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    Compliant microfluidic sample processing disks
    1.
    发明申请
    Compliant microfluidic sample processing disks 有权
    符合微流体样品处理盘

    公开(公告)号：US20070009391A1

    公开(公告)日：2007-01-11

    申请号：US11174680

    申请日：2005-07-05

    Applicant: William Bedingham ,  Barry Robole

    Inventor： William Bedingham ,  Barry Robole

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/1805

    Abstract: Microfluidic sample processing disks with a plurality of fluid structures formed therein are disclosed. Each of the fluid structures preferably includes an input well and one or more process chambers connected to the input well by one or more delivery channels. The process chambers may be arranged in a compliant annular processing ring that is adapted to conform to the shape of an underlying thermal transfer surface under pressure. That compliance may be delivered in the disks of the present invention by locating the process chambers in an annular processing ring in which a majority of the volume is occupied by the process chambers. Compliance within the annular processing ring may alternatively be provided by a composite structure within the annular processing ring that includes covers attached to a body using pressure sensitive adhesive.

    Abstract translation: 公开了具有形成在其中的多个流体结构的微流体样品处理盘。 每个流体结构优选地包括输入井和通过一个或多个输送通道连接到输入井的一个或多个处理室。 处理室可以布置成柔顺的环形加工环，其适于在压力下符合下面的热转印表面的形状。 通过将处理室定位在其中大部分体积被处理室占据的环形处理环中，可以在本发明的盘中传送顺从性。 环形加工环内的合规性可替代地由环形加工环内的复合结构提供，其包括使用压敏粘合剂附接到主体的盖。

    Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
    2.
    发明申请
    Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector 有权
    具有将多个光模块耦合到公共检测器的光纤束的多重荧光检测装置

    公开(公告)号：US20060223172A1

    公开(公告)日：2006-10-05

    申请号：US11174755

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: C12M1/34 ,  G01N21/66

    CPC classification number: G01J3/4406 ,  G01J3/0218 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/024

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system is described that includes a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of optical modules. Each of the optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of optical modules conveys the fluorescent light from the multiple optical modules to a single detector.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，描述了包括数据采集装置和耦合到数据采集装置的检测装置的系统。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个光学模块。 每个光学模块被光学配置以激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个光学模块的光纤束将来自多个光学模块的荧光传送到单个检测器。

    Sample processing device compression systems and methods
    6.
    发明申请
    Sample processing device compression systems and methods 有权
    样品处理设备压缩系统和方法

    公开(公告)号：US20070010007A1

    公开(公告)日：2007-01-11

    申请号：US11174757

    申请日：2005-07-05

    Applicant: James Aysta ,  William Bedingham ,  Barry Robole

    Inventor： James Aysta ,  William Bedingham ,  Barry Robole

    IPC: C12M1/34

    CPC classification number: B01L9/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/0803 ,  B01L2300/1805 ,  B01L2300/1861 ,  G01N35/025 ,  G01N2035/00366 ,  Y10S435/809

    Abstract: Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.

    Abstract translation: 公开了使用这些系统来处理位于样品处理装置中的样品材料的样品处理系统和方法。 样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。 该系统还包括设计成迫使样品处理装置朝向底板的盖和压缩结构。 优选的结果是，样品处理装置被迫与基板上的热结构接触。 本发明的系统和方法可以包括以下特征中的一个或多个，以增强热结构和样品处理装置之间的热耦合：成形转印表面，磁性压缩结构以及浮动或弹性安装的热结构。 该方法可以优选地包括样品处理装置的一部分的变形以符合成形的转印表面。

    Variable Valve Apparatus and Methods
    9.
    发明申请
    Variable Valve Apparatus and Methods 审中-公开
    可变阀装置及方法

    公开(公告)号：US20070148687A1

    公开(公告)日：2007-06-28

    申请号：US11684656

    申请日：2007-03-12

    Applicant: William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    Inventor： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

    Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

    Abstract translation: 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

    Heating element for a rotating multiplex fluorescence detection device
    10.
    发明申请
    Heating element for a rotating multiplex fluorescence detection device 审中-公开
    用于旋转多重荧光检测装置的加热元件

    公开(公告)号：US20070009382A1

    公开(公告)日：2007-01-11

    申请号：US11174691

    申请日：2005-07-05

    Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

    Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

    IPC: G01N35/00

    CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

    Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

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