公开(公告)号：WO2012015301A2

公开(公告)日：2012-02-02

申请号：PCT/NL2011050539

申请日：2011-07-22

Applicant: UNIV DELFT TECH ,  STICHTING TECH WETENSCHAPP ,  TOLOU NIMA ,  HERDER JUSTUS

Inventor： TOLOU NIMA ,  HERDER JUSTUS

IPC: B81B3/00

CPC classification number: B81B3/0037 ,  B81B2203/051

Abstract: Micro-electromechanical system (MEMS) comprising a substrate or substrate parts, and a compliant first segment or segments within the substrate or substrate parts with a predefined positive stiffness, wherein the first segment or segments is or are statically balanced. This is embodied by applying a second segment or segments within the substrate or substrate parts that provide a balancing force to the first segment or segments so as to counteract at least in a predefined working range of the first segment or segments the said predefined positive stiffness.

Abstract translation: 微机电系统（MEMS）包括衬底或衬底部件以及具有预定正刚度的衬底或衬底部件内的顺应性第一段或段，其中第一段或段是静态平衡的。 这是通过在衬底或衬底部件内施加第二段或段来实现的，其向第一段或段提供平衡力，以便至少在第一段的预定义工作范围内抵消或将所述预定正刚度分段。

公开(公告)号：WO2009130243A3

公开(公告)日：2009-12-30

申请号：PCT/EP2009054818

申请日：2009-04-22

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV EINDHOVEN TECH ,  SCHOLTE RICK ,  LOPEZ ARTEAGA INES

Inventor： SCHOLTE RICK ,  LOPEZ ARTEAGA INES

IPC: G01H3/12

CPC classification number: G01H3/125

Abstract: A method of performing near- field acoustic holography comprises the following steps. Establishing (102) acoustic data representing a set of near-field acoustic holography measurements at a first set of positions. Extrapolating (204) acoustic data using a model-based extrapolation to obtain extrapolated acoustic data relating to a plurality of positions outside the aperture. Applying (108) a spatial frequency transform to the padded acoustic data to obtain data in a spatial frequency domain. Propagating (110) the Fourier transformed acoustic data. Applying (112) a regularization in a wavenumber domain. Performing (114) an inverse spatial frequency transform.

Abstract translation: 执行近场声全息的方法包括以下步骤。 在第一组位置建立（102）表示一组近场声全息测量的声学数据。 使用基于模型的外推来外推（204）声学数据，以获得与孔外的多个位置相关的外推声学数据。 对填充的声学数据应用（108）空间频率变换，以获得空间频域中的数据。 传播（110）傅里叶变换声学数据。 在波数域中应用（112）正则化。 执行（114）逆空间频率变换。

公开(公告)号：WO2007030012A3

公开(公告)日：2007-10-04

申请号：PCT/NL2006050217

申请日：2006-09-05

Applicant: STICHTING TECH WETENSCHAPP ,  UNIV EINDHOVEN TECH ,  KRAHN KATHERINE BELL NASH ,  MERKX MAARTEN ,  BOUTEN CAROLINA VICTORIA CATHA ,  STRIJKERS GUSTAV J

Inventor： KRAHN KATHERINE BELL NASH ,  MERKX MAARTEN ,  BOUTEN CAROLINA VICTORIA CATHA ,  STRIJKERS GUSTAV J

IPC: G01N33/58 ,  A61K47/48 ,  A61K51/08 ,  C07K14/705 ,  C07K16/18

CPC classification number: A61K49/1812 ,  A61K49/0041 ,  A61K49/0056

Abstract: The present invention relates to labelled conjugates, for example alpha 1 intergrin A-domain or collagen adhesin of S. aureus (CNA 35), for imaging extra cellular matrix components. It also relates to compositions and kits comprising these labelled conjugates and to imaging methods in which the conjugates are used. The conjugates of the invention comprise a peptide sequence which binds to an extra cellular matrix component, i.e. to an extra cellular matrix protein or to proteoglycans, and which is coupled to an imaging agent. In particular conjugates which bind to elastin, collagen or to a glycosaminoglycan are envisaged. The conjugates according to the invention have some important advantages over existing tools for imaging extra cellular matrix components, in particular for applications in tissue-engineering experiments or MRI. The use of protein conjugates of the invention allow visualization of very small extra cellular matrix components, such as newly formed collagen fibrils.

