公开(公告)号：WO2016061247A1

公开(公告)日：2016-04-21

申请号：PCT/US2015/055560

申请日：2015-10-14

Applicant: ALAKAI DEFENSE SYSTEMS, INC.

Inventor： FORD, Alan R. ,  HOPKINS, Adam J.

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J2003/4424 ,  G01N33/227 ,  G01N2021/1793 ,  G01N2201/0683 ,  G01N2201/121

Abstract: A method for utilizing polarization as a scheme for fluorescence removal from UV Raman spectra collected in a standoff detection scheme has been invented. In this scheme, a linearly polarized ultraviolet (UV) laser interacts with a material on a surface or in a container. The material generates Raman scattering with polarization contributions relative to that of the laser. The material possibly fluoresces as well, but the fluorescence is generally unpolarized. By subtracting a scaled version of the perpendicular component from the parallel component of the returned signal both relative to the laser source polarization - it is possible to generate a spectrum that is fluorescence free and contains the strongest features of the Raman scattered light.

Abstract translation: 已经发明了利用偏振作为在间隔检测方案中收集的UV拉曼光谱进行荧光去除的方案的方法。 在该方案中，线偏振紫外（UV）激光与表面或容器中的材料相互作用。 该材料产生相对于激光的偏振贡献的拉曼散射。 该材料也可能发荧光，但荧光通常是非极化的。 通过从相对于激光源极化的返回信号的并行分量中减去垂直分量的缩放版本 - 可以产生无荧光的光谱并且包含拉曼散射光的最强特征。

公开(公告)号：WO2016057042A1

公开(公告)日：2016-04-14

申请号：PCT/US2014/060004

申请日：2014-10-10

Applicant: MEDTOR LLC

Inventor： DIETIKER, Thomas

IPC: A61B5/1455 ,  G01N21/27 ,  G01N21/31

CPC classification number: A61B5/14551 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6832 ,  A61B5/6838 ,  A61B5/6844 ,  A61B5/7207 ,  A61B5/7221 ,  G01N2201/121

Abstract: A method and system for measuring oxygen levels and various blood constituents utilizing a sensor having one or more light sources, and one or more light detectors is disclosed. The system is capable of using data collected by the one or more detectors from a non-monochromatic light source to provide accurate information during motion events occurring with an extremity the sensor. The system is also capable of detecting and providing an alert if the sensor is not properly placed on a patient or becomes disengaged therefrom.

Abstract translation: 公开了一种利用具有一个或多个光源的传感器和一个或多个光检测器来测量氧含量和各种血液成分的方法和系统。 该系统能够使用来自非单色光源的一个或多个检测器收集的数据在传感器末端发生的运动事件期间提供准确的信息。 如果传感器没有被正确放置在患者身上或者与传感器脱离接合，该系统还能检测并提供警报。

公开(公告)号：WO2015095546A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/071201

申请日：2014-12-18

Applicant: LUMINEX CORPORATION

Inventor： ESTRADA, Arnold

IPC: C12Q1/68 ,  G01N21/64 ,  G01N30/72

CPC classification number: G01N21/6428 ,  G01N21/274 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2021/6441 ,  G01N2201/121

Abstract: Techniques are disclosed relating to analysis and reduction of crosstalk between signals. These techniques may be applicable in many fields, such as single-tube PCR or DNA melt analysis, PCR or melt data from neighboring wells of a multi-well plate, capillary electrophoresis data (e.g., DNA sequencing), gas chromatography, multispectral imaging, dual-color fluorescence correlation spectrometry, electrical crosstalk, etc. According to one embodiment, crosstalk between fluorescence signals from different species may be determined based on a correlation between the time derivatives of the fluorescence signals from the fluorescent species.

