公开(公告)号：WO2009002733A1

公开(公告)日：2008-12-31

申请号：PCT/US2008/066905

申请日：2008-06-13

Applicant: H R D CORPORATION ,  HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

Inventor： HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

IPC: C07C65/21 ,  C07C65/05 ,  C07C69/78

CPC classification number: C07C51/265 ,  B01F7/00766 ,  B01F13/1013 ,  B01F13/1016 ,  B01J8/222 ,  B01J19/1806 ,  C07C63/16 ,  C07C63/26 ,  C07C63/24 ,  C07C63/06

Abstract: A method for producing benzoic acid or a methylbenzoic acid isomer is disclosed which comprises forming a dispersion comprising oxygen-containing gas bubbles dispersed in either toluene or an xylene isomer, wherein the bubbles have a mean diameter less than 1 micron. The dispersion is then subjected to reaction conditions comprising a pressure of less than about 1013 kPa and a temperature of less than about 160°C, whereby at least a portion of the toluene or xylene isomer is partially oxidized to form benzoic acid or the corresponding methylbenzoic acid isomer, respectively. In some embodiments, the methylbenzoic acid isomer is an intermediate compound, and the method further includes subjecting any unreacted xylene isomer and the intermediate compound to further oxidization, to form 1,2-benzenedicarboxylic acid, 1,3-benzenedicarboxylic acid, or 1,4-benzenedicarboxylic acid. A system or apparatus for performing the method is also disclosed.

Abstract translation: 公开了一种生产苯甲酸或甲基苯甲酸异构体的方法，其包括形成分散在甲苯或二甲苯异构体中的含氧气泡的分散体，其中气泡的平均直径小于1微米。 然后将分散体进行包括小于约1013kPa的压力和小于约160℃的温度的反应条件，由此甲苯或二甲苯异构体的至少一部分被部分氧化以形成苯甲酸或相应的甲基苯甲酸 酸异构体。 在一些实施方案中，甲基苯甲酸异构体是中间体化合物，该方法还包括使任何未反应的二甲苯异构体和中间体化合物进一步氧化，形成1,2-苯二甲酸，1,3-苯二甲酸或1， 4-苯二甲酸。 还公开了一种用于执行该方法的系统或装置。

公开(公告)号：WO2009002732A1

公开(公告)日：2008-12-31

申请号：PCT/US2008/066904

申请日：2008-06-13

Applicant: H R D CORPORATION ,  HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

Inventor： HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

IPC: C07C25/06 ,  C07C17/12 ,  B01J29/18

CPC classification number: B01F7/00766 ,  B01F13/1013 ,  B01F13/1016 ,  B01J8/025 ,  B01J8/20 ,  B01J8/222 ,  B01J19/0066 ,  B01J19/1806 ,  B01J2219/00006 ,  B01J2219/00083 ,  B01J2219/00779 ,  C07C17/12 ,  C07C25/06

Abstract: Use of a high shear mechanical device incorporated into a process for the production of chlorobenzene is capable of decreasing mass transfer limitations, thereby enhancing the chlorobenzene production process. A system for the production of chlorobenzene from benzene and chlorine, the system comprising a reactor and an external high shear device, the outlet of which is fluidly connected to the inlet of the reactor; the high shear device capable of providing a emulsion of chlorine gas bubbles within liquid benzene.

Abstract translation: 使用掺入到生产氯苯的方法中的高剪切机械装置能够降低传质限制，从而增强氯苯生产过程。 用于从苯和氯生产氯苯的系统，该系统包括反应器和外部高剪切装置，其出口流体连接到反应器的入口; 能够在液体苯内提供氯气气泡的乳液的高剪切装置。

公开(公告)号：WO2009002709A1

公开(公告)日：2008-12-31

申请号：PCT/US2008/066572

申请日：2008-06-11

Applicant: H R D CORPORATION ,  HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

Inventor： HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

IPC: C07C51/54 ,  C07C51/12 ,  C07C51/15

CPC classification number: C07C45/34 ,  B01F7/00766 ,  B01F13/1016 ,  B01J8/025 ,  B01J8/20 ,  B01J10/007 ,  B01J19/0066 ,  B01J2219/00006 ,  B01J2219/00779 ,  C07C47/06

Abstract: A method of use for a high shear device incorporated into a process or system for the production of acetaldehyde from ethylene as a reactor device is shown to be capable of decreasing mass transfer limitations, by forming a feed stream emulsion, and thereby enhancing the acetaldehyde production process in the system.