Abstract translation: 本发明涉及标记的缀合物，例如金黄色葡萄球菌的α1整合素A-结构域或胶原粘附素（CNA 35），用于成像细胞外基质成分。 它还涉及包含这些标记的缀合物的组合物和试剂盒以及其中使用缀合物的成像方法。 本发明的缀合物包含与多余的细胞基质组分结合的肽序列，即与细胞外基质蛋白或蛋白多糖结合，并与偶联成像剂的肽序列。 特别是结合弹性蛋白，胶原或糖胺聚糖的缀合物。 根据本发明的缀合物相对于用于成像超细胞基质组分的现有工具具有一些重要的优点，特别是用于组织工程实验或MRI中的应用。 使用本发明的蛋白质缀合物允许非常小的额外的细胞基质组分（例如新形成的胶原原纤维）的可视化。

公开(公告)号：WO2005045074A3

公开(公告)日：2005-10-27

申请号：PCT/NL2004000782

申请日：2004-11-05

Applicant: STICHTING TECH WETENSCHAPP ,  KARDINAAL WILLEM EDWIN ADRIANU ,  JANSE INGMAR ,  ZWART GABRIEL JACOBUS MARIA

Inventor： KARDINAAL WILLEM EDWIN ADRIANU ,  JANSE INGMAR ,  ZWART GABRIEL JACOBUS MARIA

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  B01J2219/00315 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/0063 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6837 ,  C12Q2600/156

Abstract: The present invention is concerned with the typing of cyanobacteria. Methods and nucleic acids for use therein are presented with which preparations comprising a cyanobacterium can be tested and the cyanobacterium therein classified. The classification can be used to correlate the cyanobacterium in the preparation to a pheno- and genotypic characteristics known for the typed strain. This information is useful in the variety of different applications, for instance in predicting and/or characterising toxic blooms of cyanobacteria in surface water bodies

Abstract translation: 本发明涉及蓝藻的分型。 提供了用于其中的方法和核酸，其中可以测试包含蓝细菌的制剂和其中分类的蓝细菌。 分类可用于将制剂中的蓝细菌与已知类型菌株的表型和基因型特征相关联。 这些信息在各种不同的应用中是有用的，例如在地表水体中预测和/或表征蓝细菌的有毒水华

公开(公告)号：WO03106991A8

公开(公告)日：2005-04-07

申请号：PCT/NL0300431

申请日：2003-06-13

Applicant: STICHTING TECH WETENSCHAPP ,  BASTEMEIJER JEROEN ,  LAUGERE FREDERIC PIERRE JACQUE ,  BOSSCHE ADRIANUS

Inventor： BASTEMEIJER JEROEN ,  LAUGERE FREDERIC PIERRE JACQUE ,  BOSSCHE ADRIANUS

IPC: G01N27/447

CPC classification number: G01N27/4473

Abstract: Electrophoretic system having a separation system and a detection system, where the separation system has a channel (1) and a first separation electrode (2) located at a first end of the channel (1) and a second separation electrode (3) located at the second end of the channel (1), where the separation system is arranged in such a way that a potential difference can be applied between the first and second separation electrode (2, 3), where the detection system, in use, is positioned close to the channel (1) or inside the channel (1), the system having means to reduce a voltage difference between the separation system and the detection system in order to prevent electrical breakthrough between the separation system and the detection system.

Abstract translation: 具有分离系统和检测系统的电泳系统，其中分离系统具有通道（1）和位于通道（1）的第一端的第一分离电极（2）和位于通道（1）的第一端的第一分离电极 通道（1）的第二端，其中分离系统布置成使得可以在第一和第二分离电极（2,3）之间施加电位差，使用中的检测系统被定位 靠近通道（1）或通道（1）内，系统具有降低分离系统和检测系统之间的电压差的装置，以防止分离系统和检测系统之间的电穿透。

公开(公告)号：WO2005004943A2

公开(公告)日：2005-01-20

申请号：PCT/NL2004000511

申请日：2004-07-15

Applicant: STICHTING TECH WETENSCHAPP ,  WIJLAARS MARCEL ,  HUYGHE JACQUES MARIE RENE ,  VAN DONKELAAR CORRINUS CORNELI

Inventor： WIJLAARS MARCEL ,  HUYGHE JACQUES MARIE RENE ,  VAN DONKELAAR CORRINUS CORNELI

IPC: A61L27/48 ,  A61L27/52

CPC classification number: A61L27/52 ,  A61L27/48 ,  C08L75/04

Abstract: Fibre-reinforced material that substitutes for cartilage-like tissue, consisting of a hydrophilic, relatively elastic fibre structure and a matrix of polymerised hydrogel. The fibre/matrix bonding is increased by saturating the fibre in the monomer solution before polymerisation of the hydrogel. The fibre preferably consists of a material based on polyurethane. More particularly, this material contains 10-70 % (m/m) fibres (based on the dry matter) and 1-5 % (m/m) (based on the dry matter) of a substance that contains ionised groups has been added to said hydrogel.

