公开(公告)号：US20080049432A1

公开(公告)日：2008-02-28

申请号：US11927731

申请日：2007-10-30

Applicant: Jeffrey Benoit ,  Wayde Schmidt ,  Thomas Vanderspurt

Inventor： Jeffrey Benoit ,  Wayde Schmidt ,  Thomas Vanderspurt

IPC: F21V13/00 ,  F21V13/04 ,  F21V14/00 ,  F21V8/00

CPC classification number: G06F17/5045 ,  G01N2201/0826 ,  G02B6/001 ,  G02B6/14

Abstract: A method that redistributes light from a light source. The controller can redistribute light to make an irradiance profile of the light source more uniform or make the irradiance profile match a fluid flow profile. The irradiance profile may be controlled by modifying light leakage from a plurality of waveguides or changing the light-directing properties of reflectors and/or lenses.

Abstract translation: 重新分配来自光源的光的方法。 控制器可以重新分配光，使光源的辐照度分布更均匀，或使辐照度轮廓匹配流体流动分布。 可以通过修改来自多个波导的光泄漏或改变反射器和/或透镜的导光性能来控制辐照度分布。

公开(公告)号：US20070291265A1

公开(公告)日：2007-12-20

申请号：US11735206

申请日：2007-04-13

Applicant: Steven Holman ,  Bin Guo ,  W. Wilson ,  Joseph Fanguy

Inventor： Steven Holman ,  Bin Guo ,  W. Wilson ,  Joseph Fanguy

IPC: G01J3/42 ,  G06F19/00

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/05 ,  G01N21/532 ,  G01N2021/513 ,  G01N2201/0826

Abstract: This invention relates to a fiber optic apparatus for simultaneously measuring the scattering and concentration signals of macromolecules in a flow cell 3. The apparatus is based on the delivery/focusing of both a laser and ultraviolet light source to the same physical position in a low volume flow cell 4, via a bifurcated optical fiber 3. This configuration allows the light scattering and concentration signal changes associated with a macromolecular solution passing through the flow channel to be measured simultaneously. This invention also relates to a method that uses the optical apparatus 10 to determine properties of a macromolecular solution such as the ideal crystallization and/or formulation conditions (via B22) for a given protein solution.

Abstract translation: 本发明涉及一种用于同时测量流动池3中大分子的散射和浓度信号的光纤设备。 该装置基于通过分叉光纤3将激光和紫外光源两者的传送/聚焦到低体积流动池4中相同的物理位置。 该配置允许与通过要同时测量的流动通道的大分子溶液相关联的光散射和浓度信号变化。 本发明还涉及一种使用光学装置10来确定对于给定蛋白质溶液的大分子溶液的性质，例如理想结晶和/或配制条件（通过B 22）的方法。

公开(公告)号：US20070247628A1

公开(公告)日：2007-10-25

申请号：US11662468

申请日：2004-09-10

Applicant: Petri Kivelä

Inventor： Petri Kivelä

IPC: G01N21/00

CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on microtitration plates and corresponding sample supports. An optical measurement instrumentation is provided, a sample is activated and the emission is detected, wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and elements directing the activation radiation to the sample as well as in the relative position between the sample and the elements receiving the emission radiation from the sample. This can be implemented e.g. by moving the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品在微量滴定板和相应样品载体上的测量性质。 提供光学测量仪器，激活样品并检测发射，其中在测量样品的激活和检测阶段之间，在将样品和将激活辐射指向样品的元件之间的相对位置进行偏移，作为 以及在样品和接收来自样品的发射辐射的元件之间的相对位置。 这可以被实现。 通过在样品的活化和发射阶段之间移动样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

公开(公告)号：US20070146694A1

公开(公告)日：2007-06-28

申请号：US11709019

申请日：2007-02-21

Applicant: Dov Furman ,  Gad Newmann ,  Noam Dotan

Inventor： Dov Furman ,  Gad Newmann ,  Noam Dotan

IPC: G01N21/88

CPC classification number: G01N21/9501 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2201/0697 ,  G01N2201/0826

Abstract: A fiber optical illumination delivery system, which is effective in reducing the effects of source coherence. The system preferably utilizes either a single bundle of optical fibers, or serial bundles of optical fibers. In the single bundle embodiment, the differences in optical lengths between different fibers of the bundle is preferably made to be equal to even less than the coherence length of the source illumination. In the serial bundle embodiment, the fibers in the other bundle are arranged as groups of fibers of the same length, and it is the difference in lengths of these groups which is made equal to, or even more preferably, less than the overall difference in length between the shortest and the longest fibers in the other bundle. Both of these fiber systems enable construction of illumination systems delivering a higher level of illumination, but without greatly affecting the coherence breaking abilities of the system, thus enabling a generally more applicable system to be constructed.

公开(公告)号：US20070127118A1

公开(公告)日：2007-06-07

申请号：US11670376

申请日：2007-02-01

Applicant: David Nilson ,  Brad Rice ,  Tamara Troy

Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

IPC: G02B21/06

CPC classification number: G01N21/6456 ,  A01K1/031 ,  A61M16/104 ,  A61M16/18 ,  A61M16/202 ,  A61M2016/0039 ,  G01N2021/1787 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface facing toward the view port of the imaging apparatus. The support surface defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between.

