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    BIOLOGICAL DETECTION BASED ON DIFFERENTIALLY COUPLED NANOMECHANICAL SYSTEMS USING SELF-SENSING CANTILEVERS WITH ATTONEWTON FORCE RESOLUTION
    1.
    发明申请
    BIOLOGICAL DETECTION BASED ON DIFFERENTIALLY COUPLED NANOMECHANICAL SYSTEMS USING SELF-SENSING CANTILEVERS WITH ATTONEWTON FORCE RESOLUTION 审中-公开
    基于差分联合的纳米系统的生物检测使用自感觉识别器与阿顿顿力分辨率

    公开(公告)号：WO2007014044A9

    公开(公告)日：2007-05-03

    申请号：PCT/US2006028395

    申请日：2006-07-21

    Applicant: CALIFORNIA INST OF TECHN ,  ROUKES MICHAEL ,  TANG HONGXING ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMIN ,  MALONEY JAMES

    Inventor： ROUKES MICHAEL ,  TANG HONGXING ,  ARLETT JESSICA ,  GUDLEWSKI BENJAMIN ,  MALONEY JAMES

    IPC: G01B5/28

    CPC classification number: B81B3/0021 ,  B81B2201/0214 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/036 ,  G01N33/54366 ,  G01N2291/0257

    Abstract: A biosensor is comprised of a free and a biofunctionalized recognition self- sensing nanocantilever, a dock adjacent to the ends of the nanocantilevers, and a gap between the nanocantilevers and dock. The self-sensing cantilevers each include a semiconductor piezoresistor defined in a pair of legs about which the cantilevers flex. A bias power or current is applied to the piezoresistor. The sensitivity of the cantilevers is optimized for a given ambient temperature and geometry of the cantilevers and dock by minimizing the force spectral density, S F , of the cantilevers to determine the optimum bias power, P in . A sub-aN/VHz force sensitivity is obtained by scaling down the dimensions of the cantilevers and supplying an optimum bias power as a function of temperature and geometry.

    Abstract translation: 生物传感器由免费的和生物功能化的识别自感纳米聚合物，与纳米悬臂梁的端部相邻的码头以及纳米悬臂和码头之间的间隙组成。 自感悬臂各自包括限定在一对腿部的半导体压敏电阻，悬臂弯曲在该支脚周围。 偏置电源或电流施加到压敏电阻。 通过使悬臂的力谱密度最小化来确定悬臂的灵敏度对于给定的环境温度和悬臂和基座的几何形状是优化的，以确定最佳偏压功率，P < 在。 通过缩小悬臂的尺寸并提供作为温度和几何形状的函数的最佳偏置功率，可以获得sub-aN / VHz力灵敏度。

    AN APPARATUS AND METHOD FOR TWO-DIMENSIONAL ELECTRON GAS ACTUATION AND TRANSDUCTION FOR GAAS NEMS
    2.
    发明申请
    AN APPARATUS AND METHOD FOR TWO-DIMENSIONAL ELECTRON GAS ACTUATION AND TRANSDUCTION FOR GAAS NEMS 审中-公开
    用于二维电子气体激励和传递用于脑神经元的装置和方法

    公开(公告)号：WO2004041998A2

    公开(公告)日：2004-05-21

    申请号：PCT/US2003/014566

    申请日：2003-05-07

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ROUKES, Michael, L. ,  EKINCI, Kamil, L. ,  YANG, Y., T. ,  HUANG, X., M., H. ,  TANG, H., X. ,  HARRINGTON, Darrell, A. ,  CASEY, Jean ,  ARLETT, Jessica, L.

    Inventor： ROUKES, Michael, L. ,  EKINCI, Kamil, L. ,  YANG, Y., T. ,  HUANG, X., M., H. ,  TANG, H., X. ,  HARRINGTON, Darrell, A. ,  CASEY, Jean ,  ARLETT, Jessica, L.

    IPC: C12N

    CPC classification number: B81B3/0035 ,  G01P15/08 ,  G01P15/097 ,  H03H9/02244 ,  H03H9/2457 ,  H03H9/2463 ,  H03H2009/02496 ,  H03H2009/02511 ,  H03H2009/02519 ,  H03H2009/02527

    Abstract: A doubly clamped beam has an asymmetric piezoelectric layer within the beam with a gate proximate to the beam within a submicron distance with a gate and beam dipole. A suspended beam is formed using a Cl 2 /He plasma etch supplied at a flow rate ratio of 1:9 respectively into a plasma chamber. A parametric amplifier comprises a NEMS signal beam driven at resonance and a pair of pump beams driven at twice resonance to generate a modulated Lorentz force on the pump beams to perturb the spring constant of the signal beam. A bridge circuit provides two out-of-phase components of an excitation signal to a first and second NEMS beam in a first and second arm. A DC current is supplied to an AC driven NEMS device to tune the resonant frequency. An analyzer comprises a plurality of piezoresistive NEMS cantilevers with different resonant frequencies and a plurality of drive/sense elements, or an interacting plurality of beams to form an optical diffraction grating, or a plurality of strain-sensing NEMS cantilevers, each responsive to a different analyte, or a plurality of piezoresistive NEMS cantilevers with different IR absorbers.

