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    Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
    11.
    发明公开
    Filter sterilization for production of colloidal, superparamagnetic MR contrast agents 失效
    过滤灭菌胶体超顺MR造影剂的制备

    公开(公告)号：EP0707856A3

    公开(公告)日：1999-01-20

    申请号：EP95112600.2

    申请日：1991-02-06

    Applicant: ADVANCED MAGNETICS INCORPORATED

    Inventor： Josephson, Lee ,  Groman, Ernest V. ,  Palmacci, Stephen

    IPC: A61K49/00 ,  A61L2/00 ,  A61L2/02

    CPC classification number: A61K49/1809 ,  A61K49/1863 ,  A61L2/0017 ,  A61L2/025

    Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the colloid is prepared in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement includes preserving the colloid by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion.

    SYNTHESIS OF POLYSACCHARIDE COVERED SUPERPARAMAGNETIC OXIDE COLLOIDS
    13.
    发明公开
    SYNTHESIS OF POLYSACCHARIDE COVERED SUPERPARAMAGNETIC OXIDE COLLOIDS 失效
    多糖的用涂超PARA磁性氧化物胶体合成

    公开(公告)号：EP0713602A1

    公开(公告)日：1996-05-29

    申请号：EP93920085.0

    申请日：1993-08-12

    Applicant: ADVANCED MAGNETICS INCORPORATED

    Inventor： PALMACCI, Stephen ,  JOSEPHSON, Lee ,  GROMAN, Ernest, V.

    IPC: G01R33 ,  A61B5 ,  A61K49 ,  H01F1

    CPC classification number: H01F1/445 ,  A61K49/1809 ,  A61K49/1863

    Abstract: In a method for the synthesis of a colloid including a superparamagnetic metal oxide coated with a polymer, an acidic solution of a metal salt and a polymer may be cooled, and then neutralized by the controlled addition of a cool solution of a base, and may then be converted, by the application of heat, to a homogenous superparamagnetic metal oxide colloid. According to a preferred embodiment, the polymer may be a polysaccharide. In a further embodiment of the invention, the polysaccharide may be dextran and the metal salt may be ferrous and ferric salts, which produces, according to the methods of the invention, a superparamagnetic iron oxide colloid with an extended plasma half-line.

    Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
    14.
    发明公开
    Filter sterilization for production of colloidal, superparamagnetic MR contrast agents 失效
    过滤器化学超级顺磁共振MR-Kontrastmitteln

    公开(公告)号：EP0707856A2

    公开(公告)日：1996-04-24

    申请号：EP95112600.2

    申请日：1991-02-06

    Applicant: ADVANCED MAGNETICS INCORPORATED

    Inventor： Josephson, Lee ,  Groman, Ernest V. ,  Palmacci, Stephen

    IPC: A61K49/00 ,  A61L2/00 ,  A61L2/02

    CPC classification number: A61K49/1809 ,  A61K49/1863 ,  A61L2/0017 ,  A61L2/025

    Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the colloid is prepared in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement includes preserving the colloid by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion.

    Abstract translation: 提供了一种用于获得动物或人类受试者的器官或组织的体内MR图像的方法的改进，所述方法包括给予受试者作为造影剂以增强这种MR图像有效量的胶体，包括 分散在生理上可接受的载体中的超顺磁金属氧化物颗粒。 根据改进，与末端灭菌后胶体的施用相比，胶体的制备方式与毒性相比降低。 改进包括通过冻干保存胶体。 胶体可以在相容的赋形剂存在下冻干。 所用的赋形剂可以包括葡聚糖或柠檬酸盐阴离子。

    FILTER STERILIZATION FOR PRODUCTION OF COLLOIDAL, SUPERPARAMAGNETIC MR CONTRAST AGENTS and the use thereof
    15.
    发明授权
    FILTER STERILIZATION FOR PRODUCTION OF COLLOIDAL, SUPERPARAMAGNETIC MR CONTRAST AGENTS and the use thereof 失效
    过滤灭菌制备胶体超顺磁共振造影剂及其使用

    公开(公告)号：EP0514493B1

    公开(公告)日：1996-03-27

    申请号：EP91906230.7

    申请日：1991-02-06

    Applicant: ADVANCED MAGNETICS INCORPORATED

    Inventor： JOSEPHSON, Lee ,  GROMAN, Ernest, V. ,  PALMACCI, Stephen

    IPC: A61K49/00 ,  A61L2/00 ,  A61L2/02

    CPC classification number: A61K49/1809 ,  A61K49/1863 ,  A61L2/0017 ,  A61L2/025

    Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the method includes preparing the colloid in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement may include sterilizing the colloid by filtration. In an additional embodiment, the colloid may be sterilized by filtration and preserved by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion. Other embodiments include related compositions and methods.

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