公开(公告)号：WO1995015711A1

公开(公告)日：1995-06-15

申请号：PCT/DE1994001475

申请日：1994-12-12

Applicant: CHO, Ok-Kyung ,  HOLZGREVE, Birgit

IPC: A61B05/00

CPC classification number: A61B5/14532 ,  A61B5/015

Abstract: A device is suitable both for determining with high accuracy and precision the temperature of the human body (surface temperature, temperature in layers next to the surface, temperature in bodily cavities, temperature gradient towards the inside of the body) and for detecting the heat of the human body. The device has at least one sensor head and the associated electronic control, measurement, evaluation and output units. Their measurement accuracy and precision is higher than that of conventional temperature and heat measurement devices. The device further allows temperature measurement and heat detection with a high spatial and temporal resolution. In addition, because of the high correlation discovered between the glucose concentration in human blood and body temperature and heat measured at certain points of the body, the device is extraordinarily suitable for non-invasively and even contactlessly determining the glucose concentration in parts of the human body, in particular the human blood.

Abstract translation: 描述了一种用于高度准确和精确地确定人体（表面温度，在体腔中的温度的近表面层的温度，朝向主体内部的温度梯度）的温度的装置和检测所述人体的热量，所述至少一个传感器头和相关联的电撕扯控制 包括测量，评价和Ausgabeeinnheiten，以及它们的准确度和精度超过了温度和热的常规测量仪器的。 该装置还能够使温度测量和热检测具有高空间和时间分辨率。 此外，本发明的装置 - 非常适合用于非侵入性的或甚至非接触测定在人体内的部位中的葡萄糖浓度的，特别是在人体血液 - 因为人体血液中的葡萄糖浓度之间的发现高相关性的，并在某些点体温和温暖测量。

公开(公告)号：WO1995012348A1

公开(公告)日：1995-05-11

申请号：PCT/DE1994001290

申请日：1994-10-29

Applicant: BOEHRINGER MANNHEIM GMBH ,  ESSENPREIS, Matthias ,  BÖCKER, Dirk ,  HEIN, Heinz-Michael ,  HAAR, Hans-Peter

Inventor： BOEHRINGER MANNHEIM GMBH

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/0242 ,  G01N21/41 ,  G01N21/47 ,  G01N21/49 ,  G01N2201/0696

Abstract: A process and device for the analytical determination of the glucose concentration in a biological matrix. According to said process, in a detection step, light from a light transmitter is irradiated through a boundary surface of a biological matrix thereinto as primary light and the light leaving the biological matrix through a boundary surface thereof is detected in a light receiver in order to determine a measurable physical property of the light which can vary owing to the interaction with the biological matrix and which correlates with the glucose concentration in said biological matrix. In an evaluation step, the glucose concentration is found on the basis of the change in the said physical property of the light determined in at least one detection step in relation to a calibrated value. In order, with such a process, to obtain good analytical accuracy, e.g. to observe the change in the analyte concentration (cyclic control) over a sufficient period, as the property which can be measured in the detection step correlating with the glucose concentration is used a parameter corresponding to the time of propagation of the light within the biological matrix between a defined irradiation point and a defined detection point.

Abstract translation: 葡萄糖在生物基质中的浓度由光确定通过生物基质的边界表面照射光被所述生物基质的边界表面检测出现，由相互作用的光的生物基质可变可测量物理属性来确定， 其与葡萄糖在生物基质中的浓度相关。 中的葡萄糖浓度是基于所述光的物理性质的比较来校准的变化来确定。 为了实现无试剂和非侵入性分析的精度好，例如用于分析物浓度（流量控制）足够长的时间的变化的观察中，被用作与葡萄糖的之间的生物基质内的光的一个运行时间可测量特性相关联的浓度 定义照射位点和一个限定相应的参数的检测来确定。

公开(公告)号：WO1995010976A1

公开(公告)日：1995-04-27

申请号：PCT/US1994011661

申请日：1994-10-21

Applicant: SCIMED LIFE SYSTEMS, INC.

Inventor： SCIMED LIFE SYSTEMS, INC. ,  ELLIS, Louis ,  HASTINGS, Roger, N. ,  HUMPHREY, John, W.

IPC: A61B05/00

CPC classification number: A61M25/0169 ,  A61M25/0127 ,  A61M2025/09116

Abstract: The present invention is a device and method for controlling longitudinal movement of a tube (34) relative to a shaft (36) slidably disposed within the tube, especially in the catheterization of a patient. An operative segment of the shaft cooperates with an ancillary tool to create a coupling force field between the shaft (36) and the tool (34). The tube can be moved over the shaft while the coupling force field operates through the tube to restrict movement of the shaft. In preferred embodiment, the shaft is a guide wire (36) and the tube is a catheter (34) with a lumen for slidably receiving the guide wire (36), while the coupling force is created magnetically.

