Abstract:
본명세서에는인간진피유래성체줄기세포의배양물의신규한용도가개시된다. 상기인간진피유래성체줄기세포(human dermal stem/progenitor cells, 이하 hDSPCs)의배양물을유효성분으로함유하는조성물은, Wnt 유전자의전사체또는 Wnt 단백질을인간진피유래섬유아세포의배양물에비하여증가된양으로포함할수 있다. 이에, 상기조성물은 Wnt/베타카테닌(Wnt/β-catenin) 신호전달을촉진할수 있고, 진피모유두세포의증식또는분화를증진하거나노화를억제할수 있으며, 성장인자등의발현또는활성을증진시키므로, 탈모방지또는발모촉진의효과를가질수 있다.
Abstract:
본발명은캐드헤린11(Cadherin 11) 및 N-캐드헤린(N-cadherin) 중하나이상의발현억제물질을유효성분으로포함하는피부개선용조성물및 이를포함하는피부개선키트를제공함으로써피부과색소침착증을개선할수 있으며, 피부미백효과를제공할수 있다. 피부주름생성을방지또는완화할수 있으므로, 우수한항노화효과를제공한다. 또한, 본발명은섬유아세포(fibroblast), 각질형성세포(keratinocyte) 및멜라닌생성세포(melanocyte) 중 2종이상의공배양물을포함하는피부개선물질스크리닝시스템, 및상기피부개선물질스크리닝시스템의공배양물에후보물질을처리하는단계, 및캐드헤린11 및 N-캐드헤린중 하나이상의발현변화를측정하는단계를포함하는것을특징으로하는피부개선물질의스크리닝방법을제공함으로써, 생체외(in vitro)에서도임상적으로캐드헤린11, N-캐드헤린의발현변화를용이하게측정하여, 피부개선물질을효과적으로스크리닝할수 있다.
Abstract:
본명세서에는알파인웜우드() 추출물을유효성분으로포함하는조성물이개시된다. 본명세서에개시된조성물은알파인웜우드() 추출물을포함하는것에의해멜라닌생성감소, 또는티로시나아제활성억제효과를나타낸다. 따라서, 이러한효과로인해본 명세서의알파인웜우드() 추출물은미백효과를나타낼수 있으며, 그러므로미백용조성물로서약학또는화장료분야에서널리사용될수 있다.
Abstract:
Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention contains one or more gene selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consisting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract:
The present invention relates to a composition comprising aprepitant as an active ingredient for external skin application and, more specifically, to a composition for external skin application which has excellent skin whitening effect by comprising aprepitant, which is an antagonist of neurokinin 1 receptor (NK1), as an active ingredient.
Abstract:
The present invention relates to a composition for blackening the skin, wherein the composition contains interleukin 16 (IL-16). More specifically, the present invention relates to a skin external application composition containing IL-16 so as to promote the chromogenesis and differentiation of adult melanocytes in the skin so that the skin can be blackened and skin or hair hypochromatism including leukoplakia and leukotrichia can be treated.