公开(公告)号：WO2007055981A3

公开(公告)日：2007-07-05

申请号：PCT/US2006042538

申请日：2006-11-01

Applicant: CHEMIMAGE CORP ,  TREADO PATRICK J ,  MAIER JOHN S ,  COHEN JEFFREY K ,  DEMUTH JOSEPH E

Inventor： TREADO PATRICK J ,  MAIER JOHN S ,  COHEN JEFFREY K ,  DEMUTH JOSEPH E

IPC: A61B5/00

CPC classification number: G06F19/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4519

Abstract: The invention relates to methods and devices for assessing one or more components of blood or a selected tissue in an animal. The present invention permits non-invasive assessment of blood or tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the blood or the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood or tissue component for one or more regions that exhibit the optical characteristic of the blood or the tissue of interest.

Abstract translation: 本发明涉及用于评估动物中血液或选定组织的一种或多种成分的方法和装置。 本发明允许通过针对血液或感兴趣组织的光学特性评估动物身体的多个区域并分别评估一个或多个光学（例如， 拉曼或NIR）特征的一个或多个区域，其显示血液或目标组织的光学特性。

公开(公告)号：WO2006083316A3

公开(公告)日：2006-08-10

申请号：PCT/US2005/023310

申请日：2005-06-30

Applicant: CHEMIMAGE CORPORATION ,  TREADO, Patrick ,  DEMUTH, Joseph E. ,  SCHWEITZER, Robert

Inventor： TREADO, Patrick ,  DEMUTH, Joseph E. ,  SCHWEITZER, Robert

IPC: G01N30/00

Abstract: The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

公开(公告)号：WO2006007064A3

公开(公告)日：2006-04-20

申请号：PCT/US2005016141

申请日：2005-05-06

Applicant: CHEMIMAGE CORP ,  STEWART SHONA ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E ,  TREADO PATRICK J

Inventor： STEWART SHONA ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E ,  TREADO PATRICK J

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/0297 ,  G01N21/65

Abstract: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

Abstract translation: 本公开涉及一种用于改进的光学成像光谱术的拉曼光谱表征的生物材料的检测，分辨率和成像的基底材料。 基材提供均匀的，光学平坦的高度反射表面，其可以制成疏水性的，以防止样品扩散并促进其光学评估。 此外，衬底可以涂覆有当暴露于所述照射光子时不发射拉曼散射光子的材料。 本文公开的原理允许特别适用于检查小样品或具有低浓度可疑成分的样品的低光谱背景。

公开(公告)号：WO2006028688A3

公开(公告)日：2006-03-16

申请号：PCT/US2005/029745

申请日：2005-08-19

Applicant: CHEMIMAGE CORPORATION ,  TUSCHEL, David ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E.

Inventor： TUSCHEL, David ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E.

IPC: G02B6/04 ,  G02B6/06 ,  G01J3/44

Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber (14) for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror (30) disposed at said distal end of the fiberscope such that the light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber (38) for receiving light from said illuminated sample and transmitting the received light to an optical device.