公开(公告)号：WO2011109818A2

公开(公告)日：2011-09-09

申请号：PCT/US2011/027421

申请日：2011-03-07

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GARDECKI, Joseph, A. ,  LIU, Linbo ,  MCLEOD, Robert, R.

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  GARDECKI, Joseph, A. ,  LIU, Linbo ,  MCLEOD, Robert, R.

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

Abstract translation: 可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位 每个电磁辐射具有预定值。 示例性装置可以是探针的一部分。 此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

公开(公告)号：WO2011008822A2

公开(公告)日：2011-01-20

申请号：PCT/US2010041923

申请日：2010-07-14

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SUTER MELISSA ,  BOUMA BRETT E ,  JAFFER FAROUC A

Inventor： TEARNEY GUILLERMO J ,  SUTER MELISSA ,  BOUMA BRETT E ,  JAFFER FAROUC A

IPC: A61B5/021 ,  A61B5/02 ,  A61B5/027

CPC classification number: A61B5/0261 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/024

Abstract: Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

Abstract translation: 可以提供设备，系统和方法的示例性实施例以测量解剖结构内的流体流量。 例如，可以使用至少一个第一探针装置，所述第一探针装置被构造成可插入脉管并被配置为将至少一个辐射引导至解剖结构的至少一部分。 此外，可以提供至少一个第二布置，其被配置为检测从流体经由探针布置提供的第一辐射与从参考路径提供的第二辐射之间的干涉作为其波长的函数。 此外，可以提供至少一个第三布置，其被配置为根据干涉来确定流体的至少一个特性。

公开(公告)号：WO2010090837A3

公开(公告)日：2010-11-18

申请号：PCT/US2010021514

申请日：2010-01-20

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  SUTER MELISSA J

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  SUTER MELISSA J

IPC: A61B1/04

CPC classification number: A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

Abstract: Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

Abstract translation: 可以提供用于确定生物组织上或生物组织中的位置的设备，方法和系统的示例性实施例。 例如，使用这样的示例性实施例，可以控制光学成像探头的焦点。 在另一个示例性实施例中，可以将标记设备与光学成像探针一起或者引入光学成像探针中。 根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。 此外，基于所述信息，可以使用至少一个电磁辐射在所述部分的至少位置上或其中引起可见变化。

公开(公告)号：WO2009137701A2

公开(公告)日：2009-11-12

申请号：PCT/US2009043178

申请日：2009-05-07

Applicant: GEN HOSPITAL CORP ,  COLICE CHRISTOPHER MAX ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  HA JINYONG ,  SHISHKOV MILEN

Inventor： COLICE CHRISTOPHER MAX ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  HA JINYONG ,  SHISHKOV MILEN

IPC: G01B11/24 ,  G01B7/28 ,  G01B11/25 ,  G01B17/06 ,  G01P3/00 ,  G06F17/00

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0097 ,  A61B5/1076 ,  A61B5/1114 ,  A61B5/489 ,  A61B5/6844 ,  A61B5/6852 ,  A61B8/08 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/488 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/3782 ,  G01S15/50 ,  G01S15/60 ,  G01S15/87 ,  G01S17/50 ,  G01S17/87

Abstract: Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.

Abstract translation: 可以提供装置，方法和计算机可访问介质的示例性实施例，其可以有助于确定结构的至少一个特征。 例如，可以使用至少一个第一布置，其可被构造成沿着第一轴线提供至少一个第一透射辐射以及沿着第二轴线提供至少一个第二透射辐射。 第一和第二透射辐射可以影响结构并产生相应的第一和第二反射辐射。 第一和第二轴线可以彼此相对于预定角度提供，该角度大于0.此外，可以提供至少一个第二布置，其可被配置为接收与第一和第二返回辐射有关的数据，以及 确定沿着第一和第二轴线的结构和第一布置之间的至少一个相对速度。

公开(公告)号：WO2008115965A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/057450

申请日：2008-03-19

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  VELMAHOS, George ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

Inventor： TEARNEY, Guillermo, J. ,  VELMAHOS, George ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

IPC: A61B5/00 ,  G01B9/02

CPC classification number: A61B5/0059 ,  A61B5/0066 ,  A61B5/0095 ,  A61B5/416

Abstract: Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.

Abstract translation: 可以提供示例性的装置和过程来确定解剖结构的至少一个特征。 例如，可以使用光声布置在解剖结构中产生声波。然后可以检测声波并确定至少一个血液池是否存在于解剖结构中或解剖结构中，作为 声波的至少一个属性。 此外，可以将至少一个第一电磁辐射转发到解剖结构的至少一个组织，基于在所述至少一个组织中的运动或在所述至少一个组织内检测从所述至少一个组织提供的至少一个第二电磁辐射 至少一个组织以产生检测数据，并且基于检测数据确定至少一个部分的至少一个特性。

公开(公告)号：WO2007109540A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/064174

申请日：2007-03-16

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E.

CPC classification number: A61B5/489 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/103 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848 ,  A61B5/6852 ,  A61B10/0045 ,  A61B10/0283 ,  A61B2017/00022 ,  A61B2017/00061 ,  A61B2562/228 ,  G01N21/23 ,  G01N21/4795 ,  G01N2021/1787

Abstract: An apparatus, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue can be provided. For example, it is possible to utilize a radiation source configured to provide a radiation to the tissue. In addition, a probe can be provided which may be adapted to receive the radiation returned from the tissue; Further, a system may be utilized which can be configured to process data relating to the tissue. The data can indicate whether the blood vessel is in a vicinity of an end portion of the probe.

