公开(公告)号：NL2010036C

公开(公告)日：2014-06-24

申请号：NL2010036

申请日：2012-12-21

Applicant: STICHTING TECH WETENSCHAPP ,  STICHTING VU VUMC ,  UNIV GRONINGEN ,  GRONINGEN ACAD ZIEKENHUIS

Inventor： RAAPHORST RENSKE ,  LUURTSEMA GERT ,  WINDHORST ALBERT DIRK ,  LAMMERTSMA ADRIAAN

IPC: A61K31/277 ,  A61K51/04 ,  A61K101/02 ,  C07B59/00

CPC classification number: A61K31/277 ,  A61K51/04 ,  C07B59/001

公开(公告)号：CA2622381C

公开(公告)日：2014-05-20

申请号：CA2622381

申请日：2006-09-15

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV BERNE

Inventor： VAN EIJK CAREL WILHELM EDUARD ,  GUDEL HANS-ULRICH ,  BIROWOSUTO MUHAMMAD DANANG ,  DORENBOS PIETER ,  KRAMER KARL WILHELM

IPC: C01F17/00 ,  C09K11/85 ,  C30B29/12 ,  G01T1/164 ,  G01T1/202

Abstract: The invention concerns a material comprising a compound of formula Pr(1-x-y)LnyCexX3 wherein - Ln is chosen from the elements or mixtures of at least two elements, of the group: La, Nd, Pm, Sm, Eu, Gd, Y, - X is chosen from the halides or mixtures of at least two halides, of the group: Cl, Br, I, - x is above 0.0005 and is lower than 1 , - y is from 0 to less than 1 and - x+y) is less than 1 , and its use as scintillation detector, for example in PET scanner with time of flight apabilities.

公开(公告)号：NL2009200C2

公开(公告)日：2014-01-20

申请号：NL2009200

申请日：2012-07-17

Applicant: UNIV DELFT TECH ,  STICHTING TECH WETENSCHAPP

Inventor： TOLOU NIMA ,  LASSOOIJ JOHANNES ,  HERDER JUSTUS LAURENS

IPC: A61B17/29

公开(公告)号：NL2009200C

公开(公告)日：2014-01-20

申请号：NL2009200

申请日：2012-07-17

Applicant: UNIV DELFT TECH ,  STICHTING TECH WETENSCHAPP

Inventor： TOLOU NIMA ,  LASSOOIJ JOHANNES ,  HERDER JUSTUS LAURENS

IPC: A61B17/29

CPC classification number: A61B17/29 ,  A61B2017/2937 ,  A61B2017/2941

公开(公告)号：NL2007609C2

公开(公告)日：2013-04-22

申请号：NL2007609

申请日：2011-10-18

Applicant: UNIV DELFT TECH ,  STICHTING TECH WETENSCHAPP

Inventor： HERDER JUSTUS LAURENS ,  TOLOU NIMA

IPC: H02N2/18

公开(公告)号：CA2514773C

公开(公告)日：2012-10-09

申请号：CA2514773

申请日：2003-01-29

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV AMSTERDAM

Inventor： BRUECK EKKEHARD HUBERTUS ,  TERGUSI OJIYED ,  DE BOER FRANK ROELOF

IPC: H01F1/01 ,  F25B21/00

Abstract: The invention relates to a material that can be used for magnetic refrigeration, wherein the material substantially has the general formula (AYB1-Y)2+.delta.CWDXEZ Wherein: A is selected from Mn and Co; B is selected from Fe and Cr; of C, D and E at least two are different, have a non-vanishing concentration and are selected from P, B, Se, Ge, Ga, Si, Sn and Sb; wherein at least one of C, D and E is Ge or Si; W, X, Y and Zeach is a number in the range 0-1, and W+X+Z=1; and.delta.is a number from (-0.1) - (+0.1).

