公开(公告)号：CA2609742A1

公开(公告)日：2006-11-30

申请号：CA2609742

申请日：2006-05-25

Applicant: ADA FOUNDATION

Inventor： CHOW LAWRENCE C ,  XU HUAKUN ,  SUN LIMIN ,  TAKAGI SHOZO

IPC: A61K6/884 ,  A61L27/14 ,  C08K3/04 ,  C08K3/32 ,  C08K3/34 ,  C08K3/40

Abstract: Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

公开(公告)号：CA2593543A1

公开(公告)日：2006-07-20

申请号：CA2593543

申请日：2006-01-12

Applicant: ADA FOUNDATION

Inventor： XU HUAKUN ,  WEIR MICHAEL D

IPC: A61K35/32

Abstract: Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.

公开(公告)号：CA2530481A1

公开(公告)日：2005-01-13

申请号：CA2530481

申请日：2004-07-02

Applicant: ADA FOUNDATION

Inventor： EICHMILLER FREDERICK C ,  DICKENS SABINE H

IPC: A61K6/083 ,  A61K6/00 ,  A61K6/06

Abstract: Remineralizing dental cements contain source(s) of calcium and phosphate ion s, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.

公开(公告)号：CA2570507C

公开(公告)日：2014-08-12

申请号：CA2570507

申请日：2005-04-15

Applicant: ADA FOUNDATION

Inventor： TUNG MING S

IPC: C01B15/16 ,  A01N3/00 ,  A61K8/24 ,  A61K9/16 ,  A61Q11/00 ,  C01B25/26 ,  C01B25/32

Abstract: Calcium peroxyphosphate compounds and dental compositions comprising these compounds that combine both whitening/stain removal of teeth with remineralization are disclosed. The calcium peroxyphosphate compounds are capable of releasing, in an aqueous environment, whitening and reminiralization effective amounts of calcium ion, phosphate ion, and active oxygen. Preferred compounds are calcium peroxymonophosphate or calcium diperoxymonophosphate compounds. These compounds may be used in humans and other animals, including other mammals.

公开(公告)号：BRPI0511707A

公开(公告)日：2008-01-08

申请号：BRPI0511707

申请日：2005-04-15

Applicant: ADA FOUNDATION

Inventor： TUNG MING S

IPC: A01N3/00 ,  A61K8/24 ,  A61K9/16 ,  A61Q11/00 ,  C01B15/16 ,  C01B25/26 ,  C01B25/32

公开(公告)号：CA2625143A1

公开(公告)日：2007-04-26

申请号：CA2625143

申请日：2006-10-19

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61K9/70 ,  A61C5/50 ,  A61K6/838 ,  A61K6/884 ,  A61K6/898

Abstract: Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

公开(公告)号：AU2006304730A1

公开(公告)日：2007-04-26

申请号：AU2006304730

申请日：2006-10-19

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61K31/19 ,  A61K33/42

Abstract: Disclosed are dual-phase cement precursor systems and related methods and kits. The cement precursor systems are composed of a first and second discrete phases, at least one of which is aqueous. When combined, the cement precursor phases form a cement that is suitable as a bone graft material for bone repair procedures. In preferred embodiments, the materials are highly biocompatible, osteoinductive, and bioresorbable. A number of different but not mutually exclusive cement chemistries may be employed in the cement precursor systems. For instance, hydrogel-forming polymer cements, carboxyl/calcium cements, or calcium phosphate cements may be employed.

公开(公告)号：CA2521522A1

公开(公告)日：2004-11-04

申请号：CA2521522

申请日：2004-03-11

Applicant: ADA FOUNDATION

Inventor： TAKAGI SHOZO ,  CHOW LAURENCE C

IPC: C04B12/02 ,  C09K3/00

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organi c acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.

公开(公告)号：WO2012003438A1

公开(公告)日：2012-01-05

申请号：PCT/US2011/042788

申请日：2011-07-01

Applicant: ADA FOUNDATION ,  CHOW, Laurence C. ,  TAKAGI, Shozo

Inventor： CHOW, Laurence C. ,  TAKAGI, Shozo

IPC: C09K3/00

CPC classification number: C04B28/348 ,  C04B28/34 ,  C04B2111/00836 ,  C04B14/28 ,  C04B22/064 ,  C04B22/126

Abstract: This study reports in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). Experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it biocompatible and bioinert CPC. These bioinert CPCs are candidates for use in useful applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

Abstract translation: 本研究报道了磷灰石磷酸钙水泥（CPCs）的体外和体内性质。 实验水泥含有（0〜3.1）质量％的F，对应于存在大约（0〜87）质量％的FA。 磷灰石水泥产品的结晶度随FA含量大幅度增加。 当大鼠皮下植入时，体内吸收率随着FA含量的增加而显着降低。 FA含量最高的水泥在软组织中不被吸收，使其生物相容性和生物相容性。 这些生物素CPCs是用于需要植入物缓慢或不吸收以达到期望的临床结果的有用应用的候选者。

公开(公告)号：WO2006076416A3

公开(公告)日：2009-04-16

申请号：PCT/US2006000955

申请日：2006-01-12

Applicant: ADA FOUNDATION ,  XU HUAKUN ,  WEIR MICHAEL D

Inventor： XU HUAKUN ,  WEIR MICHAEL D

IPC: C12N5/00 ,  A61K9/00

CPC classification number: A61K38/1841 ,  A61K38/1825 ,  A61K38/1858 ,  A61K38/1875 ,  A61L27/20 ,  A61L27/38 ,  A61L27/425 ,  A61L27/46 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/02 ,  C08L67/04 ,  C08L89/06 ,  C08L5/04 ,  C08L5/08

Abstract: Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.

Abstract translation: 活细胞材料被包封或放置在生物相容性，可生物降解和具有三维形式的保护材料（细胞保护剂）中。 三维形式被结合到可以植入体内的基质中，最终降解，从而被活细胞产生的材料代替。