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公开(公告)号：US20070007270A1
公开(公告)日：2007-01-11
申请号：US11174756
申请日：2005-07-05
Applicant: William Bedingham , Barry Robole
Inventor： William Bedingham , Barry Robole
CPC classification number: G01N35/025
Abstract: Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.
Abstract translation: 公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。 本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。 样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。 过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。 结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。 还公开了使用包括使处理模块和框架变形的样品处理装置的方法。
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12.发明申请公开(公告)号：US20060013732A1
公开(公告)日：2006-01-19
申请号：US11226161
申请日：2005-09-14
Applicant: Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
Inventor： Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
IPC: G01N1/10
CPC classification number: C12N15/101 , B01F11/0002 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J41/05 , B01J47/016 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
Abstract: Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material.
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公开(公告)号：US20050126312A1
公开(公告)日：2005-06-16
申请号：US10734717
申请日：2003-12-12
Applicant: William Bedingham , Barry Robole
Inventor： William Bedingham , Barry Robole
CPC classification number: G01N21/05 , B01J2219/00891 , B01L3/502738 , B01L2300/0806 , B01L2300/0864 , B01L2400/0409 , B01L2400/0677
Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
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公开(公告)号：US20080050276A1
公开(公告)日：2008-02-28
申请号：US11930628
申请日：2007-10-31
Applicant: William Bedingham , Barry Robole
Inventor： William Bedingham , Barry Robole
IPC: G01N37/00
CPC classification number: G01N35/025
Abstract: Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.
Abstract translation: 公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。 本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。 样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。 过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。 结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。 还公开了使用包括使处理模块和框架变形的样品处理装置的方法。
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公开(公告)号：US20050180890A1
公开(公告)日：2005-08-18
申请号：US11082374
申请日：2005-03-16
Applicant: William Bedingham , James Aysta , Barry Robole
Inventor： William Bedingham , James Aysta , Barry Robole
CPC classification number: B01L3/50851 , B01L7/52 , B01L7/54 , B01L9/523 , B01L2300/0803 , B01L2300/1861 , G01N35/025 , G01N2035/00326 , Y10T436/111666
Abstract: Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.
Abstract translation: 公开了用于处理位于与系统分开的样品处理装置中的样品的样品处理系统。 样品处理系统包括具有凸起和/或非平面热结构的旋转底板，其中样品处理装置在系统的操作期间位于其上。 该系统还可以包括将样品处理装置推靠在基板和热结构上的结构。
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Patent Agency Ranking
16.发明申请METHODS AND DEVICES FOR REMOVAL OF ORGANIC MOLECULES FROM BIOLOGICAL MIXTURES USING A HYDROPHILIC SOLID SUPPORT IN A HYDROPHOBIC MATRIX 审中-公开从生物混合物中移除有机分子的方法和设备使用HYDROPHILIC固体支持在疏水基质公开(公告)号：US20080103297A1
公开(公告)日：2008-05-01
申请号：US11937567
申请日：2007-11-09
Applicant: Ranjani Parthasarathy , Raj Rajagopal , Vicky Morris , William Bedingham , Barry Robole
Inventor： Ranjani Parthasarathy , Raj Rajagopal , Vicky Morris , William Bedingham , Barry Robole
CPC classification number: C12N15/1006 , Y10T428/25 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
Abstract: Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.
Abstract translation: 用于从使用固相萃取材料的生物样品混合物中去除小负电荷分子的方法和装置，所述固相萃取材料包括至少部分嵌入疏水基质内的亲水性固体支持物。
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公开(公告)号：US20070114229A1
公开(公告)日：2007-05-24
申请号：US11622643
申请日：2007-01-12
Applicant: William Bedingham , Raj Rajagopal , Barry Robole , Kannan Seshadri
Inventor： William Bedingham , Raj Rajagopal , Barry Robole , Kannan Seshadri
IPC: H05B6/78
CPC classification number: G01N35/00069 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2300/0681 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1861 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , B03C1/30 , F27B9/16 , F27D5/00 , G01N35/0098 , H05B6/80 , Y10T436/2575
Abstract: Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.
Abstract translation: 用于处理样品的设备，系统和方法。 样品材料可以位于装置中的多个处理室中，其在样品材料的加热期间旋转。
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18.发明申请公开(公告)号：US20070009383A1
公开(公告)日：2007-01-11
申请号：US11174957
申请日：2005-07-05
Applicant: William Bedingham , Peter Ludowise , Barry Robole
Inventor： William Bedingham , Peter Ludowise , Barry Robole
IPC: G01N35/00
CPC classification number: F16K99/003 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2300/021 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/004 , F16K2099/0084 , G01N21/0332 , G01N21/07 , G01N21/359 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N35/1097 , G01N2021/0325 , G01N2021/6421 , G01N2021/6441 , G01N2035/00267 , G01N2035/00415 , G01N2035/0474 , G01N2201/0407 , G01N2201/0415 , G01N2201/0612 , G01N2201/062 , G01N2201/0833 , Y10T436/11 , Y10T436/111666
Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.
Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。
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公开(公告)号：US20060223169A1
公开(公告)日：2006-10-05
申请号：US11174754
申请日：2005-07-05
Applicant: William Bedingham , Peter Ludowise , Barry Robole
Inventor： William Bedingham , Peter Ludowise , Barry Robole
CPC classification number: G01N35/00069 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/024
Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector.
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公开(公告)号：US20050242091A1
公开(公告)日：2005-11-03
申请号：US10840766
申请日：2004-05-06
Applicant: William Bedingham , Raj Rajagopal , Barry Robole , Kannan Seshadri
Inventor： William Bedingham , Raj Rajagopal , Barry Robole , Kannan Seshadri
CPC classification number: G01N35/00069 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2300/0681 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1861 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , B03C1/30 , F27B9/16 , F27D5/00 , G01N35/0098 , H05B6/80 , Y10T436/2575
Abstract: Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.
Abstract translation: 用于处理样品的设备，系统和方法。 样品材料可以位于装置中的多个处理室中，其在样品材料的加热期间旋转。
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