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公开(公告)号：US07199879B2
公开(公告)日：2007-04-03
申请号：US10784997
申请日：2004-02-25
Applicant: Raimo Harju , Janne Salonen , Hannu Turunen
Inventor： Raimo Harju , Janne Salonen , Hannu Turunen
IPC: G01N21/25
CPC classification number: G01N21/763 , G01N21/6452 , G01N2201/024 , G02B6/0001
Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrument for photoluminescence, chemiluminescence and/or AlphaScreen measurements wherein different optical modules are used for alternative measurements. The excitation pulses for the alternative measurements are guided via two different routes to optical modules, the routes reaching the module in different angles. This way it is possible to use alternative radiation sources without optical switches and without changing the optical system. The object of the invention is further achieved by providing an additional lens in the optical module when a thermo plate is used. This way it is possible to achieve a correct optical focus in different measurement modes not depending on the use of the thermo plate.
Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供用于光致发光，化学发光和/或AlphaScreen测量的光学测量仪器来实现，其中不同的光学模块用于替代测量。 用于替代测量的激励脉冲通过两个不同的路由被引导到光学模块，这些路径以不同的角度到达模块。 这样就可以使用没有光开关的替代辐射源，而不改变光学系统。 当使用热板时，通过在光学模块中提供附加透镜来进一步实现本发明的目的。 通过这种方式，可以在不同于热板的使用的不同测量模式下实现正确的光学焦点。
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公开(公告)号：US20050214863A1
公开(公告)日：2005-09-29
申请号：US11010816
申请日：2004-12-13
Applicant: John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk , Nick Christodoulides
Inventor： John McDevitt , Eric Anslyn , Jason Shear , Dean Neikirk , Nick Christodoulides
IPC: B01J19/00 , B01L3/00 , C40B40/10 , C40B60/14 , G01N21/64 , G01N21/77 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/552 , G01N33/68 , G01N33/92
CPC classification number: G01N33/5304 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , C40B40/10 , C40B60/14 , G01N21/6428 , G01N21/6454 , G01N21/77 , G01N33/54313 , G01N33/544 , G01N33/552 , G01N33/6887 , G01N33/92 , G01N2021/7783 , G01N2021/7786 , G01N2201/024 , G01N2800/32 , Y10S436/807 , Y10S436/809
Abstract: A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
Abstract translation: 用于快速表征唾液中分析物的系统。 在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施方案中，一系列化学敏感性颗粒位于空腔内。 当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。 在一个实施例中，多个空腔的每个空腔被设计成捕获并容纳特定尺寸的颗粒。 可以将柔性突出部定位在每个空腔上，以提供颗粒在空腔中的保持。
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公开(公告)号：US20050157294A1
公开(公告)日：2005-07-21
申请号：US11040709
申请日：2005-01-20
Applicant: Mark Hopkins , Yashvinder Sabharwal , Cynthia Vernold
Inventor： Mark Hopkins , Yashvinder Sabharwal , Cynthia Vernold
CPC classification number: G01N21/6458 , G01J3/0202 , G01J3/0229 , G01J3/0235 , G01J3/0237 , G01J3/024 , G01J3/0291 , G01J3/04 , G01J3/10 , G01J3/2823 , G01J3/2889 , G01J3/36 , G01N2021/6423 , G01N2021/6463 , G01N2021/6471 , G01N2201/024 , G01N2201/10 , G01N2201/103 , G02B21/26
Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.
Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。
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公开(公告)号：US20050122519A1
公开(公告)日：2005-06-09
申请号：US10826257
申请日：2004-04-19
Applicant: Jau-Jiu Ju , Yuan-Chin Lee , K. C. Chin , Kuang-Wu Hsu , Chen-I Kuo , Hae-Ruoh Huang , Yueh-Hsuan Tsai
Inventor： Jau-Jiu Ju , Yuan-Chin Lee , K. C. Chin , Kuang-Wu Hsu , Chen-I Kuo , Hae-Ruoh Huang , Yueh-Hsuan Tsai
CPC classification number: G01N21/645 , G01N2021/6471 , G01N2201/024
Abstract: A fluorescent auxiliary testing apparatus includes a light source module which emits a laser light to pass through a collimator, a dichroic mirror, and a first converging lens to project a testing object. The testing object emits a corresponding testing fluorescent light which passes through a filter assembly and a second converging lens and is received by a photo detector for generating a photoelectric signal. The photoelectric signal is transferred to a data processing equipment to perform test and analysis processes. The apparatus has a small size and a simple structure, and may be fabricated at a low cost.
