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161.发明申请公开(公告)号：US20140343860A1
公开(公告)日：2014-11-20
申请号：US14133199
申请日：2013-12-18
Applicant: NEXUS DX, INC.
Inventor： Richard EGAN , Graham LIDGARD , David BOOKER
IPC: G01N21/01 , G01N21/84 , G01N33/487
CPC classification number: G01N21/01 , G01N21/84 , G01N21/8483 , G01N33/487 , G01N2201/0446 , G01N2201/126 , G16H10/40 , Y02A90/26
Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。
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162.发明授权Systems and methods for fluorescence detection with a movable detection module 有权用可移动检测模块进行荧光检测的系统和方法公开(公告)号：US08236504B2
公开(公告)日：2012-08-07
申请号：US12827521
申请日：2010-06-30
Applicant: Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
Inventor： Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。
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公开(公告)号：US20120196775A1
公开(公告)日：2012-08-02
申请号：US13326021
申请日：2011-12-14
Applicant: Ayumu Taguchi
Inventor： Ayumu Taguchi
IPC: C40B60/12
CPC classification number: G01N21/6452 , G01N21/6454 , G01N21/6486 , G01N2021/6471 , G01N2021/6482 , G01N2201/0446 , G01N2201/061
Abstract: An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments.
Abstract translation: 一种发光强度测量装置，包括：光接收单元，其与具有容纳有样品的多个隔室的生物芯片相对设置，并且包括布置的多个光接收元件;以及确定部，其确定加权率 基于预先获取的光接收元件的噪声特性的每个光接收元件。 发光强度测量装置还包括：乘法部分，用于将每个光接收元件的输出乘以加权速率，以计算每个光接收元件的加权输出;以及相加部分，其将光的加权输出相加 接收元件与相应的一个隔室相对。
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164.发明授权Systems and methods for fluorescence detection with a movable detection module 有权用可移动检测模块进行荧光检测的系统和方法公开(公告)号：US07749736B2
公开(公告)日：2010-07-06
申请号：US11555642
申请日：2006-11-01
Applicant: Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
Inventor： Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。
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165.发明申请BLOOD ANALYSIS APPARATUS AND SETTING METHOD OF MEASUREMENT POSITION IN BLOOD ANALYSIS APPARATUS 有权血液分析装置血液分析装置和测量位置设定方法公开(公告)号：US20090268194A1
公开(公告)日：2009-10-29
申请号：US12427280
申请日：2009-04-21
Applicant: Mamoru TOMITA
Inventor： Mamoru TOMITA
IPC: G01N33/48
CPC classification number: G01N21/07 , G01N21/59 , G01N35/00584 , G01N35/025 , G01N2035/00148 , G01N2201/0415 , G01N2201/0446 , G01N2201/1247
Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.
Abstract translation: 提供血液分析装置。 血液分析装置包括：具有允许光通过并且保持用于保持测量液体的mu-TAS芯片的孔的芯片保持部分; 旋转体，其上安装有芯片保持部; 光源; 和光接收单元。 利用来自光源的光来测量测量液体的旋转体的测量位置是通过旋转旋转体来获得从光源发射并被光接收的光的光值 - 接收单元通过孔径; 并且将光值为阈值以上的旋转体的旋转位置设定为测量位置。
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Patent Agency Ranking
166.发明申请公开(公告)号：US20070132831A1
公开(公告)日：2007-06-14
申请号：US11302695
申请日：2005-12-13
Applicant: Daniel Chu
Inventor： Daniel Chu
IPC: B41J15/14
CPC classification number: G01N21/253 , G01N2201/0446 , G01N2201/1042
Abstract: Scanning of a microarray is performed through a mask that exposes a plurality, but not all, of the sites of the microarray, and either the mask is movable relative to the microarray or the microarray is movable relative to the mask, or both. The mask is useful as a means of restricting the illumination of sites on the microarray to those that can be illuminated while the scan head is traveling at a steady, target velocity, blocking the passage of light between the scan head and the microarray at those points in the scan head trajectory where the scan head is either accelerating or decelerating. The mask is also useful for reducing background noise in the microarray image by preventing light spillage to sites adjacent to those being scanned.
