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公开(公告)号：KR1020140130382A
公开(公告)日：2014-11-10
申请号：KR1020140124114
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844
Abstract: 민감성 피부에 대해서 특이적으로 유전자 발현량이 증가 또는 억제되는 바이오 마커가 개시된다. 상기 민감성 피부에 특이적인 바이오 마커를 이용하여 민감성 피부 진단 키트 및 자극감 완화제의 스크리닝 방법 등에 활용할 수 있다.
Abstract translation: 公开了具有基因表达的生物标志物，其对于敏感性皮肤特异性地增加或减少。 敏感皮肤特异性的生物标志物用于敏感皮肤的这种诊断试剂盒和刺激释放剂的筛选方法。 诊断试剂盒包括：一种或多种作为NFYA转录因子基因多核苷酸的多核苷酸或其片段，其中片段包含十个或更多个连续核苷酸，或与片段互补的多核苷酸和多核苷酸; 和具有多核苷酸结合表面的固体支持物。
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公开(公告)号：KR1020140123035A
公开(公告)日：2014-10-21
申请号：KR1020140124122
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844
Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention includes one or more genes selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consisting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物包括选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A的一种或多种基因 ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020140123033A
公开(公告)日：2014-10-21
申请号：KR1020140124117
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention contains one or more gene selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consiting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物含有选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR1020140123031A
公开(公告)日：2014-10-21
申请号：KR1020140124110
申请日：2014-09-18
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: C12Q1/6844 , C12Q1/6813
Abstract: 민감성 피부에 대해서 특이적으로 유전자 발현량이 증가 또는 억제되는 바이오 마커가 개시된다. 상기 민감성 피부에 특이적인 바이오 마커를 이용하여 민감성 피부 진단 키트 및 자극감 완화제의 스크리닝 방법 등에 활용할 수 있다.
Abstract translation: 公开了具有针对敏感皮肤特异性增加或降低的基因表达量的生物标志物。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物，选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A， FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB，H19组成的组 ，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。
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公开(公告)号：KR101411296B1
公开(公告)日：2014-06-25
申请号：KR1020070095389
申请日：2007-09-19
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 지방체 이동 신호 펩타이드 및 그의 용도에 관한 것으로서, 보다 상세하게는 서열번호 1로 기재되는 아미노산 서열을 갖는 신호 펩타이드를 코딩하는 유전자 및 이종 단백질(heterologous protein)을 코딩하는 유전자를 포함하는 발현 벡터, 상기 발현 벡터를 포함하는 이종 단백질의 지방체 이동 유도용 조성물, 및 상기 조성물을 지방세포 내로 도입하는 것을 포함하는, 이종 단백질을 지방체로 이동시키는 방법에 관한 것이다. 본 발명의 신호 펩타이드는 이종 단백질에 융합하여 그를 지방세포의 지방체로 이동시킬 수 있으므로, 지방분해효소 등을 상기 펩타이드에 융합시켜 지방체로 이동시킴으로써 선택적이고 효과적으로 지방을 분해하여, 비만, 지방간, 동맥경화 및 당뇨병 등의 지방체 이상 관련 질환을 치료 및 예방할 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020140055401A
公开(公告)日：2014-05-09
申请号：KR1020120122155
申请日：2012-10-31
Abstract: The present invention relates to a method for screening skin whitening substances, and more specifically, to a method for screening skin whitening substances comprising a step of treating a test substance on a melanin-producing cell; and a step of checking relative expression level of one or more proteins selected from a group consisting of tyrosinase, integrin alpha 6, and MITF in a cell treated with the test substance of the step.
Abstract translation: 本发明涉及一种用于筛选皮肤美白物质的方法，更具体地，涉及一种用于筛选皮肤美白物质的方法，包括在黑色素产生细胞上处理测试物质的步骤; 以及在用该步骤的测试物质处理的细胞中检查选自由酪氨酸酶，整联蛋白α6和MITF组成的组中的一种或多种蛋白质的相对表达水平的步骤。
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公开(公告)号：KR1020140034594A
公开(公告)日：2014-03-20
申请号：KR1020120101125
申请日：2012-09-12
Applicant: (주)아모레퍼시픽
IPC: A61K31/19 , A61K31/192 , A61K8/36 , A61Q19/02
Abstract: A composition for external skin application which comprises trans-communic acid as an active ingredient for skin whitening of the present invention can be usefully applied as a composition for external skin application with a purpose of skin whitening since effects of tyrosinase activity reduction and melanin generation reduction are excellent. The composition for external skin application contains 0.0025-0.025 wt% of the trans-communic acid compared to a total weight of the composition. [Reference numerals] (AA) Comparative example 1; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract translation: 作为外用皮肤应用的组合物，其含有作为本发明的皮肤美白的活性成分的反式交联酸可有效地用作皮肤美白用的外用皮肤用组合物，因为酪氨酸酶活性降低和黑色素生成降低的作用 很好 与组合物的总重量相比，用于外部皮肤应用的组合物含有0.0025-0.025wt％的反式连通酸。 （附图标记）（AA）比较例1; （BB）实施例1; （CC）实施例2; （DD）实施例3
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公开(公告)号：KR1020140027782A
公开(公告)日：2014-03-07
申请号：KR1020120093805
申请日：2012-08-27
Applicant: (주)아모레퍼시픽
Abstract: Novel melanoblast is disclosed in the present invention. A production method of the novel melanoblast is also disclosed in the present invention. Specifically, the present invention provides the novel melanoblast which has different gene expression, melanin content, tyrosinase activity, and protein expression compare to existing melanocyte. The present invention also provides the production method of the novel melanoblast for producing melanoblast from the culturing of keratinocyte. [Reference numerals] (AA) After the separation of cultured epithelial cells; (BB) In a PMA- medium; (CC) In a PMA+ medium
Abstract translation: 本发明公开了新型黑素细胞。 本发明还公开了新型黑色素细胞的制造方法。 具体地说，本发明提供与现有黑素细胞相比，具有不同基因表达，黑色素含量，酪氨酸酶活性和蛋白质表达的新型黑素细胞。 本发明还提供了用于从培养角化细胞产生黑素细胞的新型黑素细胞的制备方法。 （附图标记）（AA）培养的上皮细胞分离后; （BB）在PMA-介质中; （CC）在PMA +培养基中
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公开(公告)号：KR1020130131628A
公开(公告)日：2013-12-04
申请号：KR1020120055319
申请日：2012-05-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/4926 , A61K9/0014 , A61K31/445 , A61Q19/02
Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2
Abstract translation: 本发明涉及一种用于皮肤美白的组合物，其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成，从而表现出美白效果。 （AA）比较例1（BB）实施例1（CC）实施例2
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公开(公告)号：KR1020130128907A
公开(公告)日：2013-11-27
申请号：KR1020120053095
申请日：2012-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/133 , A23L29/035 , A23L29/045 , A23V2200/318 , A61K8/41 , A61Q19/02
Abstract: The present invention relates to a whitening composition which suppresses or prevents melanogenesis and, particularly, to a composition containing valiolamine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明涉及抑制或预防黑素生成的增白组合物，特别涉及包含化学式1的缬草烯胺衍生物或其药学上可接受的盐作为活性成分的组合物。
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