ,  G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  G01N33/551 ,  G01N33/552 ,  G01N33/553 ,  G02B5/20

CPC classification number: G01N21/6452 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/485 ,  G01N21/0303 ,  G01N21/6428 ,  G01N33/551 ,  G01N33/552 ,  G01N33/553 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/0446 ,  G02B5/207 ,  G02B5/208

Abstract: PROBLEM TO BE SOLVED: To provide an implementation method of a fluorescence assay comprising the detection of any light which can be emitted by exposing well to excitation light.
SOLUTION: In the implementation method of assay, a filter is united with (i) the main body including the well (which expose the well with an assay to be conducted in manner of positioning the filter on a photosensitive element and excitation light source) and (ii) at least a component selected from photosensitive elements (for applying the filter to at least a photosensitive plane on the surface of the photosensitive element), to detect any beam of light which can be emitted through the photosensitive element. Further a system suitable for the implementation of this method and its manufacturing method are obtained.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供荧光测定的实施方法，其包括通过良好地暴露于激发光可以发射的任何光的检测。 解决方案：在测定的实施方法中，过滤器与（i）包括井的主体（其暴露井）以使得将过滤器定位在感光元件和激发光上的方式进行测定 源）和（ii）至少一种选自感光元件（用于将滤光片施加到感光元件的表面上的至少感光平面）的成分，以检测可通过光敏元件发射的任何光束。 此外，获得适用于实施该方法及其制造方法的系统。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2007504477A

公开(公告)日：2007-03-01

申请号：JP2006532916

申请日：2004-05-10

Applicant: バイオ−ラッド ラボラトリーズ インコーポレイテッド

Inventor： イゴー コーデュンスキー ,  ジェフリー エイ ゴールドマン ,  マイケル ジェイ フィニー

IPC: G01N21/64 ,  B01L7/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/78

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1822 ,  G01N21/276 ,  G01N21/6452 ,  G01N2201/0446

Abstract: 【課題】サーマルサイクラと共に使用するための可動励起／検出モジュールを有する蛍光検出システムを提供する。
【解決手段】サーマルサイクラの複数のウエルに配置されたサンプルを分析する蛍光検出装置及び使用方法。 一実施形態では、装置は、サーマルサイクラに取付可能な支持構造体と支持構造体上に移動可能に取付け可能な検出モジュールとを含む。 検出モジュールは、共に検出モジュール内に配置された励起光発生器と放出光検出器を各々有する１以上のチャンネルを含む。 支持構造体がサーマルサイクラに取り付けられて検出モジュールが支持構造体に取付けられた時、検出器は、複数のウエルのうちの異なるウエルと光学連通状態に配置されるように移動可能である。 検出モジュールは、容易な交換を可能にするために支持構造体から取外し可能である。
【選択図】図２

公开(公告)号：US12038429B2

公开(公告)日：2024-07-16

申请号：US15907695

申请日：2018-02-28

Applicant: Specific Technologies, LLC

Inventor： Paul A. Rhodes ,  Soumitesh Chakravorty ,  Sung Hyun Lim

IPC: G01N33/50 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q3/00 ,  G01N21/03 ,  G01N21/78 ,  G01N21/01 ,  G01N21/80

CPC classification number: G01N33/5008 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q3/00 ,  G01N21/03 ,  G01N21/78 ,  G01N2021/0118 ,  G01N21/80 ,  G01N2201/0446

Abstract: Devices, systems, and methods for strain-specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism. An exemplary method includes culturing a sample containing microorganisms in a medium and in gaseous communication with a colorimetric sensor array. Sensors in the colorimetric sensor array are exposed to volatile organic compounds produced by the microorganism. The method then includes assessing a resistance of the microorganism to at least one substance. The resistance is assessed based on a response of the sensors in the colorimetric sensor array to the volatile organic compounds produced by the microorganism.

公开(公告)号：US11953439B2

公开(公告)日：2024-04-09

申请号：US16543254

申请日：2019-08-16

Applicant: Massachusetts Institute of Technology ,  The Penn State Research Foundation

Inventor： Lauren Dell Zarzar ,  Sara N. Nagelberg ,  Mathias Kolle ,  Amy Goodling

IPC: G01N21/64 ,  B29D11/00

CPC classification number: G01N21/6452 ,  B29D11/00298 ,  G01N2201/0446

Abstract: The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.

公开(公告)号：US20240085332A1

公开(公告)日：2024-03-14

申请号：US18467469

申请日：2023-09-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： William Benman ,  Lukasz Bugaj ,  Brian Chow ,  Saachi Datta ,  David Gonzalez-Martinez ,  Jose Avalos

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N2201/0446 ,  G01N2201/0627 ,  G01N2201/064

Abstract: Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

公开(公告)号：US20180100798A1

公开(公告)日：2018-04-12

申请号：US15565161

申请日：2016-04-08

Applicant: BACTUSENSE TECHNOLOGIES LTD.

Inventor： OFER DU-NOUR

IPC: G01N21/47 ,  A61B5/00 ,  G02B21/06 ,  G01D5/26 ,  G02B21/36

CPC classification number: G01N21/4788 ,  A61B5/7257 ,  G01D5/266 ,  G01N21/45 ,  G01N21/4738 ,  G01N2021/458 ,  G01N2021/4726 ,  G01N2021/4797 ,  G01N2201/0446 ,  G02B21/06 ,  G02B21/362

Abstract: Systems for the monitoring of bacterial levels in samples, using spectral analysis of the light diffracted from a substrate with an ordered array of pores having diameters enabling the targets to enter them. The trapping pore array is cyclically illuminated by light of different wavelengths, and the light diffracted from the pore array is imaged by a 2-dimensional detector array, with one pixel, or a small group of pixels receiving light from each associated pore. The temporal sequence of frames provides a series of images, each from the reflection of a different wavelength. A time sequenced readout of the signal from the pixel or pixels associated with each pore region, provides a spectral plot of the reflected light from that pore region. Spectral analysis of the light intensity from this series of different wavelength enables the effective optical thickness (EOT) of each pore to be extracted.

公开(公告)号：US09909979B2

公开(公告)日：2018-03-06

申请号：US15046354

申请日：2016-02-17

Applicant: Engineered Medical Technologies

Inventor： Bryan John Cowger ,  Megan Anzar Babb ,  Peichen Chang

IPC: G01N21/00 ,  G01N21/33 ,  G01J1/42 ,  G01N21/03 ,  G01N21/13 ,  G01N21/31 ,  G01N21/17

CPC classification number: G01N21/33 ,  G01J1/42 ,  G01N21/03 ,  G01N21/13 ,  G01N21/31 ,  G01N2021/0367 ,  G01N2021/1751 ,  G01N2201/0446 ,  G01N2201/062

Abstract: The present describes a system and method for determining the concentration of tetrahydrocannabinol (THC) including a tray comprising a first analyte including an infusion of a solvent and cannabis, a light emitting element configured to illuminate the first analyte, a light receiving element configured to receive a first light transmitted through the first analyte, and a control circuit configured to calculate a concentration of tetrahydrocannabinol in the first analyte based at least in part on the first light.

公开(公告)号：US09435734B2

公开(公告)日：2016-09-06

申请号：US14806999

申请日：2015-07-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Norikazu Sugiyama ,  Takuji Kataoka ,  Ikuo Arata

IPC: G01N21/01 ,  G01N21/47 ,  G01N33/483 ,  G02B21/08 ,  G01N21/49 ,  G01N33/50 ,  G01N21/59 ,  G02B21/36

CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.