公开(公告)号：WO2010114919A2

公开(公告)日：2010-10-07

申请号：PCT/US2010029462

申请日：2010-03-31

Applicant: STC UNM ,  HROMAS ROBERT ,  LEITAO ANDREI ,  OPREA TUDOR I ,  SKLAR LARRY A ,  WILLIAMSON ELIZABETH A ,  WRAY JUSTIN

Inventor： HROMAS ROBERT ,  LEITAO ANDREI ,  OPREA TUDOR I ,  SKLAR LARRY A ,  WILLIAMSON ELIZABETH A ,  WRAY JUSTIN

IPC: A61K31/4365 ,  A61K31/38 ,  A61K31/4353 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/47 ,  A61P35/00

CPC classification number: A61K31/38 ,  A61K31/4353 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/47

Abstract: This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical inhibitors of DNA repair proteins (Metnase) and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols.

Abstract translation: 本发明涉及新的癌症治疗组合物和相关的治疗方法。 更具体地，本发明部分涉及DNA修复蛋白（Metnase）的小化学抑制剂以及利用抑制剂增加癌症治疗方案的有效性的治疗方法。

公开(公告)号：WO2010048173A3

公开(公告)日：2010-07-08

申请号：PCT/US2009061314

申请日：2009-10-20

Applicant: STC UNM ,  HAN SANG ,  OH YOUN-JIN ,  IVORY CORNELIUS

Inventor： HAN SANG ,  OH YOUN-JIN ,  IVORY CORNELIUS

IPC: G01N27/414 ,  G01N33/68

CPC classification number: G01N33/6803 ,  G01N27/414 ,  G01N27/4473 ,  G01N27/44795

Abstract: Exemplary embodiments provide systems and methods for concentrating, focusing and/or separating proteins using nanofluidic channels and/or their arrays. In embodiments, low-abundance proteins can be focused and separated with high resolution using separation techniques including isoelectric focusing (IEF), and/or dynamic field gradient focusing (DFGF) in combination with nanofluidic channels and/or multi-gate nanofluidic field-effect-transistors (FETs).

Abstract translation: 示例性实施方案提供用于使用纳米流体通道和/或其阵列浓缩，聚焦和/或分离蛋白质的系统和方法。 在实施方案中，可以使用包括等电聚焦（IEF）和/或动态场梯度聚焦（DFGF）与纳流感通道和/或多栅极纳米流体场效应的分离技术以高分辨率聚焦和分离低丰度蛋白质 晶体管（FET）。

公开(公告)号：WO2009137129A2

公开(公告)日：2009-11-12

申请号：PCT/US2009033943

申请日：2009-02-12

Applicant: STC UNM ,  RUBIN ROBERT ,  SITDIKOV RAVIL ,  ATANASSOV PLAMEN ,  LOPEZ GABRIEL ,  KONSTANTINOV KONSTANTIN

Inventor： RUBIN ROBERT ,  SITDIKOV RAVIL ,  ATANASSOV PLAMEN ,  LOPEZ GABRIEL ,  KONSTANTINOV KONSTANTIN

CPC classification number: G01N33/564 ,  G01N33/5438 ,  G01N2800/104

Abstract: A rapid electrochemical flow-through sensor and method for detecting the presence of autoantibodies in a fluid sample such as blood is shown and described. The sensor may take either a single- or multi-plexed form. The sensor comprises a fluid inlet, a reaction region comprising immobilized autoantigens and an electrode assembly, and a fluid outlet.

Abstract translation: 显示和描述了用于检测流体样品如血液中自身抗体的存在的快速电化学流通传感器和方法。 传感器可以采用单层或多层复合形式。 传感器包括流体入口，包含固定的自身抗原的反应区域和电极组件以及流体出口。

公开(公告)号：WO2009126344A2

公开(公告)日：2009-10-15

申请号：PCT/US2009031115

申请日：2009-01-15

Applicant: STC UNM ,  EPSTEIN RICHARD I ,  MALLOY KEVIN J

Inventor： EPSTEIN RICHARD I ,  MALLOY KEVIN J

IPC: H01L35/32 ,  H01L39/18

CPC classification number: H01L37/02 ,  F25B21/00 ,  F25B2321/001 ,  Y02B30/66 ,  Y10T29/49359

Abstract: In accordance with the invention, there are electrocaloric devices, pyroelectric devices and methods of forming them. A device which can be a pyroelectric energy generator or an electrocaloric cooling device, can include a first reservoir at a first temperature and a second reservoir at a second temperature, wherein the second temperature is higher than the first temperature. The device can also include a plurality of liquid crystal thermal switches disposed between the first reservoir and the second reservoir and one or more active layers disposed between the first reservoir and the second reservoir, such that each of the one or more active layers is sandwiched between two liquid crystal thermal switches. The device can further include one or more power supplies to apply voltage to the plurality of liquid crystal thermal switches and the one or more the active layers.

