公开(公告)号：WO2011139829A3

公开(公告)日：2012-04-05

申请号：PCT/US2011034312

申请日：2011-04-28

Applicant: STC UNM ,  KEYES ROY WILLIAM ,  ROMANO CHRISTIAN ,  LUAN SHUANG ,  ARNOLD DORIAN C

Inventor： KEYES ROY WILLIAM ,  ROMANO CHRISTIAN ,  LUAN SHUANG ,  ARNOLD DORIAN C

IPC: G06F19/00 ,  G06F15/16

CPC classification number: G06F19/3481 ,  G06F9/5083 ,  G06F19/3437 ,  G16H50/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

Abstract translation: 提出了一种在网络虚拟计算群上计算辐射能量密度和能量沉积分布的方法。 通过这种方法，复杂的蒙特卡洛模拟需要广泛的设备，人员和财务资源，可以由需要放射治疗剂量计算的医院和诊所进行有效和低成本的处理。

公开(公告)号：WO2011100234A3

公开(公告)日：2012-03-15

申请号：PCT/US2011024030

申请日：2011-02-08

Applicant: STC UNM ,  CHACKERIAN BRYCE ,  PEABODY DAVID S

Inventor： CHACKERIAN BRYCE ,  PEABODY DAVID S

IPC: A61K38/17 ,  A61K38/16 ,  A61K47/30 ,  A61K47/48 ,  A61P31/00 ,  A61P31/12

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K47/48776 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2795/18123

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPsand related ompositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.

Abstract translation: 本发明提供免疫治疗和预防性噬菌体病毒样颗粒（VLP），其可用于治疗和预防人乳头状瘤病毒（HPV）感染和相关疾病，包括宫颈癌和与HPV相关的持续感染。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLPs和相关症状诱导针对HPV L2的高滴度抗体应答并且在体内保护免受HPV挑战。 VLP，含VLP的组合物和本发明的治疗方法诱导针对HPV感染的免疫原性应答，赋予HPV感染免疫，防止HPV感染，并降低HPV感染感染的可能性。

公开(公告)号：WO2011094260A3

公开(公告)日：2011-12-01

申请号：PCT/US2011022508

申请日：2011-01-26

Applicant: STC UNM ,  HROMAS ROBERT ,  LEITAO ANDREI ,  OPREA TUDOR I ,  SKLAR LARRY A ,  WILLIAMSON ELIZABETH A ,  WRAY JUSTIN ,  WANG WEI

Inventor： HROMAS ROBERT ,  LEITAO ANDREI ,  OPREA TUDOR I ,  SKLAR LARRY A ,  WILLIAMSON ELIZABETH A ,  WRAY JUSTIN ,  WANG WEI

IPC: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D215/56 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/475 ,  A61K31/496 ,  A61K31/7048 ,  A61K45/06 ,  A61N5/1001 ,  A61N5/1045 ,  A61N2005/1087 ,  A61N2005/1098 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  A61K2300/00

Abstract: This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA replication and repair proteins Metnase and/or Intnase (also termed Gypsy Integrase, Gypsy Integrease-1, Gypsy Retransposon Integrase 1, or GIN-I) that simultaneously damage DNA, and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols, including radiation therapy. In preferred embodiments, compounds, compositions and methods of treatment of the invention are used to treat a patient suffering from leukemia (e.g. acute myeloid leukemia (AML) and related cancers. In certain aspects of such treatments, compounds, compositions and methods of treatment of the invention are administered as a monotherapy (in some cases, to patients who have exhibited resistance to Topo IIalpha inhibitors such as VP- 16), or are co-administered with a Topo IIalpha inhibitor or other anti-cancer agents as otherwise described herein or in combination with radiation therapy.