Abstract translation: 荧光辅助测试装置包括发射激光以通过准直仪的光源模块，二向色镜和第一会聚透镜以投影测试对象。 测试对象发射相应的测试荧光，其通过过滤器组件和第二会聚透镜，并由光电检测器接收以产生光电信号。 光电信号被传送到数据处理设备进行测试和分析处理。 该装置具有小尺寸和简单的结构，并且可以以低成本制造。
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公开(公告)号：US20050062969A1
公开(公告)日：2005-03-24
申请号：US10784997
申请日：2004-02-25
Applicant: Raimo Harju , Janne Salonen , Hannu Turunen
Inventor： Raimo Harju , Janne Salonen , Hannu Turunen
CPC classification number: G01N21/763 , G01N21/6452 , G01N2201/024 , G02B6/0001
Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrument for photoluminescence, chemiluminescence and/or AplhaScreen measurements wherein different optical modules are used for alternative measurements. The excitation pulses for the alternative measurements are guided via two different routes to optical modules, the routes reaching the module in different angles. This way it is possible to use alternative radiation sources without optical switches and without changing the optical system. The object of the invention is further achieved by providing an additional lens in the optical module when a thermo plate is used. This way it is possible to achieve a correct optical focus in different measurement modes not depending on the use of the thermo plate.
Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供用于光致发光，化学发光和/或AplhaScreen测量的光学测量仪器来实现，其中不同的光学模块用于替代测量。 用于替代测量的激励脉冲通过两个不同的路由被引导到光学模块，这些路径以不同的角度到达模块。 这样就可以使用没有光开关的替代辐射源，而不改变光学系统。 当使用热板时，通过在光学模块中提供附加透镜来进一步实现本发明的目的。 通过这种方式，可以在不同于热板的使用的不同测量模式下实现正确的光学焦点。
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Patent Agency Ranking
公开(公告)号：US20050023445A1
公开(公告)日：2005-02-03
申请号：US10633794
申请日：2003-08-04
Applicant: Brent Horn , Ronald Renzi
Inventor： Brent Horn , Ronald Renzi
CPC classification number: G01N30/74 , B01L3/5027 , G01N21/645 , G01N2201/024
Abstract: A modular optical detector system. The detector system is designed to detect the presence of molecules or molecular species by inducing fluorescence with exciting radiation and detecting the emitted fluorescence. Because the system is capable of accurately detecting and measuring picomolar concentrations it is ideally suited for use with microchemical analysis systems generally and capillary chromatographic systems in particular. By employing a modular design, the detector system provides both the ability to replace various elements of the detector system without requiring extensive realignment or recalibration of the components as well as minimal user interaction with the system. In addition, the modular concept provides for the use and addition of a wide variety of components, including optical elements (lenses and filters), light sources, and detection means, to fit particular needs.
