公开(公告)号：WO2013010189A2

公开(公告)日：2013-01-17

申请号：PCT/US2012046979

申请日：2012-07-16

Applicant: SIRIUS XM RADIO INC ,  COX STUART A ,  MARKO PAUL ,  WADIN CRAIG

Inventor： COX STUART A ,  MARKO PAUL ,  WADIN CRAIG

IPC: H04N21/2381 ,  H04N21/233 ,  H04N21/60

CPC classification number: G06F3/0482 ,  G06N5/02 ,  G11B27/105 ,  H04H40/90 ,  H04N5/76 ,  H04N9/8205 ,  H04N21/2668 ,  H04N21/439 ,  H04W88/06

Abstract: Systems and methods are presented to facilitate caching of programming from broadcast and/or content streaming services to a user device for local playback. In addition, metadata can be provided to guide the user in selecting, caching, or playing the cachable content. In some exemplary embodiments, a receiver or other user device can automatically select the programming to be cached based on a user's historical topic interest and listening history. In some exemplary embodiments, the metadata can also include DRM information that can limit the ability of a user to playback the content, so as to comply, if necessary, with operative legal requirements related to usage of the content.

Abstract translation: 呈现系统和方法以便将节目从广播和/或内容流服务缓存到用于本地播放的用户设备。 此外，可以提供元数据以指导用户选择，缓存或播放可高速缓存的内容。 在一些示例性实施例中，接收器或其他用户设备可以基于用户的历史主题感兴趣和收听历史来自动选择要缓存的节目。 在一些示例性实施例中，元数据还可以包括可以限制用户回放内容的能力的DRM信息，以便在必要时遵守与内容的使用相关的操作性法律要求。

公开(公告)号：WO2011153008A2

公开(公告)日：2011-12-08

申请号：PCT/US2011037426

申请日：2011-05-20

Applicant: BUCYRUS MINING EQUIPMENT INC ,  CONNELL STUART A

Inventor： CONNELL STUART A

IPC: E21B17/10

CPC classification number: E21B19/24 ,  E21B7/025

Abstract: A drill system for use with a drill rod includes a support member, and a drill assembly movably associated with the support member and configured to be connected to the drill rod. The system further includes a centralizing device movably associated with the support member and configured to receive the drill rod. The centralizing device includes a movable jaw and a latch arm connected to the jaw and configured to move the jaw between an open position and a closed position for retaining the drill rod. Furthermore, the latch arm has a locking feature configured to hold the latch arm in a locked position to thereby hold the jaw in the closed position.

Abstract translation: 用于钻杆的钻孔系统包括支撑构件和与所述支撑构件可移动地相关联并构造成连接到所述钻杆的钻头组件。 该系统还包括可移动地与支撑构件相关联并构造成接收钻杆的集中装置。 集中装置包括可移动钳口和连接到钳口并且构造成将钳口移动到打开位置和关闭位置之间的夹持臂，用于保持钻杆。 此外，闩锁臂具有锁定特征，其构造成将闩锁臂保持在锁定位置，从而将钳口保持在关闭位置。

公开(公告)号：WO2011085220A2

公开(公告)日：2011-07-14

申请号：PCT/US2011/020545

申请日：2011-01-07

Applicant: WASHINGTON UNIVERSITY ,  SOLIN, Stuart A. ,  WICKLINE, Samuel A. ,  NEWAZ, Akm Shah ,  WALLACE, Kirk D.

Inventor： SOLIN, Stuart A. ,  WICKLINE, Samuel A. ,  NEWAZ, Akm Shah ,  WALLACE, Kirk D.

IPC: H01J37/252

CPC classification number: H01L27/14665 ,  B82Y15/00 ,  H01L27/1446 ,  H01L31/0304 ,  H01L31/09 ,  H01L31/108 ,  Y02E10/544

Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06xl0 11 cm√Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.

Abstract translation: 本发明人公开了一种新的高性能光学传感器，优选纳米级尺寸，其在室温下基于金属 - 半导体混合物（MSH）中的非常光导（EOC）现象，优选反EOC（I-EOC）现象起作用 ）结构具有半导体/金属界面。 这样的设计显示出没有露出半导体的高效光子传感器。 在使用示例性实施例的实验中，使用氦 - 氖激光辐射的超高空间分辨率4点光电导测量显示了对于250nm器件的显着大的光导特性，观察到的最大测量值为9460％EOC。 这样的示例性EOC装置还显示出对于632nm照明高于5.06×1011 cmvHz / W的特定检测率和40dB的高动态响应，使得这种传感器在广泛的实际应用中技术上具有竞争力。

公开(公告)号：WO2011005969A2

公开(公告)日：2011-01-13

申请号：PCT/US2010041379

申请日：2010-07-08

Applicant: GEN HOSPITAL CORP ,  BRIGHAM & WOMENS HOSPITAL ,  RAINES DOUGLAS E ,  COTTEN JOSEPH F ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED S ,  CUNY GREGORY D