Abstract translation: 本发明涉及新的癌症治疗组合物和相关的治疗方法。 更具体地说，本发明部分涉及同时损伤DNA的DNA复制和修复蛋白质Metnase和/或Intnase（也称为Gypsy整合酶，Gypsy Integrease-1，Gypsy Retransposon Integrase 1或GIN-1）的小型化学双功能抑制剂， 以及利用抑制剂增加包括放射治疗在内的癌症治疗方案的有效性的治疗方法。 在优选的实施方案中，本发明的化合物，组合物和治疗方法用于治疗患有白血病的患者（例如急性骨髓性白血病（AML）和相关的癌症）。在这些治疗的某些方面，化合物，组合物和治疗方法 本发明作为单一疗法（在某些情况下，对已显示出对Topo IIalpha抑制剂如VP-16具有抗性的患者）施用，或者与本文另有描述的Topo IIal抑制剂或其它抗癌剂共同施用，或 结合放射治疗。

公开(公告)号：WO2011069055A9

公开(公告)日：2011-11-03

申请号：PCT/US2010058870

申请日：2010-12-03

Applicant: STC UNM ,  SEN PRADEEP ,  DARABI ALIAKBAR

Inventor： SEN PRADEEP ,  DARABI ALIAKBAR

IPC: G06T17/00 ,  G06T1/00

CPC classification number: H04N19/85 ,  H04N19/59 ,  H04N19/63 ,  H04N19/80

Abstract: Compressed sensing can be mapped to a more general set of problems in computer graphics and computer imaging. Representation of a rendered scene in the formulation y = A^x produces higher-quality rendering with less samples than previous approaches. A filter formulation F makes point samples compatible with wavelet and therefore allows reconstruction of 2-D images from a set of measured pixels (point samples).

Abstract translation: 压缩感测可以映射到计算机图形学和计算机成像中更为普遍的一组问题。 在公式y = A ^ x中渲染场景的表示产生比以前的方法更少的样本的较高质量的渲染。 滤波器公式F使点样本与小波兼容，因此允许从一组测量像素（点样本）重构2-D图像。

公开(公告)号：WO2011060334A3

公开(公告)日：2011-09-22

申请号：PCT/US2010056628

申请日：2010-11-12

Applicant: STC UNM ,  SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，包括限定用于接收一定剂量的粉末药物的腔室的壳体，与腔室流体连通的吸入口，至少一个气流入口，其提供腔室与外壳之间的流体连通，以及颤动元件 并且与一定剂量的粉末状药物相关联。 颤振元件具有靠近至少一个气流入口的张紧的远端和与入口的远端和下游相对的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并使粉末状药物的剂量雾化。

公开(公告)号：WO2011112756A2

公开(公告)日：2011-09-15

申请号：PCT/US2011027797

申请日：2011-03-09

Applicant: STC UNM ,  SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B13/0207 ,  B05B15/0443

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

Abstract translation: 用于将干燥粉末微粒涂覆到表面上的装置包括喷射式粉碎机，其被配置为将干燥粉末颗粒研磨成具有期望空气动力学直径的微粒并使微粒解聚，构造并布置成将干燥粉末颗粒送入喷射式粉碎机的进料斗， 表面构造成接收干粉微粒和与喷射磨相关联的出口喷嘴。 出口喷嘴可以布置成将来自喷射磨机的解聚集的微粉化干粉颗粒引导到待涂覆的表面。 该装置还可以包括构造和布置成保持物品的保持器，其中物品包括表面。 在设备的某些方面，该项目可以是电影。

公开(公告)号：WO2011069055A3

公开(公告)日：2011-09-15

申请号：PCT/US2010058870

申请日：2010-12-03

Applicant: STC UNM ,  SEN PRADEEP ,  DARABI ALIAKBAR

Inventor： SEN PRADEEP ,  DARABI ALIAKBAR

IPC: G06T17/00 ,  G06T1/00

CPC classification number: H04N19/85 ,  H04N19/59 ,  H04N19/63 ,  H04N19/80

Abstract: Compressed sensing can be mapped to a more general set of problems in computer graphics and computer imaging. Representation of a rendered scene in the formulation y = A^x produces higher-quality rendering with less samples than previous approaches. A filter formulation F makes point samples compatible with wavelet and therefore allows reconstruction of 2-D images from a set of measured pixels (point samples).