    Abstract translation: 双夹紧光束在光束内具有非对称压电层，栅极和栅极和光束偶极子之间的亚微米距离内的栅极靠近光束。 使用以1：9的流量比提供的Cl 2 / He等离子体蚀刻分别形成悬臂，形成等离子体室。 参数放大器包括以共振驱动的NEMS信号光束和以两次谐振驱动的一对泵浦光束，以在泵浦光束上产生调制的洛伦兹力，以扰乱信号光束的弹簧常数。 桥接电路在第一和第二臂中向第一和第二NEMS波束提供激励信号的两个异相分量。 直流电流被提供给AC驱动NEMS器件以调谐谐振频率。 分析器包括具有不同谐振频率的多个压阻NEMS悬臂和多个驱动/感测元件或相互作用的多个光束以形成光学衍射光栅，或多个应变感测NEMS悬臂，每个响应于不同的 分析物或具有不同IR吸收剂的多个压阻NEMS悬臂。

    HIGHLY MULTIPLEXED OPTOGENETIC NEURAL STIMULATION USING INTEGRATED OPTICAL TECHNOLOGIES
    3.
    发明申请
    HIGHLY MULTIPLEXED OPTOGENETIC NEURAL STIMULATION USING INTEGRATED OPTICAL TECHNOLOGIES 审中-公开
    使用综合光学技术的高度多光学眼球神经刺激

    公开(公告)号：WO2014081971A1

    公开(公告)日：2014-05-30

    申请号：PCT/US2013/071321

    申请日：2013-11-21

    Applicant: ROUKES, Michael, L. ,  FOWLER, Trevor ,  ARLETT, Jessica, L.

    Inventor： ROUKES, Michael, L. ,  FOWLER, Trevor ,  ARLETT, Jessica, L.

    IPC: A61N5/06

    CPC classification number: A61N5/0622 ,  A61N2005/0665

    Abstract: A neural probe is provided. The probe includes: a base that includes an optical demultiplexer, and one or more shanks extending from the base, with each shank including one or more waveguides. In the neural probe, the optical demultiplexer is optically connected to the one or more waveguides of each shank. A system including the neural probe and an optical multiplexer optically connected to the demultiplexer of the neural probe is also provided. Further, a method of emitting light from a neural probe is provided. The method includes receiving and demultiplexing multiplexed optical signals at a base of a neural probe, and emitting the demultiplexed optical signals from one or more shanks of the neural probe.

    Abstract translation: 提供神经探针。 探针包括：包括光解复用器的基座和从基座延伸的一个或多个柄，每个柄包括一个或多个波导。 在神经探针中，光学解复用器光学地连接到每个柄的一个或多个波导。 还提供了包括神经探针和光学连接到神经探针的解复用器的光学多路复用器的系统。 此外，提供了从神经探针发射光的方法。 该方法包括在神经探针的基底处接收和解复用复用光信号，以及从神经探针的一个或多个柄发射解复用的光信号。

    AN APPARATUS AND METHOD FOR TWO-DIMENSIONAL ELECTRON GAS ACTUATION AND TRANSDUCTION FOR GAS NEMS
    8.
    发明申请
    AN APPARATUS AND METHOD FOR TWO-DIMENSIONAL ELECTRON GAS ACTUATION AND TRANSDUCTION FOR GAS NEMS 审中-公开
    用于二维电子气体致动和气体传播的装置和方法

    公开(公告)号：WO2004041998A9

    公开(公告)日：2004-07-15

    申请号：PCT/US0314566

    申请日：2003-05-07

    Applicant: CALIFORNIA INST OF TECHN ,  ROUKES MICHAEL L ,  EKINCI KAMIL L ,  YANG Y T ,  HUANG X M H ,  TANG H X ,  HARRINGTON DARRELL A ,  CASEY JEAN ,  ARLETT JESSICA L

    Inventor： ROUKES MICHAEL L ,  EKINCI KAMIL L ,  YANG Y T ,  HUANG X M H ,  TANG H X ,  HARRINGTON DARRELL A ,  CASEY JEAN ,  ARLETT JESSICA L

    IPC: B81B3/00 ,  G01N27/00 ,  G01P15/08 ,  G01P15/097 ,  H01L27/14 ,  C12N

    CPC classification number: B81B3/0035 ,  G01P15/08 ,  G01P15/097 ,  H03H9/02244 ,  H03H9/2457 ,  H03H9/2463 ,  H03H2009/02496 ,  H03H2009/02511 ,  H03H2009/02519 ,  H03H2009/02527

