公开(公告)号：JPS5946227A

公开(公告)日：1984-03-15

申请号：JP10159383

申请日：1983-06-07

Applicant: Ei Gansou Otsuto ,  Sutorando Metsuto

Inventor： OTSUTO EI GANSOU ,  METSUTO SUTORANDO

IPC: C12N15/02 ,  A61K39/395 ,  A61K51/00 ,  A61K51/10 ,  A61N5/10 ,  A61P35/00 ,  C07K16/10 ,  C07K16/18 ,  C07K16/30 ,  C12P21/08

CPC classification number: C07K16/3015 ,  A61K51/1093 ,  A61K2121/00 ,  C07K16/1036 ,  C07K16/18

公开(公告)号：WO2017164936A1

公开(公告)日：2017-09-28

申请号：PCT/US2016/059239

申请日：2016-10-27

Applicant: THE BROAD INSTITUTE, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  REGEV, Aviv ,  ZHANG, Feng ,  HABIB, Naomi ,  LI, Yinqing ,  HEIDENREICH, Matthias ,  SWIECH, Lukasz ,  WEITZ, David ,  DAVIDI, Inbal, Avraham

Inventor： REGEV, Aviv ,  ZHANG, Feng ,  HABIB, Naomi ,  LI, Yinqing ,  HEIDENREICH, Matthias ,  SWIECH, Lukasz ,  WEITZ, David ,  DAVIDI, Inbal, Avraham ,  BASU, Anindita

IPC: C12N15/10 ,  C12Q1/68

CPC classification number: C07K16/1036 ,  C12N15/1093 ,  C12N15/1096 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q2537/165 ,  C12Q2563/179 ,  C12Q2565/514 ,  C12Q2565/629

Abstract: Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are limited. Here, Applicants developed Nuc-seq, Div-Seq, and Dronc-Seq. Div-seq combines Nuc-Seq, a scalable single nucleus RNA-Seq method, with EdU-mediated labeling of proliferating cells. Nuc-Seq can sensitively identify closely related cell types within the adult hippocampus. Div-Seq can track transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead. Finally, Applicants found rare adult newborn GABAergic neurons in the spinal cord, a non-canonical neurogenic region. Taken together, Nuc-Seq, Div-Seq and Dronc-Seq allow for unbiased analysis of any complex tissue.

Abstract translation: 单个神经元的转录组提供关于细胞类型和动态状态的丰富信息。 然而，捕获罕见的动态过程如成人神经发生是困难的，因为与致密成人组织分离是具有挑战性的，并且每个阶段的标记是有限的。 在这里，申请人开发了Nuc-seq，Div-Seq和Dronc-Seq。 Div-seq将可扩展的单核RNA-Seq方法Nuc-Seq与EdU介导的增殖细胞标记结合起来。 Nuc-Seq能敏感地鉴定成年海马内密切相关的细胞类型。 Div-Seq可以追踪海马中成人神经发生区新生神经元的转录动力学。 Dronc-Seq使用微流体装置将单个细胞核与一个独特条形码的mRNA捕获珠一起共同包封在油性介质中的反向乳液水滴中。 最后，申请人在脊髓中发现了罕见的成年新生GABA能神经元，这是一种非典型的神经原性区域。 综合起来，Nuc-Seq，Div-Seq和Dronc-Seq允许对任何复杂组织进行无偏分析。

公开(公告)号：WO2013059426A1

公开(公告)日：2013-04-25

申请号：PCT/US2012/060772

申请日：2012-10-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  OREGON HEALTH & SCIENCE UNIVERSITY ,  GOVERNING COUNSEL OF THE UNIVERSITY OF TORONTO

Inventor： NIXON, Douglas ,  MICHAUD, Henri-Alexandre ,  DEEKS, Steven G. ,  SACHA, Jonah B. ,  JONES, R. Bradley ,  OSTROWSKI, Mario

IPC: A61K39/42 ,  A61K39/12 ,  C07K16/08

CPC classification number: C07K16/1036 ,  C07K2317/21

Abstract: The present disclosure provides anti-HERV-K antibodies, and compositions comprising the antibodies. An antibody to HERV-K is useful in various therapeutic and diagnostic applications, which are also provided. The present disclosure also provides HERV-K peptides, as well as compositions comprising the peptides. HERV-K peptides of the present disclosure are useful in therapeutic applications, and for generating antibodies.

