中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.024 seconds)

    PROCESS FOR PREPARATION OF BEADS FOR IMAGING
    4.
    发明申请
    PROCESS FOR PREPARATION OF BEADS FOR IMAGING 审中-公开
    制备用于成像的小珠的过程

    公开(公告)号：WO2017153605A1

    公开(公告)日：2017-09-14

    申请号：PCT/EP2017/055827

    申请日：2017-03-13

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： SRINIVAS, Mangala ,  KOSHKINA, Olga ,  FIGDOR, Carl Gustav ,  DE VRIES, Ingrid Jolanda Monique

    IPC: A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  G01N29/04 ,  G01N29/24 ,  G01N24/08

    CPC classification number: C08J3/205 ,  A61K49/0002 ,  A61K49/108 ,  A61K49/12 ,  A61K49/1818 ,  A61K49/223 ,  C08J3/093 ,  C08J3/095 ,  C08J2329/04 ,  C08J2467/04 ,  C08K3/08 ,  C08K5/02 ,  G01N29/2418 ,  G01N2291/02475 ,  G01R33/281

    Abstract: The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohoi and optionally a metal compound, comprising the steps of: a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant comprising polyvinylalcohoi under sonication to obtain a second liquid mixture, c) maintaining the sonication of the second liquid mixture while cooling, d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, e) separating the beads from the suspension and preparing a water suspension of the beads and f) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. The invention further relates to beads having close F-H20 interactions, which are suitable for imaging purposes.

    Abstract translation: 本发明涉及制备包含生物相容性疏水聚合物，全氟化碳，聚乙烯醇和任选的金属化合物的珠粒的方法，其包括以下步骤：a）将全氟化碳和任选的金属化合物 向生物相容性疏水聚合物在极性溶剂中的溶液提供第一液体混合物，b）在超声处理下，将第一液体混合物加入到包含聚乙烯醇的生物相容性表面活性剂的水溶液中以获得第二液体混合物，c）维持超声处理 d）从第二液体混合物中蒸发极性溶剂以获得包含生物相容性疏水性聚合物，全氟化碳和任选的金属化合物的珠粒的悬浮液，e）从珠粒中分离珠粒并制备 f）将所述水悬浮液冷冻干燥以获得所述珠子，其中所述珠子是水悬浮液 在步骤b）中将第一液体混合物添加到生物相容性表面活性剂中的时间在至多秒内进行，其中步骤b）中的超声处理和步骤c）中的超声处理通过例如探针直接进入液体混合物中 或流动超声波仪以至少120μm的幅度持续0.01-10分钟，并且其中生物相容性表面活性剂与生物相容性疏水聚合物的重量比为至少3：1。 本发明进一步涉及具有接近F-H 2 O相互作用的珠粒，其适于成像目的。

    POLYMERIC NANOPARTICLES FOR ENHANCING HIFU-INDUCED ABLATION
    6.
    发明申请
    POLYMERIC NANOPARTICLES FOR ENHANCING HIFU-INDUCED ABLATION 审中-公开
    用于增强HIFU诱导的ABLATION的聚合纳米粒子

    公开(公告)号：WO2017001686A1

    公开(公告)日：2017-01-05

    申请号：PCT/EP2016/065600

    申请日：2016-07-01

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： SRINIVAS, Mangala ,  FIGDOR, Carl Gustav ,  VRIES, DE, Ingrid Jolanda Monique

    IPC: A61N7/02

    CPC classification number: A61K41/0028 ,  A61K49/222 ,  A61N7/02

    Abstract: The invention is in the field of medical therapy, more in particular in the field of ablation therapy using ultrasound, such as high intensity focused ultrasound (HIFU). The invention provides means and methods for enhancing the ablation effect of HIFU. More in particular, the invention provides a polymeric particle comprising a polymer entrapping a liquid perfluorocarbon for use in high frequency ultrasound (HIFU) ablation therapy in a human or animal body, wherein the HIFU is focused in a focal region, wherein the ablation effect of the HIFU in the focal region is enhanced by administering the particles to the human or animal body, characterized in that the liquid perfluorocarbon does not undergo a phase change from liquid to gas during exposure to the HIFU.

