公开(公告)号：EP0707856A3

公开(公告)日：1999-01-20

申请号：EP95112600.2

申请日：1991-02-06

Applicant: ADVANCED MAGNETICS INCORPORATED

Inventor： Josephson, Lee ,  Groman, Ernest V. ,  Palmacci, Stephen

IPC: A61K49/00 ,  A61L2/00 ,  A61L2/02

CPC classification number: A61K49/1809 ,  A61K49/1863 ,  A61L2/0017 ,  A61L2/025

Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the colloid is prepared in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement includes preserving the colloid by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion.

公开(公告)号：EP0707856A2

公开(公告)日：1996-04-24

申请号：EP95112600.2

申请日：1991-02-06

Applicant: ADVANCED MAGNETICS INCORPORATED

Inventor： Josephson, Lee ,  Groman, Ernest V. ,  Palmacci, Stephen

IPC: A61K49/00 ,  A61L2/00 ,  A61L2/02

CPC classification number: A61K49/1809 ,  A61K49/1863 ,  A61L2/0017 ,  A61L2/025

Abstract: An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent to enhance such MR image an effective amount of a colloid including superparamagnetic metal oxide particles dispersed in a physiologically acceptable carrier. In accordance with the improvement, the colloid is prepared in a manner that provides a reduction in toxicity in comparison with that associated with administration of the colloid after terminal sterilization. The improvement includes preserving the colloid by lyophilization. The colloid may be lyophilized in the presence of a compatible excipient. The excipient utilized may include a dextran or a citrate anion.

Abstract translation: 提供了一种用于获得动物或人类受试者的器官或组织的体内MR图像的方法的改进，所述方法包括给予受试者作为造影剂以增强这种MR图像有效量的胶体，包括 分散在生理上可接受的载体中的超顺磁金属氧化物颗粒。 根据改进，与末端灭菌后胶体的施用相比，胶体的制备方式与毒性相比降低。 改进包括通过冻干保存胶体。 胶体可以在相容的赋形剂存在下冻干。 所用的赋形剂可以包括葡聚糖或柠檬酸盐阴离子。