公开(公告)号：US07265833B2

公开(公告)日：2007-09-04

申请号：US10887528

申请日：2004-07-08

Applicant: Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  Janice G. Shigeura, legal representative

Inventor： John S. Shigeura, deceased

IPC: G01J3/18

CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

公开(公告)号：US07183103B2

公开(公告)日：2007-02-27

申请号：US10370846

申请日：2003-02-20

Applicant: Michael R. Gambini ,  Susan Atwood Stone, legal representative ,  Judith K. Atwood, legal representative ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

Inventor： John G. Atwood, deceased

IPC: C12M1/34

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：US20060132786A1

公开(公告)日：2006-06-22

申请号：US11013373

申请日：2004-12-17

Applicant: Rene Helbing

Inventor： Rene Helbing

IPC: G01N21/47

CPC classification number: G01N21/77 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N2201/0628

Abstract: A sensor, such as a lateral flow sensor, which includes a chemical layer and a detector on a flexible substrate. An optical signal is produced in response to an analyte placed on the chemical layer. The detector detects the signal, to thereby detect the presence, absence or concentration of the analyte. The detector is on the substrate. The chemical layer and the substrate are laminated together, to thereby form an integrated sensor. The sensor can include a light source. The light source can be on the substrate, or on an opposite side of the chemical layer than the detector.

Abstract translation: 传感器，例如横向流量传感器，其包括柔性基板上的化学层和检测器。 响应于放置在化学层上的分析物产生光信号。 检测器检测信号，从而检测分析物的存在，不存在或浓度。 检测器位于基板上。 将化学层和基板层叠在一起，从而形成集成的传感器。 传感器可以包括光源。 光源可以在基板上，或者在化学层的与检测器相反的一侧。

公开(公告)号：US06818437B1

公开(公告)日：2004-11-16

申请号：US09700536

申请日：2001-11-29

Applicant: Michael R. Gambini ,  John G. Atwood ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

Inventor： Michael R. Gambini ,  John G. Atwood ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

IPC: C12M134

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。

公开(公告)号：US20040072335A1

公开(公告)日：2004-04-15

申请号：US10440920

申请日：2003-05-19

Inventor： Steven J. Boege ,  Howard G. King ,  Eugene F. Young ,  Johannes P. Sluis ,  Mark F. Oldham

IPC: C12M001/34

CPC classification number: G01N21/6486 ,  B01L7/52 ,  C12Q2545/101 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/0628 ,  G01N2201/0635 ,  Y10S435/808 ,  Y10S435/809

Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.

Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。 光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。 根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。 还提供了使用光学仪器的分析方法。

公开(公告)号：US20040065806A1

公开(公告)日：2004-04-08

申请号：US10432296

申请日：2003-11-03

Inventor： Donal Bradley ,  John De Mello ,  Andrew De Malio

IPC: H01L031/00

CPC classification number: G01N21/6454 ,  G01N21/05 ,  G01N21/253 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0628

Abstract: A microfabricated detection system, comprising: a substrate chip; a chamber defined by the substrate chip to which a fluid sample is in use delivered; and at least one detector comprising at least one light-emitting diode including an organic semi-conductor element for emitting light into the chamber and at least one photocell including an organic semiconductor element for receiving light from the chamber.

Abstract translation: 一种微加工检测系统，包括：基板芯片; 由流体样品在其中使用的衬底芯片限定的室; 以及至少一个检测器，包括至少一个发光二极管，所述发光二极管包括用于将光发射到所述腔室中的有机半导体元件和至少一个包含用于接收来自所述腔室的光的有机半导体元件的光电池。

公开(公告)号：US5629533A

公开(公告)日：1997-05-13

申请号：US384095

申请日：1995-02-06

Applicant: Donald E. Ackley ,  Thomas B. Harvey, III

Inventor： Donald E. Ackley ,  Thomas B. Harvey, III

IPC: G01N21/77 ,  H01L31/173 ,  H01L51/50 ,  H01L27/15 ,  H01L33/00

CPC classification number: G01N21/77 ,  H01L31/173 ,  H01L51/5012 ,  G01N2201/0628

Abstract: An optical sensor (10,30) uses a polymer light emitting diode (12, 31, 41, 51) to emit light detected by a polymer photodetector (13, 36, 46, 56). The polymer light emitting diode (12, 31, 41, 51) containing an indicator that reacts with an analyte and alters the light emitted by the polymer light emitting diode (12, 31, 41, 51). The change is detected by the polymer photodector (13, 36, 46, 56) and is used to detect the presence of the analyte.