Inventor： RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED S ,  CUNY GREGORY D

IPC: C07D207/333 ,  A61K31/4164 ,  A61P5/38 ,  A61P25/00 ,  C07D233/64

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; R4 and R5 are independently H, halogen, CN or CF3; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Abstract translation: 本发明涉及式（I）化合物：其中R1是L1C（O）OT或L1C（O）OL2C（O）OT; R2是取代或未取代的C1-C10烷基，C2-C10烯基或C2-C10炔基，或R1; n为0〜5的整数， 每个R 3独立地是卤素或R 2; R4和R5独立地为H，卤素，CN或CF3; L1和L2各自独立地为键，取代或未取代的C1-C10亚烷基，C2-C10亚烯基或C2-C10亚炔基; 和T是H，取代或未取代的C 1 -C 10烷基，C 2 -C 10烯基或C 2 -C 10炔基，硝基苯酚或环丙基。 本发明还涉及包含根据式（I）的化合物和药学上可接受的载体的药物组合物，以及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。

公开(公告)号：WO2010120389A3

公开(公告)日：2011-01-13

申请号：PCT/US2010001166

申请日：2010-04-19

Applicant: AXXIA PHARMACEUTICALS LLC ,  POLLOCK WAYNE C ,  GROOSMAN STUART A ,  OWENS ALBERT H JR

Inventor： POLLOCK WAYNE C ,  GROOSMAN STUART A ,  OWENS ALBERT H JR

IPC: A61K47/34 ,  A61K9/00 ,  A61K31/485 ,  B29C47/06

CPC classification number: A61K9/0024 ,  A61K31/485 ,  A61K47/34 ,  B29C45/00 ,  B29L2031/753

Abstract: The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.

Abstract translation: 本发明涉及用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。

公开(公告)号：WO2010127444A1

公开(公告)日：2010-11-11

申请号：PCT/CA2010/000681

申请日：2010-05-05

Applicant: UNIVERSITY HEALTH NETWORK ,  BERGER, Stuart, A.

Inventor： BERGER, Stuart, A.

IPC: C12N15/63 ,  C12N15/113 ,  C12N15/12 ,  C12N15/67 ,  C12N15/867 ,  C12P21/02 ,  C12P21/08

CPC classification number: C07K16/00 ,  C07K16/2812 ,  C07K2317/14 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2799/027 ,  C12P21/02

Abstract: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.

Abstract translation: 本公开提供了用于增加感兴趣的蛋白质的表达的方法和材料，例如细胞的抗体。 增加ABC50表达或活性，这增加了感兴趣的蛋白质或抗体的表达。 本公开还提供了通过降低ABC50的水平来增加细胞对内质网应激剂（例如依曲唑）的敏感性的方法和材料。

公开(公告)号：WO2010039871A1

公开(公告)日：2010-04-08

申请号：PCT/US2009/059084

申请日：2009-09-30

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  WOLF, Stuart, A.

Inventor： WOLF, Stuart, A.

IPC: C30B1/00 ,  B82B1/00

CPC classification number: H01L27/222 ,  B82Y10/00

Abstract: A method and apparatus of constructing magnetic automata and related structures through the development of a self-assembled thin film array of magnetic nano-pillars. The method and apparatus provides the ability to configure patterns electrically on a device without all requirements of producing a complicated pattern on a semiconductor chip. This relieves, for example, the requirement for using very expensive lithographic tools in the fabrication of these structures. Provided is an architecture made from a self assembled thin film array of magnetic nano-pillars in a cross bar array that not only performs logic operations but also stores information.

Abstract translation: 通过开发磁性纳米柱的自组装薄膜阵列，构建磁自动机和相关结构的方法和装置。 该方法和装置提供了在器件上电气配置图案的能力，而不需要在半导体芯片上产生复杂图案。 例如，这减轻了在制造这些结构中使用非常昂贵的光刻工具的要求。 提供了一种由跨组合阵列中的磁性纳米柱的自组装薄膜阵列制成的架构，其不仅执行逻辑操作，而且存储信息。

公开(公告)号：WO2009046173A2

公开(公告)日：2009-04-09

申请号：PCT/US2008/078549

申请日：2008-10-02

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HODSON, Peter D. ,  GORING, Matthew A. ,  HOWGILL, Stephen J. ,  FIELDING, John ,  BREWER, Richard D. ,  SHAW, Rachael V. ,  CHARNOCK, Paul A. ,  MCGLASSON, Stuart A. ,  HELM, Stephen D. ,  JACKSON, Graham V. ,  BALKWILL, Anthony W. ,  GRAVES, Jason A.