Abstract translation: 用于结合到从乙烯作为反应器装置生产乙醛的方法或系统中的高剪切装置的使用方法被证明能够通过形成进料流乳液来降低传质限制，从而增强乙醛生产 系统中的进程。

公开(公告)号：US20180087003A1

公开(公告)日：2018-03-29

申请号：US15830772

申请日：2017-12-04

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Gregory G. Borsinger ,  Rayford Gaines Anthony

IPC: C11B1/10 ,  C12P7/64 ,  A23D9/00 ,  C11B1/02 ,  C10L1/02 ,  C12M1/00 ,  C11B1/04 ,  B01F7/00 ,  B01F13/10

CPC classification number: C11B1/10 ,  A23D9/00 ,  A23V2002/00 ,  B01F7/00766 ,  B01F13/1016 ,  C10L1/026 ,  C10L2200/0476 ,  C10L2290/54 ,  C11B1/02 ,  C11B1/04 ,  C12M21/02 ,  C12M23/18 ,  C12M47/06 ,  C12P7/6463 ,  Y02E50/13 ,  Y02P20/142 ,  A23V2250/19 ,  A23V2250/202 ,  A23V2300/14 ,  A23V2300/41

Abstract: Herein disclosed is a method of processing a medium containing algae microorganisms to produce algal oil and by-products, comprising providing the medium containing algae microorganisms; passing the medium through a rotor-stator high shear device; disintegrating cell walls of and intracellular organelles in the algae microorganisms to release algal oil and by-products; and removing the algae medium from an outlet of the high shear device. In an embodiment, disintegration is enhanced by a penetrating gas capable of permeating the cell wall. In an embodiment, enhancement is accomplished by super-saturation of the penetrating gas in the medium or increased gas pressure in a vessel. In an embodiment, the penetrating gas is different from the gas produced by the cell during respiration. A suitable system is also discussed in this disclosure.

公开(公告)号：US09850437B2

公开(公告)日：2017-12-26

申请号：US14463858

申请日：2014-08-20

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony ,  Gregory G. Borsinger

IPC: C10G49/20 ,  C10G49/22 ,  C10G49/10 ,  C01B3/26 ,  C10G45/00 ,  C10G45/02 ,  C10G45/12 ,  C10G47/00 ,  C10G47/24 ,  C10G50/00 ,  C10G2/00 ,  C10G9/00 ,  B01J8/22 ,  B01J19/18 ,  B01F7/00 ,  B01F13/10 ,  C01B3/22 ,  C01B3/24 ,  C01B3/50

CPC classification number: C10G49/22 ,  B01F7/00766 ,  B01F13/1016 ,  B01J8/222 ,  B01J19/1806 ,  B01J2208/00283 ,  B01J2219/0011 ,  B01J2219/00189 ,  C01B3/22 ,  C01B3/24 ,  C01B3/26 ,  C01B3/50 ,  C01B2203/0272 ,  C01B2203/0277 ,  C01B2203/10 ,  C01B2203/1041 ,  C01B2203/1235 ,  C01B2203/1241 ,  C01B2203/1247 ,  C01B2203/1276 ,  C01B2203/148 ,  C10G2/30 ,  C10G2/342 ,  C10G9/00 ,  C10G45/00 ,  C10G45/02 ,  C10G45/12 ,  C10G47/00 ,  C10G47/24 ,  C10G49/10 ,  C10G49/20 ,  C10G50/00

Abstract: Herein disclosed is a method of producing value-added product from light gases, the method comprising: (a) providing light gases comprising at least one compound selected from the group consisting of C1-C6 compounds and combinations thereof; (b) intimately mixing the light gases with a liquid carrier in a high shear device to form a dispersion of gas in the liquid carrier, wherein the dispersion is supersaturated with the light gases and comprises gas bubbles at least some of which have a mean diameter of less than or equal to about 5 micron(s); (c) allowing the value-added product to form and utilizing vacuum to extract unreacted light gases from the liquid carrier; (d) extracting the value-added product; wherein the value-added product comprises at least one component selected from the group consisting of higher hydrocarbons, hydrogen, olefins, alcohols, aldehydes, and ketones. A system for producing value-added product from light gases is also disclosed.