Abstract translation: 根据本发明，存在电热装置，热电装置及其形成方法。 可以是热电能发生器或电热冷却装置的装置可以包括处于第一温度的第一贮存器和处于第二温度的第二贮存器，其中第二温度高于第一温度。 该装置还可以包括设置在第一储存器和第二储存器之间的多个液晶热开关以及设置在第一储存器和第二储存器之间的一个或多个活性层，使得一个或多个活性层中的每一个夹在 两个液晶热敏开关。 该装置可以进一步包括一个或多个电源，以向多个液晶热开关和一个或多个有源层施加电压。

公开(公告)号：WO2005031806A3

公开(公告)日：2009-04-09

申请号：PCT/US2004031381

申请日：2004-09-23

Applicant: STC UNM ,  KRISHNA SANJAY ,  TYO SCOTT J ,  HAYAT MAJEED M ,  RAGHAVAN SUNIL ,  SAKOGLU UNAL

Inventor： KRISHNA SANJAY ,  TYO SCOTT J ,  HAYAT MAJEED M ,  RAGHAVAN SUNIL ,  SAKOGLU UNAL

IPC: H01L27/146 ,  G01J1/00 ,  G01J3/28 ,  G01J3/32 ,  G01J3/50 ,  H01J5/16 ,  H01J40/14 ,  H01L20060101 ,  H01L29/205 ,  H01L31/0304 ,  H01L31/09

CPC classification number: H01L27/14649 ,  B82Y10/00 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/32

Abstract: A semiconductor detector (100) has a tunable spectral response. These detectors (100) may be used with processing techniques that permit the creation of "synthetic" sensors that have spectral responses that are beyond the spectral responses attainable by the underlying detectors (100). For example, the processing techniques may permit continuous and independent tuning of both the center wavelength and the spectral resolution of the synthesized spectral response. Other processing techniques can also generate responses that are matched to specific target signatures.

Abstract translation: 半导体检测器（100）具有可调光谱响应。 这些检测器（100）可以与允许创建具有超出由下面的检测器（100）可获得的光谱响应的光谱响应的“合成”传感器的处理技术一起使用。 例如，处理技术可以允许中心波长和合成光谱响应的光谱分辨率的连续且独立的调谐。 其他处理技术也可以产生与特定目标签名匹配的响应。

公开(公告)号：WO2008154412A2

公开(公告)日：2008-12-18

申请号：PCT/US2008066168

申请日：2008-06-06

Applicant: STC UNM ,  GUPTA GAUTAM ,  LOPEZ GABRIEL ,  ATANASSOV PLAMEN

Inventor： GUPTA GAUTAM ,  LOPEZ GABRIEL ,  ATANASSOV PLAMEN

IPC: C08J3/075 ,  C07H1/00 ,  C08G77/60

CPC classification number: A61K9/06 ,  A61K9/127 ,  Y10T428/265 ,  Y10T436/25

Abstract: The disclosure provides a simple and effective way of synthesizing robust organic- inorganic hybrid gels and ultra-thin films using vaporization of a gel precursor. The gels are synthesized at relatively low temperature allowing the activity of the immobilized species to be maintained. The disclosure provides robust, synthetic, selective, active and/or passive transport systems in the form of functional biologically active species and mechanisms for forming them. These systems allow selective and passive or active transport of ionic, molecular and biological species through the incorporation of functional biological molecules and biomolecular assemblies in a rigid matrix.

Abstract translation: 本公开提供了使用凝胶前体的蒸发来合成鲁棒的有机 - 无机杂化凝胶和超薄膜的简单而有效的方法。 凝胶在相对较低的温度下合成，允许保持固定化物质的活性。 本公开提供了功能性生物活性物质形式的强大的，合成的，选择性的，主动的和/或被动的运输系统和用于形成它们的机制。 这些系统通过将功能性生物分子和生物分子组装结合到刚性基质中来允许离子，分子和生物物质的选择性和被动或主动传递。

公开(公告)号：WO2008067103A3

公开(公告)日：2008-11-06

申请号：PCT/US2007083017

申请日：2007-10-30

Applicant: STC UNM ,  BENTLEY PAUL A ,  DAVENPORT MICHAEL

Inventor： BENTLEY PAUL A ,  DAVENPORT MICHAEL

IPC: G01N33/543 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  G01N33/53 ,  G01N33/544 ,  G01N33/551 ,  G01N33/553

CPC classification number: G01N33/54326 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22

Abstract: The present invention includes a magnetically susceptible polymer component, a method of making the same, and apparatuses and systems for mixing, separating or localizing a magnetically susceptible polymer compound in a reaction. The magnetically susceptible polymer component includes a polymer and a magnetically susceptible particle of a predetermined size, which yields a component having a much-improved magnetic reactivity due to the increase in magnetic material by mass percentage. The apparatuses and systems of the present invention employ controllable magnetic fields distributable in perpendicular directions in order to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel.

