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151.发明公开METHODS AND COMPOSITIONS FOR NANOPARTICLE-MEDIATED CANCER CELL-TARGETED DELIVERY 审中-公开方法和组合物粒子管制药物的问题癌细胞
公开(公告)号：EP2525835A2
公开(公告)日：2012-11-28
申请号：EP11733532.3
申请日：2011-01-18
Applicant: Board Of Regents, University Of Texas System
Inventor： YUAN, Zhi-Min , SEO, Seog-Jin
CPC classification number: A61K48/0041 , A61K9/5146 , A61K47/549 , A61K47/59 , A61K47/60 , A61K47/6935 , A61K47/6939 , G01N33/54346 , G01N33/574
Abstract: The present invention provides methods and compositions to selectively and directly deliver nanoparticles carrying an active agent to tumor cells. The active agent is internalized by the tumor cells, producing an anti-tumor effect for therapeutic applications and/or depositing a detectable marker for diagnostic applications. The present invention further provides a p53 chimera that circumvents the dominant negative activity of mutant p53 as a therapeutic in the treatment of cancer and reduction of tumor size.
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公开(公告)号：EP1695986A3
公开(公告)日：2012-11-07
申请号：EP06007998.5
申请日：1997-10-09
Inventor： Fendly, Brian M. , Phillips, Gail Dianne , Scheuermann, Richard H. , Uhr, Jonathan W.
IPC: C07K16/32 , A61K39/395 , C12N15/13 , C12N5/20 , G01N33/577 , G01N33/68 , A61P35/00
CPC classification number: C07K16/32 , A61K2039/505 , C07K2317/73 , C07K2317/92
Abstract: Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Uses for these antibodies are also described.
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公开(公告)号：EP2369916A2
公开(公告)日：2011-10-05
申请号：EP09830992.5
申请日：2009-12-01
Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM
Inventor： HAMRA, F., Kent
IPC: A01K67/027
CPC classification number: A01K67/0271 , A01K67/02 , A01K67/0275 , A01K2217/07 , A01K2227/10 , A01K2227/105 , C12N5/061 , C12N2500/44 , C12N2501/115 , C12N2501/13 , C12N2800/90
Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.
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公开(公告)号：EP1106183A3
公开(公告)日：2001-09-12
申请号：EP01101031.1
申请日：1997-10-09
Inventor： Fendly, Brian M.
IPC: C12N15/13 , C07K16/32 , A61K39/395 , C12N5/20 , G01N33/577 , G01N33/68
CPC classification number: C07K16/32 , A61K2039/505 , C07K2317/73 , C07K2317/92
Abstract: Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are also described.
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公开(公告)号：EP1106183A2
公开(公告)日：2001-06-13
申请号：EP01101031.1
申请日：1997-10-09
Inventor： Fendly, Brian M.
IPC: A61K39/395 , A61K31/00 , A61P35/00
CPC classification number: C07K16/32 , A61K2039/505 , C07K2317/73 , C07K2317/92
Abstract: Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are also described.
Abstract translation: 描述了与ErbB2的结构域1中的表位结合并通过细胞凋亡诱导细胞死亡的抗ErbB2抗体。 还描述了这些抗体的各种用途。
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Patent Agency Ranking
公开(公告)号：EP3110420B1
公开(公告)日：2019-02-13
申请号：EP15755054.2
申请日：2015-02-25
Applicant: Board of Regents, University of Texas System
Inventor： JONES, Philip , DI FRANCESCO, Maria, Emilia , MCAFOOS, Timothy
IPC: A61K31/42 , A61P35/00 , C07D413/14
CPC classification number: A61K31/454 , A61K31/4245 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/14
Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.