Abstract translation: 微阵列的扫描通过暴露微阵列的多个但不是全部的掩模进行，并且掩模相对于微阵列是可移动的，或者微阵列相对于掩模或两者都是可移动的。 该掩模可用作将扫描头以稳定的目标速度行进的情况下将微阵列上的部位的照明限制在可照亮的位置的手段，阻止在那些点处扫描头和微阵列之间的光通过 在扫描头轨迹中扫描头正在加速或减速。 该掩模也可用于通过防止光泄漏到与扫描的那些相邻的位置来减少微阵列图像中的背景噪声。
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167.发明授权Systems and methods for fluorescence detection with a movable detection module 有权用可移动检测模块进行荧光检测的系统和方法公开(公告)号：US07148043B2
公开(公告)日：2006-12-12
申请号：US10431708
申请日：2003-05-08
Applicant: Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
Inventor： Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。
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168.发明申请Systems and methods for fluorescence detection with a movable detection module 有权用可移动检测模块进行荧光检测的系统和方法公开(公告)号：US20040224317A1
公开(公告)日：2004-11-11
申请号：US10431708
申请日：2003-05-08
Applicant: MJ Research
Inventor： Igor Kordunsky , Jeffrey A. Goldman , Michael J. Finney
IPC: C12Q001/68 , C12M001/34
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/0654 , B01L2300/0829 , B01L2300/1822 , G01N21/276 , G01N21/6452 , G01N2201/0446
Abstract: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement.
Abstract translation: 提供了用于分析位于热循环仪中的多个孔中的样品的荧光检测装置和使用方法。 在一个实施例中，该装置包括可附接到热循环仪的支撑结构和可移动地安装在支撑结构上的检测模块。 检测模块包括一个或多个通道，每个通道具有设置在检测模块内的激发光发生器和发射光检测器。 当支撑结构附接到热循环仪并且检测模块安装在支撑结构上时，检测模块可移动以便定位成与多个井中的不同井的光通信。 检测模块可从支撑结构移除，以方便更换。
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公开(公告)号：US06768122B2
公开(公告)日：2004-07-27
申请号：US10160251
申请日：2002-06-04
Applicant: Chen-Yuan Dong , Peter T. C. So , Sunney I. Chan
Inventor： Chen-Yuan Dong , Peter T. C. So , Sunney I. Chan
IPC: G01N2164
CPC classification number: G01N21/6452 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0446 , G01N2201/0453
Abstract: A multiphoton excitaion microscope for simultaneously detecting differently colored fluorescence materials on biochips includes a multiphoton excitation source, objectives, and a plurality of detection channels. The biochip is hybridized and labeled with fluorescence materials for expressing hybridized biological signals. The multiphoton excitation source is focused to a light spot on the biochip to excite the fluorescence materials bound thereon. After that, the fluorescence emission at different wavelengths from the different fluorescent materials can be detected by the plural detection channels.
Abstract translation: 用于在生物芯片上同时检测不同颜色的荧光材料的多光子激发显微镜包括多光子激发源，物镜和多个检测通道。 将生物芯片杂交并用用于表达杂交的生物信号的荧光材料标记。 多光子激发源被聚焦到生物芯片上的光点以激发结合在其上的荧光材料。 之后，可以通过多个检测通道检测来自不同荧光材料的不同波长的荧光发射。
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公开(公告)号：US06693709B2
公开(公告)日：2004-02-17
申请号：US10266062
申请日：2002-10-07
Applicant: Mark Wechsler , Howard H. Barney , Roger A. Kaye , David G. Ogle , Michael M. Lacy , Calvin Y. Chow , Kimberly L. Crawford , Dean G. Hafeman
Inventor： Mark Wechsler , Howard H. Barney , Roger A. Kaye , David G. Ogle , Michael M. Lacy , Calvin Y. Chow , Kimberly L. Crawford , Dean G. Hafeman
IPC: G01J330
CPC classification number: G01N21/33 , G01N21/253 , G01N21/31 , G01N35/028 , G01N2201/0231 , G01N2201/0446 , G01N2201/1222 , G01N2201/127
Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.
Abstract translation: 本发明涉及一种用于测量光学参数的测光装置。 本发明通过使用单色仪在紫外光范围内起作用，并通过包括反射镜的转子组件在多个通道中分离测试光。
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