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    ARRAY LEVEL FOURIER PTYCHOGRAPHIC IMAGING
    152.
    发明申请
    ARRAY LEVEL FOURIER PTYCHOGRAPHIC IMAGING 有权
    阵列级FOORIER PTYCHOGRAPHIC IMAGING

    公开(公告)号：US20160216503A1

    公开(公告)日：2016-07-28

    申请号：US15007196

    申请日：2016-01-26

    Applicant: California Institute of Technology

    Inventor： Jinho Kim ,  Changhuei Yang

    IPC: G02B21/36 ,  G02B21/00 ,  G02B21/16

    CPC classification number: G02B21/365 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0446 ,  G02B13/0095 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/367 ,  H04N5/22541 ,  H04N5/2256 ,  H04N5/2258

    Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.

    Abstract translation: 在一个方面，成像系统包括：包括光源阵列的照明系统; 包括一个或多个透镜阵列的光学系统，每个透镜阵列包括透镜阵列，所述一个或多个透镜阵列中的每一个中的每个透镜与所述光源阵列的相应组的光源对准; 一种成像系统，包括图像传感器阵列，每个图像传感器与一个或多个透镜阵列的对应透镜或透镜组对准，每个图像传感器被配置为基于从所述一个或多个透镜阵列接收的光获取图像数据 相应的镜头或镜片组; 板接收器系统，其能够接收包括孔阵列的多孔板，所述板接收器系统被配置为使每个所述孔与所述图像传感器中的相应一个对准; 以及控制器，其被配置为控制所述光源的照明和由所述图像传感器获取图像数据，所述控制器还被配置为执行：包括多个扫描的图像获取处理，每个扫描与唯一的照明模式相关联， 每个图像传感器被配置为在每次扫描期间为相应的一个孔产生图像; 以及图像重建过程，在该图像重建过程期间，控制器基于在每个扫描期间针对相应的阱捕获的图像数据执行傅立叶ptychographic操作以生成每个孔的重建图像。

    NEPHELOMETRY METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF SUSPENDED PARTICLES IN AN ARRAY OF SAMPLE CONTAINERS
    153.
    发明申请
    NEPHELOMETRY METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF SUSPENDED PARTICLES IN AN ARRAY OF SAMPLE CONTAINERS 有权
    用于确定样品容器的阵列中悬浮颗粒浓度的测定方法和装置

    公开(公告)号：US20160209328A1

    公开(公告)日：2016-07-21

    申请号：US14913148

    申请日：2014-08-19

    Applicant: BECTON, DICKINSON AND COMPANY

    Inventor： Klaus W. Berndt ,  Timothy R. Hansen

    IPC: G01N21/51 ,  G01N15/06

    CPC classification number: G01N21/51 ,  G01N15/06 ,  G01N2015/0693 ,  G01N2021/4709 ,  G01N2021/4761 ,  G01N2021/513 ,  G01N2201/0446 ,  G01N2201/062

    Abstract: Described are devices, methods, and systems that are suitable for rapidly and simultaneously determining the concentration of suspended particles in a sample. The devices, methods, and systems allow for the rapid and simultaneous interrogation of a large number of sample wells in a single vessel, for example, samples contained in a two-dimensional array or micro-titer plate, without the need for moving reading heads or moving the sample vessel. The nephelometry system allows the user to rapidly and simultaneously measure the concentration of the particles in numerous samples, adjust the concentration of the particles in the sample with a sample handling system, and re-measure the concentration of the samples in order to achieve a desired concentration.

    Abstract translation: 描述了适于快速并同时确定样品中悬浮颗粒浓度的装置，方法和系统。 装置，方法和系统允许在单个容器中快速和同时询问大量样品孔，例如包含在二维阵列或微滴定板中的样品，而不需要移动读取头 或移动样品容器。 比浊法系统允许用户快速并同时测量多个样品中的颗粒浓度，用样品处理系统调节样品中颗粒的浓度，并重新测量样品的浓度以达到所需的 浓度。

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM
    157.
    发明申请
    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM 审中-公开
    拉曼光谱仪用于监测培养基的使用

    公开(公告)号：US20160025633A1

    公开(公告)日：2016-01-28

    申请号：US14775255

    申请日：2014-03-14

    Applicant: BIOGEN MA INC.

    Inventor： Justin Moretto ,  Brandon Berry ,  Alex Doane

    IPC: G01N21/65

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

    Abstract translation: 一方面，本公开提供了一种限定培养组分的拉曼特征的方法，所述方法包括：获得非干扰或最小干扰溶液中培养组分的拉曼光谱，鉴定拉曼光谱中的峰，其为 与培养组分相关，获得包含培养组分的培养基的拉曼光谱，并且除去与在培养物的拉曼光谱中鉴定的峰相比变形的培养基的拉曼光谱中的培养成分的峰 在非干扰或最小干扰的解决方案中的组件。

    Microplate Reader with Lid Lifter for Microplates
    158.
    发明申请
    Microplate Reader with Lid Lifter for Microplates 有权
    用于微孔板的升降器的酶标仪

    公开(公告)号：US20150233815A1

    公开(公告)日：2015-08-20

    申请号：US14697012

    申请日：2015-04-27

    Applicant: TECAN TRADING AG

    Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

    IPC: G01N21/03 ,  G01N21/76 ,  G01N21/64

    CPC classification number: G01N21/0303 ,  G01N21/6428 ,  G01N21/76 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  G01N2201/022 ,  G01N2201/0446 ,  Y10S436/807

    Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

    Abstract translation: 酶标板读取器具有壳体，至少一个光学测量/检测装置，微孔板支架，移动单元和一体式盖保持装置。 盖保持装置使微板在一个相应的至少大致垂直的方向上移动，以使微板盖远离微板。 盖保持装置作为磁性提升器布置在壳体内部，并且包括至少一个永磁体或至少三个电磁体或至少一个可切换永磁体的非阵列布置。 每个微板盖要移动离开微板包括具有物理区域的可磁化材料。 所述至少一个永磁体，电磁体或可切换永磁体的投影面积小于微板盖板的可磁化材料的物理面积。

    EMISSION INTENSITY MEASURING DEVICE
    159.
    发明申请
    EMISSION INTENSITY MEASURING DEVICE 审中-公开
    排放强度测量装置

    公开(公告)号：US20150204786A1

    公开(公告)日：2015-07-23

    申请号：US14674267

    申请日：2015-03-31

    Applicant: SONY CORPORATION

    Inventor： AYUMU TAGUCHI

    IPC: G01N21/64

    CPC classification number: G01N21/6452 ,  G01N21/6454 ,  G01N21/6486 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/0446 ,  G01N2201/061

    Abstract: An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments.

    Abstract translation: 一种发光强度测量装置，包括：光接收单元，其与具有容纳有样品的多个隔室的生物芯片相对设置，并且包括布置的多个光接收元件;以及确定部，其确定加权率 基于预先获取的光接收元件的噪声特性的每个光接收元件。 发光强度测量装置还包括：乘法部分，用于将每个光接收元件的输出乘以加权速率，以计算每个光接收元件的加权输出;以及相加部分，其将光的加权输出相加 接收元件与相应的一个隔室相对。

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