Abstract translation: 公开了关于分析和减少信号之间的串扰的技术。 这些技术可以应用于许多领域，例如单管PCR或DNA熔解分析，PCR或来自多孔板的相邻孔的熔融数据，毛细管电泳数据（例如，DNA测序），气相色谱，多光谱成像， 双色荧光相关光谱法，电串扰等。根据一个实施例，可以基于来自荧光物种的荧光信号的时间导数之间的相关性来确定来自不同物种的荧光信号之间的串扰。

公开(公告)号：WO2014201045A9

公开(公告)日：2015-04-23

申请号：PCT/US2014041781

申请日：2014-06-10

Applicant: IPHOTON SOLUTIONS LLC

Inventor： DUBOIS MARC ,  DRAKE THOMAS E JR

IPC: G01N21/00

CPC classification number: G01N21/1702 ,  G01B9/02 ,  G01B11/24 ,  G01B17/06 ,  G01N2021/1706 ,  G01N2201/06113 ,  G01N2201/121

Abstract: A laser ultrasound system may be utilized to test material quality. The laser ultrasound system may generate a laser for application to a material and measure signal generated by the application of the laser to the material. The measured signals may be altered based on correction factors and the quality of the material may be determined based on the altered signals.

Abstract translation: 激光超声系统可用于测试材料质量。 激光超声系统可产生用于施加到材料的激光并测量通过将激光施加到材料而产生的信号。 所测量的信号可以基于校正因子而改变，并且材料的质量可以基于改变的信号来确定。

公开(公告)号：WO2014152739A3

公开(公告)日：2014-11-13

申请号：PCT/US2014027680

申请日：2014-03-14

Applicant: UNIV CALIFORNIA

Inventor： TAO XIAODONG ,  KUBBY JOEL A

IPC: F21V9/16

CPC classification number: G02B27/0068 ,  G01J9/00 ,  G01N21/45 ,  G01N21/49 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/4709 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/121 ,  G02B21/16 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0927

Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

Abstract translation: 干涉测量聚焦（IF），而不是传统的几何聚焦，将激发光照射到深深嵌入组织中的导向星上，从而增加其荧光强度。 该方法能够扩大波前测量的深度并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的像差。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 尽管只有激发路径中的弹道光被校正，但波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。

公开(公告)号：WO2014152739A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/027680

申请日：2014-03-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： TAO, Xiaodong ,  KUBBY, Joel, A.

IPC: G01N21/45

CPC classification number: G02B27/0068 ,  G01J9/00 ,  G01N21/45 ,  G01N21/49 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/4709 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/121 ,  G02B21/16 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0927

Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

Abstract translation: 干涉测深（IF），而不是传统的几何聚焦，激发光到深埋在组织中的引导星，增加其荧光强度。 该方法可以延长波前测量的深度，并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的差异。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 虽然激励路径中只有弹道光被校正，波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。

公开(公告)号：WO2014087103A1

公开(公告)日：2014-06-12

申请号：PCT/FR2013/052941

申请日：2013-12-04

Applicant: SP3H

Inventor： OBERTI, Sylvain ,  FOURNEL, Johan

IPC: G01N21/35 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: L'invention concerne un procédé de commande d'un spectromètre d'analyse d'un produit, le spectromètre comprenant une source de lumière (LS) comportant plusieurs diodes électroluminescentes (LD1-LD4) ayant des spectres d'émission respectifs couvrant en combinaison une bande de longueurs d'onde d'analyse, le procédé comprenant des étapes consistant à: fournir un courant d'alimentation (I1-I4) à au moins une des diodes électroluminescentes pour l'allumer, mesurer une intensité lumineuse (LFL1- LFL4) émise par la source de lumière en mesurant un courant à une borne d'au moins une autre des diodes électroluminescentes maintenue éteinte, déterminer en fonction de chaque mesure d'intensité lumineuse, une valeur de consigne (LC1-LC4) du courant d'alimentation de chaque diode allumée, et réguler le courant d'alimentation de chaque diode allumée pour qu'il corresponde à la valeur de consigne.

Abstract translation: 本发明涉及一种控制产品分析光谱仪的方法，该光谱仪包括一个光源（LS），该光源包括若干发光二极管（LD1-LD4），该发光二极管具有各自的分析波长带组合的发射光谱，该方法包括步骤 包括：向至少一个所述发光二极管提供电源电流（I1-I4）以便照亮所述发光二极管，通过测量所述光源的端子处的电流来测量由所述光源发射的发光强度（LFL1-LFL4） 至少另外一个保持不发光的发光二极管，确定作为每个点亮二极管的供电电流的设定值（LC1-LC4）的发光强度的每次测量的函数，并且调节每个点亮的电源电流的函数 二极管，使其对应于设定值。

公开(公告)号：WO2013039587A3

公开(公告)日：2014-05-08

申请号：PCT/US2012044054

申请日：2012-06-25

Applicant: UNIV NORTHEASTERN ,  DIEM MAX ,  BIRD BENJAMIN ,  MILJKOVIC MILOS

Inventor： DIEM MAX ,  BIRD BENJAMIN ,  MILJKOVIC MILOS

IPC: G01B9/02

CPC classification number: G01N21/255 ,  G01J3/28 ,  G01N21/1702 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N2201/10 ,  G01N2201/121

Abstract: Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed.

