公开(公告)号：KR1020100031839A

公开(公告)日：2010-03-25

申请号：KR1020080090662

申请日：2008-09-16

Applicant: (주)아모레퍼시픽

Inventor： 김수정 ,  조가영 ,  노호식 ,  김은주 ,  문은정 ,  박창만 ,  김덕희 ,  김한곤

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K8/02 ,  A61K8/0208 ,  A61K8/042 ,  A61Q19/00

Abstract: PURPOSE: A skin external composition is provided to enhance gene expression of hyaluronic acid synthase 2(HAS2) and prevent skin dryness and aging. CONSTITUTION: A skin external composition for promoting hyaluronic acid generation contains extract of Punica granatum L. and Tussilago farfara. The composition further contains one or more extract selected from camellia flower and Nelumbo nucifera. The composition is used in the form of skin softener, massage cream, nutrition cream, pack, gel, lotion, ointment, patch or spray.

Abstract translation: 目的：提供皮肤外用组合物，以增强透明质酸合成酶2（HAS2）的基因表达，并防止皮肤干燥和衰老。 构成：用于促进透明质酸产生的皮肤外用组合物含有Punica granatum L.和Tussilago farfara的提取物。 组合物还包含一种或多种选自山茶花和Nelumbo nucifera的提取物。 该组合物以皮肤柔软剂，按摩霜，营养霜，包装，凝胶，洗剂，软膏，贴剂或喷雾剂的形式使用。

公开(公告)号：KR1020100021291A

公开(公告)日：2010-02-24

申请号：KR1020080080138

申请日：2008-08-14

Applicant: (주)아모레퍼시픽

Inventor： 김수정 ,  노호식 ,  김은주 ,  문은정 ,  조가영 ,  박성일 ,  김연준 ,  김덕희 ,  김한곤 ,  박준성

IPC: A61K8/49 ,  A61Q19/00

CPC classification number: A61K8/49 ,  A61Q19/00

Abstract: PURPOSE: A skin external composition containing ortho-dihydroxyisoflavone is provided to suppress inflammation-relating factors, and promote reepithelization of scar. CONSTITUTION: A skin external composition for anti-inflammation contains 7,3,',4'-trihydroxyisoflavone, 7,8,4'-trihydroxyisoflavone or 7,6,4'-trihydroxyisoflavone as an active ingredient. A skin external composition for wound healing contains the 7,3,',4'-trihydroxyisoflavone, 7,8,4'-trihydroxyisoflavone or 7,6,4'-trihydroxyisoflavone as an active ingredient. A skin external composition for anti-aging contains 7,3,',4'-trihydroxyisoflavone, 7,8,4'-trihydroxyisoflavone or 7,6,4'-trihydroxyisoflavone as an active ingredient.

Abstract translation: 目的：提供含有邻二羟基异黄酮的皮肤外用组合物，以抑制炎症相关因素，促进瘢痕再上皮化。 构成：用于抗炎的皮肤外用组合物含有7,3'，4'-三羟基异黄酮，7,8,4'-三羟基异黄酮或7,6,4'-三羟基异黄酮作为活性成分。 用于伤口愈合的皮肤外用组合物含有7,3'，4'-三羟基异黄酮，7,8,4'-三羟基异黄酮或7,6,4'-三羟基异黄酮作为活性成分。 用于抗衰老的皮肤外用组合物含有7,3'，4'-三羟基异黄酮，7,8,4'-三羟基异黄酮或7,6,4'-三羟基异黄酮作为活性成分。

公开(公告)号：KR1020100000728A

公开(公告)日：2010-01-06

申请号：KR1020080060340

申请日：2008-06-25

Applicant: (주)아모레퍼시픽

Inventor： 김수정 ,  노호식 ,  김은주 ,  문은정 ,  조가영 ,  하정철 ,  김연준 ,  김덕희 ,  김한곤

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/074 ,  A61K36/15 ,  A61K36/40 ,  A61K36/539 ,  A61K36/9068 ,  A61Q19/00

Abstract: PURPOSE: An anti-inflammatory composition and wound healing composition containing medicinal herb extract is provided to suppress inflammation-relating factors and promote reepithelization of wound. CONSTITUTION: A skin external composition contains medicinal herb extract selected from pine, corni Fructus, ganoderma or Scutellariae Radix as an active ingredient. The active ingredient is contained in 0.001~15 weight% based on the total weight. The composition is used for anti-inflammation or wound healing.

