公开(公告)号：US20120107194A1

公开(公告)日：2012-05-03

申请号：US12914675

申请日：2010-10-28

Applicant: Leon M. Bellan ,  Harold G. Craighead ,  Elizabeth A. Strychalski

Inventor： Leon M. Bellan ,  Harold G. Craighead ,  Elizabeth A. Strychalski

IPC: B29C33/42 ,  B01L3/00

CPC classification number: B81C1/00071 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2300/0816 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2203/0338 ,  B81C2201/034

Abstract: A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.

Abstract translation: 通过在基底模具上形成牺牲纤维来制造器件。 纤维和模具被第一材料覆盖。 去除基底模具，然后除去覆盖的纤维以在第一材料中形成通道。

公开(公告)号：US20110269131A1

公开(公告)日：2011-11-03

申请号：US13127207

申请日：2009-10-28

Applicant: Daniel T. Chiu ,  Jason S. Kuo

Inventor： Daniel T. Chiu ,  Jason S. Kuo

IPC: C12M1/00 ,  B01D15/08 ,  C12Q1/02 ,  G01N33/559 ,  B01L3/00 ,  C12Q1/68

CPC classification number: C12M1/00 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2300/12 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/086 ,  B29C33/44 ,  B29C65/08 ,  B29C65/14 ,  B29C65/1403 ,  B29C65/1406 ,  B29C65/1409 ,  B29C65/1412 ,  B29C66/028 ,  B29C66/1122 ,  B29C66/5346 ,  B29C66/71 ,  B29C66/73151 ,  B29C66/73365 ,  B29C66/73751 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/81267 ,  B29C66/82661 ,  B29C2791/006 ,  B29K2075/00 ,  B29K2995/0025 ,  B29K2995/0027 ,  B29K2995/007 ,  B29L2031/756 ,  B81B2201/051 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  B29K2033/12

Abstract: Embodiments of the present invention relate to a UV-curable polyurethane-methacrylate (PUMA) substrate for manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and has stable surface properties. Embodiments include two production processes that are compatible with the existing methods of rapid prototyping, and characterizations of the resultant PUMA microfluidic devices are presented. Embodiments of the present invention also relate to strategies to improve the production yield of chips manufactured from PUMA resin, especially for microfluidic systems that contain dense and high-aspect-ratio features. Described is a mold-releasing procedure that minimizes motion in the shear plane of the microstructures. Also presented are simple yet scalable able methods for forming seals between PUMA substrates, which avoids excessive compressive force that may crush delicate structures. Two methods for forming interconnects with PUMA microfluidic devices are detailed. These improvements produce a microfiltration device containing closely spaced and high-aspect-ratio fins, suitable for retaining and concentrating cells or beads from a highly diluted suspension.

Abstract translation: 本发明的实施方案涉及用于制造微流体装置的可UV固化的聚氨酯 - 甲基丙烯酸酯（PUMA）基材。 PUMA是光学透明的，生物相容的，并且具有稳定的表面性质。 实施例包括与现有快速成型方法兼容的两个生产方法，并且显示所得PUMA微流体装置的特性。 本发明的实施方案还涉及提高由PUMA树脂制造的芯片的生产成本的策略，特别是对于含有密集和高纵横比特征的微流体系统。 描述了使微结构的剪切平面中的运动最小化的脱模程序。 还提出了用于在PUMA基材之间形成密封的简单且可扩展的方法，其避免了可能破坏微细结构的过大的压缩力。 详细说明了与PUMA微流体装置形成互连的两种方法。 这些改进产生了包含紧密间隔和高纵横比的翅片的微滤装置，适用于从高度稀释的悬浮液中保留和浓缩细胞或珠粒。

公开(公告)号：US07993905B2

公开(公告)日：2011-08-09

申请号：US12166287

申请日：2008-07-01

Applicant: Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

Inventor： Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

IPC: C12N1/00 ,  C12N11/00 ,  C12N11/08

CPC classification number: C12N1/00 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B81B2201/0214 ,  B81C1/00206 ,  B81C2201/034 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0068 ,  C12N5/067 ,  C12N2535/10 ,  C12Q1/02 ,  C40B60/14

Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

Abstract translation: 本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。 该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。 岛或区域或两者可以由自组装单层（SAM）形成。

公开(公告)号：US20100230290A1

公开(公告)日：2010-09-16

申请号：US12723147

申请日：2010-03-12

Applicant: Pierre Cusin ,  Clare Golfier ,  Jean-Philippe Thiebaud

Inventor： Pierre Cusin ,  Clare Golfier ,  Jean-Philippe Thiebaud

IPC: C25D5/48 ,  C25D7/00

CPC classification number: C25D1/10 ,  B29C33/3842 ,  B81C99/009 ,  B81C2201/034

Abstract: The invention relates to a method (3) of fabricating a mould (39, 39′) including the following steps: a) depositing (9) an electrically conductive layer on the top (20) and bottom (22) of a wafer (21) made of silicon-based material; b) securing (13) said wafer to a substrate (23) using an adhesive layer; c) removing (15) one part (26) of said conductive layer from the top of the wafer (21); d) etching (17) said wafer as far as the bottom conductive layer (22) thereof in the shape (26) of said part removed from the top conductive layer (22) to form at least one cavity (25) in said mould. The invention concerns the field of micromechanical parts, particularly for timepiece movements.

