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11.发明授权公开(公告)号：US10167487B2
公开(公告)日：2019-01-01
申请号：US15238234
申请日：2016-08-16
Applicant: INVISTA North America S.à.r.l.
Inventor： Alex Van Eck Conradie
Abstract: This application describes methods, including non-naturally occurring methods, for biosynthesizing 3-hydroxy-3-methylglutaryl-coA and intermediates thereof, as well as non-naturally occurring hosts for producing 3-hydroxy-3-methylglutaryl-coA. This application also describes methods, including non-naturally occurring methods, for biosynthesizing isoprene and intermediates thereof, as well as non-naturally occurring hosts for producing isoprene.
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12.发明申请METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION 审中-公开通过碳链修饰生物合成多功能，多变量分子的方法和材料
公开(公告)号：WO2018022633A8
公开(公告)日：2018-02-01
申请号：PCT/US2017/043750
申请日：2017-07-25
Inventor： FOSTER, Alexander, Brett , CARTMAN, Stephen, Thomas , KENNEDY, Jonathan , SIMMONS, William, Joseph
Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.
Abstract translation: 该文献描述了通过形成两个末端官能团在体外或在重组宿主中或在其盐或衍生物中生成具有奇数个碳原子的双官能团产物的生物化学途径，所述两个末端官能团选自羧基，胺 （i）乙酰-CoA和丙二酰-CoA通过一个或多个甲酯保护的碳链延长循环或（ii）丙二酰 - [（甲基丙烯酰氧基）丙酸]合成的具有奇数碳原子的脂族碳链骨架中的羟基，甲酰基和羟基， 通过一个或多个甲基酯屏蔽碳链延伸的循环来进行。 本文描述的生物化学途径和代谢工程以及培养策略依赖于接受甲基酯保护的脂肪族碳链主链并维持用于至少一个进一步的酶促步骤的甲基酯屏蔽的酶或同系物，所述甲基酯屏蔽碳链延长的一个或多个循环之后。
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公开(公告)号：WO2014179035A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/034111
申请日：2014-04-15
Inventor： MICKA, Thomas A. , KELMAN, Charles R. , POINSATTE, John P. , WEST, Gary R.
Abstract: A side stream compounding unit is coupled to a continuous polyamide manufacturing system and is configured to divert polyamide from the manufacturing system, mixes additive with polyamide, and then return the polyamide-additive mixture to a main stream of polyamide in the manufacturing system.
Abstract translation: 侧流配合单元连接到连续的聚酰胺制造系统，并且构造成从制造系统中转移聚酰胺，将添加剂与聚酰胺混合，然后在制造系统中将聚酰胺 - 添加剂混合物返回到主要聚酰胺流。
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14.发明申请PROCESS FOR PRODUCING C7 COMPOUNDS STARTING FROM 9-HYDROPEROXIDIZED LINOLEIC ACID 审中-公开由9-氢化氧化亚油酸开始生产C7化合物的方法
公开(公告)号：WO2017136344A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/015842
申请日：2017-01-31
CPC classification number: C12P7/40 , C07C47/21 , C07C59/147 , C08G69/10 , C08G69/26 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12N9/90 , C12P7/04 , C12P7/24 , C12P7/42 , C12P7/46 , C12P7/50 , C12P7/6409 , C12P7/6427 , C12P13/001 , C12P17/182 , C12Y102/99006 , C12Y103/01031 , C12Y203/01032 , C12Y206/01018 , C12Y305/01 , C12Y402/99 , C12Y503/03008
Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9- oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase , a CoA ligase , an isomerase , a reductase , a thioesterase , a monooxygenase , a hydratase , and/or a thiolase . Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.
Abstract translation: 该文件描述了使用具有过氧化氢裂合酶酶活性的多肽从9-氧代癸酸形成非3-烯醛和9-氧代壬酸产生庚二酰-CoA的生物化学途径， hydroxyperoxyoctadec-10,12二烯酸酯。 可使用一种或多种具有脱氢酶活性，CoA连接酶活性的多肽将非3-烯醇和9-氧代壬酸酯酶促转化为庚二酰-CoA或其盐， ，一种异构酶，一种还原酶，一种硫酯酶，一种单加氧酶，一种水合酶， ，和/或硫解酶。 庚二酰-CoA可以酶促转化为庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇，或其相应的盐。 该文献还描述了产生庚二酰-CoA以及庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇或其相应盐的重组微生物。
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公开(公告)号：WO2016085816A1
公开(公告)日：2016-06-02
申请号：PCT/US2015/061892
申请日：2015-11-20
Inventor： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
CPC classification number: C12N9/0071 , C07C47/12 , C07C47/19 , C07C49/185 , C07C223/02 , C07C229/08 , C07C229/12 , C12N9/0008 , C12N9/0073 , C12N9/18 , C12N9/20 , C12P7/42 , C12P7/44 , C12P7/6409 , C12Y114/13 , C12Y114/14001 , C12Y301/01001 , C12Y301/01003
Abstract: This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a monooxygenase to form a 7-hydroxyoctanoate intermediate, which can be converted to 6-hydroxyhexanoate using a polypeptide having monooxygenase , secondary alcohol dehydrogenase , or esterase activity. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
Abstract translation: 该文献描述了使用单加氧酶形成7-羟基辛酸酯中间体生产6-羟基己酸的生物化学途径，其可以使用具有单加氧酶，仲醇脱氢酶或酯酶活性的多肽转化为6-羟基己酸酯。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。 该文献还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。
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Patent Agency Ranking16.发明申请METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION 审中-公开通过碳链修饰生物合成多功能，多变量分子的方法和材料
公开(公告)号：WO2018022633A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043750
申请日：2017-07-25
Inventor： FOSTER, Alexander, Brett , CARTMAN, Stephen, Thomas , KENNEDY, Jonathan , SIMMONS, William, Joseph
CPC classification number: C12P7/62 , C07C47/12 , C07C47/19 , C07C55/16 , C07C59/147 , C07C223/02 , C07C225/06 , C07C229/08 , C12N9/0006 , C12N9/1096 , C12N9/16 , C12N9/88 , C12N15/09 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/625 , C12P7/6409 , C12P13/001 , C12P13/005 , C12Y101/01035 , C12Y101/01061 , C12Y101/01258 , C12Y301/02 , C12Y402/01017
Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation, The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.