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157.发明公开METHODS AND COMPOSITIONS FOR CHLAMYDIAL ANTIGENS FOR DIAGNOSIS AND TREATMENT OF CHLAMYDIAL INFECTION AND DISEASE 审中-公开方法和组合物衣原体抗原诊断和治疗衣原体感染与-ERKRANUNG的
公开(公告)号：EP2544715A2
公开(公告)日：2013-01-16
申请号：EP11708379.0
申请日：2011-03-09
Applicant: Board Of Regents, University Of Texas System
Inventor： ZHONG, Guangming
IPC: A61K39/118
CPC classification number: A61K39/118
Abstract: The present invention provides
Chlamydia proteins and methods of use in treatment and immunization protocols as well as in diagnostic and detection assays.-
158.发明公开NANOSCALING ORDERING OF HYBRID MATERIALS USING GENETICALLY ENGINEERED MESOSCALE VIRUS 审中-公开杂交分子纳米级布置使用的基因所制造的病毒中尺度
公开(公告)号：EP1488010A2
公开(公告)日：2004-12-22
申请号：EP02795498.1
申请日：2002-10-02
Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM
Inventor： BELCHER, Angela, M. , LEE, Seung-Wuk
CPC classification number: H01L29/045 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C30B7/00 , C30B7/005 , C30B29/58 , G01N33/588 , H01L21/02 , H01L51/0012 , H01L51/0093 , Y10T428/31504
Abstract: The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the present invention is a method to construct ordered nanoparticles within the liquid crystal of the self-assembling biological molecule.
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公开(公告)号：EP0156537A3
公开(公告)日：1987-05-13
申请号：EP85301442
申请日：1985-03-01
Inventor： Poynton, Christopher H. , Reading, Christopher L.
CPC classification number: B03C1/01 , A61K9/5094 , A61M1/3618 , G01N33/5434 , G01N2333/76 , G01N2446/20 , G01N2446/30 , G01N2446/84
Abstract: A biological magnetic fluid includes a magnetic colloidal disperse phase distributed throughout a liquid dispersion medium. The disperse phase may be made up of magnetic particles coated with cross-linked biologically compatible polymers. The biologically compatible polymers may be connected by way of covalent linkages to biologically active macromolecules. This may be accomplished by covalently linking immunoglobulin to the biologically compatible polymers and then attaching antibodies with predefined specificity to the immunoglobulin. These antibodies may target the magnetic particles on desired cells, for a variety of medical applications. The magnetic particles may be made up of magnetite cores with cobalt or cobalt and boron coatings. In addition magnetic particles may be made of icobalt and boron with the boron being in sufficient concentration to enable radiation activation. The magnetic colloid may be formed by incorporating the biologically compatible polymer into the colloid as the colloid is being formed by reducing a magnetic metallic salt. The colloid is advantageously produced in a multi-stage process in order to achieve very uniform particle sizes. The magnetic colloid may also be made by forming a biologically incompatible magnetic colloid, and slowly adding the colloid to a vigorous I biologically compatible polymer. These biological magnetic fluids are useful, for example, in separating cancerous cells from normal cells in bone marrow transplants.
Abstract translation: 生物磁性流体包括分散在液体分散介质中的磁性胶体分散相。 分散相可以由涂覆有交联的生物相容性聚合物的磁性颗粒组成。 生物相容的聚合物可以通过共价键与生物活性大分子连接。 这可以通过将免疫球蛋白共价连接到生物相容性聚合物上，然后将具有预定义特异性的抗体连接到免疫球蛋白来实现。 这些抗体可以靶向所需细胞上的磁性颗粒，用于各种医学应用。 磁性颗粒可以由具有钴或钴和硼涂层的磁铁矿芯组成。 此外，磁性颗粒可以由钴和硼制成，硼具有足够的浓度以使辐射活化。 磁性胶体可以通过将生物相容的聚合物掺入胶体中而形成，因为通过还原磁性金属盐形成胶体。 有利地，在多阶段方法中制备胶体以获得非常均匀的粒度。 磁性胶体也可以通过形成生物不相容的磁性胶体，并将胶体缓慢加入到生物相容性较强的聚合物中制成。 这些生物磁性流体可用于例如在骨髓移植中从正常细胞分离癌细胞。
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公开(公告)号：EP3519073A1
公开(公告)日：2019-08-07
申请号：EP17787695.0
申请日：2017-09-26
Inventor： DASGUPTA, Purnendu, K. , HUANG, Weixiong , POHL, Christopher, A.
IPC: B01D15/22 , B01D15/36 , B01J20/286 , B01J20/32 , G01N30/60
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