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    METHOD AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LESIONS IN ULTRASOUND IMAGES
    11.
    发明申请
    METHOD AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LESIONS IN ULTRASOUND IMAGES 审中-公开
    超声图像自动分析的方法和系统

    公开(公告)号：WO9904680A3

    公开(公告)日：1999-04-08

    申请号：PCT/US9815166

    申请日：1998-07-24

    Applicant: ARCH DEV CORP

    Inventor： GIGER MARYELLEN L ,  AL-HALLAQ HANIA ,  WOLVERTON DULCY ,  BICK ULRICH

    IPC: A61B20060101 ,  A61B8/00 ,  G06T7/00

    CPC classification number: G06T7/0012 ,  G06T2207/30068

    Abstract: The present invention is a method (100), and apparatus (1000) for the computerized automatic analysis of lesions in ultrasound images, including the computerized analysis of lesions in the breast using gradient, gray level, and texture based measures (108, 1007, 1010, 1011). Echogenicity features are developed to assess the characteristics of the lesions (110, 1014), and in some cases give an estimate of the likelihood of malignancy or of prognosis for the automated segmentation of the lung regions in lateral chest radiographs. The output from the computerized analysis (112, 1020) is used in making a diagnosis, and/or prognosis. For example, with the analysis of the ultrasound images of the breast, the features can be used to either distinguish between malignant and benign lesions, or distinguish between (i.e., diagnosis) the types of benign lesions such as benign solid lesions (e.g. fibroadenoma), simple cysts, complex cysts, and benign cysts. The ultrasound image features can be merged with those from mammographic, and/or magnetic resonance images of the same lesion for classification by means of a common artificial neural network.

    Abstract translation: 本发明是一种用于计算机化自动分析超声图像中的损伤的方法（100）和装置（1000），包括使用梯度，灰度和基于纹理的测量来对乳房中的病变进行计算机化分析（108,1007， 1010,1011）。 开发Echogenicity特征以评估病变的特征（110,1014），并且在某些情况下给出对于胸部横断面X线照片中肺区域的自动分割的恶性程度或预后的可能性的估计。 计算机化分析（112,1020）的输出用于诊断和/或预后。 例如，通过对乳房超声图像的分析，可以将特征用于区分恶性和良性病变，或区分（即，诊断）良性病变的类型，例如良性固体病变（例如纤维腺瘤） ，简单囊肿，复杂囊肿和良性囊肿。 可以将超声图像特征与来自相同病变的乳房X线照相和/或磁共振图像的那些融合，以通过常见的人造神经网络进行分类。

    ITERATIVE WARPING FOR TEMPORAL SUBTRACTION OF RADIOGRAPHS
    15.
    发明申请
    ITERATIVE WARPING FOR TEMPORAL SUBTRACTION OF RADIOGRAPHS 审中-公开
    迭代加热对时间延迟的影响

    公开(公告)号：WO9954705A3

    公开(公告)日：2002-12-27

    申请号：PCT/US9904290

    申请日：1999-04-02

    Applicant: ARCH DEV CORP

    Inventor： ISHIDA TAKAYUKI ,  KATSURAGAWA SHIGEHIKO ,  DOI KUNIO

    IPC: A61B6/00 ,  G01N20060101 ,  G06K9/00 ,  G06K9/80 ,  G06T1/00 ,  G06T3/00 ,  G06T5/40 ,  G06T7/00 ,  G06T7/20 ,  H04N5/325

    CPC classification number: G06T7/0016 ,  G06T3/0068 ,  G06T7/254 ,  G06T7/337 ,  G06T2207/30061

    Abstract: A method of computerized analysis of temporally sequential digital images, including (a) determining first shift values between pixels of a first digital image and corresponding pixels of a second digital image (440); (b) warping the second digital image based on the first shift values to obtain a first warped image in which spatial locations of pixels are varied in relation to the first shift values (450); (c) determining second shift values between pixels of the first digital image and pixels of the first warped image; and (d) warping the first warped image based on the second shift values to obtain a second warped image (470). Iterative warping enhances image for the first subtraction of the first digital image and the final warped image to produce a difference image (480).

    Abstract translation: 一种对时间顺序数字图像进行计算机化分析的方法，包括：（a）确定第一数字图像的像素与第二数字图像的对应像素之间的第一移位值（440）; （b）基于第一移位值对第二数字图像进行翘曲以获得其中像素的空间位置相对于第一移位值变化的第一翘曲图像（450）; （c）确定第一数字图像的像素与第一翘曲图像的像素之间的第二移位值; 和（d）基于第二偏移值使第一翘曲图像翘曲以获得第二扭曲图像（470）。 迭代翘曲增强了第一数字图像和最终的弯曲图像的第一次减法的图像以产生差分图像（480）。

    FLAVOPIRIDOL DRUG COMBINATIONS AND METHODS WITH REDUCED SIDE EFFECTS
    16.
    发明申请
    FLAVOPIRIDOL DRUG COMBINATIONS AND METHODS WITH REDUCED SIDE EFFECTS 审中-公开
    氟维拉多药物组合和方法具有降低的副作用

    公开(公告)号：WO0180896A3

    公开(公告)日：2002-07-11

    申请号：PCT/US0112526

    申请日：2001-04-12

    Applicant: ARCH DEV CORP ,  RATAIN MARK J ,  INNOCENTI FEDERICO ,  IYER LALITHA

    Inventor： RATAIN MARK J ,  INNOCENTI FEDERICO ,  IYER LALITHA

    IPC: A61K31/445 ,  A61K45/06 ,  A61P35/00

    CPC classification number: A61K31/445 ,  A61K45/06 ,  A61K31/00 ,  A61K2300/00

    Abstract: This invention provides methods, formulations and kits to reduce the toxicity of flavopiridol and analogs thereof. Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs. The invention also characterizes specific isoforms of glucuronyltransferase enzymes involved in glucuronidation of flavopiridols and their analogs.

    Abstract translation: 本发明提供了降低黄曲南醇及其类似物的毒性的方法，制剂和试剂盒。 公开了使用这些药物与增加共轭酶活性或葡糖醛酸基转移酶活性的试剂组合的治疗和治疗方法，以及降低胆道转运蛋白活性的试剂，例如环孢菌素A，其结果是减少先前相关的显着副作用 用这些药物治疗。 本发明还描述了参与黄曲霉素及其类似物葡糖醛酸化的葡糖醛酸转移酶的特异性同工型。

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