公开(公告)号：AU2018372917A1

公开(公告)日：2020-06-18

申请号：AU2018372917

申请日：2018-11-19

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV ,  WILLIAM MARSH RICE UNIV

Inventor： NOT GIVEN

IPC: A61K31/661 ,  A61K45/06 ,  A61P35/00

Abstract: The disclosure relates to the treatment of primary and metastatic cancer using radiation. Specifically, the disclosure relates to methods providing for the selective accretion of cytoprotective agent in tissues and/or organs, sensitive to radiation that are adjacent to malignant tumors prior to radiation of the tumors at a dose that otherwise would be toxic to the tissues and/or organs, but are necessary to achieve ablative outcome on the tumors.

公开(公告)号：AU2006270325A1

公开(公告)日：2007-01-25

申请号：AU2006270325

申请日：2006-07-13

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： BRABANDER JEF DE ,  JIANG XIN

IPC: C07D407/06 ,  A61K31/351 ,  A61K31/365 ,  A61P35/00 ,  C07D309/10

公开(公告)号：AU2004228050A1

公开(公告)日：2004-10-21

申请号：AU2004228050

申请日：2004-04-05

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM ,  MAGDA DARREN ,  PHARMACYCLICS INC ,  SESSLER JONATHAN ,  WANG ZHONG

Inventor： MAGDA DARREN ,  SESSLER JONATHAN L ,  WANG ZHONG

IPC: A61B5/055 ,  A61B10/00 ,  A61K20060101 ,  A61K31/40 ,  A61K31/409 ,  A61K31/555 ,  A61K41/00 ,  C07B47/00 ,  C07D245/00 ,  C07D487/22

Abstract: The present invention relates to compounds of Formula (I): their pharmaceutical composition and their utility in treating neoplasm.

公开(公告)号：AU2016287661B2

公开(公告)日：2020-07-16

申请号：AU2016287661

申请日：2016-06-30

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： LEWIS RICHARD THOMAS ,  JONES PHILIP ,  PETROCCHI ALESSIA ,  REYNA NAPHTALI ,  HAMILTON MATTHEW ,  SOTH MICHAEL J ,  HEFFERNAN TIMOTHY ,  HAN MICHELLE ,  BURKE JASON P

IPC: C07D207/00 ,  A61K31/501 ,  C07D417/14

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLSl mediated diseases, such as cancer, having the structure of Formula (I). Methods of inhibition GLSl activity in a human or animal subject are also provided.

公开(公告)号：AU2003270678A1

公开(公告)日：2004-04-08

申请号：AU2003270678

申请日：2003-09-19

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： GARNER HAROLD R ,  WREN JONATHAN D

IPC: G06F7/00 ,  G06F19/24 ,  G06F19/28 ,  G06N5/02 ,  G06N5/04

Abstract: The present invention is a system, method for accessing domains of information to identify heretofore unknown relationships between disparate sources of data to seek and obtain knowledge, the invention includes a source of data with one or more domains of information, an Object-Relationship Database for integrating objects from one or more domains of information and a knowledge discovery engine where relationships between two or more objects are identified, retrieved, grouped, ranked, filtered and numerically evaluated.

公开(公告)号：AU2015283850A1

公开(公告)日：2016-12-15

申请号：AU2015283850

申请日：2015-07-02

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： CZAKO BARBARA ,  LIU GANG ,  THEROFF JAY ,  HERRERA ZACHARY ,  YAU ANNE ,  DI FRANCESCO MARIA EMILIA ,  JONES PHILIP ,  HEFFERNAN TIMOTHY ,  HAMILTON MATTHEW ,  KANG ZHIJUN ,  SOTH MICHAEL P ,  BURKE JASON P ,  LE KANG ,  CARROLL CHRISTOPHER LAWRENCE ,  PALMER WYLIE ,  LEWIS RICHARD ,  MCAFOOS TIMOTHY

IPC: C07D401/06 ,  A61K31/4439 ,  C07D417/14

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS I mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS I activity in a human or animal subject are also provided. Accordingly, the inventors herein disclose new compositions and methods for inhibiting glutaminase activity. The present disclosure relates to new heterocyclic compounds and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of GLS 1 activity in a human or animal subject are also provided for the treatment of diseases such as cancer.

公开(公告)号：AU2003298590B2

公开(公告)日：2009-11-19

申请号：AU2003298590

申请日：2003-09-24

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： IVERSON BRENT L ,  BELCHER ANGELA M ,  LEE SEUNG-WUK ,  LEE SOO-KWAN

IPC: A01N1/00 ,  C12N11/00

公开(公告)号：AU2008221594A1

公开(公告)日：2008-10-16

申请号：AU2008221594

申请日：2008-09-19

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： BELCHER ANGELA M ,  LEE SEUNG-WUK

IPC: B82B3/00 ,  C12N7/00 ,  C12N15/00 ,  C30B7/00 ,  C30B29/54 ,  G01N33/58 ,  H01L21/02 ,  H01L29/04 ,  H01L29/06 ,  H01L51/00 ,  H01L51/30 ,  H01L51/40

Abstract: The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the present invention is a method to construct ordered nanoparticles within the liquid crystal of the self-assembling biological molecule.

公开(公告)号：ZA200504163B

公开(公告)日：2007-03-28

申请号：ZA200504163

申请日：2005-05-23

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： KIRKEN ROBERT A ,  KAHAN BARRY D ,  STEPKOWSKI STANISLAW M ,  WALDEMAR PRIEBE ,  IZABELA FOKT ,  SZYMON KOSINSKI

IPC: A61K20090101 ,  A61K31/12 ,  A61K31/13 ,  A61K31/21 ,  A61K31/335 ,  C07C225/12 ,  C07D20090101 ,  G01N33/50

Abstract: Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.

公开(公告)号：AU2003298587A1

公开(公告)日：2004-05-04

申请号：AU2003298587

申请日：2003-09-22

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

Inventor： BELCHER ANGELA M ,  REISS BRIAN ,  MAO CHUANBIN ,  SOLIS DANIEL

IPC: A61K49/18 ,  B01J19/00 ,  B01J19/08 ,  C07K1/00 ,  C07K1/04 ,  C07K17/14

Abstract: The present invention includes methods of producing magnectic na nocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific b inding to a magnectic material.