公开(公告)号：WO2018197416A1

公开(公告)日：2018-11-01

申请号：PCT/EP2018/060348

申请日：2018-04-23

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： KOUWER, Paul ,  ROWAN, Alan ,  JASPERS, Maarten ,  DE ALMEIDA, Paula

IPC: C08J3/075 ,  C08J3/24 ,  C08L33/02 ,  C08L33/26 ,  C09D133/02 ,  C09D133/26

Abstract: The invention relates to a double network hydrogel comprising a polymer (A) having a persistence length between 10 and 1000 nm; a flexible polymer (B), wherein the persistence length is measured according to single molecule force microscopy measurement, wherein polymer (B) has an extended coil conformation at a first condition and a collapsed globular conformation at a second condition. Polymer (A) preferably is a polyisocyanate, while polymer (B) is a crosslinked flexible polymer like for example PNIPAM. The invention also relates to a method for making a double network hydrogel.

公开(公告)号：WO2017217855A1

公开(公告)日：2017-12-21

申请号：PCT/NL2017/050403

申请日：2017-06-16

Applicant: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM ,  STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： SCHOLTE, Bob Johan ,  FEITERS, Martinus Christiaan ,  DAMEN, Mark

IPC: C07K5/083 ,  C07K5/103 ,  C07K5/113 ,  C07K7/06 ,  C07K7/08 ,  C07K5/09 ,  C07K5/072 ,  A61K38/04 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08

Abstract: Disclosed are geminoid peptide-like compound according to Formula (I): R 1 - C(=0) - Z n - NR 3 - R 2 in which R 1 and R 2 are each independently saturated, partly saturated or unsaturated, straight, branched or cyclic alkyl chains, wherein R 1 has a number of C atoms of 11 or more, preferably 11 to 19, and R 2 has a number of C atoms of 12 or more, preferably 12 to 20; R3 is hydrogen or C 1 -C- 6 alkyl; n is an integer from 1 - 15; each Z independently is an amino acid residue, wherein Z n comprises an N- terminus attached to C(=0) and a C-terminus that is attached to NR 3 , for use as a medicament.

Abstract translation: 公开了根据式（I）的锗基酰胺肽样化合物：R1-C（= O）-Zn-NR- 其中R 1和R 2各自独立地为饱和的，部分饱和的或不饱和的，直链的，支链或环状的， 支链或环状的烷基链，其中R 1具有11或更多，优选11至19的C原子数，并且R 2具有12个碳原子数 或更多，优选12至20; R 3是氢或C 1 -C 6 - 烷基; n是1-15的整数; 每个Z独立地为氨基酸残基，其中Z n包含连接到C（= O）的N端和连接到NR 3的C端， 用作药物。

公开(公告)号：WO2017153605A1

公开(公告)日：2017-09-14

申请号：PCT/EP2017/055827

申请日：2017-03-13

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： SRINIVAS, Mangala ,  KOSHKINA, Olga ,  FIGDOR, Carl Gustav ,  DE VRIES, Ingrid Jolanda Monique

IPC: A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  G01N29/04 ,  G01N29/24 ,  G01N24/08

CPC classification number: C08J3/205 ,  A61K49/0002 ,  A61K49/108 ,  A61K49/12 ,  A61K49/1818 ,  A61K49/223 ,  C08J3/093 ,  C08J3/095 ,  C08J2329/04 ,  C08J2467/04 ,  C08K3/08 ,  C08K5/02 ,  G01N29/2418 ,  G01N2291/02475 ,  G01R33/281

Abstract: The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohoi and optionally a metal compound, comprising the steps of: a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant comprising polyvinylalcohoi under sonication to obtain a second liquid mixture, c) maintaining the sonication of the second liquid mixture while cooling, d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, e) separating the beads from the suspension and preparing a water suspension of the beads and f) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. The invention further relates to beads having close F-H20 interactions, which are suitable for imaging purposes.

Abstract translation: 本发明涉及制备包含生物相容性疏水聚合物，全氟化碳，聚乙烯醇和任选的金属化合物的珠粒的方法，其包括以下步骤：a）将全氟化碳和任选的金属化合物 向生物相容性疏水聚合物在极性溶剂中的溶液提供第一液体混合物，b）在超声处理下，将第一液体混合物加入到包含聚乙烯醇的生物相容性表面活性剂的水溶液中以获得第二液体混合物，c）维持超声处理 d）从第二液体混合物中蒸发极性溶剂以获得包含生物相容性疏水性聚合物，全氟化碳和任选的金属化合物的珠粒的悬浮液，e）从珠粒中分离珠粒并制备 f）将所述水悬浮液冷冻干燥以获得所述珠子，其中所述珠子是水悬浮液 在步骤b）中将第一液体混合物添加到生物相容性表面活性剂中的时间在至多秒内进行，其中步骤b）中的超声处理和步骤c）中的超声处理通过例如探针直接进入液体混合物中 或流动超声波仪以至少120μm的幅度持续0.01-10分钟，并且其中生物相容性表面活性剂与生物相容性疏水聚合物的重量比为至少3：1。 本发明进一步涉及具有接近F-H 2 O相互作用的珠粒，其适于成像目的。