Abstract translation: 目的：提供含有药草提取物的抗炎组合物和伤口愈合组合物，以抑制炎症相关因素并促进伤口再通透。 构成：皮肤外用组合物含有选自松树，角us，灵芝或黄芩的药草提取物作为活性成分。 活性成分占总重量的0.001〜15重量％。 该组合物用于抗炎或伤口愈合。

公开(公告)号：KR1020080051235A

公开(公告)日：2008-06-11

申请号：KR1020060121955

申请日：2006-12-05

Applicant: (주)아모레퍼시픽

Inventor： 신의석 ,  신동욱 ,  이형호 ,  김대건 ,  이정아 ,  윤준원 ,  노호식 ,  백흥수

IPC: A61K31/12 ,  A61K31/05 ,  A61K31/136 ,  A61P3/04

Abstract: A pharmaceutical composition for treating and preventing lipid metabolism-related diseases is provided to increase activity of isocitrate dehydrogenase 3alpha(IDH3alpha) promoter and carnitine palmitoyl transferase 1A(CPT1A) promoter, so that blood sugar and neutral fat are reduced. A pharmaceutical composition for treating and preventing lipid metabolism-related diseases comprises compounds represented by the formula(1), wherein R1 is H or C1-C5 alkyl, R2 is H or OH and n is an integer from 1 to 3, and is formulated as tablet, pill, powder, sachet, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, sterile injection solution or sterile powder, wherein the daily dosage of the compounds is 0.1-100 mg/kg. Further, the lipid metabolism-related diseases are obesity, hyperlipemia and diabetes.

Abstract translation: 提供了用于治疗和预防脂质代谢相关疾病的药物组合物，以增加异柠檬酸脱氢酶3α（IDH3alpha）启动子和肉碱棕榈酰转移酶1A（CPT1A）启动子的活性，从而降低血糖和中性脂肪。 用于治疗和预防脂质代谢相关疾病的药物组合物包括由式（1）表示的化合物，其中R 1为H或C 1 -C 5烷基，R 2为H或OH，n为1至3的整数， 作为片剂，丸剂，粉末，香囊，酏剂，悬浮液，乳剂，溶液，糖浆，气溶胶，软或硬明胶胶囊，无菌注射溶液或无菌粉末，其中化合物的日剂量为0.1-100mg / kg。 此外，脂质代谢相关疾病是肥胖，高脂血症和糖尿病。

公开(公告)号：KR1020080029342A

公开(公告)日：2008-04-03

申请号：KR1020060095279

申请日：2006-09-29

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  이진영 ,  심종원 ,  최동원 ,  김덕희

IPC: C07C233/11 ,  C07C233/21

Abstract: A retinoic acid derivative is provided to exhibit a collagen production effect and a collagenase expression inhibition effect and cause less skin irritation. A method for preparing a retinoic acid derivative includes the steps of: (i) reacting retinoic acid with alkylchloroformate to prepare an anhydride compound represented by the following formula 2; and (ii) reacting the prepared anhydride compound with an amine hydrochloride represented by the following formula 3 to prepare the retinoic acid derivative represented by the following formula 1. In the formulae, R1 is hydrogen, linear or branched C1-7 alkyl or C3-7 cycloalkyl, R2 is hydroxyl, linear or branched C1-7 alkyl substituted by 1-4 hydroxyl groups, or linear branched C1-5 alkyl substituted by hydroxy pyranone, and R3 is C1-7 alkyl.