Abstract translation: 本公开提供抗HERV-K抗体和包含抗体的组合物。 HERV-K的抗体可用于各种治疗和诊断应用，其也被提供。 本公开还提供HERV-K肽以及包含肽的组合物。 本公开的HERV-K肽可用于治疗应用和用于产生抗体。

公开(公告)号：WO2012118974A3

公开(公告)日：2012-10-26

申请号：PCT/US2012027289

申请日：2012-03-01

Applicant: UNIV NEW JERSEY MED ,  TSIAGBE VINCENT K ,  OLD LLOYD ,  LI YU

Inventor： TSIAGBE VINCENT K ,  OLD LLOYD ,  LI YU

IPC: C07K16/00 ,  G01N33/53

CPC classification number: C07K16/1063 ,  C07K16/1036 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/55 ,  C12Q1/703 ,  G01N33/56988 ,  G01N33/574 ,  G01N33/57426

Abstract: The invention relates to human endogenous retrovirus env (HERV-WL) polypeptides, nucleotide sequences, HERV-WL antibodies, methods to detect cancer, and methods to determine the effectiveness of the treatment of cancer.

Abstract translation: 本发明涉及人内源性逆转录病毒env（HERV-WL）多肽，核苷酸序列，HERV-WL抗体，检测癌症的方法以及确定癌症治疗有效性的方法。

公开(公告)号：WO2012118974A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/027289

申请日：2012-03-01

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  TSIAGBE, Vincent, K. ,  OLD, Lloyd ,  LI, Yu

Inventor： TSIAGBE, Vincent, K. ,  OLD, Lloyd ,  LI, Yu

IPC: C12Q1/70

CPC classification number: C07K16/1063 ,  C07K16/1036 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/55 ,  C12Q1/703 ,  G01N33/56988 ,  G01N33/574 ,  G01N33/57426

Abstract: The invention relates to human endogenous retrovirus env (HERV-WL) polypeptides, nucleotide sequences, HERV-WL antibodies, methods to detect cancer, and methods to determine the effectiveness of the treatment of cancer.

Abstract translation: 本发明涉及人内源性逆转录病毒env（HERV-WL）多肽，核苷酸序列，HERV-WL抗体，检测癌症的方法和确定癌症治疗有效性的方法。

公开(公告)号：WO2010132886A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/035144

申请日：2010-05-17

Applicant: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  SINGH, Ila Ramnaresh ,  THAKER, Harshwardhan Manohar ,  SCHLABERG, Robert ,  SHIN, Clifford

Inventor： SINGH, Ila Ramnaresh ,  THAKER, Harshwardhan Manohar ,  SCHLABERG, Robert ,  SHIN, Clifford

IPC: C12Q1/04 ,  C12N7/00 ,  C07K16/08 ,  G01N33/53

CPC classification number: A61K9/0056 ,  A61K9/2068 ,  A61K31/5025 ,  C07K16/1036 ,  C07K16/3069 ,  C12N2740/13022 ,  G01N33/56983 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57434 ,  G01N2333/15 ,  G01N2800/56

Abstract: Disclosed herein are methods and compositions relating to the diagnosis of XMRV infection and XMRV-related diseases, including but not limited to malignancies such as prostate cancer, lymphomas, leukemias, myelodysplastic diseases, thymomas and also non-cancerous conditions such as chronic fatigue syndrome, and other neuroimmune disorders. The methods involve detection of XMRV RNA or DNA, or XMRV proteins, or antibodies to XMRV, and the use of these methods for diagnosis, for monitoring the progression of disease, and in monitoring treatment efficacy of various XMRV-associated diseases. Also disclosed herein are methods and compositions relating to the assessment of the cancer grade and long-term prognosis of a subject with cancer through the detection of anti-XMRV antibodies.

