公开(公告)号：WO2008048371A3

公开(公告)日：2008-04-24

申请号：PCT/US2007/008394

申请日：2007-04-04

Applicant: SINGULEX, INC. ,  GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

IPC: G01N21/76 ,  G01N21/64

Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.

公开(公告)号：WO2008048371A2

公开(公告)日：2008-04-24

申请号：PCT/US2007008394

申请日：2007-04-04

Applicant: SINGULEX INC ,  GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

Inventor： GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

IPC: B01J19/00 ,  C40B30/04 ,  G01N21/63 ,  G01N33/566 ,  G01N33/68 ,  G01N35/10

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.

Abstract translation: 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。

公开(公告)号：WO2006058136A2

公开(公告)日：2006-06-01

申请号：PCT/US2005/042573

申请日：2005-11-23

Applicant: BLACK, Jeffery, D. ,  BLACK, Alexander, D. ,  TODD, John, H.

Inventor： BLACK, Jeffery, D. ,  BLACK, Alexander, D. ,  TODD, John, H.

IPC: H04L12/56

CPC classification number: H04L29/06027 ,  H04L29/1216 ,  H04L61/157 ,  H04L65/1043 ,  H04L65/1069 ,  H04L67/306 ,  H04W8/18 ,  H04W76/10 ,  H04W76/20 ,  H04W88/182

Abstract: Disclosed are systems and methods that enable an end user to control the parameters, behavior, and identity of network communications regardless of the limitations placed upon these controls by the end user's communications device or communications service provider. An intermediate media proxy resides on a telecommunications network and accepts inbound and outbound communications to and from a network communication device. The intermediate media proxy functions as an intermediary for network communications that occur between the network communications device and other network communications devices. In this manner, the intermediate media proxy can control various features of the communications independent of limitations enacted by the end user's communications device or communications service provider.

Abstract translation: 公开了允许最终用户控制网络通信的参数，行为和身份的系统和方法，而不管最终用户的通信设备或通信服务提供商对这些控制的限制。 中间媒体代理驻留在电信网络上，并接受来自网络通信设备的入站和出站通信。 中间媒体代理作为在网络通信设备和其他网络通信设备之间发生的网络通信的中介。 以这种方式，中间媒体代理可以独立于最终用户的通信设备或通信服务提供商所制定的限制来控制通信的各种特征。

公开(公告)号：WO2004076692A1

公开(公告)日：2004-09-10

申请号：PCT/GB2004/000770

申请日：2004-02-26

Applicant: SOLEXA LIMITED ,  SWERDLOW, Harold, Philip ,  BARNES, Colin ,  TODD, John, Andrew ,  DURBIN, Richard, Michael

Inventor： SWERDLOW, Harold, Philip ,  BARNES, Colin ,  TODD, John, Andrew ,  DURBIN, Richard, Michael

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q2525/301 ,  C12Q2561/125

Abstract: There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a. contacting a sample genome, under conditions which permit template dependant oligonucleotide ligation, with a plurality of different oligonucleotide molecules which comprise (i) a first set of oligonucleotides each comprising a sequence of nucleotides that is complementary to a region on said genome that includes a known SNP site and which oligonucleotides are complementary to said region other than at a base at or near the 5' end of said oligonucleotides that is to be tested for complementarity to a base at the SNP site, each of said oligonucleotides comprising a unique label to identify both the base to be tested and the position of the SNP to be scored, (ii) a second set of oligonucleotides each comprising a sequence of nucleotides complementary to a region on said target genome for hybridisation with said target genome adjacent the 5' end of an oligonucleotide of said first oligonucleotide set, and a surface capture moiety, a phosphate moiety being located at any of either the 5' end of said first set of oligonucleotides or the 3' end of said second set of oligonucleotides, any resulting ligated oligonucleotide being immobilised on a solid support via the surface capture moiety, b. analysing said solid support for the identity of one or more of said unique labels and comparing the defined bases in any of said immobilised oligonucleotides to those of the reference one or more SNPs.