Abstract translation: 本发明涉及一种制造模具（39,39'）的方法（3），包括以下步骤：a）在晶片（21）的顶部（20）和底部（22）上沉积（9）导电层 ）由硅基材料制成; b）使用粘合剂层将所述晶片固定（13）到基底（23）上; c）从晶片（21）的顶部去除（15）所述导电层的一部分（26）; d）将所述晶片刻蚀（17）所述晶片至所述部分的形状（26）的底部导电层（22）从顶部导电层（22）去除，以在所述模具中形成至少一个空腔（25）。 本发明涉及微机械部件领域，特别是用于钟表运动。

公开(公告)号：US07767135B2

公开(公告)日：2010-08-03

申请号：US11975414

申请日：2007-10-19

Applicant: Diane Kimberlie Guilfoyle ,  Paul John Shustack ,  Lung-Ming Wu

Inventor： Diane Kimberlie Guilfoyle ,  Paul John Shustack ,  Lung-Ming Wu

IPC: C04B33/34 ,  B28B1/00 ,  C04B33/32 ,  C04B33/36 ,  B28B3/00 ,  B28B5/00

CPC classification number: C03C17/28 ,  B81B2201/058 ,  B81C1/00071 ,  B81C2201/034 ,  C03B19/06 ,  C03C11/00 ,  C03C17/04 ,  C03C17/324 ,  C03C23/0005

Abstract: Disclosed is a method of forming a structured sintered article including providing a mixture comprising a sinterable particulate material and a binder, the binder comprising, as a function of total resin content of the binder, at least 50% by weight of a thermoplastic binder material and at least 5% by weight of a radiation-curable binder material; shaping the mixture with a mold to form a structure; setting the structure by cooling the structure or by allowing the structure to cool; separating the structure from the mold; irradiating the structure so as to at least partially cure the radiation-curable binder material, and debinding and sintering the structure so as to form a structured sintered article. Shaping may include forming a structure having one or more open channels, and sintering may include sintering in together in contact with at least one additional structure so as to cover or enclose the channels.

Abstract translation: 公开了一种形成结构化烧结制品的方法，包括提供包含可烧结颗粒材料和粘合剂的混合物，所述粘合剂包含作为粘合剂的总树脂含量的函数，至少50重量％的热塑性粘合剂材料和 至少5重量％的可辐射固化粘合剂材料; 用模具成型混合物以形成结构; 通过冷却结构或通过使结构冷却来设定结构; 将结构与模具分离; 照射该结构以至少部分地固化可辐射固化的粘合剂材料，以及脱结和烧结该结构以便形成结构化的烧结制品。 成形可以包括形成具有一个或多个开放通道的结构，并且烧结可以包括与至少一个附加结构接触在一起的烧结以覆盖或封闭通道。

公开(公告)号：US20100130005A1

公开(公告)日：2010-05-27

申请号：US11461086

申请日：2006-07-31

Applicant: Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

Inventor： Byung Chul Lee ,  Jeong Oen Lee ,  Yang Kyu Choi ,  Jun-Bo Yoon

IPC: H01L21/441 ,  B28B7/36 ,  B05D5/12

CPC classification number: H01L21/76877 ,  B81B2203/04 ,  B81B2207/07 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y10/00 ,  H01F41/041 ,  H01L21/76885 ,  H01L23/5223 ,  H01L23/5227 ,  H01L23/53276 ,  H01L51/0048 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A method of fabricating a semiconductor device by filling carbon nanotubes in a recess is disclosed. The method of fabricating the semiconductor device comprises patterning a mold on a substrate, coating carbon nanotubes on an entire surface of the recess and the mold formed by the patterning, filling the carbon nanotubes coated on the an entire surface of the mold in the recess, and removing the mold.

Abstract translation: 公开了一种通过在凹槽中填充碳纳米管来制造半导体器件的方法。 制造半导体器件的方法包括在基底上图案化模具，在凹部的整个表面上涂覆碳纳米管和通过图案化形成的模具，填充涂覆在凹部中的模具的整个表面上的碳纳米管， 并移除模具。

公开(公告)号：US20100055459A1

公开(公告)日：2010-03-04

申请号：US12439281

申请日：2007-08-30

Applicant: Joseph M. Desimone ,  Robert L. Henn ,  Jake Sprague

Inventor： Joseph M. Desimone ,  Robert L. Henn ,  Jake Sprague

IPC: B32B1/00 ,  B27N3/02

CPC classification number: H01B1/08 ,  B81C99/0095 ,  B81C2201/034 ,  B81C2201/038 ,  H01B1/02 ,  H01B13/00 ,  H01F1/01 ,  Y10T428/2982

Abstract: A plurality of nanoparticles, a structure assembled therefrom, a method of forming the structure, including a plurality of particles where each particle of the plurality of particles is configured with a substantially predetermined shape and a largest dimension less than about 100 micrometers, and where each particle of the plurality of particles includes an opening through the particle.