公开(公告)号：WO2015132338A1

公开(公告)日：2015-09-11

申请号：PCT/EP2015/054615

申请日：2015-03-05

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： SAUERWEIN, Robert Wilhelmus ,  RIJPMA, Sanna Ramona ,  JANSE, Christoffel Jan ,  FAYARD, Blandine Marie Danièle ,  KHAN, Shahid Mahmood ,  RUSSEL, François Gérard Marie ,  KOENDERINK, Jan Bernhard

IPC: C12N1/10 ,  C12N1/36 ,  C07K14/445 ,  A61K39/015

CPC classification number: C12N1/10 ,  A61K39/015 ,  A61K2039/522 ,  C07K14/445 ,  C12N1/36 ,  Y02A50/412

Abstract: The present invention relates to a new genetically attenuated, live organism against malaria. The present invention further relates to a pharmaceutical composition comprising such live attenuated organism. The present invention further relates to methods of treatment and/or prevention using such live attenuated organism.

Abstract translation: 本发明涉及一种新的基因减毒活疟疾生物体。 本发明还涉及包含这种活的减毒生物体的药物组合物。 本发明还涉及使用这种活的减毒生物体的治疗和/或预防的方法。

公开(公告)号：WO2015101609A1

公开(公告)日：2015-07-09

申请号：PCT/EP2014/079398

申请日：2014-12-29

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： DEEN, Petrus Meinardus Theodorus ,  GROOT, DE, Antonius Isodorus Maria

IPC: A61K31/18 ,  A61K31/37 ,  A61P5/00

CPC classification number: A61K31/37 ,  A61K31/17 ,  A61K31/4425 ,  A61K31/53 ,  A61K31/635 ,  A61K31/7048

Abstract: This invention is in the field of medical treatments. It provides means and methods for the prevention and treatment of cystic renal and liver diseases, in particular renal diseases caused by lithium. More in particular it provides a method for the treatment or prevention of nephrogenic diabetes insipidus by administering a specific carbonic anhydrase 9 and or 12 inhibitor to a subject in need of such a treatment.

Abstract translation: 本发明在医疗领域。 它提供预防和治疗囊性肾脏和肝脏疾病的手段和方法，特别是由锂引起的肾脏疾病。 更具体地，其提供了通过向需要这种治疗的受试者施用特定的碳酸酐酶9和/或抑制剂来提供治疗或预防肾源性尿崩症的方法。

公开(公告)号：WO2015072856A2

公开(公告)日：2015-05-21

申请号：PCT/NL2014/050787

申请日：2014-11-14

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN

Inventor： RASING, Theodorus Henricus Maricus Maria ,  SAVOINI, Matteo

CPC classification number: G11C11/02 ,  G11C11/16 ,  G11C13/04 ,  G11C13/06

Abstract: The present invention is in the field of a magneto optical device comprising a magnetic unit and an optical unit, an electronic device comprising the magneto-optic device, a method of energy saving using the magneto- optical device, an array comprising the magneto-optical devices, and a method of changing magnetic orientation.

Abstract translation: 本发明涉及包括磁单元和光学单元的磁光学装置领域，包括磁光装置的电子装置，使用磁光装置的节能方法，包括磁光学的阵列 装置和改变磁方向的方法。

公开(公告)号：WO2015026787A2

公开(公告)日：2015-02-26

申请号：PCT/US2014/051636

申请日：2014-08-19

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  STICHTING KATHOLIEKE UNIVERSITEIT (D/B/A RADBOUD UNIVERSITY MEDICAL CENTRE)

Inventor： STRUIJK, Pieter, C. ,  CLARK, Edward, B.

IPC: A61B8/04

CPC classification number: A61B8/4477 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06 ,  A61B8/0866 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/4483 ,  A61B8/4488 ,  A61B8/4494 ,  A61B8/461 ,  G01S15/8915 ,  G01S15/892 ,  G01S15/8929 ,  G01S15/8984

Abstract: An ultrasound transducer system. The system includes at least three ultrasound transducer arrays including a central transducer array and at least two lateral transducer arrays located adjacent the central transducer array, wherein the at least three ultrasound transducer arrays are arranged such that ultrasound beam paths of the at least three ultrasound transducer arrays overlap in an approximately planar location.

