公开(公告)号：WO1995020348A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001122

申请日：1995-01-27

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  PANESCU, Dorin ,  SWANSON, David, K.

IPC: A61B05/04

CPC classification number: A61B18/00 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6855 ,  A61B5/6858 ,  A61B18/14 ,  A61B2562/0209 ,  A61B2562/043

Abstract: Systems (10) and methods examine heart tissue morphology for the purpose of locating a potential ablation site. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs (38) based, at least in part, upon sensing tissue impedances. The systems and methods also sense the timing of local depolarization events in the tissue in which impedance is sensed and derive therefrom the propagation velocities of the sensed depolarization events. The systems and methods match the derived tissue electrical characteristics with the derived propagation velocities in spatial relation to the electrodes to characterize the morphology of the contacted heart tissue to identify a potential ablation site.

Abstract translation: 系统（10）和方法检查心脏组织形态，以定位潜在的消融部位。 系统和方法至少部分地基于感测组织阻抗而导出位于电极对（38）之间的组织的电特性。 系统和方法还感测组织中局部去极化事件的定时，其中阻抗被感测并从其导出感测去极化事件的传播速度。 系统和方法将衍生的组织电特征与衍生的与电极空间关系的传播速度相匹配，以表征所接触的心脏组织的形态以鉴定潜在的消融部位。

公开(公告)号：WO1995016393A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014450

申请日：1994-12-15

Applicant: PACESETTER, INC.

Inventor： PACESETTER, INC. ,  MORGAN, Wayne, A. ,  RICHARDS, Tom, W.

IPC: A61B05/04

CPC classification number: A61N1/3787 ,  A61B5/0031 ,  A61N1/37252 ,  Y10S128/903

Abstract: During the telemetering of telemetry signals between an implantable medical device and an external programmer, the transmitter power of the implantable device is dynamically adjusted. The programmer measures the strength of the telemetry signals transmitted by the implantable device (202). A power control signal is generated as a function of the measured signal strength, and the transmitter power of the implantable device is set to a power level specified by the power control signal (206). For example, if the measured signal strength falls below a predetermined minimum signal strength threshold, power must be increased. This process is repeated until the measured signal strength satisfies a predetermined signal strength condition (208).

Abstract translation: 在可植入医疗设备和外部编程器之间的遥测信号遥测期间，动态地调节可植入装置的发射机功率。 编程器测量由可植入装置（202）传输的遥测信号的强度。 作为测量信号强度的函数产生功率控制信号，并且将可植入装置的发射机功率设置为由功率控制信号（206）指定的功率电平。 例如，如果测量的信号强度低于预定的最小信号强度阈值，则必须增加功率。 重复该过程，直到测量的信号强度满足预定的信号强度条件（208）。

公开(公告)号：WO1995013742A1

公开(公告)日：1995-05-26

申请号：PCT/US1994013306

申请日：1994-11-18

Applicant: CMC ASSEMBLERS, INC.

Inventor： CMC ASSEMBLERS, INC. ,  BOGUSIEWICZ, Valentine ,  EINCK, Cydney, Alison

IPC: A61B05/04

CPC classification number: A61N1/0456 ,  A61B5/0416 ,  A61B2562/0215 ,  A61N1/0452 ,  A61N1/046 ,  A61N1/0496

Abstract: A water-degradable electrode, its method of preparation and a method of reclaiming valuable metal or metal alloy from such water-degradable electrode after use are provided. The water-degradable electrode (100) contains a water-degradable, electrically nonconductive substrate (110) and a nonphotosensitive, electrically conductive layer (140) containing a metal or metal alloy. The metal- or metal-alloy-containing, nonphotosensitive, electrically conductive layer is disposed on the water-degradable nonconductive substrate. After the electrode has been used, the nonphotosensitive, electrically conductive material can be reclaimed by degrading in water the electrically nonconductive substrate on which the conductive material is disposed.

Abstract translation: 提供了一种可降解水的电极，其制备方法以及从使用后的这种水可降解电极回收有价金属或金属合金的方法。 所述水可降解电极（100）包含含有金属或金属合金的可水降解的不导电基材（110）和非光敏导电层（140）。 含金属或金属合金的非光敏导电层设置在可水解的非导电基底上。 在使用电极之后，可以通过在其中设置导电材料的非导电基底上的水中降解来回收非感光导电材料。

公开(公告)号：WO1995010227A1

公开(公告)日：1995-04-20

申请号：PCT/US1994011671

申请日：1994-10-13

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： CASE WESTERN RESERVE UNIVERSITY ,  DURAND, Dominique, M. ,  TYLER, Dustin, J.