    Abstract translation: 本发明在医学治疗领域，特别是在使用超声的消融治疗领域，如高强度聚焦超声（HIFU）。 本发明提供了增强HIFU消融效果的手段和方法。 更具体地，本发明提供了一种聚合物颗粒，其包含聚合液体全氟化碳的聚合物，用于人或动物体内的高频超声（HIFU）消融治疗，其中HIFU聚焦在焦点区域中，其中消融效应 通过将颗粒施用于人或动物体来增强聚焦区域中的HIFU，其特征在于液体全氟化碳在暴露于HIFU期间不会从液体发生相变。

    CONTRAST AGENT AND ITS USE FOR IMAGING
    7.
    发明申请
    CONTRAST AGENT AND ITS USE FOR IMAGING 审中-公开
    对比剂及其成像用途

    公开(公告)号：WO2014041150A1

    公开(公告)日：2014-03-20

    申请号：PCT/EP2013/069079

    申请日：2013-09-14

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： FIGDOR, Carl Gustav ,  VRIES, DE, Ingrid Jolanda Monique ,  SRINIVAS, Mangala ,  CRUZ RICONDO, Luis Javier

    IPC: A61K49/00 ,  A61K49/22 ,  A61K49/18 ,  A61P35/00 ,  A61P9/00 ,  A61P37/00 ,  B82Y5/00 ,  B82Y15/00

    CPC classification number: A61K49/225 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0093 ,  A61K49/1818 ,  A61K49/221

    Abstract: The present invention relates to contrast agent enhanced medical ultrasound imaging. In particular, the contrast agents provided are useful for cell imaging and cell therapy, as well as in vivo targeting, drug delivery and perfusion or vascular imaging applications. More specifically, it provides a particle comprising a fluorinated organic compound and a metal. Such particles may be advantageously employed in qualitative or quantitative imaging such as acoustic imaging including photoacoustic and ultrasound imaging, MRI imaging, such as 19F imaging, 1H imaging including T1 and T2 weighted imaging, SPECT, PET, scintigraphy, fluorescence imaging and optical coherence imaging and tomographic applications. This may then be employed in cell labeling, microscopy, histology or for imaging vasculature or perfusion in vivo and in vitro.

    Abstract translation: 本发明涉及造影剂增强医学超声成像。 特别地，提供的造影剂可用于细胞成像和细胞治疗，以及体内靶向，药物递送和灌注或血管成像应用。 更具体地，其提供了包含氟化有机化合物和金属的颗粒。 这种颗粒可以有利地用于定性或定量成像，例如包括光声和超声成像的声学成像，MRI成像，例如19F成像，包括T1和T2加权成像的1H成像，SPECT，PET，闪烁扫描，荧光成像和光学相干成像 和断层摄影应用。 然后可以将其用于细胞标记，显微镜，组织学或用于体内和体外成像脉管系统或灌注成像。

    POLYMERIC NANOPARTICLES FOR ENHANCING HIFU-INDUCED ABLATION
    9.
    发明公开
    POLYMERIC NANOPARTICLES FOR ENHANCING HIFU-INDUCED ABLATION 审中-公开
    用于增强HIFU诱导的消融的聚合物纳米颗粒

    公开(公告)号：EP3316966A1

    公开(公告)日：2018-05-09

    申请号：EP16738702.6

    申请日：2016-07-01

    Applicant: Stichting Katholieke Universiteit

    Inventor： SRINIVAS, Mangala ,  FIGDOR, Carl Gustav ,  VRIES, DE, Ingrid Jolanda Monique

    IPC: A61N7/02

    CPC classification number: A61K41/0028 ,  A61K49/222 ,  A61N7/02

    Abstract: In the field of medical therapy, more in particular in the field of ablation therapy using ultrasound, such as high intensity focused ultrasound (HIFU), devices and methods are disclosed for enhancing the ablation effect of HIFU. More in particular, a polymeric particle is disclosed, including a polymer entrapping a liquid perfluorocarbon for use in high frequency ultrasound (HIFU) ablation therapy in a human or animal body, wherein the HIFU is focused in a focal region, wherein the ablation effect of the HIFU in the focal region is enhanced by administering the particles to the human or animal body, and the liquid perfluorocarbon does not undergo a phase change from liquid to gas during exposure to the HIFU.

Patent Agency Ranking