Abstract translation: 本发明包括易感磁性聚合物组分，其制备方法以及用于在反应中混合，分离或定位易感磁性高分子化合物的设备和系统。 磁敏感聚合物组分包括聚合物和预定尺寸的磁敏颗粒，由于磁性材料质量百分比的增加，其产生具有大大提高的磁反应性的组分。 本发明的装置和系统采用可在垂直方向上分配的可控磁场，以便精确地控制反应容器内的任何磁性敏感组分的取向，位置和相对运动。

公开(公告)号：WO2008048704A3

公开(公告)日：2008-07-03

申请号：PCT/US2007063673

申请日：2007-03-09

Applicant: STC UNM ,  HERSEE STEPHEN M ,  WANG XIN ,  SUN XINYU

Inventor： HERSEE STEPHEN M ,  WANG XIN ,  SUN XINYU

IPC: H01L21/20

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10- 1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供了包括高质量（即，无缺陷）III-N族纳米线和均匀III-N族纳米线阵列的半导体器件以及它们用于制造的可缩放工艺，其中位置，取向，横截面特征，长度和 每个纳米线的结晶度可以精确控制。 可以使用脉冲生长模式来制造提供约10nm至约1000微米的均匀长度的具有恒定横截面特征的公开的III-N纳米线和/或纳米线阵列，所述恒定横截面特征包括约10-1000nm的示例性直径。 另外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构以促进可见LED和激光器的制造。 此外，可以通过在每个纳米线的非极性侧壁上的核 - 壳生长来形成核 - 壳纳米线/ MQW有源结构。

公开(公告)号：WO2007001334A3

公开(公告)日：2007-11-29

申请号：PCT/US2005028552

申请日：2005-08-11

Applicant: STC UNM ,  BREVNOV DMITRI A ,  OLSON TIM S ,  LOPEZ GABRIEL P ,  ATANASSOV PLAMEN B

Inventor： BREVNOV DMITRI A ,  OLSON TIM S ,  LOPEZ GABRIEL P ,  ATANASSOV PLAMEN B

IPC: C25D5/20 ,  C25D21/10

CPC classification number: C25D5/44 ,  C23C18/1844 ,  C23C18/54 ,  C23F1/20 ,  C25D11/18

Abstract: Method for treating an aluminum alloy surface for electrodeposition or electroless deposition of a metal or alloy on the surface, the surface is oxidized (e.g. anodized) to form aluminum oxide, and then the oxidized surface is chemically etched to render the surface amenable for electrodeposition or electroless deposition of the metal or alloy thereon. A metallic coating can be electrodeposited or electroless deposited on the treated surface.

Abstract translation: 用于处理铝合金表面以在表面上电沉积或无电沉积金属或合金的方法，表面被氧化（例如阳极氧化）以形成氧化铝，然后氧化表面被化学蚀刻以使表面适于电沉积或 在其上无电沉积金属或合金。 金属涂层可以被电沉积或无电沉积在经处理的表面上。

公开(公告)号：WO2006133111A2

公开(公告)日：2006-12-14

申请号：PCT/US2006021773

申请日：2006-06-05

Applicant: STC UNM ,  SIBBITT WILMER L JR ,  MICHAEL ADRIAN A

Inventor： SIBBITT WILMER L JR ,  MICHAEL ADRIAN A

IPC: A61M5/315

CPC classification number: A61M5/3148 ,  A61M5/31501 ,  A61M5/31511 ,  A61M2005/3152

Abstract: A reciprocating syringe assembly may include a housing having a receptacle structured and arranged to removably receive a syringe and a syringe removably disposed in the receptacle. The syringe comprising a syringe plunger, and the housing may include at least one track. The assembly may include a plunger slidable in the track. The plunger may be mechanically coupled to the syringe plunger such that movement of the plunger in a first direction causes movement of the syringe plunger in a second direction opposite to the first direction and movement of the syringe plunger in the first direction causes movement of the plunger in the second direction.

Abstract translation: 往复式注射器组件可以包括具有构造和布置成可移除地容纳注射器的插座和可移除地设置在容器中的注射器的壳体。 包括注射器柱塞的注射器和壳体可以包括至少一个轨道。 组件可以包括可在轨道中滑动的柱塞。 柱塞可以机械地联接到注射器柱塞，使得柱塞在第一方向上的运动引起针筒柱塞在与第一方向相反的第二方向上的移动，并且注射器柱塞在第一方向上的移动导致柱塞的移动 在第二个方向。