Abstract translation: 压缩传感可以映射到计算机图形和计算机成像中更常见的一组问题。 在公式y = A ^ x中呈现的场景的表示以比之前的方法更少的样本产生更高质量的呈现。 滤波器公式F使点样本与小波相容，因此允许从一组测量像素（点样本）重建二维图像。

公开(公告)号：WO2011031564A3

公开(公告)日：2011-07-14

申请号：PCT/US2010047043

申请日：2010-08-27

Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN J

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

Abstract translation: 将粉末状药剂涂覆到用于干粉吸入器的载体颗粒上的方法可包括将超声波能量应用于聚集粉末药剂以将药剂颗粒解聚并雾化成具有期望平均粒度的颗粒， 至少一种载体颗粒与期望量的药物的解聚和雾化颗粒。

公开(公告)号：WO2011011064A3

公开(公告)日：2011-05-05

申请号：PCT/US2010002049

申请日：2010-07-21

Applicant: STC UNM ,  SMOLYAKOV GENNADY A ,  OSINSKI MAREK A

Inventor： SMOLYAKOV GENNADY A ,  OSINSKI MAREK A

IPC: C01B3/04 ,  B01J21/06 ,  B01J23/38 ,  B01J23/89 ,  B82B3/00

CPC classification number: C01B3/042 ,  B01J21/063 ,  B01J23/60 ,  B01J23/6484 ,  B01J23/80 ,  B01J23/8474 ,  B01J35/0013 ,  B01J35/004 ,  B01J35/008 ,  B01J35/0086 ,  B01J37/035 ,  Y02E60/364 ,  Y02P20/134

Abstract: Photocatalytic water splitting is employed as a method to directly obtain clean hydrogen from solar radiation by using hybrid nanoparticles with metallic cores and semiconductor photocatalytic shells. Efficient unassisted overall photocatalytic splitting of water is based on resonant absorption from surface plasmon in metal core/semiconductor shell hybrid nanoparticles, which can extend the absorption spectra further towards the visible-near infrared range, thus dramatically increasing the solar energy conversion efficiency. When used in combination with scintillator nanoparticles, the hybrid photocatalytic nanoparticles can be used for conversion of nuclear energy into hydrogen.

Abstract translation: 采用光催化水分解法，通过使用金属核和半导体光催化壳的混合纳米粒子直接从太阳辐射获得清洁氢。 水的有效无辅助整体光催化分解是基于金属核/半导体壳混合纳米粒子中表面等离子体激元的共振吸收，这可以将吸收光谱进一步扩展到可见光近红外范围，从而大大提高太阳能转换效率。 当与闪烁体纳米颗粒组合使用时，杂化光催化纳米颗粒可用于将核能转化为氢。

公开(公告)号：WO2011002836A2

公开(公告)日：2011-01-06

申请号：PCT/US2010040522

申请日：2010-06-30

Applicant: STC UNM ,  BOEDEKER EDGAR C ,  BYRD ISAAC WYATT

Inventor： BOEDEKER EDGAR C ,  BYRD ISAAC WYATT

IPC: A61K39/108 ,  A61K39/02 ,  A61K39/395 ,  A61P31/00 ,  C12N15/70

CPC classification number: A61K39/0258 ,  A61K2039/522 ,  A61K2039/523

Abstract: An attenuated enterohemorrhagic E. coli-based vaccine vector is disclosed. Enterotoxigenic E. coli colonization factor antigen 1 and the B subunit of E. coli heat labile toxin have been expressed in the attenuated enterohemorrhagic E. coli vector strain. Immunized animals are further protected against lethal and non lethal challenges with the enterotoxigenic E. coli strain. Immunization of mice with the vaccine construct induces mucosal antibody against both antigens, establishing the attenuated E. coli vector strain as a generally useful vector for presenting one or more antigens to a subject in a vaccine.

Abstract translation: 公开了一种减毒的基于肠出血性大肠杆菌的疫苗载体。 产肠毒素的大肠杆菌定居因子抗原1和大肠杆菌热不稳定毒素的B亚基已在减毒的肠出血性大肠杆菌载体菌株中表达。 用产肠毒素大肠杆菌菌株进一步保护免疫的动物免受致命和非致死的挑战。 用疫苗构建体免疫小鼠诱导针对两种抗原的粘膜抗体，建立减毒的大肠杆菌载体菌株作为用于在疫苗中向受试者呈递一种或多种抗原的通常有用的载体。