Abstract translation: 提供视黄酸衍生物以表现出胶原产生效果和胶原酶表达抑制作用，并且引起较少的皮肤刺激。 视黄酸衍生物的制备方法包括以下步骤：（i）使视黄酸与氯甲酸烷基酯反应，制备下式2表示的酸酐化合物; 和（ii）使所制备的酸酐化合物与由下式3表示的胺盐酸盐反应以制备由下式1表示的视黄酸衍生物。在式中，R 1是氢，直链或支链C 1-7烷基或C 3- 7环烷基，R2是羟基，被1-4个羟基取代的直链或支链C 1-7烷基，或被羟基吡喃酮取代的直链支链C 1-5烷基，R 3是C 1-7烷基。

公开(公告)号：KR1020080014279A

公开(公告)日：2008-02-14

申请号：KR1020060075755

申请日：2006-08-10

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  유재원 ,  노호식 ,  김덕희

IPC: C07C233/10 ,  C07C233/11 ,  C07C235/36

CPC classification number: C07C235/36 ,  C07C231/02

Abstract: A hydroxycinnamic acid derivative compound is provided to realize improved anti-oxidation property and skin permeability, effects of inhibiting active oxygen and melanin generation and stimulating procollagen generation, thereby providing a cosmetic composition for improving wrinkles and whitening. A hydroxycinnamic acid derivative compound has an adamantyl amide linking group and is represented by the following formula I. In formula I, R1 is H or a C1-C7 alkyl group; and A is -CH=CH- or -CH2-CH2-. The hydroxycinnamic acid derivative compound is obtained by the method comprising the steps of: (1) substituting the hydroxyl group of hydroxycinnamic acid with an acetyl group to provide an acetylated compound; (2) reacting the acetylated compound with ethyl chloroformate and oleophilic group-containing adamantanamine to provide an amide compound; and (3) hydrolyzing the acetyl group of the amide compound.

Abstract translation: 提供羟基肉桂酸衍生物以提高抗氧化性和皮肤渗透性，抑制活性氧和黑色素产生的作用，刺激前胶原生成，从而提供改善皱纹和美白的化妆品组合物。 羟基肉桂酸衍生物具有金刚烷基酰胺连接基团，由下式I表示。在式I中，R 1为H或C 1 -C 7烷基; A是-CH = CH-或-CH 2 -CH 2 - 。 通过包括以下步骤的方法获得羟基肉桂酸衍生物化合物：（1）用乙酰基取代羟基肉桂酸的羟基以提供乙酰化合物; （2）使乙酰化化合物与氯甲酸乙酯和含亲油基团的金刚烷胺反应，得到酰胺化合物; 和（3）水解酰胺化合物的乙酰基。

公开(公告)号：KR100786300B1

公开(公告)日：2007-12-18

申请号：KR1020060090560

申请日：2006-09-19

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  김수정 ,  윤준원 ,  안성연 ,  김덕희

IPC: A61K8/49 ,  A61Q19/08

CPC classification number: A61Q19/08 ,  A61K8/498

Abstract: A 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety is provided to promote the biosynthesis of main constituents of skin dermis such as collagen, elastin, fibrillin, glycosaminoglycan(GAG) closely related to skin wrinkles, thereby being usefully used as medicines and skin external applying agents for preventing aging and improving the wrinkles. An anti-aging cosmetic composition comprises 0.01-20.0 wt.% of a 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety and represented by the formula(I), wherein R1 is -CH2- or -CH2=CH2-, R2 is the structural formula(Ia), and R3 is H, methyl or ethyl. A method for preparing the 4-substituted benzoic acid derivative compound comprises the steps of: (a) preparing a compound(1) represented by the formula(1) from 3,4-methylenedioxybenzoic acid or 3,4-ethylenedioxybenzoic acid; and (b) hydrolyzing the compound of the formula(1) with a base to prepare a compound(2) represented by the formula(2).

