公开(公告)号：WO2013070079A3

公开(公告)日：2013-07-11

申请号：PCT/NL2012050793

申请日：2012-11-09

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： REIJERKERK ARIE ,  DE VRIES HELGA EVELINE

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/178

Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以用特定的核酸序列增加血脑屏障功能，特别是患有或诊断患有多发性硬化症的患者。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

公开(公告)号：WO2012161581A1

公开(公告)日：2012-11-29

申请号：PCT/NL2012/050367

申请日：2012-05-24

Applicant: STICHTING VU-VUMC ,  NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

Inventor： NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

IPC: H04J3/06 ,  H04J14/02

CPC classification number: H04L7/0075 ,  H04J3/0682 ,  H04J14/02 ,  H04J14/0272 ,  H04J14/0275

Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream. In an embodiment wherein the network provides for an optical supervisory channel, the optical filters for combining the optical supervisory channel signal with the unidirectional data signal and separating the optical supervisory channel signal from the unidirectional data signal are used to combine and separate the reference frequency and timing signal and to pass the optical return timing signal. For this purpose, further optical filters may be added outside the main optical data channel to combine and separate the reference frequency and timing signal and the optical supervisory channel and to pass the optical return signal back to the filter that separates the optical supervisory channel signal from the data signal.

Abstract translation: 参考频率和定时信息在网络中的分布涉及从响应于参考频率的传输和定时信号之间的时间延迟以及接收光学返回定时信号来确定第一和第二节点之间的等待时间。 在网络节点之间的光纤连接中具有成对的第一和第二光纤的网络中，为了分别在网络节点之间彼此相反的方向上分别传输光数据信号，提供传输参考频率和定时信号，并且由此得到 通过相同光纤的光返回信号，一个在与该光纤上的单向数据信号相同的方向上，另一个在上游。 节点之间的中继器可以被修改以在上游和下游传递这样的信号。 在网络提供光学监控信道的实施例中，用于将光监控信道信号与单向数据信号组合并将光监控信道信号与单向数据信号分离的滤光器用于组合和分离参考频率和 定时信号并通过光学返回定时信号。 为此，可以将另外的光学滤波器添加到主光学数据通道外部，以组合和分离参考频率和定时信号和光学监控通道，并将光学返回信号传回到将光学监控通道信号与 数据信号。

公开(公告)号：WO2012128616A1

公开(公告)日：2012-09-27

申请号：PCT/NL2012/050025

申请日：2012-01-16

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG ,  STICHTING VU-VUMC ,  WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

Inventor： WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

IPC: G01N33/48

CPC classification number: C12Q1/6834 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及分析受试者的血液样品中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的无核血细胞中提取核酸 提供无核血细胞提取的核酸组分，和b）分析所述无核血细胞提取的核酸组分是否存在疾病标志物，其中所述疾病标志物是细胞基因中的疾病特异性突变 所述受试者，或者其中所述疾病标志物是所述受试者细胞的基因的疾病特异性表达谱。

公开(公告)号：GB202212594D0

公开(公告)日：2022-10-12

申请号：GB202212594

申请日：2022-08-31

Applicant: STICHTING VU

公开(公告)号：GB202115600D0

公开(公告)日：2021-12-15

申请号：GB202115600

申请日：2021-10-29

Applicant: STICHTING VU

公开(公告)号：GB202017718D0

公开(公告)日：2020-12-23

申请号：GB202017718

申请日：2020-11-10

Applicant: STICHTING VU

公开(公告)号：BR112013001136B1

公开(公告)日：2020-12-15

申请号：BR112013001136

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  STICHTING VUMC

Inventor： ROLF JONAS NILSSOM ,  THOMAS WÜRDINGER

IPC: G01N33/48

Abstract: processo de análise de uma amostra de sangue de um sujeito para a presença de um marcador de doença. a presente invenção refere-se a um processo de análise de uma amostra de sangue de um sujeito para a presença de um marcador de doença, o dito processo compreendendo as etapas de a) extração de ácido nucléico de células de sangue anucleadas na dita amostra de sangue para prover uma fração de ácido nucléico extraída com células de sangue anucleadas, e b) análise de dita fração de ácido nucléico de células de sangue anucleadas para a presença de um marcador de doença, onde o dito marcador de doença é uma mutação específica de doença em um gene de uma célula do dito sujeito, ou onde o dito marcador de doença é um perfil de expressão específico de doença de genes de uma células do dito sujeito.

公开(公告)号：NL2023123B1

公开(公告)日：2020-12-01

申请号：NL2023123

申请日：2019-05-13

Applicant: STICHTING VU

Inventor： DAVIDE IANNUZZI

IPC: G01N21/17 ,  G01B11/16 ,  G01H9/00

Abstract: System for photoacoustic spectroscopy, the system comprising: . a light system comprising a light source, wherein the light system is configured to generate a light beam, to modulate the light beam at a modulation frequency, and to direct the light beam to a space; . an optical waveguide, comprising a first measurement part; . a vibration unit arranged in the space, comprising: o a first fixation structure and a second fixation structure, wherein the first 10 fixation structure and the second fixation structure are arranged remotely from each other in the space, and wherein the first measurement part of the optical waveguide is tightened between the first fixation structure and the second fixation structure, and wherein the first measurement part extends through the space and is in immediate contact with the space; . a detection unit, configured to detect a first vibration of the first measurement part based on changes in optical propagation properties of the optical waveguide, the detection unit comprising: o a sensor light source coupled to the optical waveguide, wherein the sensor light source is configured to generate a sensor light beam propagating through the optical waveguide; o a sensor light detector coupled to the optical waveguide, wherein the sensor light detector is configured to measure the sensor light beam having propagated through the optical waveguide; o a signal processing unit, configured to detect the first vibration of the first measurement part based on the generated sensor light beam and the measured sensor light beam.

公开(公告)号：AU2019257105A1

公开(公告)日：2020-11-26

申请号：AU2019257105

申请日：2019-04-18

Applicant: STICHTING VU

Inventor： GROSSMANN TOM NORBERT ,  PELAY GIMENO MARTA ,  HENNIG SVEN ,  NEUBACHER SASKIA ANTONIE

IPC: C12N9/96 ,  C12N9/52 ,  C12N9/64

Abstract: The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.

公开(公告)号：NL2022418B1

公开(公告)日：2020-08-18

申请号：NL2022418

申请日：2019-01-18

Applicant: STICHTING VU

Inventor： DAVIDE IANNUZZI ,  JULIEN SERGE SCHELTES

IPC: H04R1/10 ,  H04R1/08

Abstract: The present invention relates to a headphone for use with an audio or mobile communication device, comprising at least one earbud, a microphone, and a wire. The 5 headphone further comprises a stiffening mechanism, which is constructed to be arranged in an actuated state, in which the stiffening mechanism has a first bending stiffness and in which the stiffening mechanism is in a stiff configuration, and in a relaxed state, in which the stiffening mechanism has a second bending stiffness and in which the stiffening mechanism is in a free-hanging configuration. The first bending stiffness is |argerthan the second 10 bending stiffness. The invention further relates to a method for communicating by means of a headphone, which comprises the steps of arranging, at the onset of communication, a stiffening mechanism of the headphone in an actuated state, in order to position a microphone of the headphone in front of a mouth of the user, and arranging, at the end of communication, the 15 stiffening mechanism in a relaxed state, in order to freely suspend the microphone.