Abstract translation: 本发明是一种用于控制管（34）相对于可滑动地设置在管内的轴（36）的纵向运动的装置和方法，特别是在患者的导尿中。 轴的操作段与辅助工具协作以在轴（36）和工具（34）之间产生联接力场。 管可以在轴上移动，同时耦合力场通过管操作以限制轴的运动。 在优选实施例中，所述轴是导丝（36），并且所述管是具有用于可滑动地接收所述导丝（36）的内腔的导管（34），同时所述耦合力是磁力产生的。

公开(公告)号：WO1995003736A1

公开(公告)日：1995-02-09

申请号：PCT/EP1994002507

申请日：1994-07-28

Applicant: PFEIFFER, Ulrich ,  KNOLL, Reinhold ,  MÖGERLEIN, Markus

IPC: A61B05/00

CPC classification number: A61B5/1459

Abstract: A device is proposed for determining the concentration of substances in the blood, in particular of haemoglobin, oxyhaemoglobin and/or diagnostic dyes. A light source (12, 30, 40) emits light in the range of at least one wavelength, the light being made to pass via an optical coupler (50) and an optical waveguide connected thereto in the blood. Light emerging from the blood passes through the coupler (50) to a photodetector (60, 70), whose output signal passes through an evaluation device which determines the required concentration on the basis of the intensity of the light leaving the blood. The photodetector detects light in the range of at least two light wavelengths, one of which corresponds to the wavelength of the fluorescent light from the substance whose concentration is to be measured, the other corresponding to the wavelength of the fluorescent light from at least one other substance present in the blood. The range of the wavelength of light from the light source (30, 40) is spectrally separated from those of the light detected by the light detector (70, 60). The evaluation device calculates the required concentration of the substance in the blood on the basis of an empirically predetermined function into which are incorporated the respective intensities of fluorescent light from the substance to be measured and of the at least one other substance, in particular according to a multidimensional power series of those intensities.

Abstract translation: 装置用于确定物质的浓度在血液中，特别是用于确定血红蛋白，氧合血红蛋白和/或诊断的染料浓度。 一种光源（12，30,40）通过一个光耦合器（50）和相关联的光纤在血液照射从该至少一个波长范围内发射光。 从血液中的光线是耦合器（50）的光检测器（60，70）的输出信号被施加到确定要从光的从血液来的强度测定的浓度的评估装置的上方。 光检测器检测在至少两个波长的光，一个对应于荧光灯，其浓度是待确定的物质的波长的范围的光，而另一个对应于血液中的至少一种其它物质的荧光的光的波长。 在这种情况下，光从光源（30，40）由光检测器（60，70）的光的波长分别的区域中检测到的光谱的波长的范围内。 评价装置计算根据预先凭经验确定的函数，其中，所述物质的荧光的强度，desses浓度被确定为在血液测定的物质的浓度，并达到一个多维幂级数这些强度的接收的至少一种其它物质，尤其如此。

公开(公告)号：WO1995001122A3

公开(公告)日：1995-01-12

申请号：PCT/US1994006980

申请日：1994-06-21

Applicant: ADVANCED MEDICAL CONCEPTS, INC.

Inventor： ADVANCED MEDICAL CONCEPTS, INC. ,  TEVES, Leonides, Y.

IPC: A61B05/00

CPC classification number: G01K13/002 ,  A61B2017/00084 ,  A61M16/04 ,  A61M16/0434

Abstract: An endotracheal tube (10) has a temperature sensor (42) positioned proximal of a patient's larynx when the tube (10) is in use. Thus, the sensor (42) overlies the tongue. A heat insulator (46) and an electrical insulator (48) surround the temperature sensor (42). The temperatore sensor (42) can be linear or serpentine. An oxymeter (50) can also be used with the tube.