Abstract translation: 提供具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分的4-取代苯甲酸衍生物化合物，以促进皮肤真皮主要成分的生物合成，如与皮肤皱纹密切相关的胶原蛋白，弹性蛋白，纤维蛋白，糖胺聚糖（GAG） 从而有效地用作用于防止老化和改善皱纹的药物和皮肤外用施用剂。 抗衰老化妆品组合物包含0.01-20.0重量％的具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分并由式（I）表示的4-取代苯甲酸衍生物化合物，其中R 1是-CH 2 - 或-CH 2 = CH 2 - ，R 2是结构式（Ia），R 3是H，甲基或乙基。 制备4-取代苯甲酸衍生物化合物的方法包括以下步骤：（a）由3,4-亚甲二氧基苯甲酸或3,4-亚乙二氧基苯甲酸制备由式（1）表示的化合物（1） 和（b）用碱水解式（1）的化合物以制备由式（2）表示的化合物（2）。

公开(公告)号：KR100740575B1

公开(公告)日：2007-07-18

申请号：KR1020060029631

申请日：2006-03-31

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  백흥수 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D319/18 ,  C07D317/60

Abstract: 2,3-Dihydroxybenzoic acid derivatives, a preparation method thereof, and a skin-whitening cosmetic composition containing the same compounds are provided to inhibit activity of tyrosinase and melanin formation while cytotoxicity of the compounds is very low, so that the compounds are useful for improvement of pigmentation in the skin. The method for preparing the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1) comprises the steps of: (A) reacting 2,3-dihydroxybenzoic acid with acetic acid anhydride in the presence of base to prepare a 2,3-diacetyloxybenzoic acid compound represented by the formula(2); (B) preparing an amide compound represented by the formula(3) from the 2,3-diacetyloxybenzoic acid compound by using ethylchloroformate and amine having a lipophilic group; and (C) hydrolyzing an acetyl group of the amide compound represented by formula (3) to prepare 2,3-dihydroxybenzoic acid represented by the formula (1), wherein R is 4-ethoxyphenyl, 2-cyclohexenylethyl, cycloheptyl, cyclohexyl, tert-octyl, 4-isopropylphenyl, 2,3-dihydrobenzo[1,4]dioxin-7-yl, benzo[1,3]-dioxol-6-yl or adamantyl-1-yl; and the amine having the lipophilic group is an amine selected from 4-ethoxyphenylamine, 2-cyclohexenylethylamine, cycloheptylamine, cyclohexylamine, tert-octylamine, 4-isopropylphenylamine, 2,3-dihydrobenzo[1,4]dioxin-7-amine, benzo[1,3]-dioxol-6-amine or adamantyl-1-amine. The skin-whitening cosmetic composition contains 0.01-20 wt.% of the 2,3-dihydroxybenzoic acid derivatives represented by the formula(1).

Abstract translation: 提供了2,3-二羟基苯甲酸衍生物，其制备方法和含有相同化合物的美白化妆品组合物，以抑制酪氨酸酶的活性和黑色素形成，同时化合物的细胞毒性非常低，使得该化合物可用于 改善皮肤色素沉着。 制备式（1）代表的2,3-二羟基苯甲酸衍生物的方法包括以下步骤：（A）使2,3-二羟基苯甲酸与乙酸酐在碱存在下反应，制得2,3-二羟基苯甲酸衍生物， 由式（2）表示的二乙酰氧基苯甲酸化合物; （B）使用氯甲酸乙酯和具有亲油性基团的胺，由2,3-二乙酰氧基苯甲酸化合物制备式（3）所示的酰胺化合物; （C）水解式（3）所示的酰胺化合物的乙酰基，制备式（1）所示的2,3-二羟基苯甲酸，其中R为4-乙氧基苯基，2-环己烯基乙基，环庚基，环己基，叔丁基 - 辛基，4-异丙基苯基，2,3-二氢苯并[1,4]二氧杂环己烯-7-基，苯并[1,3] - 二氧杂环戊烯-6-基或金刚烷基-1-基; 具有亲脂性基团的胺是选自4-乙氧基苯胺，2-环己烯基乙胺，环庚胺，环己胺，叔辛胺，4-异丙基苯胺，2,3-二氢苯并[1,4]二氧杂环己烯-7-胺，苯并[ 1,3] - 二氧六环-6-胺或金刚烷基-1-胺。 该美白化妆品组合物含有0.01-20重量％的由式（1）表示的2,3-二羟基苯甲酸衍生物。

