公开(公告)号：WO2005123079A2

公开(公告)日：2005-12-29

申请号：PCT/US2005/020895

申请日：2005-06-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar A., ,  LUNDQUIST, Gregory D. Jr., ,  CELEBI, Abdulaziz A., ,  GRIESGRABER, George W., ,  JOHANNESSEN, Sarah C., ,  HEPPNER, Philip D., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  LANGER, Scott E.,

Inventor： KSHIRSAGAR, Tushar A., ,  LUNDQUIST, Gregory D. Jr., ,  CELEBI, Abdulaziz A., ,  GRIESGRABER, George W., ,  JOHANNESSEN, Sarah C., ,  HEPPNER, Philip D., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  LANGER, Scott E.,

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005048945A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038033

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2009045752A3

公开(公告)日：2011-02-10

申请号：PCT/US2008076959

申请日：2008-09-19

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KALGUTKAR RAJDEEP S ,  AMOS DAVID T ,  MCKENZIE TAUN L

Inventor： KALGUTKAR RAJDEEP S ,  AMOS DAVID T ,  MCKENZIE TAUN L

IPC: A61K6/083 ,  A61C7/12 ,  C08L33/00

CPC classification number: A61K6/0023 ,  A61C7/16 ,  A61K6/0008 ,  A61K6/0052 ,  A61K6/083 ,  C08L33/12 ,  C08L25/06 ,  C08L25/14 ,  C08L33/10

Abstract: Orthodontic adhesives are claimed which use polymeric filler particles with defined particle size characteristics. The particle size characteristics are controlled such that these adhesives provide comparable mechanical retention and cohesive strength of conventional orthodontic adhesives when used to bond orthodontic appliances to teeth. Because polymeric fillers are generally softer than inorganic fillers, these adhesives are easier to remove from the tooth than conventional adhesives after debonding an orthodontic appliance. Embodiments of the invention include both self-curing and two-part adhesives, packaged adhesive-coated orthodontic appliances, and methods for removing a cured adhesive from a tooth surface.

Abstract translation: 要求使用具有确定的粒度特性的聚合物填料颗粒的正畸粘合剂。 控制粒度特征，使得这些粘合剂当用于将正畸器具粘合到牙齿上时，提供了常规正畸粘合剂相当的机械保持性和内聚强度。 因为聚合物填料通常比无机填料柔软，因此在脱粘矫正器具之后，这些粘合剂比常规粘合剂更容易从牙齿上除去。 本发明的实施例包括自固化和两部分粘合剂，包装的粘合剂涂覆的正畸矫治器，以及从牙齿表面去除固化的粘合剂的方法。

公开(公告)号：WO2009045752A2

公开(公告)日：2009-04-09

申请号：PCT/US2008/076959

申请日：2008-09-19

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KALGUTKAR, Rajdeep S. ,  AMOS, David T. ,  MCKENZIE, Taun L.

Inventor： KALGUTKAR, Rajdeep S. ,  AMOS, David T. ,  MCKENZIE, Taun L.

IPC: A61K6/027

CPC classification number: A61K6/0023 ,  A61C7/16 ,  A61K6/0008 ,  A61K6/0052 ,  A61K6/083 ,  C08L33/12 ,  C08L25/06 ,  C08L25/14 ,  C08L33/10

Abstract: Orthodontic adhesives are claimed which use polymeric filler particles with defined particle size characteristics. The particle size characteristics are controlled such that these adhesives provide comparable mechanical retention and cohesive strength of conventional orthodontic adhesives when used to bond orthodontic appliances to teeth. Because polymeric fillers are generally softer than inorganic fillers, these adhesives are easier to remove from the tooth than conventional adhesives after debonding an orthodontic appliance. Embodiments of the invention include both self-curing and two-part adhesives, packaged adhesive-coated orthodontic appliances, and methods for removing a cured adhesive from a tooth surface.

Abstract translation: 要求使用具有确定的粒度特性的聚合物填料颗粒的正畸粘合剂。 控制粒度特征，使得这些粘合剂当用于将正畸器具粘合到牙齿上时，提供了常规正畸粘合剂相当的机械保持性和内聚强度。 因为聚合物填料通常比无机填料柔软，因此在脱粘矫正器具之后，这些粘合剂比常规粘合剂更容易从牙齿上除去。 本发明的实施例包括自固化和两部分粘合剂，包装的粘合剂涂覆的正畸矫治器，以及从牙齿表面去除固化的粘合剂的方法。

公开(公告)号：WO2005123079A3

公开(公告)日：2006-06-22

申请号：PCT/US2005020895

申请日：2005-06-14

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  CELEBI ABDULAZIZ A ,  GRIESGRABER GEORGE W ,  JOHANNESSEN SARAH C ,  HEPPNER PHILIP D ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  LANGER SCOTT E

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  CELEBI ABDULAZIZ A ,  GRIESGRABER GEORGE W ,  JOHANNESSEN SARAH C ,  HEPPNER PHILIP D ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  LANGER SCOTT E

IPC: C07D471/14 ,  A61K31/437 ,  A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005094531A3

公开(公告)日：2006-03-09

申请号：PCT/US2005009880

申请日：2005-03-24

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  MOSER WILLIAM H

Inventor： KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  MOSER WILLIAM H

IPC: C07D471/04 ,  C07D471/14 ,  C07D471/02 ,  C07D471/06

CPC classification number: C07D471/04 ,  C07D413/14 ,  C07D471/02 ,  C07D471/12 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 含有1位酰胺取代基的咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005048933A3

