公开(公告)号：WO2013066764A2

公开(公告)日：2013-05-10

申请号：PCT/US2012/062218

申请日：2012-10-26

Applicant: MERCK SHARP & DOHME CORP. ,  LOBODA, Andrey ,  NEBOZHYN, Michael ,  PODTELEZHNIKOV, Alexei ,  STONE, David, J. ,  TANIS, Keith ,  RAY, William, J.

Inventor： LOBODA, Andrey ,  NEBOZHYN, Michael ,  PODTELEZHNIKOV, Alexei ,  STONE, David, J. ,  TANIS, Keith ,  RAY, William, J.

IPC: A01K67/027

CPC classification number: C12Q1/6883 ,  A01K67/0275 ,  C12Q2600/158 ,  G01N33/6896

Abstract: Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimer's disease (AD). In one embodiment, BioAge (biological age), NdStress (neurodegenerative stress), Alz (Alzheimer), and Inflame (inflammation) are used as biomarkers of AD progression. In another aspect, the invention comprises a gene signature for evaluating disease progression. In still another embodiment, methods for evaluating disease progression are provided. In yet another embodiment, the invention can be used to identify animal models for use in the development and evaluation of therapeutics for the treatment of AD.

Abstract translation: 公开了评估阿尔茨海默氏病（AD）疾病进展的方法，生物标志物和表达特征。 在一个实施方案中，使用BioAge（生物学年龄），NdStress（神经变性应激），Alz（阿尔茨海默）和Inflame（炎症））作为AD进展的生物标志物。 另一方面，本发明包括用于评估疾病进展的基因特征。 在另一个实施方案中，提供了评估疾病进展的方法。 在另一个实施方案中，本发明可用于鉴定用于开发和评估治疗AD的动物模型。

公开(公告)号：WO2013039758A1

公开(公告)日：2013-03-21

申请号：PCT/US2012/053924

申请日：2012-09-06

Applicant: ADC TELECOMMUNICATIONS, INC. ,  STONE, David

Inventor： STONE, David

IPC: H01R13/73 ,  H02G3/08

CPC classification number: H01R13/514 ,  H01R43/18 ,  H02G3/00 ,  H02G3/086 ,  Y10T29/49169

Abstract: Certain types of wall-mount boxes provide a local power receptacle in a first interior region that is physically isolated from a second interior region. The local power receptacle is accessible from an exterior of the box. The local power receptacle is electrically connected to an internal connector interface that is accessible from the second interior region. An electronic device may be installed in the second interior region and electrically connected to the local power receptacle via the internal connector interface. Second receptacles are disposed in the second interior region and coupled to (or are integral with) the electronic device. The second receptacles are accessible from the exterior of the box.

Abstract translation: 某些类型的壁挂式盒子在与第二内部区域物理隔离的第一内部区域中提供局部电源插座。 本地电源插座可从盒子的外部进入。 本地电源插座电连接到可从第二内部区域接近的内部连接器接口。 电子设备可以安装在第二内部区域中并且经由内部连接器接口电连接到本地电源插座。 第二容器设置在第二内部区域中并且与电子设备耦合（或与其成一体）。 第二个插座可从盒子的外部进入。

公开(公告)号：WO2011100619A2

公开(公告)日：2011-08-18

申请号：PCT/US2011/024635

申请日：2011-02-11

Applicant: ADC TELECOMMUNICATIONS, INC. ,  ANDERSON, Chad ,  KOSTECKA, Ryan ,  STONE, David, George ,  WENTWORTH, Michael, J. ,  COFFEY, Joseph, C.

Inventor： ANDERSON, Chad ,  KOSTECKA, Ryan ,  STONE, David, George ,  WENTWORTH, Michael, J. ,  COFFEY, Joseph, C.

IPC: H04Q1/08

CPC classification number: H05K7/1487 ,  G02B6/3897 ,  G02B6/428 ,  G02B6/4292 ,  G02B6/4452 ,  G02B6/4453 ,  G06F1/16 ,  G06F13/409 ,  H04Q1/023 ,  H04Q1/03 ,  H04Q1/06 ,  H04Q1/08 ,  H04Q1/13 ,  H04Q1/155 ,  H05K5/0026 ,  H05K5/0204 ,  H05K5/0217 ,  H05K7/14 ,  H05K7/1401 ,  H05K7/1489 ,  H05K7/1491 ,  Y10T29/49002 ,  Y10T29/49826

Abstract: A fiber panel system includes a chassis including a backplane; and at least a first blade configured to mount to the chassis. The first blade is moveable relative t the chassis between a retracted (closed) position and at least one extended position. The first blade includes a coupler arrangement for connecting together media segments. Each blade includes a blade processor and a plurality of smart couplers. A chassis processor is electrically coupled to a processor port of the chassis backplane.