Abstract translation: 本文公开了与XMRV感染和XMRV相关疾病的诊断相关的方法和组合物，包括但不限于恶性肿瘤，例如前列腺癌，淋巴瘤，白血病，骨髓增生异常性疾病，胸腺瘤，以及非癌性病症如慢性疲劳综合征， 和其他神经免疫疾病。 该方法涉及检测XMRV RNA或DNA或XMRV蛋白或XMRV的抗体，以及使用这些方法进行诊断，用于监测疾病进展以及监测各种XMRV相关疾病的治疗效果。 本文还公开了通过检测抗XMRV抗体来评估癌症受试者的癌症级别和长期预后的方法和组合物。

公开(公告)号：WO2007137279A2

公开(公告)日：2007-11-29

申请号：PCT/US2007/069497

申请日：2007-05-22

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  WANG-JOHANNING, Feng

Inventor： WANG-JOHANNING, Feng

IPC: A61K31/7088 ,  A61K39/12 ,  A61K39/395 ,  A61P31/12 ,  C07H21/00 ,  C07K16/08 ,  C12N15/63 ,  C12Q1/02 ,  G01N33/53

CPC classification number: G01N33/57415 ,  A61K39/0011 ,  A61K47/6839 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/1036 ,  C07K16/3015 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/55 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492

Abstract: Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-K + cancers are provided. One example of a method may involve a method for preventing or inhibiting cancer cell proliferation by administering to a subject a cancer cell proliferation blocking or reducing amount of a HERV-K env protein binding antibody.

Abstract translation: 提供了癌症诊断和治疗的方法和组合物。 更具体地，提供了用于检测，预防和治疗HERV-K + +癌症的方法和组合物。 方法的一个实例可以涉及通过向受试者施用癌细胞增殖阻断或减少HERV-K env蛋白结合抗体的量来预防或抑制癌细胞增殖的方法。

公开(公告)号：WO2007090967A2

公开(公告)日：2007-08-16

申请号：PCT/FR2007000236

申请日：2007-02-09

Applicant: BIOMERIEUX SA ,  MALLET FRANCOIS ,  ORIOL GUY ,  CHEYNET VALERIE

Inventor： MALLET FRANCOIS ,  ORIOL GUY ,  CHEYNET VALERIE

IPC: C07K14/15

CPC classification number: C07K14/005 ,  A61K38/162 ,  A61K39/12 ,  A61K39/21 ,  C07K16/1036 ,  C07K2317/34 ,  C12N7/00 ,  C12N2740/10022 ,  C12N2740/10034 ,  C12N2740/10063 ,  G01N2333/15

Abstract: The invention relates to a peptide domain required for interaction between the envelope of a virus pertaining to the HERV-W interference group and an hASCT receptor, comprising an N end point and a C end point. Said peptide domain is defined, at the N end point thereof, by a pattern formed by the amino acids L (Z) a -proline-cysteine-X-cysteine in which Z is any amino acid, a is a whole number between 2 and 30, and X is any amino acid, and at the C end point thereof, by a pattern formed by the amino acids serine-aspartic acid-X a -X b -X c -X d -X e -aspartic acid-X f X g -(Z) ß in which X a , X b , X c , X d , X e , X f X g are any amino acids, Z is any amino acid, ß is a whole number between 15 and 25, preferably 20. The peptide domain comprises, between the N end point and the C end point , at least one pattern selected from the following patterns: a pattern formed by the amino acids cysteine-tyrosine-X 2 -X 3 -X 4 -X 5 - X 6 -cysteine in which X 2 , X 3 , X 4 , X 5 , X 6 are any amino acids, and a pattern formed by the amino acids cysteine-X 7 -X 8 -X 9 -X 10 -X 11 - X 12 - X 13 -X 14 -X 15 -cysteine-trytophane in which X 7 , X 8 , X 9 , X 10 , X 11 , X 12 , X 13 , X 14 , X 15 are any amino acids.