Abstract translation: 纤维增强材料代替软骨样组织，由亲水的，相对弹性的纤维结构和聚合的水凝胶基质组成。 在水凝胶聚合之前，通过使单体溶液中的纤维饱和来增加纤维/基质粘合。 纤维优选由基于聚氨酯的材料组成。 更具体地说，该材料含有10-70％（m / m）纤维（基于干物质）和1-5％（m / m）（基于干物质）含有电离基团的物质已被加入 到水凝胶。

公开(公告)号：WO2004073861A3

公开(公告)日：2005-01-20

申请号：PCT/NL2004000129

申请日：2004-02-20

Applicant: STICHTING TECH WETENSCHAPP ,  MIES MARTIJN JACOBUS MARINUS ,  REBROV EVGENI VICTOROVICH ,  DE CROON MARTIEN HENDRIK JOZEF ,  SCHOUTEN JACOB CORNELIS

Inventor： MIES MARTIJN JACOBUS MARINUS ,  REBROV EVGENI VICTOROVICH ,  DE CROON MARTIEN HENDRIK JOZEF ,  SCHOUTEN JACOB CORNELIS

IPC: B01J4/00 ,  B01J12/00 ,  B01J19/00 ,  B01J19/02 ,  C07C45/35 ,  G01N31/10

CPC classification number: B01J12/007 ,  B01J4/001 ,  B01J4/008 ,  B01J19/0093 ,  B01J19/02 ,  B01J2219/00013 ,  B01J2219/00058 ,  B01J2219/00094 ,  B01J2219/00788 ,  B01J2219/024 ,  B01J2219/0277 ,  C07C45/35

Abstract: Microreactor, in particular a test reactor with high throughput rate, with a reaction section (3) in which reactions can take place. The microreactor furthermore comprises an inlet section (2), connected to the reaction section (3), for feeding reactants to the reaction section (3) and an outlet section (4), connected to the reaction section (3), for discharging reaction products. The reaction section (3) comprises at least two reaction compartments (10) in which catalyst material to be tested can be placed. At least the reaction section (3) of the microreactor (1) is essentially made of a material that is able to withstand temperatures above 500 °C, for example above 700 °C, and that has good thermal conductivity of more than 50 W/mK, for example more than 100 W/mK. An example of such a material is molybdenum.

Abstract translation: 微反应器，特别是具有高生产率的试验反应器，其中可以发生反应的反应段（3）。 微反应器还包括连接到反应部分（3）的入口部分（2），用于将反应物供给到反应部分（3）和连接到反应部分（3）的出口部分（4），用于排放反应 产品。 反应部分（3）包括至少两个反应室（10），其中可以放置待测试的催化剂材料。 至少微反应器（1）的反应部分（3）基本上由能够承受高于500℃的温度（例如高于700℃）的材料制成，并且具有高于50W / mK，例如超过100W / mK。 这种材料的一个例子是钼。

公开(公告)号：WO2004049191A3

公开(公告)日：2004-12-02

申请号：PCT/NL0300824

申请日：2003-11-24

Applicant: STICHTING TECH WETENSCHAPP ,  KAPPEN HILBERT JOHAN ,  HESKES THOMAS MARIA

Inventor： KAPPEN HILBERT JOHAN ,  HESKES THOMAS MARIA

IPC: G06F17/17 ,  G06F17/18 ,  G06F19/00 ,  G06K9/62 ,  G06N7/00

CPC classification number: G06K9/6217 ,  G06N7/005 ,  G16H50/20

Abstract: Method for computing at least one marginal probability for an observed phenomenon in a probability model which describes probabilities for relationships between said phenomenon and physical parameters by using a Cluster Variation Method (CVM), said model comprising a set of variables xi said variables xi representing observations of said physical parameters, the set of variables including a plurality of subsets; the marginal probability including a subset of the set of variables, the probability model being defined by a probability distribution ppsi(x), the probability distribution ppsi(x) having a potential psi(xi) for each of the subsets.