Abstract translation: 公开了一种确定基因组中一个或多个突变或单核苷酸多态性（SNP）的身份的方法，其包括：a。 在允许模板依赖性寡核苷酸连接的条件下使样品基因组与多个不同的寡核苷酸分子接触，所述寡核苷酸分子包含（i）第一组寡核苷酸，每一寡核苷酸包含与所述基因组上的区域互补的核苷酸序列，其包括已知的 SNP位点，哪些寡核苷酸与所述区域互补，而不是在待测试的寡核苷酸的5'端或附近的碱基处，与SNP位点的碱基互补，所述寡核苷酸中的每一个包含唯一的标记以鉴定 要测试的碱基和待评估的SNP的位置，（ii）第二组寡核苷酸，每个寡核苷酸包含与所述靶基因组上的区域互补的核苷酸序列，用于与邻近5'末端的所述靶基因组杂交 所述第一寡核苷酸组的寡核苷酸和表面捕获部分，磷酸酯部分位于5'末端的任一个 所述第一组寡核苷酸或所述第二组寡核苷酸的3'端的任何所得连接的寡核苷酸经由表面捕获部分固定在固体支持物上，b。 分析所述固体支持物中的一种或多种所述独特标记的身份，并将任何所述固定的寡核苷酸中的所定义的碱基与所述参考的一个或多个SNP的那些进行比较。

公开(公告)号：WO1996025367A1

公开(公告)日：1996-08-22

申请号：PCT/GB1996000335

申请日：1996-02-13

Applicant: PROCEFF LIMITED ,  TODD, John, James ,  HOPWOOD, Adrian

Inventor： PROCEFF LIMITED

IPC: C02F03/10

CPC classification number: C02F3/085 ,  B01J2/006 ,  C02F3/10 ,  Y02W10/15 ,  Y10T428/2993 ,  Y10T428/2998

Abstract: Granules of plastics material have grains of an inert mineral such as sand coated thereon to provide a habitat for microorganisms effective in waste water treatment, the granules having a predetermined particle size range, and the grains having a predetermined particle size range and being disposed at a predetermined packing density range on the granules. The particles have an average density of approximately 1.0 g/cc such that a proportion tend to float and a proportion tend to sink in the waste water. The particles are manufactured by contacting the granules of plastics material with a mixture of grains of the inert mineral and grains of a soluble substance such as salt, at an elevated temperature, to coat the granules with the mixture, and subsequently dissolving the soluble substance grains from the coating to provide the granules coated with the grains of inert mineral in the predetermined packing density range.

Abstract translation: 塑料颗粒具有包覆在其上的惰性矿物颗粒，以提供有效处理废水的微生物的栖息地，颗粒具有预定的粒度范围，并且具有预定粒度范围的颗粒并且设置在 颗粒上预定的包装密度范围。 颗粒的平均密度为约1.0g / cc，使得比例倾向于浮起，并且比例倾向于在废水中下沉。 颗粒是通过使塑料材料颗粒与惰性矿物颗粒和可溶性物质如谷物的混合物在高温下接触来制造的，以将混合物涂覆在颗粒上，随后将可溶物质颗粒 从涂层中提供涂覆有预定填充密度范围的惰性矿物颗粒的颗粒。

公开(公告)号：WO1995032383A1

公开(公告)日：1995-11-30

申请号：PCT/CA1995000238

申请日：1995-04-25

Applicant: TODD, John, M.

IPC: F16L47/00

CPC classification number: B29C61/10 ,  B29C53/40 ,  B29C53/58 ,  B29C61/0608 ,  B29K2067/00 ,  B29K2077/00 ,  B29K2079/08 ,  B29L2031/7732 ,  F16L47/22

Abstract: Cable, wire, optical fibre and other elongated objects may be encased in a tube (1d) which has a longitudinal axis and is made from an elongated strip of oriented crystalline thermoplastic polymer film, wherein the strip is memory-set into a split tubular shape. The split (13) may be parallel to the longitudinal axis or follow a helical path along the tube. Preferably, the strip is memory-set so portions adjacent its longitudinal edges overlap or are adapted to be interlocked (21, 22). After forming into tubular form, the split tube may be splayed open and wound up on a roll for easy transportation; the memory-set tube will re-form when the strip is unwound from the roll.

