公开(公告)号：WO2007120996A3

公开(公告)日：2008-10-30

申请号：PCT/US2007063344

申请日：2007-03-05

Applicant: CHEMIMAGE CORP ,  GARDNER CHARLES W ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PARTRICK J ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H ,  WANG CHENHUI

Inventor： GARDNER CHARLES W ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PARTRICK J ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H ,  WANG CHENHUI

IPC: G01J3/44 ,  G01J3/28 ,  G01J3/45

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2201/0221

Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

Abstract translation: 本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像 使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

公开(公告)号：WO2007120996A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/063344

申请日：2007-03-05

Applicant: CHEMIMAGE CORPORATION ,  GARDNER, Charles, W. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Partrick, J. ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H. ,  WANG, Chenhui

Inventor： GARDNER, Charles, W. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Partrick, J. ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H. ,  WANG, Chenhui

IPC: G01J3/44 ,  G01J3/45

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2823 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2201/0221

Abstract: The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

Abstract translation: 本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像 使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

公开(公告)号：WO2007101279A2

公开(公告)日：2007-09-07

申请号：PCT/US2007/063348

申请日：2007-03-05

Applicant: CHEMIMAGE CORPORATION ,  GARDNER, Charles, W. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Patrick, J. ,  WANG, Chenhul ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H.

Inventor： GARDNER, Charles, W. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Patrick, J. ,  WANG, Chenhul ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H.

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32 ,  G01J3/36 ,  G01J3/447 ,  G01N21/65 ,  G01N2201/0846

Abstract: The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

Abstract translation: 本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质 具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

公开(公告)号：WO2007055981A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/042538

申请日：2006-11-01

Applicant: CHEMIMAGE CORPORATION ,  TREADO, Patrick, J. ,  MAIER, John, S. ,  COHEN, Jeffrey, K. ,  DEMUTH, Joseph, E.

Inventor： TREADO, Patrick, J. ,  MAIER, John, S. ,  COHEN, Jeffrey, K. ,  DEMUTH, Joseph, E.

IPC: A61B5/00

CPC classification number: G06F19/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4519

Abstract: The invention relates to methods and devices for assessing one or more components of blood or a selected tissue in an animal. The present invention permits non-invasive assessment of blood or tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the blood or the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood or tissue component for one or more regions that exhibit the optical characteristic of the blood or the tissue of interest.

Abstract translation: 本发明涉及用于评估动物中血液或选定组织的一种或多种组分的方法和装置。 本发明通过评估动物身体的多个区域以获得血液或感兴趣的组织的光学特征，并且分别评估一种或多种光学（例如，血液或组织）的身体结构中的血液或组织成分的非侵入性评估。 ，拉曼或NIR）特征，其表现出血液或感兴趣的组织的光学特征的一个或多个区域。

公开(公告)号：WO2007101279A3

公开(公告)日：2008-05-08

申请号：PCT/US2007063348

申请日：2007-03-05

Applicant: CHEMIMAGE CORP ,  GARDNER CHARLES W ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PATRICK J ,  WANG CHENHUL ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H

Inventor： GARDNER CHARLES W ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PATRICK J ,  WANG CHENHUL ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32 ,  G01J3/36 ,  G01J3/447 ,  G01N21/65 ,  G01N2201/0846

Abstract: The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.

Abstract translation: 本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质 具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

公开(公告)号：WO2007103897A2

公开(公告)日：2007-09-13

申请号：PCT/US2007/063346

申请日：2007-03-05

Applicant: CHEMIMAGE CORPORATION ,  GARDNER, Charles, W., JR. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Patrick, J. ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H. ,  WANG, Chenhui

Inventor： GARDNER, Charles, W., JR. ,  MAIER, John, S. ,  NELSON, Matthew, P. ,  SCHWEITZER, Robert, C. ,  TREADO, Patrick, J. ,  VANNI, G., Steven ,  WOLFE, Julianne ,  DEMUTH, Joseph, E. ,  NEISS, Jason, H. ,  WANG, Chenhui

IPC: G06F19/00

CPC classification number: G01N21/65 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2201/0221

Abstract: The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

Abstract translation: 本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。 公开了采用拉曼光谱法和其他分光光度法的方法。 还公开了适于执行这种多点方法的设备和系统。

公开(公告)号：WO2006083316A2

公开(公告)日：2006-08-10

申请号：PCT/US2005023310

申请日：2005-06-30

Applicant: CHEMIMAGE CORP ,  TREADO PATRICK ,  DEMUTH JOSEPH E ,  SCHWEITZER ROBERT

Inventor： TREADO PATRICK ,  DEMUTH JOSEPH E ,  SCHWEITZER ROBERT

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J3/32 ,  G01N21/6456 ,  G01N21/65

Abstract: The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

Abstract translation: 本发明涉及通过对样品进行多点光谱分析来评估样品中危险剂的发生的装置和方法。 公开了采用拉曼光谱法和其他分光光度法的方法。 还公开了适于执行这种多点方法的设备和系统。

公开(公告)号：WO2006028688A2

公开(公告)日：2006-03-16

申请号：PCT/US2005029745

申请日：2005-08-19

Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E

Inventor： TUSCHEL DAVID ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E

IPC: G02B6/06 ,  G01J3/44

CPC classification number: A61B1/00165 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1213 ,  G01N21/33 ,  G01N21/359 ,  G01N21/474 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/3155 ,  G01N2021/4742 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2021/656 ,  G02B6/06 ,  G02B6/29398 ,  G02B23/2423 ,  G02B23/2469

Abstract: The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.

Abstract translation: 本发明一般涉及一种纤维镜的方法和装置。 在一个实施方案中，本公开涉及一种用于从具有至少一个照明光纤的样品成像和收集光谱的化学成像光纤镜，用于将光从第一光源发射到纤维内窥镜的远端; 分光镜，设置在所述纤维内窥镜的所述远端处，使得来自所述第一光源的光基本上直线穿过所述反射镜，并且来自所述第二光源的预定波长的光被所述反射镜基本上反射到所述样品，从而照亮所述样品 ; 以及至少一个收集光纤，用于接收来自所述被照亮样品的光，并将所接收的光传输到光学装置。

公开(公告)号：WO2006007064A2

公开(公告)日：2006-01-19

申请号：PCT/US2005/016141

申请日：2005-05-06

Applicant: CHEMIMAGE CORPORATION ,  STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

Inventor： STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/0297 ,  G01N21/65

Abstract: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

Abstract translation: 本公开涉及用于通过光学成像光谱的拉曼的光谱表征的生物材料的改进的检测，分辨和成像的基底材料。 衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。 此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。 本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。

公开(公告)号：WO2007103897A3

公开(公告)日：2008-07-10

申请号：PCT/US2007063346

申请日：2007-03-05

Applicant: CHEMIMAGE CORP ,  GARDNER CHARLES W JR ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PATRICK J ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H ,  WANG CHENHUI

Inventor： GARDNER CHARLES W JR ,  MAIER JOHN S ,  NELSON MATTHEW P ,  SCHWEITZER ROBERT C ,  TREADO PATRICK J ,  VANNI G STEVEN ,  WOLFE JULIANNE ,  DEMUTH JOSEPH E ,  NEISS JASON H ,  WANG CHENHUI

IPC: G01J3/44 ,  G01J3/28

CPC classification number: G01N21/65 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2201/0221

Abstract: The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

Abstract translation: 本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。 公开了采用拉曼光谱法和其他分光光度法的方法。 还公开了适于执行这种多点方法的设备和系统。