Abstract translation: 光纤面板系统包括：底盘，其包括背板; 以及至少第一刀片，其被配置为安装到所述底盘。 第一刀片相对于底盘在缩回（关闭）位置和至少一个延伸位置之间是可移动的。 第一叶片包括用于将介质段连接在一起的耦合器装置。 每个刀片包括刀片处理器和多个智能耦合器。 机箱处理器电耦合到机箱背板的处理器端口。

公开(公告)号：WO2010093988A2

公开(公告)日：2010-08-19

申请号：PCT/US2010/024184

申请日：2010-02-12

Applicant: ADC Telecommunications, Inc. ,  RAZA, Mohammad ,  PATEL, Kamlesh ,  ANDERSON, John ,  COFFEY, Joseph ,  DAY, Michael ,  COBURN, Hutch ,  STONE, David

Inventor： RAZA, Mohammad ,  PATEL, Kamlesh ,  ANDERSON, John ,  COFFEY, Joseph ,  DAY, Michael ,  COBURN, Hutch ,  STONE, David

IPC: H04L12/56 ,  H04L12/28

CPC classification number: H04L49/15 ,  H01R13/6658 ,  H01R24/64 ,  H04L41/12 ,  H04L41/22 ,  H04L41/24 ,  H04L41/26 ,  H04L45/66 ,  H04L49/351 ,  H04L67/16

Abstract: One exemplary embodiment is directed to an inter-networking device that performs at least one inter-networking function using physical layer information about the network of which the device is a part. Another exemplary embodiment is directed to capturing physical layer information about physical communication media that is attached to an inter-networking device. Another exemplary embodiment is directed to a technique for generating a spanning tree and/or forwarding database information for a plurality of switches in a network at a central location. The spanning tree and/or forwarding database information is generated at the central location using information including physical layer information about devices and physical communication media in the network. Another exemplary embodiment is directed to an ETHERNET physical layer device having integrated support for capturing physical layer information about the physical communication media connected to the ETHERNET physical layer device.

Abstract translation: 一个示例性实施例涉及使用关于设备是其一部分的网络的物理层信息来执行至少一个网络间联网功能的联网设备。 另一个示例性实施例涉及捕获关于附连到网络间设备的物理通信介质的物理层信息。 另一个示例性实施例涉及用于在中心位置处生成网络中的多个交换机的生成树和/或转发数据库信息的技术。 使用包括关于网络中的设备和物理通信介质的物理层信息的信息在中心位置生成生成树和/或转发数据库信息。 另一个示例性实施例涉及具有集成支持的ETHERNET物理层设备，用于捕获关于连接到ETHERNET物理层设备的物理通信介质的物理层信息。

公开(公告)号：WO2009148468A1

公开(公告)日：2009-12-10

申请号：PCT/US2008/075185

申请日：2008-09-04

Applicant: INFOPRINT SOLUTIONS COMPANY ,  WARDELL, Glenn ,  STONE, David ,  HOHENSEE, Reinhard ,  TREPPENDAHL, Jamsie

Inventor： WARDELL, Glenn ,  HOHENSEE, Reinhard ,  TREPPENDAHL, Jamsie

IPC: G06F3/12

CPC classification number: G06F17/217 ,  G06F3/1205 ,  G06F3/1219 ,  G06F3/1247 ,  G06F3/125 ,  G06F3/1252 ,  G06F3/1285 ,  H04N1/00222

Abstract: Methods and systems herein provide for flexible formatting of print jobs and their associated logical pages. One N-up printing system is adapted to receive a print job from a host system for printing to a tangible medium. The print job includes at least a first logical page. The printing system includes an N-up formatter interface adapted to receive formatting parameters. The printing system also includes an N-up formatter that is communicatively coupled to the N-up formatter interface. The N-up formatter is adapted to generate a first page inclusion object based on the formatting parameters. The N-up formatter is further adapted to input the first logical page to the first page inclusion object and position the first logical page within the first page inclusion object.

Abstract translation: 这里的方法和系统提供打印作业及其相关逻辑页面的灵活格式化。 一个N-up打印系统适于从主机系统接收打印作业以打印到有形介质。 打印作业至少包括第一逻辑页。 打印系统包括适于接收格式化参数的N-up格式化器接口。 打印系统还包括通信地耦合到N-up格式器接口的N-up格式器。 N-up格式器适于基于格式化参数生成第一页包含对象。 N-up格式化器还适于将第一逻辑页面输入到第一页面包含对象，并且将第一逻辑页面定位在第一页面包含对象内。

公开(公告)号：WO2009146417A1

公开(公告)日：2009-12-03

申请号：PCT/US2009/045645

申请日：2009-05-29

Applicant: SIGMA-ALDRICH CO. ,  EASTLUND , Erik, E ,  DAVIS , Greg, D ,  DOUGLAS , Derek, K ,  STONE , David, K .

Inventor： EASTLUND , Erik, E ,  DAVIS , Greg, D ,  DOUGLAS , Derek, K ,  STONE , David, K .

IPC: A01N43/04

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/319 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2320/53 ,  C12Y207/10002 ,  C12N2310/3521 ,  C12N2310/3533

Abstract: The present invention provides methods modified oligonucleotides and methods of using the modified oligonucleotides for silencing nucleic acids, wherein the nonspecific effects of nucleic acid silencing are reduced.