Inventor： HODSON, Peter D. ,  GORING, Matthew A. ,  HOWGILL, Stephen J. ,  FIELDING, John ,  BREWER, Richard D. ,  SHAW, Rachael V. ,  CHARNOCK, Paul A. ,  MCGLASSON, Stuart A. ,  HELM, Stephen D. ,  JACKSON, Graham V. ,  BALKWILL, Anthony W. ,  GRAVES, Jason A.

IPC: A61M15/00 ,  A61M11/00 ,  B65D83/14

CPC classification number: A61M15/009 ,  B65D83/54

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.

Abstract translation: 一种气雾剂计量阀，包括：（a）在静止位置和击发位置之间可移动的阀杆，其包括：主体部分，其包括周向密封表面;（b）阀体，其包括：主体壁 以及至少部分地由体壁限定的内室; 和（c）具有限定孔的内周边的计量垫圈，所述计量垫片设置在所述内室的最内端附近并且构造成能够形成瞬时的，基本上流体密封的面密封，抵靠 其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内并且随着阀杆从其静止位置朝向其击发位置移动，阀杆的圆周密封表面接触 计量垫圈形成面密封，从而关闭计量室，并且此后阀杆朝其击发位置的进一步运动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中处于非偏压构型的计量垫圈是具有大致平面形式的环形盘，并且其中所述阀被构造和布置成使得计量垫圈的内周在阀的静止位置被推动离开所述大致平面形式 或者其中计量垫圈预先偏置成碟形。

公开(公告)号：WO2008108813A3

公开(公告)日：2008-11-06

申请号：PCT/US2007020470

申请日：2007-09-21

Applicant: SOLAR TURBINES INC ,  LOCKYER JOHN F ,  GREENWOOD STUART A ,  DUTTA PARTHA X ,  GROOCOCK TED E ,  FOX MICHAEL D

Inventor： LOCKYER JOHN F ,  GREENWOOD STUART A ,  DUTTA PARTHA X ,  GROOCOCK TED E ,  FOX MICHAEL D

IPC: F23R3/00

CPC classification number: F23R3/04 ,  F23R3/002 ,  F23R2900/03044 ,  Y02T50/675

Abstract: A combustor liner assembly (46) includes a liner assembly (56), including a hot dome (82), a hot wall (78, 80), and an impingement shield (76, 96). The liner assembly further includes a convector assembly (58). The combustor liner assembly further includes an impingement dome assembly (60), including a ring-shaped portion (104) defining a plurality of apertures (106) configured to receive a plurality of fuel injectors, and a face (126). The ring- shaped portion and the face define an annular passage (128), and the face defines a plurality of apertures and a plurality of orifices (130). The convector assembly and the impingement dome assembly are operably coupled to one another, and the plurality of orifices of the face are configured such that the hot dome is exposed to air flowing in the annular passage of the impingement dome assembly. The combustor liner assembly is configured to provide flow communication between the annular passage of the impingement dome assembly and the plurality of fuel injectors.

Abstract translation: 燃烧器衬里组件（46）包括衬里组件（56），衬里组件包括热圆顶（82），热壁（78,80）和冲击护罩（76,96）。 衬套组件还包括对流器组件（58）。 燃烧器衬里组件进一步包括冲击圆顶组件（60），该冲击圆顶组件包括限定被构造成接收多个燃料喷射器的多个孔（106）的环形部分（104）和面（126）。 环形部分和面限定环形通道（128），并且该面限定多个孔和多个孔（130）。 对流器组件和冲击圆顶组件可操作地彼此联接，并且面的多个孔构造成使得热圆顶暴露于在冲击圆顶组件的环形通道中流动的空气。 燃烧器衬里组件构造成提供冲击圆顶组件的环形通道与多个燃料喷射器之间的流动连通。

公开(公告)号：WO2008108825A2

公开(公告)日：2008-09-12

申请号：PCT/US2007/021748

申请日：2007-10-10

Applicant: BURNHAM INSTITUTE FOR MEDICAL RESEARCH ,  LIPTON, Stuart, A. ,  SATOH, Takumi

Inventor： LIPTON, Stuart, A. ,  SATOH, Takumi

IPC: A61K31/366

CPC classification number: C07C62/32 ,  C07C62/38 ,  C07C69/757 ,  C07C2602/26

Abstract: Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keapl, a negative regulator of the transcription factor Nrf2, and prevent Keapl -mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keapl /Nrf2 complex.

Abstract translation: 神经突起促进前列腺素（NEPPs）和其他亲电子化合物与转录因子Nrf2的负调节物Keapl结合，并且防止了Keapl介导的Nrf2的失活，从而增强了Nrf2易位到神经元细胞核中。 因此，提供了神经保护组合物和相关方法，其使用这种神经保护性化合物和这些化合物的前药引起Nrf2与Keap1 / Nrf2复合物的解离。