Abstract translation: 可以提供用于识别包含在组织内的血管的至少一部分的特征的装置，方法和计算机可访问介质。 例如，可以利用被配置为向组织提供辐射的辐射源。 此外，可以提供可以适于接收从组织返回的辐射的探针; 此外，可以使用可以被配置为处理与组织有关的数据的系统。 数据可以指示血管是否在探针的端部附近。

公开(公告)号：WO2007101026A2

公开(公告)日：2007-09-07

申请号：PCT/US2007/062465

申请日：2007-02-21

Applicant: THE GENERAL HOSPITAL CORPORATION ,  DESJARDINS, Adrien, E. ,  VAKOC, Benjamin, J. ,  TEANEY, Guillermo, J. ,  BOUMA, Brett, E.

Inventor： DESJARDINS, Adrien, E. ,  VAKOC, Benjamin, J. ,  TEANEY, Guillermo, J. ,  BOUMA, Brett, E.

IPC: G01B9/02 ,  G01N21/47 ,  A61B5/00

CPC classification number: G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

Abstract: Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro- magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.

Abstract translation: 根据本发明的示例性实施例提供了安排，装置和方法。 特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。 第二电磁辐射可以与第一电磁辐射相关联。 可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。 可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。 可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

公开(公告)号：WO2007084995A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/060787

申请日：2007-01-19

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J. ,  NISHIOKA, Norman, S.

Inventor： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J. ,  NISHIOKA, Norman, S.

IPC: A61B1/04 ,  A61B5/00 ,  A61B1/12

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

Abstract: Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Abstract translation: 提供了安排，装置，系统和系统以获得至少一个管腔或空心样品中的至少一个部分的数据。 该装置，系统或装置可以（可经由患者的口或鼻中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可视） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

公开(公告)号：WO2006024014A2

公开(公告)日：2006-03-02

申请号：PCT/US2005/030294

申请日：2005-08-24

Applicant: THE GENERAL HOSPITAL CORPORATION ,  BOUMA, Brett, E. ,  CHAN, Raymond, C. ,  TEARNEY, Guillermo, J.

Inventor： BOUMA, Brett, E. ,  CHAN, Raymond, C. ,  TEARNEY, Guillermo, J.

IPC: A61B5/00

CPC classification number: A61B5/0066 ,  A61B5/0059 ,  A61B5/02007

Abstract: A system, process and software arrangement are provided to determining data associated with at least one structural change of tissue. In particular, a first optical coherence tomography ("OCT”) signal which contains first information regarding the tissue at a first stress level, and a second OCT signal which contains second information regarding the tissue at a second stress level are received. The first and second information are compared to produce comparison information. The data associated with the at least one structural change is determined as a function of the comparison information and further information associated with (i) at least one known characteristics of the tissue and/or (ii) characteristics of an OCT system. Further, at least one optical coherence tomography ("OCT”) signal which contains information regarding the tissue can be received, and the modulus of the tissue may be determined as a function of the received at least one OCT signal.

Abstract translation: 提供系统，过程和软件布置以确定与组织的至少一个结构变化相关联的数据。 特别地，接收包含关于第一应力水平的组织的第一信息的第一光学相干断层摄影（“OCT”）信号和包含关于第二应力水平的组织的第二信息的第二OCT信号。 比较第一和第二信息以产生比较信息。 与至少一个结构变化相关联的数据被确定为比较信息和与（i）组织的至少一个已知特征和/或（ii）OCT系统的特征相关联的进一步信息的函数。 此外，可以接收包含关于组织的信息的至少一个光学相干断层摄影（“OCT”）信号，并且可以根据所接收的至少一个OCT信号来确定组织的模量。

公开(公告)号：WO2004065994A3

公开(公告)日：2004-12-23

申请号：PCT/US2004001499

申请日：2004-01-21

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  PITRIS CONSTANTINOS ,  SHISHKOV MILEN ,  BOUMA BRETT E

Inventor： TEARNEY GUILLERMO J ,  PITRIS CONSTANTINOS ,  SHISHKOV MILEN ,  BOUMA BRETT E

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33 ,  A16B1/06 ,  A16B6/00

CPC classification number: G02B21/0072 ,  G02B21/006 ,  G02B21/02 ,  G02B21/33

Abstract: A confocal microscope lens arrangement is provided. The confocal microscope lens arrangement includes a lens assembly housing which has a lens assembly, and an exterior housing including a distal end and a proximal end. The exterior housing is configured to allow the lens assembly housing to be placed therein, and translated between the proximal end and the distal end of the exterior housing to focus the lens assembly. The exterior housing has an aperture formed through a distal end thereof. The arrangement also includes an immersion media filling the volume of area between the exterior housing and the lens assembly housing.

Abstract translation: 提供共聚焦显微镜镜头布置。 共聚焦显微镜透镜装置包括具有透镜组件的透镜组件外壳以及包括远端和近端的外壳。 外部壳体被构造成允许透镜组件壳体放置在其中并且在外部壳体的近端和远端之间平移以聚焦透镜组件。 外壳具有穿过其远端形成的孔。 该装置还包括填充外部壳体和透镜组件壳体之间的区域的体积的浸没介质。