公开(公告)号：WO2007014044A3

公开(公告)日：2008-09-25

申请号：PCT/US2006028395

申请日：2006-07-21

Applicant: CALIFORNIA INST OF TECHN ,  ROUKES MICHAEL ,  TANG HONGXING ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMIN ,  MALONEY JAMES

Inventor： ROUKES MICHAEL ,  TANG HONGXING ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMIN ,  MALONEY JAMES

IPC: G01N33/00

CPC classification number: B81B3/0021 ,  B81B2201/0214 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/036 ,  G01N33/54366 ,  G01N2291/0257

Abstract: A biosensor is comprised of a free and a biofunctionalized recognition self- sensing nanocantilever, a dock adjacent to the ends of the nanocantilevers, and a gap between the nanocantilevers and dock. The self-sensing cantilevers each include a semiconductor piezoresistor defined in a pair of legs about which the cantilevers flex. A bias power or current is applied to the piezoresistor. The sensitivity of the cantilevers is optimized for a given ambient temperature and geometry of the cantilevers and dock by minimizing the force spectral density, S F , of the cantilevers to determine the optimum bias power, P in . A sub-aN/VHz force sensitivity is obtained by scaling down the dimensions of the cantilevers and supplying an optimum bias power as a function of temperature and geometry.

Abstract translation: 生物传感器由免费的和生物功能化的识别自感纳米聚合物，与纳米悬臂梁的端部相邻的码头以及纳米悬臂和码头之间的间隙组成。 自感悬臂各自包括限定在一对腿部的半导体压敏电阻，悬臂弯曲在该支脚周围。 偏置电源或电流施加到压敏电阻。 通过使悬臂的力谱密度最小化来确定悬臂的灵敏度对于给定的环境温度和悬臂和基座的几何形状是优化的，以确定最佳偏压功率，P < 在。 通过缩小悬臂的尺寸并提供作为温度和几何形状的函数的最佳偏置功率，可以获得sub-aN / VHz力灵敏度。

公开(公告)号：WO2005081929A3

公开(公告)日：2005-10-20

申请号：PCT/US2005005597

申请日：2005-02-24

Applicant: CALIFORNIA INST OF TECHN ,  BARGATIN IGOR ,  MYERS EDWARD B ,  LI MO ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMI ,  ROUKES MICHAEL L ,  YOUNG DARRON K ,  TANG HONG X

Inventor： BARGATIN IGOR ,  MYERS EDWARD B ,  LI MO ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMI ,  ROUKES MICHAEL L ,  YOUNG DARRON K ,  TANG HONG X

IPC: G01L3/02 ,  G01L3/10 ,  G01L3/12 ,  G01L3/14

CPC classification number: G01Q20/04

Abstract: A system containing a micro-mechanical or nano-mechanical device and a method of operating the same is provided. The device includes a resonator and a piezoresistive element connected to the resonator. The method includes AC biasing the piezoresistive element at a first frequency, driving the resonator at a second frequency different from the first frequency, and detecting a mechanical response of the resonator at one or both of a difference frequency and a sum frequency of the first and second frequencies.

Abstract translation: 提供了一种包含微机械或纳米机械装置的系统及其操作方法。 该器件包括连接到谐振器的谐振器和压阻元件。 该方法包括以第一频率对压阻元件进行AC偏置，以不同于第一频率的第二频率驱动谐振器，并且检测谐振器在第一和第二频率的差频率和和频之一或两者处的机械响应 第二频率。

公开(公告)号：WO2003095616A3

公开(公告)日：2003-11-20

申请号：PCT/US2003/014284

申请日：2003-05-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMON, Jerry, E. ,  CROSS, Michael, C. ,  ARLETT, Jessica, L.

Inventor： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMON, Jerry, E. ,  CROSS, Michael, C. ,  ARLETT, Jessica, L.

IPC: H01J37/26

Abstract: A bioNEMS device is disclosed comprising a BioNEMS cantilever (10) coupled to a constriction region (12) comprising a plurality of legs (20) such that the device operates in fluid and is used to investigate ligand properties using receptors implanted on the cantilever assembly.