Abstract translation: 本发明涉及与HERV-W干扰组有关的病毒的包膜与hASCT受体之间的相互作用所需的肽结构域，其包含N个终点和C个终点。 所述肽结构域在N末端被由氨基酸L（Z）Λ-脯氨酸 - 半胱氨酸-X-半胱氨酸形成的图案定义，其中Z是任何氨基酸， 是2至30之间的整数，X是任何氨基酸，并且在C末端，由氨基酸丝氨酸 - 天冬氨酸-XA-N _{- - - - - - - - - - - - - - - - - - - - - - - - - - - - - 其中X aα，X B 2，X C 1，N 2，Z 3，...， X，X，X，X，X，X，X是任何氨基酸，Z是任何氨基酸 ，β是15至25之间，优选为20的整数。肽结构域在N端点和C端点之间包含至少一种选自以下模式的图案：由氨基酸半胱氨酸 - 酪氨酸形成的图案 -X 2 -X 3 -X 3 -X 5 -X 6 -X 3 - 半胱氨酸，其中X 2，X 3，X 4，X 5， X，X 6是任何氨基酸，并且由氨基酸半胱氨酸-X7 -X-X ，X 15是任何氨基酸。}

公开(公告)号：WO2006119527A8

公开(公告)日：2007-02-01

申请号：PCT/AT2006000197

申请日：2006-05-11

Applicant: GREENHILLS BIOTECHNOLOGY RES D ,  MAYER BERND ,  HUMER JOHANNES ,  MUSTER THOMAS

Inventor： MAYER BERND ,  HUMER JOHANNES ,  MUSTER THOMAS

IPC: A61K39/21 ,  A61K38/16

CPC classification number: A61K38/162 ,  A61K39/00 ,  C07K14/005 ,  C07K14/4748 ,  C07K16/1036 ,  C07K2317/34 ,  C12N2740/10022 ,  G01N33/5743 ,  G01N2333/15 ,  G01N2469/20

Abstract: The present invention provides antigenic polypeptides derived from the melanoma-associated endogenous retrovirus (MERV). These antigens are useful compounds for the detection of cancerous cells and melanoma-diagnosis as well as melanoma-prognosis. Furthermore these antigenic polypeptides of the present invention form the basis for anti-cancer vaccines.

Abstract translation: 本发明提供衍生自黑素瘤相关内源性逆转录病毒（MERV）的抗原多肽。 这些抗原是检测癌细胞和黑素瘤诊断以及黑素瘤预后的有用化合物。 此外，本发明的这些抗原性多肽构成抗癌疫苗的基础。

公开(公告)号：WO1994018322A1

公开(公告)日：1994-08-18

申请号：PCT/US1994001170

申请日：1994-02-02

Applicant: GENELABS TECHNOLOGIES, INC. ,  LELAND STANFORD JUNIOR UNIVERSITY

Inventor： GENELABS TECHNOLOGIES, INC. ,  LELAND STANFORD JUNIOR UNIVERSITY ,  HADLOCK, Kenneth, G. ,  GOH, Chin-Joo ,  FONG, Steven, K., H.

IPC: C12N15/12

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1036 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2740/14022

Abstract: Novel HTLV-I and HTLV-II peptides are disclosed for use in diagnostic assays for detecting and confirming HTLV-I and HTLV-II infection in human sera. The peptides are derived from analogous regions of HTLV-I and HTLV-II gp21 envelope protein, and are diagnostic of HTLV-I or HTLV-II infection. The invention also includes an assay kit and method for detecting, and discriminating between, HTLV-I and HTLV-II infection in humans.

Abstract translation: 公开了新的HTLV-I和HTLV-II肽用于诊断测定以检测和确认人血清中的HTLV-1和HTLV-II感染。 肽衍生自HTLV-1和HTLV-II gp21包膜蛋白的类似区域，并且是HTLV-1或HTLV-II感染的诊断。 本发明还包括用于检测和鉴别人类HTLV-1和HTLV-II感染的测定试剂盒和方法。