公开(公告)号：CA2447450C

公开(公告)日：2011-12-20

申请号：CA2447450

申请日：2002-05-17

Applicant: UNIV UTRECHT ,  STICHTING TECH WETENSCHAPP

Inventor： ROTTIER PETRUS JOSEPHUS MARIE ,  DE HAAN CORNELIS ALEXANDER MARIA ,  HAIJEMA BERT JAN ,  BOSCH BEREND JAN

IPC: C12N15/09 ,  C12N15/86 ,  A61K35/76 ,  A61K38/00 ,  A61K39/215 ,  A61K39/225 ,  A61K39/395 ,  A61K48/00 ,  A61K49/00 ,  A61P1/16 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P11/00 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P31/20 ,  A61P31/22 ,  A61P35/02 ,  A61P37/04 ,  C07K14/165 ,  C12N5/06 ,  C12N5/16 ,  C12N7/00 ,  C12N7/04 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

Abstract: The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. The invention provides replicative coronaviruses and replicative virus-like particles (VLPs) from which large parts of their genome are (at least functionally) deleted without abolishing their replicative capacities. Said deletion is preferably resulting in at least a functional deletion in that the corresponding gene is not or only partly expressed whereby the resulting gene product is dysfunctional or at least functionally distinct from a corresponding wild-type gene product. One striking result seen with VLPs provided with deletions as provided herein is that said deleted VLP, albeit capable of replication in vitro and in vivo, are in general well attenuated, in that they do not cause disease in the target host, making them very suitable for therapeutic use, said as a delivery vehicle for genes and other cargo (whereby specific targeting may be provided as well when desired), and for use as a vaccine, being attenuated while carrying important immunogenic determinants that help elicit an immune response.

公开(公告)号：CA2793087A1

公开(公告)日：2011-09-22

申请号：CA2793087

申请日：2011-03-15

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN ,  STICHTING TECH WETENSCHAPP

Inventor： OSSENDORP FERDINAND ANTONIUS ,  MELIEF CORNELIS JOSEPH MARIA ,  DRIJFHOUT JAN WOUTER

IPC: A61K39/395 ,  C07K14/33 ,  C07K16/12

Abstract: The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.

公开(公告)号：CA2490620C

公开(公告)日：2011-09-20

申请号：CA2490620

申请日：2003-06-23

Applicant: STICHTING TECH WETENSCHAPP

Inventor： STEENNIS EVERT FREDERIK ,  WOUTERS PETRUS ARNOLDUS ANTONIUS FRANCISCA ,  VAN DER WIELEN PETRUS CAROLINA JOHANNES MARIA ,  VEEN JEROEN

IPC: G01R31/12 ,  G01R31/08 ,  H04B3/56

Abstract: The invention relates to a method for inputting an information signal into a power cable which is connected to a voltage supply and which comprises at least one or more conductors, a dielectric provided around the conductors and a conductive earth sheath arranged wholly or partially around the dielectric, the method comprising of inputting a pulse-like information signal at a first position via the earth sheath in order to produce a corresponding pulse-like information signal which is propagated to a second position in the dielectric of the power cable.

公开(公告)号：AR076555A1

公开(公告)日：2011-06-22

申请号：ARP100101582

申请日：2010-05-10

Applicant: STICHTING TECH WETENSCHAPP ,  VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS

Inventor： DIE IRMA MARIANNE ,  TEFSEN BORIS ,  VAN DIE IRMA MARIANNE

IPC: A61K39/002 ,  A61K39/395 ,  A61P33/00 ,  A61P33/10 ,  C07H3/06

Abstract: La presente solicitud se refiere al campo de la inmunología parasitaria veterinaria. En forma más específica, la solicitud se refiere a una estructura de carbohidratos util para el tratamiento inmunoprotector y para la prevencion o reduccion de las infecciones causadas por los nematodos parasíticos en los rumiantes. Particularmente, la solicitud se refiere a un antígeno que comprende la estructura de carbohidratos, a un anticuerpo específico para la estructura de carbohidratos, a una vacuna que comprende el antígeno o el anticuerpo, al uso del antígeno, el anticuerpo o la vacuna, y a los métodos de tratamiento y métodos de fabricacion. Reivindicacion 1: Un antígeno que comprende un carbohidrato correspondiente a la formula estructural Gala1-3GalNAcb1-4(Fuca1-3)GlcNAc (en lo sucesivo: Gal-LDNF). Reivindicacion 2: El antígeno de acuerdo con la reivindicacion 1, que comprende la Gal-LDNF en una estructura química de la formula: Gal-LDNF-R, caracterizado porque R denota una estructura inmunogénica, a la cual se adjunta la unidad de GlcNAc de la Gal-LDNF. Reivindicacion 3: El antígeno de acuerdo con la reivindicacion 2, caracterizado porque la estructura inmunogénica R se selecciona entre el grupo que consiste en carbohidratos, proteínas y lípidos. Reivindicacion 5: El antígeno de acuerdo con la reivindicacion 4, caracterizado porque R2 comprende, adicionalmente, una porcion de diaminopiridina que adjunta R2 a R1.