公开(公告)号：WO02096479A2

公开(公告)日：2002-12-05

申请号：PCT/US0215118

申请日：2002-05-14

Applicant: INFRAREDX INC ,  RYAN S ERIC ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  FURNISH SIMON ,  TANG JING ,  ZULUAGA ANDRES

Inventor： RYAN S ERIC ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  FURNISH SIMON ,  TANG JING ,  ZULUAGA ANDRES

IPC: A61B5/00 ,  A61M

CPC classification number: A61B5/6853 ,  A61B5/0086 ,  A61B5/0507 ,  A61B5/6886

Abstract: An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.

Abstract translation: 一种装置包括用于控制安装在导管上的球囊的壁与插入其中的内腔的壁之间的间隙的程度的反馈回路。 该装置包括安装在气球内的放射线检测器，用于产生具有指示间隙的程度是否大于或小于期望值的信息的反馈信号。 反馈回路接收反馈信号并控制气囊的尺寸以使间隙的程度接近所需值。

公开(公告)号：WO2012058381A2

公开(公告)日：2012-05-03

申请号：PCT/US2011/058007

申请日：2011-10-27

Applicant: THE GENERAL HOSPITAL CORPORATION ,  WARGER, William, C., II ,  SCHLACHTER, Simon, C. ,  GARDECKI, Joseph ,  BOUMA, Brett, E. ,  TEARNEY, Gillermo, J.

Inventor： WARGER, William, C., II ,  SCHLACHTER, Simon, C. ,  GARDECKI, Joseph ,  BOUMA, Brett, E. ,  TEARNEY, Gillermo, J.

IPC: A61B5/021 ,  A61B5/01 ,  A61B5/02

CPC classification number: A61B5/021 ,  A61B3/14 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/02055 ,  A61B5/12 ,  A61B5/14558 ,  A61B5/202 ,  A61B5/4064 ,  A61B5/407 ,  A61B5/42 ,  A61B2576/00

Abstract: Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro-magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).

Abstract translation: 可以提供用于获得至少一个结构的信息的示例性装置和方法。 例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。 可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。 也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据 （S）。

公开(公告)号：WO2011109818A3

公开(公告)日：2012-01-12

申请号：PCT/US2011027421

申请日：2011-03-07

Applicant: GEN HOSPITAL CORP ,  UNIV COLORADO ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO ,  MCLEOD ROBERT R

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO ,  MCLEOD ROBERT R

IPC: A61B5/05 ,  A61B5/02

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

Abstract translation: 可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位 每个电磁辐射具有预定值。 示例性装置可以是探针的一部分。 此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

公开(公告)号：WO2011153434A2

公开(公告)日：2011-12-08

申请号：PCT/US2011/039066

申请日：2011-06-03

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GORA, Michalina ,  SUTER, Melissa ,  YOO, Hongki ,  SHISHKOV, Milen

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GORA, Michalina ,  SUTER, Melissa ,  YOO, Hongki ,  SHISHKOV, Milen

IPC: A61B1/227 ,  A61B1/24 ,  G01B9/02

CPC classification number: A61B1/00082 ,  A61B1/00165 ,  A61B1/00179

Abstract: In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

Abstract translation: 根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。 示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。 在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。 根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像 接触，例如，不压缩组织。

公开(公告)号：WO2011109828A3

公开(公告)日：2011-09-09

申请号：PCT/US2011/027437

申请日：2011-03-07

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo J. ,  BOUMA, Brett E. ,  GARDECKI, Joseph A. ,  LIU, Linbo

Inventor： TEARNEY, Guillermo J. ,  BOUMA, Brett E. ,  GARDECKI, Joseph A. ,  LIU, Linbo

IPC: A61B5/00 ,  G01B9/02

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

公开(公告)号：WO2010068764A3

公开(公告)日：2010-08-19

申请号：PCT/US2009067512

申请日：2009-12-10

Applicant: GEN HOSPITAL CORP ,  VAKOC BENJAMIN J ,  OH WANG Y ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

Inventor： VAKOC BENJAMIN J ,  OH WANG Y ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01N21/17 ,  G01B9/02 ,  G01N21/47 ,  G01N33/483

CPC classification number: A61B5/6852 ,  A61B5/0066

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

Abstract translation: 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样本，以便从样本提供至少一个第二辐射，该第二辐射可以基于 第一辐射。 另外，使用至少一个第二布置，可以接收来自样本的第二辐射，基于第二辐射产生关于样本的至少一部分的多个不同测量值， 并且在与不同测量相关联的多个连续可分辨深度点上表征该部分。 此外，至少一部分的表征可以在大于不同测量的数量的多个深度点处被解析和明确表征。

公开(公告)号：WO2010091190A3

公开(公告)日：2010-08-12

申请号：PCT/US2010/023215

申请日：2010-02-04

Applicant: THE GENERAL HOSPITAL CORPORATION ,  OH, Wang-Yuhl ,  VAKOC, Benjamin, J. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

Inventor： OH, Wang-Yuhl ,  VAKOC, Benjamin, J. ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

IPC: H01S3/10 ,  H01S3/00

Abstract: Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

公开(公告)号：WO2009137701A3

公开(公告)日：2009-11-12

申请号：PCT/US2009/043178

申请日：2009-05-07

Applicant: THE GENERAL HOSPITAL CORPORATION ,  COLICE, Christopher, Max ,  BOUMA, Brett, E. ,  TEARNEY, Guillermo, J. ,  HA, Jinyong ,  SHISHKOV, Milen

Inventor： COLICE, Christopher, Max ,  BOUMA, Brett, E. ,  TEARNEY, Guillermo, J. ,  HA, Jinyong ,  SHISHKOV, Milen

IPC: G01B11/24 ,  G01B11/25 ,  G01B7/28 ,  G01B17/06 ,  G06F17/00 ,  G01P3/00

Abstract: Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.

公开(公告)号：WO2007084995A3

公开(公告)日：2008-07-03

申请号：PCT/US2007060787

申请日：2007-01-19

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  NISHIOKA NORMAN S

Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  NISHIOKA NORMAN S

IPC: A61B5/00 ,  A61B1/07

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

Abstract: Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Abstract translation: 提供了布置，装置，系统和系统以获得至少一个管腔或空心样品中的至少一部分的数据。 该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

公开(公告)号：WO2008049118A2

公开(公告)日：2008-04-24

申请号：PCT/US2007/081982

申请日：2007-10-19

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  YELIN, Dvir

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  YELIN, Dvir

CPC classification number: A61B1/07 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/22 ,  A61B2017/00061

Abstract: Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) at least two first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation are provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion. First information of the portion based on the first transverse location and the relative depth location, and second information of the portion based on the second transverse location and the relative depth location can be obtained. The imaging information may include the first and second information.

Abstract translation: 可以提供示例性的设备和过程用于与样本的至少一部分相关联的成像信息。 例如，（i）至少一个第一电磁辐射的至少两个第一不同波长可以设置在样本的该部分上提供的第一波长范围内，以便确定该部分的至少一个第一横向位置， （ii）至少一个第二电磁辐射的至少两个第二不同波长被提供在设置在该部分上的第二波长范围内，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上向东部分重叠。 此外，可以获得从样本返回的至少一个第三电磁辐射电磁辐射与从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。 可以获得基于第一横向位置和相对深度位置的部分的第一信息以及基于第二横向位置和相对深度位置的部分的第二信息。 成像信息可以包括第一和第二信息。