IPC: A61B05/04

CPC classification number: A61N1/0556 ,  Y10T29/49117

Abstract: A self-curling sheet (A) of a nonconductive material is biased to curl into a tight cylinder. Inwardly extending conductive members (B) are disposed on the surface of the sheet forming the inside of the cylinder. Circumferentially separated longitudinal slices (30) are made in the cylinder adjacent the conductive members (B) forming spring members (52) such that, as the sheet (A) relaxes over time, electrodes (11) on the spring members (52) engage and pierce a nerve surrounded by the cuff. The conductive members (B) may be electrically conductive for applying electrical impulses or fluid conductive for infusing medications. In use, a first edge of the self-curling sheet (A) is disposed adjacent a nerve trunk which is to receive the cuff there around. The self-curling sheet (A) is controllably permitted to curl around the nerve into its original cylindrical shape. Over a period of a few days, the electrodes (11) riding on spring members (52) formed by longitudinal slices (30) into the cylinder are embedded in the nerve without damage to the perineurium membrane surrounding the nerve axons. The electrodes (11) displace the fascicles rather than damaging them by piercing the perineurium.

Abstract translation: 非导电材料的自卷曲片（A）被偏压以卷曲成紧密的圆柱体。 向内延伸的导电构件（B）设置在形成气缸内部的薄片的表面上。 周向分开的纵向切片（30）在与形成弹簧构件（52）的导电构件（B）相邻的圆柱体中制成，使得随着片材（A）随着时间的推移而松弛，弹簧构件（52）上的电极（11）接合 并刺穿由袖口包围的神经。 导电构件（B）可以是导电的，用于施加电脉冲或用于输注药物的流体导电。 在使用中，自卷曲片（A）的第一边缘邻近于在其周围接收袖带的神经干线。 自动卷曲片（A）可控制地卷绕在原来的圆柱形状的神经周围。 在几天的时间内，将由纵向切片（30）形成的弹簧部件（52）上的电极（12）嵌入到圆筒中，而不会损伤神经轴突周围的神经束膜。 电极（11）移动束筒，而不是通过刺穿围网来破坏它们。

公开(公告)号：WO1995010226A1

公开(公告)日：1995-04-20

申请号：PCT/US1994011495

申请日：1994-10-12

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  McGEE, David, L. ,  HOUSER, Russell, A. ,  SWANSON, David, K.

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/6857 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1861 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056 ,  A61N1/06 ,  A61N1/3686 ,  A61N1/403

Abstract: Systems and methods sense electrical events about a selected annulus region (26, 30) of the heart (10) to identify the location of an accessory pathway. They establish a contact site between heart tissue and a multi-electrode array (E1-E10) conforming to the circumferential geometry of the selected annulus region (26, 30). The system and methods maintain this site, while conveying signals representing electrical events sensed by bipolar pairs of the electrodes (E1-E10). The systems and methods display the signals as graphic information that represents the time differences (T1, T2) between the atrium (A) and ventricular (V) electrogram complexes sensed by the pairs (E1-E10) on the selected annulus region (26, 30). The pairs (E1-E10) displaying the least time separation between the complexes (A, V) identifies the region of the accessory pathway. With this information, energy is conveyed to the electrodes of the selected pair to ablate tissue.

Abstract translation: 系统和方法检测关于心脏（10）的选定环区（26,30）的电事件，以识别附件通路的位置。 它们在心脏组织和符合所选择的环空区域（26,30）的圆周几何形状的多电极阵列（E1-E10）之间建立接触位置。 系统和方法维护该站点，同时传送表示由双极电极对（E1-E10）感测的电气事件的信号。 所述系统和方法将所述信号显示为图形信息，所述图形信息表示由所选择的环面区域（26）上的对（E1-E10）感测的心房（A）和心室（V）电描绘图复合体之间的时间差（T1，T2） 30）。 在复合体（A，V）之间显示最小时间间隔的对（E1-E10）标识附件通路的区域。 利用该信息，将能量传送到所选择的对的电极以烧蚀组织。

公开(公告)号：WO1995010225A1

公开(公告)日：1995-04-20

申请号：PCT/US1994011494

申请日：1994-10-12

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  McGEE, David, L. ,  HOUSER, Russell, A. ,  SWANSON, David, K.