公开(公告)号：WO1995000069A1

公开(公告)日：1995-01-05

申请号：PCT/US1994005881

申请日：1994-05-19

Applicant: CYBERRX INCORPORATED

Inventor： CYBERRX INCORPORATED ,  GOLDBERG, Michael, S. ,  HORRES, Charles, R., Jr.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/1495

Abstract: A device and method for monitoring the pH value of the aspirated gastric fluid of a patient includes a monitor (10), a sensor assembly (18) engageable with the monitor (10), and a collecting reservoir (22) engageable with the sensor assembly (18). The sensor assembly (18) includes a sensor (48) which is moveable on a base member (42) between a cleansing cavity (74), calibration cavities (56, 70), and a monitoring cavity (78). The monitor (10) includes a suction generating member (14) which is connectable with the patient, and a microprocessor (90) which is connectable with the sensor (48) of the sensor assembly (18). In the operation of the device, gastric contents from the patient are aspirated by the suction generating member (14) into the monitoring cavity (78). There, the sensor (48) generates a signal indicative of the pH value of the gastric contents which is transmitted to the microprocessor (90). Periodically, during operation, the sensor (48) is moved to the cleansing cavity (74) for cleaning and subsequent calibration by successive contact with pH 7 and pH 1 solutions in the calibration cavities (56, 70) of the sensor assembly (18).

Abstract translation: 用于监测患者的吸入胃液的pH值的装置和方法包括监测器（10），可与监测器（10）接合的传感器组件（18）和可与传感器组件接合的收集容器（22） （18）。 传感器组件（18）包括可在清洁腔（74），校准腔（56,70）和监测腔（78）之间的基底构件（42）上移动的传感器（48）。 监视器（10）包括可与患者连接的抽吸产生构件（14）和可与传感器组件（18）的传感器（48）连接的微处理器（90）。 在装置的操作中，来自患者的胃内容物被抽吸产生构件（14）吸入监测腔（78）。 在那里，传感器（48）产生指示传送到微处理器（90）的胃内容物的pH值的信号。 定期地，在操作期间，传感器（48）移动到清洁腔（74），用于通过在传感器组件（18）的校准腔（56,70）中连续接触pH7和pH1溶液进行清洁和随后的校准， 。

公开(公告)号：WO1994027494A1

公开(公告)日：1994-12-08

申请号：PCT/US1994005301

申请日：1994-05-11

Applicant: SOMANETICS CORPORATION

Inventor： SOMANETICS CORPORATION ,  SCHEUING, Richard, S.

IPC: A61B05/00

CPC classification number: A61B5/14552

Abstract: A sensor (10) for spectrophotometric-type patient examination devices includes a thin, flexible, elongated support frame (22) of opaque material which defines integral socket-like mounting bases (32, 32a, 32b) for positioning an electro-optical light source (14) and detectors (16, 18) in particular relative locations, and the support frame further defines light passages (30, 30', 30") in alignment with each such electro-optical component. A thin metallic member (24, 34) overlays each side of the frame to shield the electro-optical components from electric noise-producing fields, and a compliant outer cover (12) overlies the shield on one side for contact with the patient. An adhesive outer layer on the cover secures the sensor to the patient. The cover and shield have apertures (24a, 24b) aligned with the electro-optical components for passage of light to and from the latter. The source and detectors are solid-state devices, which are mounted on lead-frame assemblies and have an optically clear lens-like deposit covering them.

Abstract translation: 用于分光光度型患者检查装置的传感器（10）包括薄的，柔性的不透明材料的细长支撑框架（22），其限定用于定位电光源的整体式插座状安装基座（32,32a，32b） （14）和检测器（16,18），特别是相对位置，并且支撑框架还限定与每个这样的电光部件对准的光通道（30,30'，30“），薄金属部件 ）覆盖框架的每一侧以屏蔽电光部件免受电噪声产生场，并且柔性外盖（12）覆盖在一侧的屏蔽件上以与患者接触，盖上的粘合剂外层固定 传感器到患者，盖子和屏蔽罩具有与电光部件对准的孔（24a，24b），用于使光通过光源和从光电部件通过，源和检测器是固态器件，其安装在引线框架 装配并具有光学特性 透明的透镜状沉积物覆盖着它们。

公开(公告)号：WO1994027493A1

公开(公告)日：1994-12-08

申请号：PCT/US1994005224

申请日：1994-05-11

Applicant: SOMANETICS CORPORATION

Inventor： SOMANETICS CORPORATION ,  LEWIS, Gary, D. ,  STODDART, Hugh, F.