Abstract translation: 光学传感器（10,30）使用聚合物发光二极管（12,31,41,51）发射由聚合物光电探测器（13,36,46,56）检测到的光。 所述聚合物发光二极管（12,31,41,51）包含与分析物反应并改变由所述聚合物发光二极管（12,31,41,51）发射的光的指示剂。 该变化由聚合物光敏剂（13,36,46,56）检测，并用于检测分析物的存在。

公开(公告)号：TW201231952A

公开(公告)日：2012-08-01

申请号：TW100104774

申请日：2011-02-14

Applicant: 財團法人工業技術研究院

Inventor： 蔡榮源 ,  朱正煒 ,  陳秀香

IPC: G01N ,  B82Y

CPC classification number: G01N21/6454 ,  B82Y40/00 ,  G01N21/6428 ,  G01N21/648 ,  G01N2201/0628

Abstract: 本發明針對一種用以偵測由單一及個別分析物分子所發出的螢光訊號之偵測裝置及其製作方法。將激發光源、偵測器陣列以及奈米井陣列全都整合在此偵測裝置中，被捕獲在奈米井中的單一分析物分子可被光源激發而發出螢光訊號至偵測器陣列。

Abstract in simplified Chinese: 本发明针对一种用以侦测由单一及个别分析物分子所发出的萤光信号之侦测设备及其制作方法。将激发光源、侦测器数组以及奈米井数组全都集成在此侦测设备中，被捕获在奈米井中的单一分析物分子可被光源激发而发出萤光信号至侦测器数组。

公开(公告)号：EP2988807B1

公开(公告)日：2018-05-23

申请号：EP14722567.6

申请日：2014-04-16

Applicant: Sanofi-Aventis Deutschland GmbH

Inventor： BLEI, Gertrud ,  BOCK, Mario

IPC: A61M5/315 ,  G01D5/39 ,  G06F19/00 ,  A61M5/31

CPC classification number: G01N21/4738 ,  A61M5/31 ,  A61M5/3155 ,  A61M5/31568 ,  A61M2005/3126 ,  A61M2205/3306 ,  A61M2205/3379 ,  A61M2205/3553 ,  A61M2205/3592 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/6081 ,  A61M2205/8206 ,  A61M2209/04 ,  G01N2201/021 ,  G01N2201/0628 ,  G01N2201/0634 ,  G06F19/00 ,  G06F19/3468

Abstract: A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device having an OLED having a transparent first electrode, a transparent second electrode and a central layer disposed between the first and second electrodes, the central layer comprising at least one organic layer, the at least one organic layer configured to emit light through the transparent first electrode, and an optical sensor arranged to receive light reflected from a surface of the drug delivery device, wherein the central layer of the OLED has a region without the at least one organic layer and wherein the optical sensor is arranged, when the sensor device is attached to the drug delivery device, to view a predetermined area of the surface of the drug delivery device through the region without the at least one organic layer.

公开(公告)号：EP3093649A3

公开(公告)日：2017-04-26

申请号：EP16172036.2

申请日：1999-05-17

Applicant: Life Technologies Corporation

Inventor： Gambini, Michael R. ,  Atwood, John G. ,  Young, Eugene F. ,  Lakatos, Edward J. ,  Cerrone, Anthony L.

IPC: G01N21/03 ,  G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument (A) for monitoring polymerase chain reaction replication of DNA may include a thermal cycler block (1c) for holding a plurality of vials (1b), each containing a suspension of ingredients that include a fluorescent primary dye. The instrument may include a light source (11) for emitting a source beam, a first means (7) disposed to be receptive of the source beam, a primary focusing means (3) disposed to focus the excitation beam simultaneously into a plurality of suspensions and being receptive of and passing emission beams, a second means (8) disposed to be receptive of emission beams, an emission focusing means (10) for focusing emission beams, a detector, and a processing means for computing concentration of DNA. The optical system being arranged without a beam splitter (6) but with one or more folding mirrors (5), and with excitation and emission beams being on slightly different optical paths angularly.

Abstract translation: 用于监测DNA的聚合酶链式反应复制的光学仪器（A）可以包括用于保持多个小瓶（1b）的热循环器块（1c），每个小瓶包含含有荧光初级染料的成分的悬浮液。 该仪器可以包括用于发射源光束的光源（11），被设置为接收源光束的第一装置（7），被设置为将激发光束同时聚焦到多个悬置装置中的主聚焦装置（3） （8），用于接收发射光束的第二装置（8），用于聚焦发射光束的发射聚焦装置（10），检测器以及用于计算DNA浓度的处理装置。 该光学系统没有分束器（6）而是具有一个或多个折叠镜（5），并且激励光束和发射光束在角度上处于略微不同的光路上。