公开(公告)号：US20220259748A1

公开(公告)日：2022-08-18

申请号：US17588597

申请日：2022-01-31

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Jadhav Amol

IPC: C25B11/053 ,  C25B1/04

Abstract: The present application relates to an electrode catalyst for water electrolysis including a first transition metal foam, a metal layered double hydroxide (LDH)/metal oxide mixed layer which contains a second transition metal and a third transition metal that are formed on the surface of the first transition metal foam, and fourth transition metal oxyhydroxide nanoparticles formed on the surface of the mixed layer, in which the mixed layer surface contains the metal layered double hydroxide.

公开(公告)号：US20220243343A1

公开(公告)日：2022-08-04

申请号：US17585021

申请日：2022-01-26

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Yang LIU

IPC: C25B11/093 ,  C25B1/04 ,  C25B9/17

Abstract: Summary
The present application relates to a catalyst for hydrogen evolution reaction (HER) including a transition metal matrix and noble metal atoms formed in the transition metal matrix, in which the noble metal atoms have oxygen adsorbed thereto, and oxygen is derived from the transition metal matrix.

公开(公告)号：US20220205118A1

公开(公告)日：2022-06-30

申请号：US17560979

申请日：2021-12-23

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Jinsun LEE ,  Ashwani KUMAR

IPC: C25B11/073 ,  C25B1/04 ,  C25B11/054

Abstract: The present disclosure relates to a water splitting catalyst including a porous carbon layer, a bimetallic metal alloy core dispersed on the porous carbon layer, and a single-atom precious metal dispersed on the bimetallic metal alloy core, in which oxygen is adsorbed on the surface of the bimetallic metal alloy core.

公开(公告)号：US20220126262A1

公开(公告)日：2022-04-28

申请号：US17424996

申请日：2020-01-22

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Cybulski OLGIERD ,  Dygas MIROSLAW ,  Mikulak-klucznik BARBARA ,  Sobolev YAROSLAV ,  Grzybowski BARTOSZ A

IPC: B01J19/28 ,  B01J19/00

Abstract: The present invention relates to a reaction method for forming a layered structure of immiscible liquid-phase concentric layers within a rotary reactor and a reaction system including the layered structure, and may provide a basis capable of efficiently performing a multistage reaction in terms of time and space.

公开(公告)号：US11236343B2

公开(公告)日：2022-02-01

申请号：US16346251

申请日：2017-11-01

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong Kim ,  Jeong Hun Kim ,  Jihyun Lee ,  Byung Joo Lee

IPC: C12N15/115 ,  A61K47/61 ,  A61P27/02 ,  A61P35/00 ,  A61K31/713

Abstract: The present invention relates to a method for producing dextran polymer-based amplified nucleic acid aptamer nanoconstructs which efficiently and selectively capture a specific target molecule, the method comprising linking a short nucleic acid sequence or a complementary sequence for formation of nanoconstructs and a nucleic acid aptamer sequence for capture of the specific target molecule to a dextran polymer by a chemical reaction, mixing the resulting polymer/nucleic acid substances with each other to form nanostructures, subjecting the nanostructures to rolling circle amplification, thereby forming a nucleic acid aptamer having a repeated structure. The dextran polymer-based amplified nucleic acid aptamer nanoconstructs have the effect of efficiently and selectively capturing a specific target molecule.

公开(公告)号：US20220019846A1

公开(公告)日：2022-01-20

申请号：US17375650

申请日：2021-07-14

Applicant: Institute for Basic Science

Inventor： Meeyoung CHA ,  Sungwon HAN ,  Sungwon PARK ,  Sundong KIM ,  Sungkyu PARK

IPC: G06K9/62 ,  G06K9/42

Abstract: Disclosed is an image analysis system which includes a first analyzer and a second analyzer. The first analyzer generates first features by encoding images through a first model and adjusts a weight of the first model based on the first features. The second analyzer generates second features based on the first features by encoding the images through a second model, classifies the second features into classes, respectively, and adjusts a weight of the second model based on mutual information and a correlation between a first class among the classes which features corresponding to an original image group from among the second features are classified as and a second class among the classes which features corresponding to an augmentation group of the original image group from among the second features are classified as.

公开(公告)号：US11197935B2

公开(公告)日：2021-12-14

申请号：US15807850

申请日：2017-11-09

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dong Wook Kim ,  Jin Soo Kim ,  Chul Yong Park ,  Duk Hyoung Kim ,  Jung Eun Kim ,  Jiyeon Kweon

IPC: A61K48/00 ,  C12N5/074 ,  C12N9/22 ,  C12N15/11 ,  A61K35/545 ,  C07K14/755 ,  C12N15/113 ,  A61K35/12

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

公开(公告)号：US11155604B2

公开(公告)日：2021-10-26

申请号：US15742874

申请日：2016-12-21

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Won Do Heo ,  Yun Ju Lee ,  Daseuli Yu ,  Byung Ouk Park

IPC: C07K16/00 ,  C07K14/00 ,  C07K16/14 ,  C07K16/18

Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.

公开(公告)号：US20210254161A1

公开(公告)日：2021-08-19

申请号：US17181142

申请日：2021-02-22

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE ,  ANLBIO

Inventor： Kee Tae KIM ,  Hong Gil NAM ,  Chand Parvez DANKA MOHAMMED

IPC: C12Q1/6883 ,  C12N15/113 ,  G01N33/50 ,  G01N33/68

Abstract: Provided are a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions.

公开(公告)号：US20210152348A1

公开(公告)日：2021-05-20

申请号：US16845601

申请日：2020-04-10

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Kyung Ah SHIM ,  Hyun Suk MOON

IPC: H04L9/08 ,  H04L9/30 ,  G06F17/11

Abstract: A method of generating a public key and a secret key using a key generator is disclosed. The method includes acquiring an affine map and a secret central map, and generating a public key and a secret key using the affine map and the secret central map, in which the secret central map is expressed as a system of o multivariate quadratic polynomials, the system of o multivariate quadratic polynomials can be expressed as a structured matrix or a product of a submatrix of a structured matrix and a vector when v linear equations and v variables defined on a finite field are given.