IPC: A61B05/00

CPC classification number: A61B5/6814 ,  A61B5/14552 ,  A61B5/14553 ,  A61B2562/164

Abstract: A method and apparatus for spectrophotometrically determining internal physiological parameters such as blood constituents, wherein a source (132) of selected electromagnetic wavelenghts is disposed at a first location and at least two detectors (128, 130) are located at particular different distances from the source, selected such that both detectors receive energy that has traversed not only perimetral layers (114, 142, 214, 242, 314, 342) such as bone, tissue, etc. but also internal tissue (140, 240, 340) disposed beyond such perimetral layers, and one such detector (130) receives energy which has traversed only a small amount of the selected internal tissue while the other (128) receives energy which has traversed substantially more of such tissue, whereby comparative analysis of the data from the two detectors provides information which consistently characterizes only the selected internal tissue. In cerebral oximetry, where the detector and receivers are applied to the forehead, the particular distances from the source to the two detectors are about 30 and 40 mm., respectively.

Abstract translation: 一种用于分光光度测定内部生理参数（如血液成分）的方法和装置，其中所选择的电磁波长的源极（132）设置在第一位置处，并且至少两个检测器（128,130）位于离源极特别不同的距离处 被选择为使得两个检测器接收不仅穿过周边层（114,142,214,242,314,342）的能量，所述周边层（114,142,214,242,314,342）例如骨，组织等，而且还包括设置在该外部层之外的内部组织（140,240,340） 周边层，并且一个这样的检测器（130）接收仅穿过少量所选择的内部组织的能量，而另一个（128）接收到已经穿过该组织的实质上更多的能量，由此对来自两个 检测器提供的信息始终只表示所选择的内部组织。 在脑血氧测定法中，检测器和接收器应用于前额，从源到两个检测器的特定距离分别为30和40 mm。

公开(公告)号：WO1994027491A2

公开(公告)日：1994-12-08

申请号：PCT/US1994003771

申请日：1994-04-06

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  BURGIO, Paul, A. ,  SIMONSEN, Richard, J.

IPC: A61B05/00

CPC classification number: H01R4/50 ,  A61B18/16 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0488 ,  A61N1/0492 ,  A61N1/0551 ,  H01R4/04 ,  H01R2201/12

Abstract: Intraoral-procedures TENS electrodes (10, 30, 40, 50, 60, 70, 80) are disclosed. Intraoral electrodes (60, 70, 80, 170) include active electrodes and return electrodes having a common carrier with a field of pressure sensitive adhesive for adhering the electrode to a hand (finger or thumb) of the practitioner or an applicator. Extraoral electrodes (10, 30, 40, 50) adhere to facial skin of mammals and provide TENS treatment for intraoral-procedures. The electrodes can be dual channel to combine active electrodes and return electrodes on one electrode. Optionally, a dual channel electrode is used in combination with an elongated applicator (140) having a bifurcated end in order to facilitate guiding a syringe needle toward a desired injection site.

Abstract translation: 公开了口内手术TENS电极（10,30,40,50,60,70,80）。 口内电极（60,70,80,170）包括具有共同载体的活性电极和返回电极，所述载体具有压敏粘合剂领域，用于将电极粘附到从业者或施用器的手（手指或拇指）。 额外电极（10,30,40,50）粘附于哺乳动物的面部皮肤，并为口腔内手术提供TENS治疗。 电极可以是双通道，以组合有效电极和一个电极上的返回电极。 任选地，双通道电极与具有分叉端的细长施用器（140）组合使用，以便于将注射器针导向所需的注射部位。

公开(公告)号：WO1994023645A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004202

申请日：1994-04-15

Applicant: ARGUS CRITICAL CARE, INC.

Inventor： ARGUS CRITICAL CARE, INC. ,  SALZMAN, Andrew, L. ,  FINK, Mitchell, P. ,  KANE, Jeffrey, B.

IPC: A61B05/00

CPC classification number: A61B5/42 ,  A61B5/1459 ,  A61B5/412

Abstract: A method and apparatus for measuring or monitoring pCO2, and optionally pO2, on a real-time basis, in the stomach or the intestine using air tonometry. The intraluminal measurements are made using a catheter (14) having a pCO2 sensor (12), and optionally a pO2 sensor, at its tip (14a) for in situ measurements, or by circulating a fixed amount of air through the catheter (14) with measurement occurring at the proximal end (14b) of the catheter (14). Instrumentation (16) supporting the sensor may be adapted for location within a patient or external to a patient.

Abstract translation: 一种用于使用空气眼压测量法在胃或肠中实时地测量或监测pCO2和任选的pO2的方法和装置。 使用具有pCO 2传感器（12）的导管（14）和其可选的pO2传感器在其尖端（14a）进行原位测量，或通过使固定量的空气通过导管（14）循环来进行管腔内测量， 其中测量发生在导管（14）的近端（14b）处。 支持传感器的仪器（16）可以适于位于患者体内或病人外部。