    Abstract: A doubly clamped beam has an asymmetric piezoelectric layer within the beam with a gate proximate to the beam within a submicron distance with a gate and beam dipole. A suspended beam is formed using a Cl2/He plasma etch supplied at a flow rate ratio of 1:9 respectively into a plasma chamber. A parametric amplifier comprises a NEMS signal beam driven at resonance and a pair of pump beams driven at twice resonance to generate a modulated Lorentz force on the pump beams to perturb the spring constant of the signal beam. A bridge circuit provides two out-of-phase components of an excitation signal to a first and second NEMS beam in a first and second arm. A DC current is supplied to an AC driven NEMS device to tune the resonant frequency. An analyzer comprises a plurality of piezoresistive NEMS cantilevers with different resonant frequencies and a plurality of drive/sense elements, or an interacting plurality of beams to form an optical diffraction grating, or a plurality of strain-sensing NEMS cantilevers, each responsive to a different analyte, or a plurality of piezoresistive NEMS cantilevers with different IR absorbers.

    Abstract translation: 双夹紧光束在光束内具有非对称压电层，栅极和栅极和光束偶极子之间的亚微米距离内的栅极靠近光束。 使用以1：9的流量比提供的Cl 2 / He等离子体蚀刻分别形成悬臂，形成等离子体室。 参数放大器包括以共振驱动的NEMS信号光束和以两次谐振为驱动的一对泵浦光束，以在泵浦光束上产生调制的洛伦兹力，以扰乱信号光束的弹簧常数。 桥接电路在第一和第二臂中向第一和第二NEMS波束提供激励信号的两个异相分量。 直流电流被提供给AC驱动NEMS器件以调谐谐振频率。 分析器包括具有不同谐振频率的多个压阻NEMS悬臂和多个驱动/感测元件或相互作用的多个光束以形成光学衍射光栅，或多个应变感测NEMS悬臂，每个响应于不同的 分析物或具有不同IR吸收剂的多个压阻NEMS悬臂。

    DYNAMICS BIONEMS SENSORS AND ARRAYS OF BIONEMS SENSOR IMMERSED IN FLUIDS
    9.
    发明申请
    DYNAMICS BIONEMS SENSORS AND ARRAYS OF BIONEMS SENSOR IMMERSED IN FLUIDS 审中-公开
    动力传感器和液体传感器的传感器阵列

    公开(公告)号：WO2003095616A2

    公开(公告)日：2003-11-20

    申请号：PCT/US2003/014284

    申请日：2003-05-07

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMON, Jerry, E. ,  CROSS, Michael, C. ,  ARLETT, Jessica, L.

    Inventor： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMON, Jerry, E. ,  CROSS, Michael, C. ,  ARLETT, Jessica, L.

    IPC: C12N

    CPC classification number: G01N33/54373

    Abstract: A bioNEMS device comprises a piezoresistive cantilever having flexing legs of which attach the cantilever to a support and a biofunctionalized portion at the tip. A bias current applied to the legs is limited by a maximal acceptable temperature increase at the biofunctionalized tip. The length of the cantilever has a magnitude chosen to minimize background Johnson noise. A catalyzed receptor on the device binds to a ligand whose binding rate coefficient is enhanced. The catalyst lowers the receptor-ligand binding activation energy and is designed by forced evolution to preferentially bind with the ligand. A carrier signal is injected by a magnetic film disposed on the cantilever which is electromagnetically coupled to a source of the carrier signal. A plurality of NEMS fluidicly coupled transducers generate a plurality of output signals from which a collective output signal is derived, either by averaging or thresholding. The NEMS devices are disposed in microfluidic flow channels and fabricated in a membrane. A linking molecule is attached to the tip of the transducer and a fluffball attached to the linking molecule to increase damping.

    Abstract translation: bioNEMS装置包括压阻悬臂，其具有将悬臂连接到支撑件上的弯曲腿和尖端处的生物功能化部分。 施加到腿上的偏置电流受生物功能化尖端的最大可接受的温度升高的限制。 悬臂的长度具有选择的最小化背景约翰逊噪声的大小。 器件上的催化受体与结合速率系数增强的配体结合。 催化剂降低受体 - 配体结合活化能，并通过强制进化来优先与配体结合而设计。 载体信号由布置在悬臂上的磁膜注入，该磁膜电磁耦合到载波信号源。 多个NEMS流体耦合的换能器产生多个输出信号，通过平均或阈值从该输出信号导出集体输出信号。 NEMS装置设置在微流体流动通道中并制成膜。 连接分子连接到换能器的尖端，并且连接到连接分子上的绒毛增加阻尼。

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