公开(公告)号：KR100738434B1

公开(公告)日：2007-07-12

申请号：KR1020060088196

申请日：2006-09-12

Applicant: (주)아모레퍼시픽

Inventor： 김태형 ,  이동성 ,  박원석 ,  노호식 ,  한지숙

IPC: A61K8/49 ,  A61Q5/06

Abstract: 본 발명은 피롤리디닐 디아미노피리미딘 옥사이드(Pyrrolidinyl Diaminopyrimidine Oxide) 화합물을 함유하는 것을 특징으로 하는 화장료 조성물에 관한 것으로, 보다 상세하게는 유효성분으로 피롤리디닐 디아미노피리미딘 옥사이드 화합물을 함유함으로써 모발 및 피부에 탁월한 보습효과를 제공하여 두피의 가려움 또는 비듬을 감소시키고, 모발의 볼륨감 또는 탄력을 증진시키며, 두피의 염증을 완화시키는 모발 화장료 조성물 및 피부의 자극을 완화시키고, 피부의 주름을 개선시키며, 미백 또는 다크써클이나 기미제거 효과를 가지는 피부 화장료 조성물에 관한 것이다.
피롤리디닐 디아미노피리미딘 옥사이드 * 모발 * 피부 * 보습 * 컨디셔닝 * 자극완화

公开(公告)号：KR100706475B1

公开(公告)日：2007-04-10

申请号：KR1020060031749

申请日：2006-04-07

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  노호식 ,  김덕희 ,  장이섭

IPC: C07D407/12

Abstract: 본 발명은 강력한 미백효과를 가지며 하기 화학식 1로 표시되는 신규 히드록시피라논 이합체 또는 하기 화학식 2로 표시되는 그의 염 화합물, 이의 제조방법 및 이를 함유하는 피부 미백용 조성물에 관한 것으로, 하기 화학식 1 또는 2의 화합물은 멜라닌 생성을 억제함으로써 피부의 색소침착을 개선시켜 미백 효과를 나타내는 효능이 있으므로, 이를 함유하는 피부 미백용 조성물은 화장료 조성물로써 유용하게 이용될 수 있다.
[화학식 1]

(상기 식 중,
R1 는 CH
2 -CH
2 , CH
2 -CH
2 -CH
2 , CH
2 -CH
2 -CH
2 -CH
2 또는 CH(CH
3 )-CH(CH
3 )이다.)
[화학식 2]

(상기 식 중,
R1 는 CH
2 -CH
2 , CH
2 -CH
2 -CH
2 , CH
2 -CH
2 -CH
2 -CH
2 또는 CH(CH
3 )-CH(CH
3 )이고,
R2 는 Na, Ca, K, Cu 또는 Zn 이다.)
히드록시피라논 이합체, 멜라닌, 미백, 화장료

Abstract translation: 本发明涉及它们的盐，似乎有强烈的美白效果到新羟甲基 - 吡非二聚体或式（2）由通式（1）化合物，其制造方法及用于皮肤的组合物表示增白含有它们，于式（1）或 2通过抑制黑色素的产生和改善皮肤色素沉着，因此效力表示美白效果的化合物中，对于皮肤增白组合物包含它们可以用作化妆品组合物是有用的。