公开(公告)号：WO2009046173A3

公开(公告)日：2009-05-22

申请号：PCT/US2008078549

申请日：2008-10-02

Applicant: 3M INNOVATIVE PROPERTIES CO ,  HODSON PETER D ,  GORING MATTHEW A ,  HOWGILL STEPHEN J ,  FIELDING JOHN ,  BREWER RICHARD D ,  SHAW RACHAEL V ,  CHARNOCK PAUL A ,  MCGLASSON STUART A ,  HELM STEPHEN D ,  JACKSON GRAHAM V ,  BALKWILL ANTHONY W ,  GRAVES JASON A

Inventor： HODSON PETER D ,  GORING MATTHEW A ,  HOWGILL STEPHEN J ,  FIELDING JOHN ,  BREWER RICHARD D ,  SHAW RACHAEL V ,  CHARNOCK PAUL A ,  MCGLASSON STUART A ,  HELM STEPHEN D ,  JACKSON GRAHAM V ,  BALKWILL ANTHONY W ,  GRAVES JASON A

IPC: A61M15/00 ,  A61M11/00 ,  B65D83/14

CPC classification number: A61M15/009 ,  B65D83/54

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.

Abstract translation: 一种气溶胶计量阀，包括：（a）可在静止位置和击发位置之间移动的阀杆，包括：主体部分，其包括周向密封表面（b）阀体，所述阀体包括：主体壁和至少限定的内部腔 部分由身体壁; 和（c）具有限定孔的内周边的计量垫片，其设置在内室的最内端附近，并且构造成能够形成一个瞬时的，基本上是流体密封的，面对密封面 阀杆，其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内，并且当阀杆从其静止位置朝向其击发位置移动时，阀杆的圆周密封表面接触 计量垫圈以形成面密封件，从而封闭计量室，此后阀杆朝向其点火位置的进一步移动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中所述计量垫片为无偏置构型，是具有基本上平面形状的环形盘，并且所述阀被构造和布置成使得所述计量垫片的内周边在所述阀的静止位置处被推出所述基本平面形状 杆，或其中计量垫片预偏置成碟形。

公开(公告)号：WO2009046173A2

公开(公告)日：2009-04-09

申请号：PCT/US2008/078549

申请日：2008-10-02

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HODSON, Peter D. ,  GORING, Matthew A. ,  HOWGILL, Stephen J. ,  FIELDING, John ,  BREWER, Richard D. ,  SHAW, Rachael V. ,  CHARNOCK, Paul A. ,  MCGLASSON, Stuart A. ,  HELM, Stephen D. ,  JACKSON, Graham V. ,  BALKWILL, Anthony W. ,  GRAVES, Jason A.

Inventor： HODSON, Peter D. ,  GORING, Matthew A. ,  HOWGILL, Stephen J. ,  FIELDING, John ,  BREWER, Richard D. ,  SHAW, Rachael V. ,  CHARNOCK, Paul A. ,  MCGLASSON, Stuart A. ,  HELM, Stephen D. ,  JACKSON, Graham V. ,  BALKWILL, Anthony W. ,  GRAVES, Jason A.

IPC: A61M15/00 ,  A61M11/00 ,  B65D83/14

CPC classification number: A61M15/009 ,  B65D83/54

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.

Abstract translation: 一种气雾剂计量阀，包括：（a）在静止位置和击发位置之间可移动的阀杆，其包括：主体部分，其包括周向密封表面;（b）阀体，其包括：主体壁 以及至少部分地由体壁限定的内室; 和（c）具有限定孔的内周边的计量垫圈，所述计量垫片设置在所述内室的最内端附近并且构造成能够形成瞬时的，基本上流体密封的面密封，抵靠 其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内并且随着阀杆从其静止位置朝向其击发位置移动，阀杆的圆周密封表面接触 计量垫圈形成面密封，从而关闭计量室，并且此后阀杆朝其击发位置的进一步运动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中处于非偏压构型的计量垫圈是具有大致平面形式的环形盘，并且其中所述阀被构造和布置成使得计量垫圈的内周在阀的静止位置被推动离开所述大致平面形式 或者其中计量垫圈预先偏置成碟形。

公开(公告)号：WO2009046074A1

公开(公告)日：2009-04-09

申请号：PCT/US2008/078406

申请日：2008-10-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  CHILD, Andrew D. ,  HELM, Stephen D.

Inventor： CHILD, Andrew D. ,  HELM, Stephen D.

IPC: A61M15/00 ,  A61M11/00 ,  B65D83/14

CPC classification number: B65D83/54 ,  B05B11/3077 ,  C09K3/30 ,  F16F1/123

Abstract: A metered dose inhaler containing a medicinal formulation of medicament, HFA 134a and/or HFA227, and being substantially free of ethanol and surfactant, with a metering valve comprising a helical spring, a seal, a seal support and a sliding valve stem, wherein the valve is configured and arranged such that a region of compressive contact is defined where a surface applying force to the seal is substantially flat and extends in an arc through an angle in the range from about 180 to about 360 degrees.

Abstract translation: 含有药物HFA134a和/或HFA227的药物制剂并基本上不含乙醇和表面活性剂的计量吸入器，其中计量阀包括螺旋弹簧，密封件，密封件支撑件和滑动阀杆，其中， 阀被构造和布置成使得压缩接触区域被限定在其中对密封件的表面施加力基本上平坦并且以弧形延伸大约180度至大约360度范围内的角度的区域。