公开(公告)号：WO2006028545A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

Inventor： STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘啶），含有化合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005051324A2

公开(公告)日：2005-06-09

申请号：PCT/US2004/039673

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KREPSKI, Larry R., ,  DELLARIA, Joseph F., Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  SQUIRE, David J., ,  MARSZALEK, Gregory J., ,  HEPPNER, Philip D., ,  KSHIRSAGAR, Tushar A.,

Inventor： KREPSKI, Larry R., ,  DELLARIA, Joseph F., Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  SQUIRE, David J., ,  MARSZALEK, Gregory J., ,  HEPPNER, Philip D., ,  KSHIRSAGAR, Tushar A.,

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括 公开了病毒和肿瘤疾病。

公开(公告)号：WO2006028545A3

公开(公告)日：2007-08-23

申请号：PCT/US2005021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

Inventor： STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

IPC: C07D471/14 ,  A61K31/437

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005018551A3

公开(公告)日：2006-05-11

申请号：PCT/US2004026065

申请日：2004-08-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

Inventor： KSHIRSAGAR TUSHAR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  HEPPNER PHILIP D ,  LANGER SCOTT E ,  ZIMMERMANN BERNHARD M

IPC: A61K20060101 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4745 ,  A61P31/12 ,  A61P37/02 ,  C07D471/04 ,  C07D471/14 ,  C07D471/12

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位具有肟取代基的含咪唑的化合物（例如咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有这些化合物的化合物，中间体和使用这些化合物作为免疫调节剂的方法用于在动物中诱导细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2005123079A2

公开(公告)日：2005-12-29

申请号：PCT/US2005/020895

申请日：2005-06-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar A., ,  LUNDQUIST, Gregory D. Jr., ,  CELEBI, Abdulaziz A., ,  GRIESGRABER, George W., ,  JOHANNESSEN, Sarah C., ,  HEPPNER, Philip D., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  LANGER, Scott E.,

Inventor： KSHIRSAGAR, Tushar A., ,  LUNDQUIST, Gregory D. Jr., ,  CELEBI, Abdulaziz A., ,  GRIESGRABER, George W., ,  JOHANNESSEN, Sarah C., ,  HEPPNER, Philip D., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  LANGER, Scott E.,

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005048945A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038033

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2006026760A2

公开(公告)日：2006-03-09

申请号：PCT/US2005031414

申请日：2005-09-02

Applicant: 3M INNOVATIVE PROPERTIES CO ,  STOERMER DORIS ,  DRESSEL LUKE T ,  MANSKE KARL J ,  GRIESGRABER GEORGE W ,  ZIMMERMANN BERNHARD M ,  DELLARIA JOSEPH F JR

Inventor： STOERMER DORIS ,  DRESSEL LUKE T ,  MANSKE KARL J ,  GRIESGRABER GEORGE W ,  ZIMMERMANN BERNHARD M ,  DELLARIA JOSEPH F JR

IPC: A61K31/4745

CPC classification number: C07D471/04

Abstract: Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位具有氨基取代基的含咪唑化合物（例如咪唑并吡啶，咪唑并吡啶），含有这些化合物的化合物的药物组合物和这些化合物作为免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒 并发现肿瘤性疾病。

公开(公告)号：WO2005051324A3

公开(公告)日：2006-01-05

申请号：PCT/US2004039673

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  SQUIRE DAVID J ,  MARSZALEK GREGORY J ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A

Inventor： KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  SQUIRE DAVID J ,  MARSZALEK GREGORY J ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A

IPC: A61K20060101 ,  A61K31/44 ,  A61K31/42 ,  C07D471/02 ,  C07D471/06

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括 公开了病毒和肿瘤疾病。

公开(公告)号：WO2005094531A2

公开(公告)日：2005-10-13

申请号：PCT/US2005/009880

申请日：2005-03-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KREPSKI, Larry R., ,  DELLARIA, Joseph F. Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  MOSER, William H.,

Inventor： KREPSKI, Larry R., ,  DELLARIA, Joseph F. Jr., ,  DUFFY, Daniel E., ,  AMOS, David T., ,  ZIMMERMANN, Bernhard M., ,  MOSER, William H.,

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D413/14 ,  C07D471/02 ,  C07D471/12 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005018556A3

公开(公告)日：2005-03-03

申请号：PCT/US2004/026158

申请日：2004-08-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar A. ,  AMOS, David T., ,  DELLARIA, Joseph F. Jr., ,  HEPPNER, Philip D., ,  LANGER, Scott E., ,  ZIMMERMANN, Bernhard M.,

Inventor： KSHIRSAGAR, Tushar A. ,  AMOS, David T., ,  DELLARIA, Joseph F. Jr., ,  HEPPNER, Philip D., ,  LANGER, Scott E., ,  ZIMMERMANN, Bernhard M.,

IPC: A61K31/437

Abstract: Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, imidazopyridines) with a hydroxylamine substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.