IPC: A61B05/04

CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/6857 ,  A61B5/6858 ,  A61B18/1492 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/00869 ,  A61B2018/126 ,  A61B2018/1435 ,  A61B2018/1861 ,  A61B2562/0209 ,  A61B2562/043 ,  A61M25/0041 ,  A61M2025/09141 ,  A61N1/06 ,  A61N1/403

Abstract: Systems and methods sense electrical events in heart tissue to identify the location of an arrhythmogenic focus for ablation. The systems and methods establish a contact site between heart tissue and a curvilinear electrode array (e1-e4 or E1-E4). The systems and methods monitor signals representing electrical events sensed by the electrodes in the contact site. The signals are displayed as graphic information that represents the time sequence in which the electrodes sense a given electrical event. By moving the electrode array (e1-e4 or E1-E4) to one or more additional contact sites in the general direction of the electrode that first sensed the electrical event, the physician homes in on a contact site in which all electrodes on the array sense the given electrical event at generally the same time. This contact site contains the arrhythmogenic focus. The systems and methods convey ablating energy to bipolar pairs of the electrodes to form large bipolar lesins in heart tissue.

Abstract translation: 系统和方法检测心脏组织中的电事件以识别用于消融的致心律失常焦点的位置。 系统和方法建立心脏组织与曲线电极阵列（e1-e4或E1-E4）之间的接触部位。 系统和方法监测表示由接触部位中的电极感测的电气事件的信号。 信号被显示为表示电极感测给定电气事件的时间顺序的图形信息。 通过将电极阵列（e1-e4或E1-E4）移动到首先感测到电气事件的电极的大致方向上的一个或多个附加接触位置，医生将在阵列上的所有电极 通常在同一时间感测给定的电气事件。 该接触部位包含致心律失常的焦点。 系统和方法将烧蚀能量传递给双极对的电极，以在心脏组织中形成大的双极性损伤。

公开(公告)号：WO1994024930A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004699

申请日：1994-04-28

Applicant: WEBSTER, Wilton, W., Jr.

IPC: A61B05/04

CPC classification number: A61M25/0141 ,  A61B5/0422 ,  A61B5/6857 ,  A61M25/0041 ,  A61M25/0045 ,  A61M25/0147 ,  A61M25/0152 ,  A61M2025/015 ,  A61M2025/0161

Abstract: An electrode catheter (10) for mapping right sided supra-ventricular accessory electrical pathways comprises an elongated tubular catheter body (11) and a tip portion (12) which comprises a compound curve. The plane of the compound curve lies transverse to and preferably at an angle of about 30 DEG to the axis of the catheter body (11). The compound curve carries a plurality of electrodes (21). A puller wire (30) extends through the catheter body (11) and into the tip portion (12), the distal end of the puller wire (30) being fixedly attached to the distal end of the tip portion (12). A handle (13) is provided at the proximal end of the catheter (10) for controlling longitudinal movement of the puller wire (30) relative to the catheter body (11). Proximal movement of the puller wire relative (30) to the catheter body (11) results in the angle of the first bend becoming more acute and a decrease in the diameter of the generally circular curve of the tip portion (12).

Abstract translation: 用于映射右侧超心室附件电通路的电极导管（10）包括细长管状导管主体（11）和包括复合曲线的末端部分（12）。 复合曲线的平面与导管主体（11）的轴线横向并优选地成约30°的角度。 复合曲线载有多个电极（21）。 拉线（30）延伸穿过导管主体（11）并进入尖端部分（12），牵引线（30）的远端固定地附接到尖端部分（12）的远端。 在导管（10）的近端处设置有手柄（13），用于控制拉线器（30）相对于导管体（11）的纵向移动。 牵引线相对（30）到导管主体（11）的近端运动导致第一弯曲的角度变得更加尖锐，并且尖端部分（12）的大致圆形曲线的直径减小。

公开(公告)号：WO1994021166A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002795

申请日：1994-03-15

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  KORDIS, Thomas, F. ,  PANESCU, Dorin ,  WHAYNE, James, G.