Abstract translation: 该文献描述了通过形成两个末端官能团在体外或在重组宿主中或在其盐或衍生物中生成具有奇数个碳原子的双官能团产物的生物化学途径，所述两个末端官能团选自羧基，胺 （i）乙酰-CoA和丙二酰-CoA通过一个或多个甲酯保护的碳链延长循环或（ii）丙二酰 - [（甲基丙烯酰氧基）丙酸]合成的具有奇数碳原子的脂族碳链骨架中的羟基，甲酰基和羟基， 通过一个或多个循环的甲基酯屏蔽碳链延长，本文描述的生物化学途径和代谢工程以及培养策略依赖于接受甲基酯保护的脂肪族碳链主链并维持甲酯屏蔽至少一个的酶或同系物 经过一个或多个甲基酯屏蔽碳链延长循环后的酶促步骤。
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公开(公告)号：WO2014179037A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/034123
申请日：2014-04-15
Inventor： MICKA, Thomas A. , KELMAN, Charles R. , WEST, Gary R.
IPC: C08G69/28 , C08G69/04 , B24B31/116
CPC classification number: C08G69/04 , B24B31/116 , C08G69/28
Abstract: Described herein are methods of preparing high molecular weight polyamides which reduce or eliminate the production of unwanted gels during the production process. These methods reduce the formation of undesired polyamide gel by polishing the internal surfaces of the production equipment, thereby providing surfaces with smaller surface roughness values.
Abstract translation: 本文描述的是制备高分子量聚酰胺的方法，其在生产过程中减少或消除不想要的凝胶的产生。 这些方法通过抛光生产设备的内表面来减少不期望的聚酰胺凝胶的形成，从而提供具有较小表面粗糙度值的表面。
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18.发明申请MATERIALS AND METHODS FOR THE BIOSYNTHESIS OF SEVEN CARBON CHEMICALS IN THE PRESENCE OF METHANOL OXIDATION 审中-公开在甲醇氧化存在条件下七种碳化合物生物合成的材料和方法
公开(公告)号：WO2018022613A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043712
申请日：2017-07-25
Abstract: This disclosure describes methods for regulating the biosynthesis of pimelic acid, 7-arninoheptanoate, 7-hydroxyheptanoate, heptamethyJenediamine, 7-aminoheptanol, or 1,7-heptanedioi by channeling increased flux through the biosynthesis pathway to obtain an intermediate required for growth of the host microorganism.
Abstract translation: 本公开内容描述了通过提高通过生物合成途径的通量来调节庚二酸，7-氨基庚酸，7-羟基庚酸，七甲基二胺，7-氨基庚醇或1,7-庚二醇的生物合成的方法，以获得 宿主微生物生长所需的中间体。
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公开(公告)号：WO2016138498A2
公开(公告)日：2016-09-01
申请号：PCT/US2016/019966
申请日：2016-02-26
Applicant: INVISTA NORTH AMERICA S.À.R.L.
Inventor： BOTES, Adriana, L. , KADI, Nadia
IPC: C07K14/435
CPC classification number: C12N9/88 , A61K31/01 , C07C11/167 , C07C11/18 , C07C11/21 , C07K16/40 , C08F136/06 , C08F136/08 , C08F136/22 , C11B9/0007 , C12P5/026 , C12Y402/01 , C12Y402/01127
Abstract: The present disclosure provides novel polypeptides with improved 3-buten-2- ol dehydratase activity, polypeptides with improved linalool dehydratase activity, and polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene. Methods of making and using the polypeptides are also provided.
Abstract translation: 本公开提供了具有改善的3-丁烯-2-醇脱水酶活性的新型多肽，具有改进的芳樟醇脱水酶活性的多肽，以及在将3-甲基-3-丁烯-2-醇转化为异戊二烯时具有催化活性的多肽。 还提供了制备和使用多肽的方法。
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公开(公告)号：EP2794047A1
公开(公告)日：2014-10-29
申请号：EP12795271.1
申请日：2012-11-20
Applicant: INVISTA North America S.à.r.l.
Inventor： TENN, William, J.
CPC classification number: C07F15/045 , B01D11/0426 , B01D11/0457 , B01J23/755 , B01J31/185 , B01J31/26 , B01J31/4053 , C07F9/141 , C07F9/145 , C07F9/65746 , Y02P20/582
Abstract: Disclosed herein are methods for recovering diphosphite-containing compounds from mixtures comprising organic mononitriles and organic dinitriles, using liquid-liquid extraction. Also disclosed are pre-treatments to enhance extractability of the diphosphite-containing compounds.
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