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    11.
    发明专利
    未知

    公开(公告)号：DE60223370D1

    公开(公告)日：2007-12-20

    申请号：DE60223370

    申请日：2002-05-16

    Applicant: GUAVA TECHNOLOGIES INC

    Inventor： KOCHY THOMAS E ,  O'NEILL ROGER A ,  SMILEY TERAH W ,  SMITH VIDAL O

    IPC: G01N15/14 ,  G01N21/64

    Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.

    15.
    发明专利
    未知

    公开(公告)号：AT377750T

    公开(公告)日：2007-11-15

    申请号：AT02739288

    申请日：2002-05-16

    Applicant: GUAVA TECHNOLOGIES INC

    Inventor： KOCHY THOMAS ,  O'NEILL ROGER ,  SMILEY TERAH ,  SMITH VIDAL

    IPC: G01N15/14 ,  G01N21/64

    Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.

    METHOD AND APPARATUS FOR DETECTING MICROPARTICLES IN FLUID SAMPLES
    16.
    发明专利
    METHOD AND APPARATUS FOR DETECTING MICROPARTICLES IN FLUID SAMPLES 未知

    公开(公告)号：CA2293426C

    公开(公告)日：2007-05-15

    申请号：CA2293426

    申请日：1998-06-09

    Applicant: GUAVA TECHNOLOGIES INC

    Inventor： GOIX PHILIPPE

    IPC: G01N21/64 ,  G01N15/14 ,  G01N33/48

    Abstract: A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle past a a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle, and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.

    DIFFERENTIATION OF FLOW CYTOMETRY PULSES AND APPLICATIONS
    19.
    发明申请
    DIFFERENTIATION OF FLOW CYTOMETRY PULSES AND APPLICATIONS 审中-公开
    流动细胞计数脉冲和应用的差异

    公开(公告)号：WO2008042718A3

    公开(公告)日：2008-12-11

    申请号：PCT/US2007079761

    申请日：2007-09-27

    Applicant: GUAVA TECHNOLOGIES INC ,  PITTARO RICHARD ,  GOLDMAN BRUCE ,  LEFEBVRE RAY ,  KING DAVID A

    Inventor： PITTARO RICHARD ,  GOLDMAN BRUCE ,  LEFEBVRE RAY ,  KING DAVID A

    IPC: G01P3/36 ,  G01F1/36

    CPC classification number: G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

    Abstract: A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

    Abstract translation: 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

    ASYMMETRIC CAPILLARY FOR CAPILLARY-FLOW CYTOMETERS
    20.
    发明申请
    ASYMMETRIC CAPILLARY FOR CAPILLARY-FLOW CYTOMETERS 审中-公开
    毛细管流式细胞仪的不对称毛细管

    公开(公告)号：WO2007121179A3

    公开(公告)日：2008-07-24

    申请号：PCT/US2007066331

    申请日：2007-04-10

    Applicant: GUAVA TECHNOLOGIES INC ,  ILKOV FEDOR A

    Inventor： ILKOV FEDOR A

    IPC: G01N21/00

    CPC classification number: G01N15/1404 ,  G01N2015/0053 ,  G01N2015/1415

    Abstract: The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.

    Abstract translation: 本发明提供改进的毛细血管，其导致常规毛细血管流式细胞仪中分辨率的提高。 根据本发明制造的毛细管的横截面形状缺乏对称中心。 在一些实施例中，毛细管具有相对于收集系统光轴以角度倾斜的内侧壁，使得内孔的最宽尺寸最靠近收集光学系统并且具有最靠近收集光学系统的外壁 其尺寸足够大以最小化外壁折射对所收集的光信号的贡献。 示例性毛细管实施例包括具有矩形外壁和梯形内壁，矩形外壁和三角形内壁，三角形外壁和内壁，具有梯形内壁的三角形外壁和半球形或菱形外壁的管，以及 梯形或三角形内壁。

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