IPC: A61B05/04

CPC classification number: A61B5/6858 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2562/0209 ,  A61B2562/043

Abstract: An electrode support structure has spline elements (22) radiating from a center hub (90) in a circumferentially spaced relationship. The spline elements (22) include terminal ends spaced from the hub which are joined to a base member (62) to form a three-dimensional structure for supporting electrodes (38). The center hub (90) lies essentially within the envelope of the spline elements (22) to present a surface free of projections that can poke into and cause tissue trauma during use.

Abstract translation: 电极支撑结构具有花键元件（22），其沿圆周间隔开地从中心毂（90）辐射。 花键元件（22）包括与轮毂间隔开的末端，其与基座构件（62）接合以形成用于支撑电极（38）的三维结构。 中心毂（90）基本上位于花键元件（22）的外壳内，以呈现没有突起的表面，其可以在使用过程中进入并引起组织损伤。

公开(公告)号：WO1993020749A1

公开(公告)日：1993-10-28

申请号：PCT/US1992003241

申请日：1992-04-16

Applicant: GEVINS, Alan, S. ,  LE, Jian

IPC: A61B05/04

CPC classification number: A61B5/0476 ,  A61B5/7264

Abstract: In an electrographic (EEG) system and method the subject's brain waves are recorded using electrodes removably connected to the scalp. The spatial resolution may be improved, in one embodiment, by "Deblurring", based on digital computer processing measurements of the positions of the electrodes; measurements of the subject's head size, shape, scalp thickness, skull thickness and brain shape; and estimates of the conductivity of the skull, scalp and cerebral spinal fluid. The system includes head support (10), adjustable guides (11), probe (12), and computer (13).

Abstract translation: 在电摄影（EEG）系统和方法中，使用可去除地连接到头皮的电极记录受试者的脑波。 在一个实施例中，可以通过基于数字计算机处理电极位置的测量来“改善”来改善空间分辨率。 受试者头部大小，形状，头皮厚度，颅骨厚度和脑部形状的测量; 并估计颅骨，头皮和脑脊液的电导率。 该系统包括头部支撑件（10），可调节导向件（11），探针（12）和计算机（13）。

公开(公告)号：WO1993017616A1

公开(公告)日：1993-09-16

申请号：PCT/EP1993000282

申请日：1993-02-05

Applicant: SIEMENS AKTIENGESELLSCHAFT ,  ABRAHAM-FUCHS, Klaus

Inventor： SIEMENS AKTIENGESELLSCHAFT

IPC: A61B05/04

CPC classification number: A61B5/04005

Abstract: A process is disclosed for suppressing disturbances during the position and/or direction finding of an electrophysiological activity (8) in a living being (4). The field distribution (10) generated by the electrophysiological activity is simultaneously measured at a plurality (n) of measurement sites by a multiple-channel measurement device (12). The measurement values (Mi(t)) measured by the individual channels contain, as multi-dimensional measurement signal vectors (M &cir& NOt (t)), a useful signal component which corresponds to the field parameters of the electrophysiological activity at the measurement sites, and a disturbing signal component whose characteristic field pattern is known. The characteristic field pattern may be represented by the direction of a multi-dimensional disturbing signal vector, without taking into account the absolute amplitude. When finding the position of the electrophysiological activity (8), only the component (Q &cir& NOt '(t)) orthogonal to the disturbing field vector of a multi-dimensional source field vector (Q &cir& NOt (t)) predetermined by a back-up source is compared with the component (M &cir& NOt '(t)) of the measurement signal vector (M(t)) orthogonal to the disturbing field vector.

Abstract translation: 公开了一种用于抑制在生活中的电生理活动（8）的位置和/或方向发现期间的紊乱的过程（4）。 通过多通道测量装置（12）在多个（n）个测量点同时测量由电生理活动产生的场分布（10）。 作为多维测量信号向量（M＆Cir＆NOt（t）），通过各个通道测量的测量值（Mi（t））包含对应于测量位置处的电生理活动的场参数的有用信号分量 以及其特征场图案已知的干扰信号分量。 特征场模式可以由多维干扰信号矢量的方向表示，而不考虑绝对振幅。 当找到电生理活动的位置（8）时，只有与背景预定的多维源场矢量（Q＆cir＆NOt（t））的干扰场矢量正交的分量（Q＆cir＆NOt'（t）） 将源与与干扰场矢量正交的测量信号矢量（M（t））的分量（M＆cir＆NOt'（t））进行比较。