公开(公告)号：US20170051230A1

公开(公告)日：2017-02-23

申请号：US14831453

申请日：2015-08-20

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Gregory G. Borsinger ,  Rayford Gaines Anthony

IPC: C11B1/10 ,  C10L1/02 ,  C12M1/00 ,  C12M1/42 ,  C11B1/04 ,  C12M1/26

CPC classification number: C11B1/10 ,  A23D9/00 ,  A23V2002/00 ,  B01F7/00766 ,  B01F13/1016 ,  C10L1/026 ,  C10L2200/0476 ,  C10L2290/54 ,  C11B1/02 ,  C11B1/04 ,  C12M21/02 ,  C12M23/18 ,  C12M47/06 ,  C12P7/6463 ,  A23V2250/19 ,  A23V2250/202 ,  A23V2300/14 ,  A23V2300/41

Abstract: Herein disclosed is a method of processing a medium containing algae microorganisms to produce algal oil and by-products, comprising providing the medium containing algae microorganisms; passing the medium through a rotor-stator high shear device; disintegrating cell walls of and intracellular organelles in the algae microorganisms to release algal oil and by-products; and removing the algae medium from an outlet of the high shear device. In an embodiment, disintegration is enhanced by a penetrating gas capable of permeating the cell wall. In an embodiment, enhancement is accomplished by super-saturation of the penetrating gas in the medium or increased gas pressure in a vessel. In an embodiment, the penetrating gas is different from the gas produced by the cell during respiration. A suitable system is also discussed in this disclosure.

Abstract translation: 本文公开了一种处理含有藻类微生物以产生藻油和副产物的培养基的方法，包括提供含有藻类微生物的培养基; 使介质通过转子 - 定子高剪切装置; 在藻类微生物中分解细胞壁和细胞内细胞器以释放藻油和副产物; 以及从高剪切装置的出口去除藻类培养基。 在一个实施方案中，通过能够渗透细胞壁的穿透性气体增强了崩解。 在一个实施例中，通过介质中的穿透气体的过饱和或容器中的气体压力增加来实现增强。 在一个实施方案中，穿透气体与呼吸期间由细胞产生的气体不同。 在本公开中还讨论了合适的系统。

公开(公告)号：US09381138B2

公开(公告)日：2016-07-05

申请号：US14085420

申请日：2013-11-20

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony

IPC: A61J3/00 ,  B01F7/00 ,  B01F13/10 ,  A61M5/142 ,  A61K9/00

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Abstract translation: 在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生分散体; 并将产生的分散体静脉内施用于患者; 其中所制备的分散体含有平均直径小于约1.5μm的治疗液体的治疗气体或液滴的纳米气泡。 在本公开中，还描述了一种系统，其中系统包括治疗气体源或治疗液体源或其组合; 液体载体源; 具有入口，出口，至少一个转子和由剪切间隔分开的至少一个定子的高剪切装置（HSD）; 以及构造成控制通过高剪切装置的流体的流速和停留时间的泵。

公开(公告)号：US09290716B2

公开(公告)日：2016-03-22

申请号：US14029504

申请日：2013-09-17

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony

IPC: B01F3/00 ,  B01F3/04 ,  C07C51/00 ,  C11B3/00 ,  B01F7/00 ,  B01F13/10 ,  A23D9/007 ,  A23D9/04 ,  C10G3/00

CPC classification number: C11B3/001 ,  A23D9/007 ,  A23D9/04 ,  B01F3/00 ,  B01F3/04 ,  B01F3/04099 ,  B01F7/00766 ,  B01F13/1016 ,  C07C51/00 ,  C10G3/00 ,  C10G2300/1011 ,  C10G2300/1014 ,  C10G2300/1018 ,  Y02P30/20

Abstract: Herein disclosed is a method of processing oil, comprising providing a high shear device comprising at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; contacting a gas with an oil in the high shear device, wherein the gas is an inert gas or a reactive gas; and forming a product, wherein the product is a solution, a dispersion, or combination thereof. Herein also disclosed is a high shear system for processing oil, comprising; at least one high shear device, having an inlet and at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; a gas source fluidly connected to the inlet; an oil source fluidly connected to the inlet; and a pump positioned upstream of a high shear device, the pump in fluid connection with the inlet and the oil source.