公开(公告)日：2005-12-01

申请号：PCT/US2004037854

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

IPC: A61K20060101 ,  C07D471/02 ,  C07D471/06

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D519/00

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 含有在2-位具有肟取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并萘啶和咪唑并吡啶），含有这些化合物作为免疫调节剂的化合物，中间体和方法的药物组合物 ，用于在动物中诱导细胞因子生物合成以及用于治疗包括病毒和肿瘤疾病的疾病。

公开(公告)号：WO2005018556A2

公开(公告)日：2005-03-03

申请号：PCT/US2004026158

申请日：2004-08-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

Inventor： KSHIRSAGAR TUSHAR A ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

IPC: A61K20060101 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4745 ,  A61P31/12 ,  A61P37/02 ,  C07D471/04 ,  C07D471/14 ,  A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydroxylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位具有羟胺取代基的含咪唑化合物（例如咪唑并喹啉，咪唑并吡啶，咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法，用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2013173588A1

公开(公告)日：2013-11-21

申请号：PCT/US2013/041361

申请日：2013-05-16

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FUNG, Simon S. ,  AMOS, David T. ,  LIU, Junkang J. ,  DIETZ, Timothy M. ,  MA, Jing ,  OPP, Charles W.

Inventor： FUNG, Simon S. ,  AMOS, David T. ,  LIU, Junkang J. ,  DIETZ, Timothy M. ,  MA, Jing ,  OPP, Charles W.

IPC: C09J7/02 ,  C09J183/02 ,  C08J5/18

CPC classification number: A61L24/046 ,  A61M25/02 ,  A61M2025/0266 ,  C08G77/26 ,  C08L83/00 ,  C09J7/21 ,  C09J7/29 ,  C09J7/38 ,  C09J183/08 ,  C09J2201/20 ,  C09J2400/263 ,  C09J2400/28 ,  C09J2433/006 ,  C09J2475/006 ,  C09J2477/006 ,  C09J2483/00 ,  C09J2483/006

Abstract: Adhesive articles suitable for use in medical applications include a siloxane-based pressure sensitive adhesive layer, and a breathable conformable backing having a first surface and a second surface. The siloxane-based pressure sensitive adhesive layer is coated on the first surface of the breathable conformable backing, and the second surface of the breathable conformable backing comprises a treated surface. The siloxane-based pressure sensitive adhesive layer can be attached to skin and other adhesive articles can be releasably adhered to the treated surface to form adhesive constructions.

Abstract translation: 适合用于医疗应用的粘合剂制品包括硅氧烷基压敏粘合剂层和具有第一表面和第二表面的透气贴合背衬。 基于硅氧烷的压敏粘合剂层涂覆在透气适形背衬的第一表面上，并且透气贴合背衬的第二表面包括经处理的表面。 硅氧烷类压敏粘合剂层可以附着在皮肤上，其它粘合剂制品可以可剥离地粘附到经处理的表面上以形成粘合剂结构。

公开(公告)号：WO2013096535A1

公开(公告)日：2013-06-27

申请号：PCT/US2012/070772

申请日：2012-12-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FUNG, Simon, S. ,  DETERMAN, Michael, D. ,  TSE, Kiu-yuen ,  AMOS, David, T.

Inventor： FUNG, Simon, S. ,  DETERMAN, Michael, D. ,  TSE, Kiu-yuen ,  AMOS, David, T.

IPC: A61L15/22 ,  A61L15/26 ,  A61L15/56 ,  C09J183/04 ,  C08L71/02 ,  C08L83/04

CPC classification number: A61L15/58 ,  A61L15/225 ,  A61L15/26 ,  C08G18/4837 ,  C08G18/758 ,  C08G77/12 ,  C08G77/20 ,  C08K5/56 ,  C08L71/02 ,  C08L83/00 ,  C09J7/25 ,  C09J7/50 ,  C09J183/04 ,  C09J2467/006 ,  C09J2471/003 ,  C09J2471/006 ,  C09J2475/006 ,  C09J2483/00 ,  Y10T428/2809 ,  Y10T428/2843 ,  Y10T428/2852 ,  C08L83/04 ,  C08G18/10 ,  C08G18/282 ,  C08L75/04 ,  C08L67/00

Abstract: Adhesive articles that include a substrate and a silicone adhesive are disclosed. The articles also include a polymer containing poly (propylene oxide) units and optionally poly (ethylene oxide) units and having a number average molecular weight of at least 1000 grams per mole. The polymer may either be incorporated into the substrate or may be used as a primer on the substrate. If the polymer includes poly (ethylene oxide) units, the copolymer typically has a weight ratio of poly(ethylene oxide) to poly (propylene oxide) of up to 3 : 1, or if the copolymer has a number average molecular weight of at least 10,000 grams per mole, the weight ratio of poly (ethylene oxide) to poly (propylene oxide) is up to 2: 1. Methods of making the adhesive articles are also disclosed.

Abstract translation: 公开了包括基底和硅氧烷粘合剂的粘合制品。 制品还包括含有聚（环氧丙烷）单元和任选的聚（环氧乙烷）单元并且数均分子量至少为1000克/摩尔的聚合物。 聚合物可以掺入基材中，或者可以用作底物上的底漆。 如果聚合物包括聚（环氧乙烷）单元，则共聚物的聚（环氧乙烷）与聚（环氧丙烷）的重量比通常高达3:1，或者如果共聚物的数均分子量至少为 10,000克/摩尔，聚（环氧乙烷）与聚（环氧丙烷）的重量比高达2:1。还公开了制备粘合剂制品的方法。