Abstract translation: 在概率模型中计算观察现象的至少一个边缘概率的方法，其通过使用聚类变异方法（CVM）描述所述现象与物理参数之间的关系的概率，所述模型包括一组变量xi，所述变量xi表示观察值 的所述物理参数，所述变量集合包括多个子集; 所述边际概率包括所述变量集合的子集，所述概率模型由概率分布ppsi（x）定义，所述概率分布ppsi（x）对于每个子集具有潜在的psi（xi）。

公开(公告)号：WO02092827A2

公开(公告)日：2002-11-21

申请号：PCT/NL0200318

申请日：2002-05-17

Applicant: UNIV UTRECHT ,  STICHTING TECH WETENSCHAPP ,  ROTTIER PETRUS JOSEPHUS MARIE ,  DE HAAN CORNELIS ALEXANDER MAR ,  HAIJEMA BERT JAN ,  BOSCH BEREND JAN

Inventor： ROTTIER PETRUS JOSEPHUS MARIE ,  DE HAAN CORNELIS ALEXANDER MAR ,  HAIJEMA BERT JAN ,  BOSCH BEREND JAN

IPC: C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K39/215 ,  A61K39/225 ,  A61K39/395 ,  A61K48/00 ,  A61K49/00 ,  A61P1/16 ,  A61P7/00 ,  A61P7/04 ,  A61P7/06 ,  A61P11/00 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P31/20 ,  A61P31/22 ,  A61P35/02 ,  A61P37/04 ,  C07K14/165 ,  C12N5/06 ,  C12N5/16 ,  C12N7/00 ,  C12N7/04 ,  C12N15/86 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

CPC classification number: A61K39/215 ,  A61K38/00 ,  A61K39/12 ,  A61K39/225 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/12034 ,  C12N2710/16034 ,  C12N2740/13034 ,  C12N2750/14334 ,  C12N2760/16034 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2800/204 ,  G01N33/56983 ,  G01N2333/165

Abstract: The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. The invention provides replicative coronaviruses and replicative virus-like particles (VLPs) from which large parts of their genome are (at least functionally) deleted without abolishing their replicative capacities. Said deletion is preferably resulting in at least a functional deletion in that the corresponding gene is not or only partly expressed whereby the resulting gene product is dysfunctional or at least functionally distinct from a corresponding wild-type gene product. One striking result seen with VLPs provided with deletions as provided herein is that said deleted VLP, albeit capable of replication in vitro and in vivo, are in general well attenuated, in that they do not cause disease in the target host, making them very suitable for therapeutic use, said as a delivery vehicle for genes and other cargo (whereby specific targeting may be provided as well when desired), and for use as a vaccine, being attenuated while carrying important immunogenic determinants that help elicit an immune response.

Abstract translation: 本发明涉及冠状病毒和诊断领域，治疗用途及其衍生的疫苗。 本发明提供复制性冠状病毒和复制病毒样颗粒（VLP），其基因组的大部分（至少在功能上）被删除，而不消除其复制能力。 所述缺失优选导致至少一个功能缺失，因为相应的基因不是或仅部分表达，由此得到的基因产物在相应的野生型基因产物中功能失调或至少在功能上是不同的。 如本文提供的具有缺失的VLP所见到的一个引人注目的结果是所述缺失的VLP虽然在体外和体内都能复制，但通常很好地减弱，因为它们不会在靶宿主中引起疾病​​，使得它们非常合适 被称为用于基因和其他货物的递送载体（因此，当需要时也可以提供特异性靶向），并且用作疫苗，同时减毒，同时携带有助于引发免疫应答的重要的免疫原性决定簇。

公开(公告)号：WO9945972A3

公开(公告)日：1999-10-14

申请号：PCT/NL9900124

申请日：1999-03-08

Applicant: STICHTING TECH WETENSCHAPP ,  LEEUWEN REINIER THEODORUS JACO ,  MIDDELKOOP ESTHER

Inventor： VAN LEEUWEN REINIER THEODORUS ,  MIDDELKOOP ESTHER

IPC: A61L15/32 ,  A61L15/44 ,  A61L27/54 ,  A61L27/60 ,  A61L27/00 ,  A61K38/55 ,  A61L15/42

CPC classification number: A61L15/44 ,  A61L15/325 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/434 ,  A61L2300/64

Abstract: The invention relates to a skin substitute which is suitable for the promotion of the healing of skin wounds. The skin substitute according to the present invention comprises a degradable, hydrophilic matrix, which matrix is permeable for cells, contituted by a collagen and elastin comprising biocompatible matrix material, wherein the matrix of the skin substitute comprises an inhibitor of a protease. Furthermore, the invention relates to a composition showing a protease inhibiting action for the topical application on skin wounds, which composition comprises a protease inhibitor and a pharmaceutically acceptable carrier.

Abstract translation: 本发明涉及适合于促进皮肤伤口愈合的皮肤替代物。 根据本发明的皮肤替代物包含可降解的亲水基质，该基质对于细胞是可渗透的，由包含生物相容性基质材料的胶原蛋白和弹性蛋白构成，其中皮肤替代物的基质包含蛋白酶的抑制剂。 此外，本发明涉及一种显示用于皮肤伤口局部施用的蛋白酶抑制作用的组合物，该组合物包含蛋白酶抑制剂和药学上可接受的载体。