公开(公告)号：US09227196B2

公开(公告)日：2016-01-05

申请号：US13790733

申请日：2013-03-08

Applicant: H R D Corporation

Inventor： Abbas Hassan ,  Aziz Hassan ,  Rayford G. Anthony ,  Gregory G. Borsinger

IPC: B02C23/08 ,  C10G1/04 ,  C10G31/08

CPC classification number: B02C23/08 ,  B02C23/18 ,  C10G1/045 ,  C10G31/08

Abstract: Herein disclosed in a method comprising: shearing a feed comprising a solid component in a high shear device to produce a product, at least a portion of which comprises sheared solids; and separating at least some of the sheared solids from the product to produce a component-reduced product, wherein the solid component in the feed stream comprises a first particle density, and wherein the sheared solids in the product comprise a second particle density greater than the first particle density. In some embodiments, the solid component of the feed comprises gas trapped therein, and wherein at least a portion of said gas is released from the solid component upon shearing. Herein also is disclosed a method of comminuting solids in a feed stream comprising a solid component by processing the feed stream in a high shear device to produce a product stream comprising comminuted solids.

Abstract translation: 本文公开的方法包括：在高剪切装置中剪切包含固体组分的进料以产生产品，其中至少一部分包括剪切固体; 以及从产品中分离出至少一些剪切的固体以产生组分还原产物，其中进料流中的固体组分包含第一颗粒密度，并且其中产物中的剪切固体包含大于 第一颗粒密度。 在一些实施方案中，进料的固体组分包含被捕获在其中的气体，并且其中至少一部分所述气体在剪切时从固体组分释放。 本文还公开了通过在高剪切装置中处理进料流以在包含固体组分的进料流中粉碎固体以产生包含粉碎固体的产物流的方法。

公开(公告)号：US20140093951A1

公开(公告)日：2014-04-03

申请号：US14095211

申请日：2013-12-03

Applicant: H R D Corporation

Inventor： Abbas HASSAN ,  Aziz Hassan ,  Rayford G. Anthony ,  Gregory G. Borsinger

IPC: C12M1/00

CPC classification number: C12M21/12 ,  C12M21/02 ,  C12M45/02 ,  C12N1/066 ,  C12N1/12 ,  Y02E50/17

Abstract: A method for culturing algae comprising, forming an emulsion comprising a gaseous stream and a media utilizing a high shear device, wherein the emulsion comprises gas bubbles, and wherein the high shear device comprises at least one toothed rotor and at least one stator; introducing the emulsion into a bioreactor; and introducing an algae into the bioreactor for growing the algae culture. Additionally, a method for producing liquids from an algae culture, the method comprising forming an emulsion comprising a buffer and algal components, wherein the emulsion comprises algal component globules; separating algal hydrocarbons; and processing algal hydrocarbons to form liquid hydrocarbons. Additionally, a system for producing liquids from an algae culture comprising at least one high shear device.

Abstract translation: 一种用于培养藻类的方法，包括：使用高剪切装置形成包含气流的乳液和介质，其中所述乳液包括气泡，并且其中所述高剪切装置包括至少一个齿形转子和至少一个定子; 将乳液引入生物反应器; 并将藻类引入用于生长藻类培养物的生物反应器中。 另外，一种从藻类培养物生产液体的方法，所述方法包括形成包含缓冲液和藻类成分的乳液，其中所述乳液包含藻类组分球; 分离藻类碳氢化合物; 并处理藻类碳氢化合物以形成液态烃。 另外，一种用于从包含至少一个高剪切装置的藻类培养物生产液体的系统。