Abstract translation: 本发明提供方法修饰的寡核苷酸和使用修饰的寡核苷酸沉默核酸的方法，其中降低了核酸沉默的非特异性作用。

公开(公告)号：WO2009011778A1

公开(公告)日：2009-01-22

申请号：PCT/US2008/008440

申请日：2008-07-09

Applicant: MERCK & CO., INC. ,  MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

Inventor： MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

IPC: G01N33/567 ,  C07H21/04

CPC classification number: G01N33/5032 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/2828

Abstract: Methods for identifying modulators of LRRTM1, LRRTM2 and LRRTM4 are described. The methods are particularly useful for identifying analytes that stimulate LRRTM1or LRRTM2 activity or inhibit LRRTM4 activity such that they antagonize processing of amyloid precursor protein (APP) to Aβ peptide (Aβ). Such methods can be used to identify analyties for treating Alzheimer disease.

Abstract translation: 描述了用于鉴定LRRTM1，LRRTM2和LRRTM4的调节剂的方法。 该方法特别可用于鉴定刺激LRRTM1或LRRTM2活性或抑制LRRTM4活性的分析物，使得它们拮抗淀粉样蛋白前体蛋白（APP）对Aβ肽（Aß）的加工。 这些方法可用于鉴定治疗阿尔茨海默病的分析。

公开(公告)号：WO2004000997A3

公开(公告)日：2007-08-16

申请号：PCT/US0317512

申请日：2003-06-04

Applicant: CURAGEN CORP ,  ANDERSON DAVID W ,  BOLDOG FERENC L ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  EDINGER SHLOMIT R ,  EISEN ANDREW ,  ELLERMAN KAREN ,  GERLACH VALERIE L ,  GORMAN LINDA ,  GUO XIAOJIA ,  GUSEV VLADIMIR Y ,  JI WEIZHEN ,  LI LI ,  MACDOUGALL JOHN R ,  MALYANKAR URIEL M ,  MILLET ISABELLE ,  ORT TATIANA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS K ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  PEYMAN JOHN A ,  RIEGER DANIEL K ,  ROTHENBERG MARK E ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  TCHERNEV VELIZAR T ,  VERNET CORINE A M ,  VOSS EDWARD Z ,  ZERHUSEN BRYAN D ,  ZHONG MEI

Inventor： ANDERSON DAVID W ,  BOLDOG FERENC L ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  EDINGER SHLOMIT R ,  EISEN ANDREW ,  ELLERMAN KAREN ,  GERLACH VALERIE L ,  GORMAN LINDA ,  GUO XIAOJIA ,  GUSEV VLADIMIR Y ,  JI WEIZHEN ,  LI LI ,  MACDOUGALL JOHN R ,  MALYANKAR URIEL M ,  MILLET ISABELLE ,  ORT TATIANA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS K ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  PEYMAN JOHN A ,  RIEGER DANIEL K ,  ROTHENBERG MARK E ,  SCIORE PAUL ,  SHENOY SURESH G ,  SMITHSON GLENNDA ,  SPYTEK KIMBERLY A ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  TCHERNEV VELIZAR T ,  VERNET CORINE A M ,  VOSS EDWARD Z ,  ZERHUSEN BRYAN D ,  ZHONG MEI

IPC: A61K38/17 ,  A61K39/395 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/00 ,  C07K16/18 ,  C12N20060101 ,  C12N1/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2007080389A3

公开(公告)日：2007-07-19

申请号：PCT/GB2007/000045

申请日：2007-01-09

Applicant: DE LA RUE INTERNATIONAL LIMITED ,  HOLMES, Brian, William ,  KNIGHT, Malcolm, Robert, Murray ,  STONE, David, Allen

Inventor： HOLMES, Brian, William ,  KNIGHT, Malcolm, Robert, Murray ,  STONE, David, Allen

IPC: B42D15/00 ,  B42D15/10

Abstract: An optically variable magnetic stripe assembly includes a magnetic layer (5), an optically variable effect generating layer (1, 2) over the magnetic layer (5), and, an electrically non-conductive reflective layer (12) between the magnetic layer (5) and the optically variable effect generating layer (1).

公开(公告)号：WO2006138363A2

公开(公告)日：2006-12-28

申请号：PCT/US2006/023144

申请日：2006-06-14

Applicant: MERCK & CO., INC. ,  MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

Inventor： MAJERCAK, John, M. ,  RAY, William, J. ,  STONE, David, J.

IPC: G01N33/53

CPC classification number: G01N33/5038 ,  G01N33/5023 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2500/02 ,  G01N2800/2821

Abstract: Methods for identifying modulators of KEAH6 are described. The methods are particularly useful for identifying analytes that antagonize KEAH6's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.

Abstract translation: 描述了用于鉴定KEAH6调节剂的方法。 该方法特别适用于鉴定拮抗KEAH6对淀粉样前体蛋白加工成Aβ肽的作用的分析物，因此可用于鉴定可用于治疗阿尔茨海默病的分析物。