Abstract translation: 电缆，电线，光纤和其它细长物体可以被封装在具有纵向轴线的管（1d）中，并且由长条状的定向结晶热塑性聚合物膜制成，其中该条带被记忆设置成分开的管状 。 裂口（13）可以平行于纵向轴线或者沿着沿着管的螺旋路径。 优选地，条带是记忆集，因此与其纵向边缘相邻的部分重叠或适于互锁（21,22）。 成形为管状后，可以将开口开放并卷绕在卷上以便于运输; 当条从卷退出时，记忆集管将重新形成。

公开(公告)号：US20180133638A1

公开(公告)日：2018-05-17

申请号：US15352711

申请日：2016-11-16

Applicant: Todd John Shafer

Inventor： Todd John Shafer

IPC: B01D46/00 ,  B01D46/10

CPC classification number: B01D46/0028 ,  B01D46/0035 ,  B01D46/10 ,  B01D2275/10

Abstract: An improved air filter assembly for removing particles from air flow across the filter assembly utilizing a tackifier material in combination with an antibacterial substance. The air filter assembly comprises a peripheral frame adapted to be supported in communication with an intake opening in a residential return air duct; and a filter media mounted within the frame for removing particulate from air flowing from an upstream side of the filter assembly to a downstream side of the air filter assembly. The downstream side of the filter media comprises a layer of filter media treated with the tackifier material or a sticky oil and the antimicrobial substance.

公开(公告)号：US20160030874A1

公开(公告)日：2016-02-04

申请号：US14818259

申请日：2015-08-04

Applicant: TODD JOHN SHAFER

Inventor： TODD JOHN SHAFER

IPC: B01D46/00

CPC classification number: B01D46/10 ,  B01D46/0035

Abstract: An improved air filter assembly for removing particles from air flow across the filter assembly utilizing a tackifier material. The air filter assembly comprises a peripheral frame adapted to be supported in communication with an intake opening in a residential return air duct; and a filter media mounted within the frame for removing particulate from air flowing from an upstream side of the filter assembly to a downstream side of the air filter assembly. The downstream side of the filter media comprises a layer of filter media treated with a tackifier material or a sticky oil.

Abstract translation: 一种改进的空气过滤器组件，其利用增粘材料从空气流中除去过滤器组件的颗粒。 空气过滤器组件包括适于与住宅回风管道中的进气口连通地支撑的外围框架; 以及安装在所述框架内的过滤介质，用于从所述过滤器组件的上游侧流到所述空气过滤器组件的下游侧的空气中除去颗粒。 过滤介质的下游侧包括用增粘材料或粘性油处理的一层过滤介质。

公开(公告)号：US07370336B2

公开(公告)日：2008-05-06

申请号：US10662933

申请日：2003-09-15

Applicant: Syed Mohammad Amir Husain ,  Todd John Enright ,  Barry W. Thornton

Inventor： Syed Mohammad Amir Husain ,  Todd John Enright ,  Barry W. Thornton

IPC: G06F3/00

CPC classification number: H04L67/104 ,  G06F9/54 ,  G06F11/1662 ,  G06F11/202 ,  G06F11/203 ,  G06F11/2033 ,  G06F11/2038 ,  G06F11/2097 ,  H04L12/1818 ,  H04L29/06 ,  H04L41/0803 ,  H04L41/0813 ,  H04L41/0816 ,  H04L41/0856 ,  H04L41/0859 ,  H04L41/0863 ,  H04L41/0879 ,  H04L41/0886 ,  H04L41/22 ,  H04L41/5009 ,  H04L41/5067 ,  H04L51/066 ,  H04L67/02 ,  H04L67/1002 ,  H04L67/1048 ,  H04L67/1068 ,  H04L67/1097 ,  H04L67/2823 ,  H04L67/2842 ,  H04L67/325 ,  H04L67/34 ,  H04L67/40 ,  H04L69/08 ,  H04L69/328 ,  H04L69/329 ,  H04L2029/06054