Abstract translation: 超声换能器系统。 该系统包括至少三个超声换能器阵列，其包括中心换能器阵列和邻近中心换能器阵列的至少两个横向换能器阵列，其中至少三个超声换能器阵列布置成使得至少三个超声换能器的超声波束路径 阵列在大致平面的位置重叠。

公开(公告)号：WO2013092996A1

公开(公告)日：2013-06-27

申请号：PCT/EP2012/076628

申请日：2012-12-21

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： KENTGENS, Arnold Peter Maria ,  VAN BENTUM, Petrus Johannes Maria

IPC: G01R33/62 ,  G01R33/30

CPC classification number: G01R33/48 ,  G01N33/50 ,  G01R33/282 ,  G01R33/302 ,  G01R33/307 ,  G01R33/31 ,  G01R33/3456 ,  G01R33/465 ,  G01R33/62

Abstract: The invention provides a rapid cycle dynamic nuclear polarization (DNP) NMR apparatus (100) comprising (i) a cooling unit (10), configured to cool a sample (70) in a capillary (60), (b) a DNP polarization unit (20) configured to polarize the sample (70) in the capillary (60), (c) a stripline-based NMR detector (30) comprising a stripline (32) for NMR analysis of the sample (70) in the capillary (60), (d) a transport unit (40) configured to guide the capillary (60) from the DNP polarization unit (20) to the stripline (32) of stripline-based NMR detector (30); and (e) a heating unit (50) configured to heat the sample (70) in the capillary (60) before analysis of the sample (70) by the stripline-based NMR detector (30). Fast (1D-3D) NMR measurements with high resolution may be obtained.

Abstract translation: 本发明提供了一种快速循环动态核极化（DNP）NMR装置（100），包括（i）冷却单元（10），其构造成冷却毛细管（60）中的样品（70），（b）DNP偏振单元 （20），被配置为使毛细管（60）中的样品（70）偏振，（c）带状线NMR检测器（30），其包括用于毛细管（60）中的样品（70）的NMR分析的带状线（32） ），（d）构造成将毛细管（60）从DNP偏振单元（20）引导到带状线NMR检测器（30）的带状线（32）的传送单元（40）; 以及（e）加热单元（50），其构造成在通过带状线NMR检测器（30）分析样品（70）之前加热毛细管（60）中的样品（70）。 可以获得具有高分辨率的快速（1D-3D）NMR测量。

公开(公告)号：WO2013032334A1

公开(公告)日：2013-03-07

申请号：PCT/NL2012/050600

申请日：2012-08-31

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  DIRVEN, Richard ,  BEETZ, Antonius Godefriedus Gerardus ,  MARRES, Henry August Marie

Inventor： DIRVEN, Richard ,  BEETZ, Antonius Godefriedus Gerardus ,  MARRES, Henry August Marie

IPC: A61M16/04

CPC classification number: A61M16/0497 ,  A61M16/0468 ,  A61M25/02 ,  A61M2025/0206 ,  A61M2025/0213

Abstract: Automatic tracheostoma speech valve (ATSV) fixation brace, comprising a fixation part (2) for keeping an ATSV base element (8) in position during use, and a holding part (3) for holding the ATSV fixation brace (1) to a patient, wherein at least the holding part (3) comprises a thermoplastic material, the thermoplastic material being moldable to the local anatomic shape of the patient.

Abstract translation: 自动气管造口阀（ATSV）固定支架，包括用于在使用期间将ATSV基座元件（8）保持在适当位置的固定部分（2）和用于将ATSV固定支架（1）保持在患者身上的保持部分（3） ，其中至少所述保持部分（3）包括热塑性材料，所述热塑性材料可模制成患者的局部解剖形状。

公开(公告)号：WO2013006044A1

公开(公告)日：2013-01-10

申请号：PCT/NL2012/050460

申请日：2012-06-29

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  LUCAS, Petrus Johannes Franciscus

Inventor： LUCAS, Petrus Johannes Franciscus

IPC: G06F19/00

CPC classification number: A61B5/08 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/6898 ,  A61B5/7275 ,  G06F19/00 ,  G06F19/3418 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70

Abstract: Patient mobile computing system (1) and method for predicting exacerbations in a patient illness related status. The method comprises collecting patient sensor data using sensors (8), and executing a local prediction model. The local prediction model comprising a Bayesian network (6) to obtain a probability of an exacerbation of a patient status. The Bayesian network (6) receives patient input data, patient sensor data, and providing probability data,and the local prediction model provides guidance data based on the probability data. The local prediction model (6) is implemented both in a portable device (1), such as a smart phone, and in a centralized patient data processing system (20).

Abstract translation: 患者移动计算系统（1）和预测患者疾病相关状况恶化的方法。 该方法包括使用传感器（8）收集患者传感器数据，并执行局部预测模型。 本地预测模型包括贝叶斯网络（6），以获得患者状态恶化的概率。 贝叶斯网络（6）接收患者输入数据，患者传感器数据和提供概率数据，并且本地预测模型基于概率数据提供指导数据。 在诸如智能电话的便携式设备（1）中和在集中的患者数据处理系统（20）中都实现了本地预测模型（6）。