Abstract translation: 提供了一种宏观荧光照明组件，用于与具有不透光成像室的成像装置一起使用。 该成像设备包括限定了一个视图端口的内壁，该视图端口延伸到成像室中以使得能够观察其中容纳的样本。 照明组件包括面向成像设备的视口的样本支撑表面。 支撑表面限定了能够使光通过的窗口部分。 窗口部分被选择性地定尺寸和尺寸使得当被支撑在支撑表面上方时，样本可以以基本上在其之间形成不透光密封的方式被定位和安置在窗口部分上。

公开(公告)号：US20060244956A1

公开(公告)日：2006-11-02

申请号：US11476322

申请日：2006-06-28

Applicant: Dov Furman ,  Gad Neumann ,  Mark Wagner ,  Noam Dotan ,  Ram Segal ,  Shai Silberstein

Inventor： Dov Furman ,  Gad Neumann ,  Mark Wagner ,  Noam Dotan ,  Ram Segal ,  Shai Silberstein

IPC: G01N21/88

CPC classification number: G01N21/9501 ,  G01N21/8806 ,  G01N21/95607 ,  G01N21/95623 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2201/0697 ,  G01N2201/0826

Abstract: Fast on-line electro-optical detection of wafer defects by illuminating with a short light pulse from a repetitively pulsed laser, a section of the wafer while it is moved across the field of view of an imaging system, and imaging the moving wafer onto a focal plane assembly, optically forming a continuous surface of photo-detectors at the focal plane of the optical imaging system. The continuously moving wafer is illuminated by a laser pulse of duration significantly shorter than the pixel dwell time, such that there is effectively no image smear during the wafer motion. The laser pulse has sufficient energy and brightness to impart the necessary illumination to each sequentially inspected field of view required for creating an image of the inspected wafer die. A novel fiber optical illumination delivery system, which is effective in reducing the effects of source coherence is described. Other novel aspects of the system include a system for compensating for variations in the pulse energy of a Q-switched laser output, methods for autofocussing of the wafer imaging system, and novel methods for removal of repetitive features of the image by means of Fourier plane filtering, to enable easier detection of wafer defects.

公开(公告)号：US07057726B2

公开(公告)日：2006-06-06

申请号：US11130848

申请日：2005-05-17

Applicant: Claire Elizabeth Hooper, legal representative

Inventor： John Gordon Rushbrooke, deceased

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fiber optic epi-fluorescence imaging system in which the optical fibers are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibers (32, 46) or bundles of fibers which lead to a CCD camera (74), the fibers or bundles of fibers from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibers formed therefrom to have a higher numerical aperature than those of the first set.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。 该系统包括通向CCD照相机（74）的至少两根光纤（32,46）或纤维束，来自所有样品的纤维或纤维束被布置成两组，第一组由 非荧光材料和第二组，其由可以发荧光但使得由其形成的纤维具有比第一组更高的数值的材料形成。

公开(公告)号：US20060038988A1

公开(公告)日：2006-02-23

申请号：US10921882

申请日：2004-08-20

Applicant: Anthony Thermos

Inventor： Anthony Thermos

IPC: G01N21/88

CPC classification number: G01N21/954 ,  G01N2201/0696 ,  G01N2201/0826 ,  G02B23/2423 ,  G02B23/2469 ,  G02B23/2476

Abstract: A borescope assembly is suitable for detecting a condition of a rotating part. The assembly includes a borescope disposed in a borescope housing and including structure that relays an image to an image viewer. A plurality of fiber optic lines are disposed in the borescope housing, and a strobe light source is coupled with the fiber optic lines. An image processor is coupled with the image viewer. With this structure, the condition of a rotating part can be detected without stopping the part.

Abstract translation: 管路器组件适用于检测旋转部件的状况。 组件包括设置在管道镜壳体中的管状镜，并且包括将图像中继到图像观看者的结构。 多个光纤线路设置在管道镜壳体中，并且频闪光源与光纤线路耦合。 图像处理器与图像查看器耦合。 利用这种结构，可以在不停止部件的情况下检测旋转部件的状态。

公开(公告)号：US20050213099A1

公开(公告)日：2005-09-29

申请号：US11130848

申请日：2005-05-17

Applicant: John Rushbrooke ,  Claire Hooper

Inventor： John Rushbrooke ,  Claire Hooper

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic epi-fluorescence imaging system in which the optical fibres are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibres (32, 46) or bundles of fibres which lead to a CCD camera (74), the fibres or bundles of fibres from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibres formed therefrom to have a higher numerical aperature than those of the first set.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。 该系统包括通向CCD照相机（74）的至少两根光纤（32,46）或纤维束，来自所有样品的纤维或纤维束被布置成两组，第一组由 非荧光材料和第二组，其由可以发荧光但使得由其形成的纤维具有比第一组更高的数值的材料形成。

公开(公告)号：US20050007792A1

公开(公告)日：2005-01-13

申请号：US10888302

申请日：2004-07-09

Applicant: Falai Li

Inventor： Falai Li

IPC: F21V7/00 ,  G01N21/88 ,  G01N21/95 ,  H01L21/00

CPC classification number: H01L21/67288 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/8822 ,  G01N2201/08 ,  G01N2201/0826

Abstract: A fiber optic darkfield ring light with many angled fiber optic light lines with direct illumination in a very small package. The fiber optic darkfield ring light includes a base with multiple light heads and multiple light covers attached thereto, a main cover, an optional cord grip, and an optional hood. It incorporates multiple fiber optic line arrays positioned at low angle and used in conjunction with a strobe light source.

Abstract translation: 一种光纤暗场环形灯，具有许多成角度的光纤光线，具有非常小的封装中的直接照明。 光纤暗场环形灯包括具有多个光头的基座和附接到其上的多个灯罩，主盖，可选的绳把和可选的罩。 它集成了多个光栅线阵列，它们以低角度定位并与闪光灯光源一起使用。