Abstract translation: 模块化光学检测器系统。 探测器系统设计用于通过用激发辐射诱导荧光并检测发射的荧光来检测分子或分子物质的存在。 因为该系统能够精确地检测和测量皮摩尔浓度，所以它理想地适用于通常用于微量化学分析系统和特别是毛细管色谱系统。 通过采用模块化设计，检测器系统提供了替换检测器系统的各种元件的能力，而不需要对组件进行大量的重新对准或重新校准，以及最小化与系统的用户交互。 此外，模块化概念提供了各种组件的使用和添加，包括光学元件（透镜和滤光片），光源和检测装置，以适应特殊需要。
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公开(公告)号：US06369894B1
公开(公告)日：2002-04-09
申请号：US09563086
申请日：2000-05-01
Applicant: Jeffrey P. Rasimas , Michael J. Fehr , John E. Hoots
Inventor： Jeffrey P. Rasimas , Michael J. Fehr , John E. Hoots
IPC: G01N2125
CPC classification number: G01N21/645 , G01N2201/024 , Y10T436/25
Abstract: Described and claimed is a modular fluorometer and a method of using same to control an industrial water system, wherein said modular fluorometer comprises: one or more units with each unit comprising: a channel comprising an optically appropriate cell through which a water sample flows; a light source positioned outside said optically appropriate cell; an optional excitation filter positioned between the light source and the optically appropriate cell; a reference detector positioned outside the optically appropriate cell; an emission detector positioned outside the optically appropriate cell; an optional emission filter positioned between said emission detector and said optically appropriate cell; wherein if more than one unit is present in said modular fluorometer, said optically appropriate cells through which said water sample flows are aligned such that only one channel through which a water sample flows exists in said fluorometer.
Abstract translation: 描述和要求保护的是模块化荧光计及其使用方法来控制工业水系统，其中所述模块化荧光计包括：一个或多个单元，每个单元包括：通道，包括水样品流过的光学适合的单元; 光源位于所述光学适当的单元之外;可选的激发滤光器，位于光源和光学适当的单元之间;基准检测器，位于光学适当的单元的外部;发射检测器，位于光学适当的单元之外;可选的发射滤光器，位于 所述发射检测器和所述光学适当的电池;其中如果在所述模块化荧光计中存在多于一个单元，则所述水样品流过的所述光学适当电池对准，使得在所述荧光计中仅存在一个水样品流过的通道。
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188.发明授权
公开(公告)号：US6124937A
公开(公告)日：2000-09-26
申请号：US308262
申请日：1999-05-14
Applicant: Klaus-Henrik Mittenzwey , Gert Sinn
Inventor： Klaus-Henrik Mittenzwey , Gert Sinn
CPC classification number: G01N21/645 , G01N21/031 , G01N21/41 , G01N21/47 , G01N21/5907 , G01N2021/6484 , G01N2021/6491 , G01N2201/024
Abstract: The invention relates to the synchronous determination of the absorption, fluorescence, dispersion and refraction of liquids, gases and solids (measurement volumes) with high sensitivity. Radiation of defined wavelength is coupled into a multiple reflection device. The transmitted coupling radiation is measured with a receiver that is located immediately behind a semireflecting mirror. The diffuse reflecting that is directed against the direction of incidence and the radiation which is specularly reflected at the boundary surface with the measurement volume are measured with a receiver that is directed at the measurement volume and located on the coupling mirror. The absorbing power is determined from the reciprocal value of the transmitted coupling radiation. The scattering power and fluorescence power are determined indirectly from the combination of diffuse reflection and transmitted radiation. The refraction is determined from the combination of specularly reflected radiation and transmitted radiation. The invention describes a method and a simple and robust device designed in modular system. Ranges of application are analysis, quality control and inspection in industry, environment and medicine.