Abstract translation: 多个纳米颗粒，由其组装的结构，形成该结构的方法，包括多个颗粒，其中多个颗粒的每个颗粒被构造成具有基本上预定的形状和最小尺寸小于约100微米，并且其中每个 多个颗粒的颗粒包括穿过颗粒的开口。

公开(公告)号：US20090166903A1

公开(公告)日：2009-07-02

申请号：US12398132

申请日：2009-03-04

Applicant: Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

Inventor： Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

IPC: B29D11/00

CPC classification number: B81C1/00206 ,  A61K47/6957 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/0043 ,  B01J2219/00466 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00713 ,  B29C31/04 ,  B29C33/42 ,  B29C37/0053 ,  B29C39/24 ,  B29C43/021 ,  B29C67/246 ,  B29D11/00346 ,  B29D11/00663 ,  B29K2105/0002 ,  B29L2011/0016 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/7703 ,  G01N2021/7776 ,  G02B6/138 ,  H05K3/0079 ,  H05K3/061

Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.

Abstract translation: 化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。 化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。 衬底表面可以是平面的或非平面的。 聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。 制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。 涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。 可以制作波导阵列，组合化学或生化图谱等。 波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。 干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。 改变和折射率可以通过光化学，化学等方式产生。 还公开了传感器，包括生化传感器。

公开(公告)号：US07531120B2

公开(公告)日：2009-05-12

申请号：US10433275

申请日：2001-12-03

Applicant: Cornelis Johannes Maria Van Rijn ,  Laura Vogelaar ,  Wietze Nijdam ,  Jonathan Nathaniel Barsema ,  Matthias Wessling

Inventor： Cornelis Johannes Maria Van Rijn ,  Laura Vogelaar ,  Wietze Nijdam ,  Jonathan Nathaniel Barsema ,  Matthias Wessling

IPC: B29C39/00

CPC classification number: B01D67/0088 ,  A61F2/06 ,  A61F2002/044 ,  A61F2002/046 ,  A61L27/50 ,  A61L27/56 ,  B01D67/0009 ,  B01D67/0018 ,  B01D67/002 ,  B01D67/0069 ,  B01D67/0072 ,  B01D67/0093 ,  B01D69/00 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/02 ,  B01D71/64 ,  B01D71/68 ,  B01D2323/06 ,  B01D2323/08 ,  B01D2323/30 ,  B01D2325/022 ,  B01D2325/04 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00864 ,  B01J2219/00907 ,  B01L3/0241 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0819 ,  B29C33/0033 ,  B29C41/08 ,  B29C41/38 ,  B29C67/02 ,  B29K2105/0073 ,  B29L2031/737 ,  B81B2201/10 ,  B81C99/008 ,  B81C2201/0115 ,  B81C2201/034 ,  G01N27/44704 ,  H01L31/18 ,  Y10T428/24

Abstract: Using phase separation technique perforated as well as non-perforated polymeric structures can be made with high aspect ratios (>5). By varying the phase separation process the properties (e.g. porous, non-porous, dense, open skin) of the moulded product can be tuned. Applications are described in the field of micro fluidics (e.g. micro arrays, electrophoretic boards), optics, polymeric solar cells, ball grid arrays, and tissue engineering.

Abstract translation: 使用相分离技术穿孔以及非穿孔聚合物结构可以制成高纵横比（> 5）。 通过改变相分离方法，可以调节模制产品的性质（例如多孔，无孔，致密，开放的皮肤）。 应用在微流体学（例如微阵列，电泳板），光学，聚合太阳能电池，球栅阵列和组织工程领域中描述。

公开(公告)号：US20090085235A1

公开(公告)日：2009-04-02

申请号：US11277527

申请日：2006-03-27

Applicant: Erwin BURKLE ,  Steffen Burr ,  Martin Eichlseder ,  Bernd Klotz

Inventor： Erwin BURKLE ,  Steffen Burr ,  Martin Eichlseder ,  Bernd Klotz

IPC: B29C45/00

CPC classification number: B81C1/00206 ,  B29C37/0028 ,  B29C37/0053 ,  B29C37/0082 ,  B29C45/1679 ,  B29C45/372 ,  B29C2059/023 ,  B81C2201/034

Abstract: In a method and apparatus for making an article with a microstructure or nanostructure, an injection molding process or an injection-compression molding process is used to produce a substrate and to apply a microstructure or nanostructure upon a surface of the substrate. Subsequently, the substrate is inundated with a cross-linking, curing material.

Abstract translation: 在用于制造具有微结构或纳米结构的制品的方法和装置中，使用注射成型工艺或注射压缩模制方法来生产基底并将微结构或纳米结构施加到基底的表面上。 随后，用交联固化材料淹没基底。