Abstract translation: 本文公开了一种校正光谱的反射失真的过程和系统。 此外，公开了补偿反射失真的光谱系统。

公开(公告)号：WO2007083991A1

公开(公告)日：2007-07-26

申请号：PCT/NL2006/000029

申请日：2006-01-19

Applicant: Erasmus University Medical Center Rotterdam ,  STERENBORG, Henricus Josephus Cornelus Maria ,  AMELINK, Arjen ,  KUIJPERS, Johannes Antonius Maria

Inventor： STERENBORG, Henricus Josephus Cornelus Maria ,  AMELINK, Arjen ,  KUIJPERS, Johannes Antonius Maria

IPC: A61B5/00 ,  G01N21/00

CPC classification number: G01N21/474 ,  A61B5/1495 ,  A61B2560/0233 ,  A61B2560/0271 ,  A61B2562/085 ,  G01N21/4785 ,  G01N2201/121

Abstract: An optical analysis apparatus is provided with an exchangeable probe that contains an optical fibre for performing measurements or applying treatment. The apparatus has a base unit that contains a light source and/or a light detector for supplying to the optical fibre and/or detecting light from the optical fibre. The probe contains a computer readable information providing element. Before operation the base unit reads probe dependent probe information into the base unit from the information providing element that is part of the probe and controls operation of the base unit dependent on the probe information. In one embodiment the probe information comprises (or refers to) results of calibration measurements for the probe and supply of light to the probe and/or signal processing of signals received from the probe is corrected according to the results of the calibration measurements read using the information element. In other embodiments the information is used to prevent re-use of probes that have been used in operations that can compromise sterility.

Abstract translation: 光学分析装置具有包含用于进行测量或施加处理的光纤的可交换探针。 该装置具有包含用于向光纤供给和/或检测来自光纤的光的光源和/或光检测器的基座单元。 探测器包含计算机可读信息提供元素。 在操作之前，基本单元从作为探头一部分的信息提供元件将与探针相关的探针信息读取到基本单元中，并且根据探针信息控制基本单元的操作。 在一个实施例中，探针信息包括（或指）针对探针的校准测量结果和对探头的光的供应和/或从探头接收的信号的信号处理，根据使用 信息元素。 在其他实施方案中，该信息用于防止在可能损害不育的操作中已经使用的探针的重复使用。

公开(公告)号：US12111212B2

公开(公告)日：2024-10-08

申请号：US18048772

申请日：2022-10-21

Applicant: Excelitas Technologies Corp.

Inventor： Lowell Brunson ,  John Christopher Freitag ,  Theresa Thompson

IPC: G01N21/27 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J3/44 ,  G01N21/05 ,  G01N21/64 ,  G01N30/74 ,  G02B5/28 ,  G02B19/00 ,  G02B27/10 ,  G02B27/14 ,  G01N30/62

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0275 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/4406 ,  G01N21/274 ,  G01N21/64 ,  G01N30/74 ,  G02B5/283 ,  G02B19/0028 ,  G02B19/0047 ,  G02B27/1006 ,  G02B27/14 ,  G01J2003/102 ,  G01J2003/2866 ,  G01J2003/425 ,  G01N21/05 ,  G01N2021/6491 ,  G01N2030/621 ,  G01N2030/746 ,  G01N2201/0639 ,  G01N2201/0695 ,  G01N2201/121

Abstract: Systems and methods are provided for a UV-VIS spectrophotometer, such as a UV-VIS detector unit included in a high-performance liquid chromatography system. In one example, a system for the UV-VIS detector unit may include a first light source, a signal detector, a flow path positioned intermediate the first light source and the signal detector, a second light source, and a reference detector. The first light source, the signal detector, and the flow path may be aligned along a first axis, and the second light source and the reference detector may be aligned along a second axis, different than the first axis.