Abstract: Systems and methods are disclosed for a distributed computing infrastructure on a computer network comprising a plurality of computers. The distributed computing infrastructure (DCI) provides a software platform for creating, running, and managing distributed applications. DCI may include XML-capable software applications on a peer-to-peer network. DCI may include small, network-unaware applications called peerlets. DCI may include a system and method for creating complex distributed applications using pre-complied binaries. DCI may include a capability for multiple, independent collaborative sessions for distributed collaborative applications (e.g., chat, instant messaging, shared whiteboard, etc.). DCI may include systems and methods for reducing interactions between users and applications to archivable form and then playing back the interactions. DCI may include a system and method for automatic software retrieval on a peer-to-peer network.

Abstract translation: 公开了在包括多个计算机的计算机网络上的分布式计算基础设施的系统和方法。 分布式计算基础设施（DCI）为创建，运行和管理分布式应用程序提供了一个软件平台。 DCI可以在对等网络上包括支持XML的软件应用。 DCI可能包括称为“小区”的小型网络不知情的应用程序。 DCI可以包括使用预先编译的二进制文件创建复杂分布式应用程序的系统和方法。 DCI可以包括用于分布式协作应用（例如聊天，即时消息，共享白板等）的多个独立协作会话的能力。 DCI可以包括用于减少用户和应用之间的可交换形式的交互，然后回放交互的系统和方法。 DCI可以包括用于在对等网络上自动软件检索的系统和方法。

公开(公告)号：US07370083B2

公开(公告)日：2008-05-06

申请号：US11557606

申请日：2006-11-08

Applicant: Syed Mohammad Amir Husain ,  Todd John Enright ,  Barry W. Thornton

Inventor： Syed Mohammad Amir Husain ,  Todd John Enright ,  Barry W. Thornton

IPC: G06F12/00 ,  G06F15/167 ,  G06F15/06

CPC classification number: H04L67/1097 ,  H04L41/0803 ,  H04L41/22 ,  H04L41/509 ,  H04L67/104 ,  H04L67/2819 ,  H04L67/2842 ,  H04L67/288 ,  H04L67/325 ,  H04L67/34 ,  H04L69/08 ,  H04L69/328 ,  H04L69/329 ,  H04L2029/06054

Abstract: A system and method are disclosed for using free storage capacity on a plurality of storage media as a virtual storage device on a computer network comprising a plurality of computers. A first portion of each storage medium stores data. To implement Virtual Network Attached Storage (VNAS), the respective “free” second portions of each storage medium are aggregated into a shared storage volume. Computers on the network may mount the shared storage volume at one of a plurality of mount points and may store data on the shared storage volume. VNAS may be implemented in a peer-to-peer manner whereby each computer acts as a server for the data stored on its part of the shared storage volume (i.e., the second portion of its storage media). VNAS may be used to implement a system and method for managing data fail-over.

Abstract translation: 公开了一种用于在多个存储介质上使用空闲存储容量作为包括多个计算机的计算机网络上的虚拟存储设备的系统和方法。 每个存储介质的第一部分存储数据。 为了实现虚拟网络连接存储（VNAS），每个存储介质的相应“空闲”第二部分被聚合成共享存储卷。 网络上的计算机可以将共享存储卷安装在多个安装点中的一个上，并且可以将数据存储在共享存储卷上。 VNAS可以以对等方式实现，由此每个计算机充当存储在其共享存储卷的一部分（即，其存储介质的第二部分）上的数据的服务器。 VNAS可用于实现用于管理数据故障转移的系统和方法。