Abstract translation: PCT No.PCT / DE97 / 02718 Sec。 371日期1999年5月12日 102（e）日期1999年5月12日PCT 1997年11月14日PCT公布。 第WO98 / 22802号公报 日期1998年5月28日本发明涉及具有高灵敏度的液体，气体和固体（测量体积）的吸收，荧光，分散和折射的同步测定。 限定波长的辐射被耦合到多重反射装置中。 传输的耦合辐射用位于半反射镜后面的接收器测量。 用与测量体积在边界表面镜面反射的入射方向和辐射的漫反射用针对测量体积并位于耦合镜上的接收器测量。 吸收功率由透射的耦合辐射的倒数确定。 从漫反射和透射辐射的组合间接地确定散射光和荧光强度。 折射由镜面反射辐射和透射辐射的组合确定。 本发明描述了一种在模块化系统中设计的方法和简单而鲁棒的设备。 应用范围是行业，环境和医学领域的分析，质量控制和检验。
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公开(公告)号：US5440145A
公开(公告)日：1995-08-08
申请号：US211233
申请日：1994-03-25
Applicant: Martin T. Cole
Inventor： Martin T. Cole
CPC classification number: G01N21/274 , G01N21/53 , G08B17/107 , G08B17/113 , G01N21/4785 , G01N2201/024 , G01N2201/0636 , G01N2201/0642 , G01N2201/0696
Abstract: A pollution/smoke detector apparatus is disclosed having a sample chamber of two part molded plastic construction having a pair of matching interlocking pairs including a series of interfitting baffles forming a series of irises spaced along the chamber, the apparatus including at one end a light receptor and a light absorber at the other end, and an air sample area between the subject of a flash light emitted from a light source module having a novel reflector element. The overall construction is easily assembled and disassembled for maintenance and yet provides effective and efficient operation.
Abstract translation: PCT No.PCT / AU92 / 00546 Sec。 371日期：1994年3月25日 102（e）日期1994年3月25日PCT提交1992年10月14日PCT公布。 公开号WO93 / 08461 公开了一种污染/烟雾探测器装置，其具有两部分模制塑料结构的样品室，该样品室具有一对匹配的互锁对，包括一系列相互隔离的挡板，所述一对相互作用的挡板形成沿腔室间隔的一系列虹膜， 在另一端包括光接收器和光吸收器，以及从具有新型反射器元件的光源模块发射的闪光的被摄体之间的空气样本区域。 整体结构易于组装和拆卸进行维护，并提供有效和高效的操作。
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公开(公告)号：US3806259A
公开(公告)日：1974-04-23
申请号：US30185072
申请日：1972-10-30
Applicant: SARGENT WELCH SCIENTIFIC CO
Inventor： MALTER L , BOOSTROM R , MANDELL A
CPC classification number: G01J3/02 , G01J3/021 , G01J3/0291 , G01N21/253 , G01N2201/024
Abstract: A combination teaching aid and modular instrumental analysis system in which a plurality of modules are provided, each having a separate function, and in which the different modules are adapted to be placed together in different combinations to provide different optical analysis instruments. The modules include a light source for providing light, a detector module for receiving light which has been exposed to a sample compartment module which receives one or more samples to be analyzed, and may include display means in the form of a meter or the like for reading the output of the detector module. The combination may also include a monochromator unit for providing substantially monochromatic light, and a filter module which is adapted to contain one or more filters through which a light beam may be passed for obtaining a beam of desired frequency. Different arrangements of the various modules will produce a spectrophotometer, a filter photometer, or a nephelometer. The described module units are arranged so that at least some of them may be disposed on a base and optically aligned by means of combination adjusting and clamping means, so that the units may be thereafter moved, or replaced as desired without affecting the alignment thereof. The described units are constructed and arranged so that all the significant operational and functional properties of each module may be directly observed by the student. Therefore, each module is adapted to perform a minimum number of functions, and the modular concept and the construction features are used as a teaching aid used to emphasize the relation between various systems of optical instrumental analysis. The filter compartment module and the sample compartment module include holder means for holding light filters or sample units, and the holder unit is constructed so as to facilitate interchange of sample holders and filter units, and to be adapted for use without change to perform different functions in different instrumental combinations.
Abstract translation: 一种组合教学辅助和模块化仪器分析系统，其中提供多个模块，每个模块具有单独的功能，并且其中不同的模块适于以不同的组合放置在一起以提供不同的光学分析仪器。 模块包括用于提供光的光源，用于接收已经暴露于接收要分析的一个或多个样品的样品室模块的光的检测器模块，并且可以包括以米的形式的显示装置， 读取检测器模块的输出。 该组合还可以包括用于提供基本单色光的单色仪单元和适于容纳一个或多个滤光器的滤光片模块，通过该滤光器可以通过光束以获得期望频率的光束。
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